{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:20Z","timestamp":1791352220471,"version":"4.3.1"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060099"],"award-info":[{"award-number":["82060099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760091"],"award-info":[{"award-number":["81760091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800380"],"award-info":[{"award-number":["81800380"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chronic stress severely impairs physical and mental health and is a critical risk factor for cardiovascular diseases. Formononetin (FMN) has shown promising cardiovascular protective effects, yet its functional role and molecular mechanism in chronic stress-triggered arterial neointimal hyperplasia and concomitant mood disturbances remain poorly elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Network pharmacology was used to predict the underlying mechanisms of FMN against cardiovascular disease-depression comorbidity. A dual mouse model recapitulating chronic stress and carotid artery injury was established for\n                      <jats:italic>in vivo<\/jats:italic>\n                      validation. Histological staining, behavioral tests, Western blotting,\n                      <jats:italic>\u03b2<\/jats:italic>\n                      -galactosidase staining, and\n                      <jats:italic>in vitro<\/jats:italic>\n                      VSMC assays were performed to assess the effects of FMN and the HDAC6 inhibitor TubA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Network pharmacology identified 111 overlapping targets, with functional enrichment and molecular docking revealing that FMN primarily regulates inflammation, apoptosis, and autophagy via binding to core hub proteins including HDAC6, Bcl-2, and AKT1.\n                      <jats:italic>In vivo<\/jats:italic>\n                      , chronic stress aggravated arterial intimal hyperplasia and aortic senescence, and induced anxiety- and depression-like behaviors. FMN treatment notably improved emotional disorders, reduced HDAC6 expression, activated autophagy (increased LC3B\/A ratio), inhibited apoptosis (elevated Bcl-2\/Bax ratio), attenuated NLRP3 and IL-6 expression, and alleviated intimal thickening. The HDAC6 inhibitor TubA recapitulated the vascular protective effects of FMN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>FMN attenuates chronic stress-induced vascular injury and emotional dysfunction via suppressing HDAC6 signaling to restore autophagy, inhibit inflammation, and reduce apoptosis. This study unveils the dual cardio-neuroprotective capacities of FMN and provides novel mechanistic insights for the treatment of chronic stress-related cardiocerebral comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1865656","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:53:44Z","timestamp":1791348824000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Formononetin relieves chronic stress-related neointimal hyperplasia in mice by regulating HDAC6"],"prefix":"10.3389","volume":"13","author":[{"given":"Shanqian","family":"Li","sequence":"first","affiliation":[{"name":"The School of Public Health, Guilin Medical University","place":["Guilin, Guangxi, China"]},{"name":"Key Cultivation Laboratory of Life Cycle Health Care Research","place":["Guilin, Guangxi, China"]},{"name":"Guangxi Key Laboratory of Environmental Exposures and Whole Life Cycle Health","place":["Guilin, Guangxi, China"]},{"name":"Department of Clinical Nutrition, Liuzhou Workers\u2019 Hospital","place":["Liuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhua","family":"Wu","sequence":"additional","affiliation":[{"name":"The School of Public Health, Guilin Medical University","place":["Guilin, Guangxi, China"]},{"name":"Key Cultivation Laboratory of Life Cycle Health Care Research","place":["Guilin, Guangxi, China"]},{"name":"Guangxi Key Laboratory of Environmental Exposures and Whole Life Cycle Health","place":["Guilin, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaozhi","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Artificial Intelligent Medicine, Guilin Medical University","place":["Guilin, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixian","family":"Wu","sequence":"additional","affiliation":[{"name":"The School of Public Health, Guilin Medical University","place":["Guilin, Guangxi, China"]},{"name":"Key Cultivation Laboratory of Life Cycle Health Care Research","place":["Guilin, Guangxi, China"]},{"name":"Guangxi Key Laboratory of Environmental Exposures and Whole Life Cycle Health","place":["Guilin, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Ding","sequence":"additional","affiliation":[{"name":"The School of Public Health, Guilin Medical University","place":["Guilin, Guangxi, China"]},{"name":"Key Cultivation Laboratory of Life Cycle Health Care Research","place":["Guilin, Guangxi, China"]},{"name":"Guangxi Key Laboratory of Environmental Exposures and Whole Life Cycle Health","place":["Guilin, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Communicable Disease Control Branch, Qingdao Municipal Center for Disease Control and Prevention","place":["Qingdao, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Second People\u2019s Hospital of Ya'an City","place":["Ya'an, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meimei","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Health and Hygiene, Beihai Health and Wellness Vocational College","place":["Beihai, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Hu","sequence":"additional","affiliation":[{"name":"The School of Public Health, Guilin Medical University","place":["Guilin, Guangxi, China"]},{"name":"Key Cultivation Laboratory of Life Cycle Health Care Research","place":["Guilin, Guangxi, China"]},{"name":"Guangxi Key Laboratory of Environmental Exposures and Whole Life Cycle Health","place":["Guilin, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e010931","DOI":"10.1161\/CIRCIMAGING.120.010931","article-title":"Disentangling the links between psychosocial stress and cardiovascular disease","volume":"13","author":"Osborne","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"key":"B2","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.tem.2016.04.007","article-title":"The dichotomous effect of chronic stress on obesity","volume":"27","author":"Razzoli","year":"2016","journal-title":"Trends Endocrinol Metab"},{"key":"B3","doi-asserted-by":"publisher","first-page":"4121173","DOI":"10.1155\/2022\/4121173","article-title":"Recent progress of chronic stress in the development of atherosclerosis","volume":"2022","author":"Gao","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1111\/brv.12750","article-title":"Chronic stress and Alzheimer\u2019s disease: the\u2009interplay between the hypothalamic-pituitary-adrenal axis, genetics and microglia","volume":"96","author":"Milligan","year":"2021","journal-title":"Biol Rev Camb Philos Soc"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1001\/jama.298.14.1722","article-title":"JAMA Patient page chronic stress and the heart","volume":"298","author":"Torpy","year":"2007","journal-title":"JAMA"},{"key":"B6","doi-asserted-by":"publisher","first-page":"738252","DOI":"10.3389\/fonc.2021.738252","article-title":"Chronic stress effects on tumor: pathway and mechanism","volume":"11","author":"Hong","year":"2021","journal-title":"Front Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3389\/fpsyt.2019.00200","article-title":"Impacts of psychological stress on osteoporosis: clinical implications and treatment interactions","volume":"10","author":"Kelly","year":"2019","journal-title":"Front Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5334\/gh.1288","article-title":"The heart of the world","volume":"19","author":"Di Cesare","year":"2024","journal-title":"Glob Heart"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990\u20132019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.1016\/S0140-6736(23)02117-7","article-title":"Impact of the COVID-19 pandemic on delayed care of cardiovascular diseases in Europe: a systematic review","volume":"402","author":"Khan","year":"2023","journal-title":"Lancet"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1007\/s12272-021-01360-4","article-title":"Role of mitochondrial dynamics and mitophagy of vascular smooth muscle cell proliferation and migration in progression of atherosclerosis","volume":"44","author":"Huynh","year":"2021","journal-title":"Arch Pharm Res"},{"key":"B12","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.wneu.2019.02.065","article-title":"Risk factors for restenosis after carotid revascularization: a meta-analysis of hazard ratios","volume":"125","author":"Texakalidis","year":"2019","journal-title":"World Neurosurg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1161\/ATVBAHA.115.307110","article-title":"Cathepsin S activity controls injury-related vascular repair in mice via the TLR2-mediated p38MAPK and PI3K-akt\/p-HDAC6 signaling pathway","volume":"36","author":"Wu","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s42255-021-00515-3","article-title":"Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity","volume":"4","author":"\u00c7ak\u0131r","year":"2022","journal-title":"Nat Metab"},{"key":"B15","doi-asserted-by":"publisher","first-page":"eaas8995","DOI":"10.1126\/science.aas8995","article-title":"HDAC6 Mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation","volume":"369","author":"Magupalli","year":"2020","journal-title":"Science"},{"key":"B16","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.cca.2020.01.006","article-title":"Autophagy in chronic stress induced atherosclerosis","volume":"503","author":"Li","year":"2020","journal-title":"Clin Chim Acta"},{"key":"B17","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1146\/annurev-immunol-090222-105848","article-title":"Genetic regulation of cell death: insights from autoinflammatory diseases","volume":"43","author":"Oda","year":"2025","journal-title":"Annu Rev Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1493981","DOI":"10.3389\/fphar.2025.1493981","article-title":"Acacetin as a natural cardiovascular therapeutic: mechanisms and preclinical evidence","volume":"16","author":"Zhou","year":"2025","journal-title":"Front Pharmacol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1080\/14786419.2019.1693563","article-title":"Network pharmacology predicted HDAC6 as a potential target of flavones from Daphne giraldii on hepatocellular carcinoma","volume":"35","author":"Chen","year":"2021","journal-title":"Nat Prod Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3892\/ijmm.2020.4805","article-title":"Formononetin protects against cisplatin-induced acute kidney injury through activation of the PPAR\u03b1\/Nrf2\/HO-1\/NQO1 pathway","volume":"47","author":"Hao","year":"2021","journal-title":"Int J Mol Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"4273","DOI":"10.12659\/MSM.916662","article-title":"Pharmacological targets and the biological mechanisms of formononetin for Alzheimer\u2019s disease: a network analysis","volume":"25","author":"Xiao","year":"2019","journal-title":"Med Sci Monit"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.7150\/thno.38115","article-title":"Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE(-\/-) mice","volume":"10","author":"Ma","year":"2020","journal-title":"Theranostics"},{"key":"B23","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/fsn3.3761","article-title":"(-)-Epigallocatechin gallate alleviates chronic unpredictable mild stress-induced depressive symptoms in mice by regulating the mTOR autophagy pathway and inhibiting NLRP3 inflammasome activation","volume":"12","author":"Zhang","year":"2024","journal-title":"Food Sci Nutr"},{"key":"B24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/ame2.12107","article-title":"Optimization of food deprivation and sucrose preference test in SD rat model undergoing chronic unpredictable mild stress","volume":"3","author":"He","year":"2020","journal-title":"Animal Model Exp Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/s41398-021-01747-3","article-title":"Exercise rather than fluoxetine promotes oligodendrocyte differentiation and myelination in the hippocampus in a male mouse model of depression","volume":"11","author":"Tang","year":"2021","journal-title":"Transl Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"3768","DOI":"10.1038\/s41467-019-11641-8","article-title":"Activating newborn neurons suppresses depression and anxiety-like behaviors","volume":"10","author":"Tunc-Ozcan","year":"2019","journal-title":"Nat Commun"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e011994","DOI":"10.1161\/JAHA.119.011994","article-title":"Cathepsin S deficiency mitigated chronic stress-related neointimal hyperplasia in mice","volume":"8","author":"Wang","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"B28","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s12026-014-8517-0","article-title":"Effects of stress on immune function: the good, the bad, and the beautiful","volume":"58","author":"Dhabhar","year":"2014","journal-title":"Immunol Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3390\/biom12030430","article-title":"The mechanisms of restenosis and relevance to next generation stent design","volume":"12","author":"Clare","year":"2022","journal-title":"Biomolecules"},{"key":"B30","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.ijcard.2017.05.062","article-title":"Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress","volume":"243","author":"Lei","year":"2017","journal-title":"Int J Cardiol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e006421","DOI":"10.1161\/JAHA.117.006421","article-title":"Chronic psychological stress accelerates vascular senescence and impairs ischemia-induced neovascularization: the role of dipeptidyl peptidase-4\/glucagon-like peptide-1-adiponectin axis","volume":"6","author":"Piao","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2017.07.014","article-title":"Exenatide mitigated diet-induced vascular aging and atherosclerotic plaque growth in ApoE-deficient mice under chronic stress","volume":"264","author":"Yang","year":"2017","journal-title":"Atherosclerosis"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1111\/bph.14938","article-title":"Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3\/NF-\u03baB pathway in mice","volume":"177","author":"Wang","year":"2020","journal-title":"Br J Pharmacol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1161\/HYPERTENSIONAHA.122.19137","article-title":"Cathepsin K deficiency prevented kidney damage and dysfunction in response to 5\/6 nephrectomy injury in mice with or without chronic stress","volume":"79","author":"Yue","year":"2022","journal-title":"Hypertension"},{"key":"B35","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.iccl.2015.12.006","article-title":"In-stent restenosis","volume":"5","author":"Lee","year":"2016","journal-title":"Interv Cardiol Clin"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1161\/CIRCULATIONAHA.119.045115","article-title":"High-Resolution transcriptomic profiling of the heart during chronic stress reveals cellular drivers of cardiac fibrosis and hypertrophy","volume":"142","author":"McLellan","year":"2020","journal-title":"Circulation"},{"key":"B37","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jep.2010.11.047","article-title":"Vasorelaxant and antihypertensive effect of Cocos nucifera linn. Endocarp on isolated rat thoracic aorta and DOCA salt-induced hypertensive rats","volume":"134","author":"Bankar","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"905898","DOI":"10.3389\/fphar.2022.905898","article-title":"Focusing on formononetin: recent perspectives for its neuroprotective potentials","volume":"13","author":"Tian","year":"2022","journal-title":"Front Pharmacol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.canlet.2018.05.038","article-title":"Formononetin-induced oxidative stress abrogates the activation of STAT3\/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model","volume":"431","author":"Kim","year":"2018","journal-title":"Cancer Lett"},{"key":"B40","article-title":"Association of cathepsin K with sex-related neointimal hyperplasia in chronic stress-induced mice (Master's thesis)","author":"Hu","year":"2021"},{"key":"B41","doi-asserted-by":"publisher","first-page":"3946320221111117","DOI":"10.1177\/03946320221111117","article-title":"Formononetin regulates endothelial nitric oxide synthase to protect vascular endothelium in deep vein thrombosis rats","volume":"36","author":"Zhou","year":"2022","journal-title":"Int J Immunopathol Pharmacol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1002\/jcb.10431","article-title":"Expression of interleukin-1 beta and interleukin-1 receptor antagonist in oxLDL-treated human aortic smooth muscle cells and in the neointima of cholesterol-fed endothelia-denuded rabbits","volume":"88","author":"Lin","year":"2003","journal-title":"J Cell Biochem"},{"key":"B43","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.cardiores.2004.02.002","article-title":"Cathepsin S expression is up-regulated following balloon angioplasty in the hypercholesterolemic rabbit","volume":"62","author":"Burns-Kurtis","year":"2004","journal-title":"Cardiovasc Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"115799","DOI":"10.1016\/j.biopha.2023.115799","article-title":"Formononetin ameliorates airway inflammation by suppressing ESR1\/NLRP3\/caspase-1 signaling in asthma","volume":"168","author":"Zhang","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"B45","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s10142-023-01247-1","article-title":"Formononetin ameliorates the LPS-induced inflammatory response and apoptosis of neuronal cells via NF-\u03baB\/NLRP3 signaling pathway","volume":"23","author":"Zhou","year":"2023","journal-title":"Funct Integr Genomics"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e111389","DOI":"10.15252\/embj.2022111389","article-title":"The lysosomal ragulator complex activates NLRP3 inflammasome in vivo via HDAC6","volume":"42","author":"Tsujimoto","year":"2023","journal-title":"EMBO J"},{"key":"B47","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.3892\/mmr.2018.9544","article-title":"Formononetin may protect aged hearts from ischemia\/reperfusion damage by enhancing autophagic degradation","volume":"18","author":"Huang","year":"2018","journal-title":"Mol Med Rep"},{"key":"B48","doi-asserted-by":"publisher","first-page":"108214","DOI":"10.1016\/j.jnutbio.2019.07.005","article-title":"Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy","volume":"73","author":"Wang","year":"2019","journal-title":"J Nutr Biochem"},{"key":"B49","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.dnarep.2018.07.008","article-title":"Multiple functions of p27 in cell cycle, apoptosis, epigenetic modification and transcriptional regulation for the control of cell growth: a double-edged sword protein","volume":"69","author":"Abbastabar","year":"2018","journal-title":"DNA Repair (Amst)"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1007\/s10565-022-09727-z","article-title":"Knockdown of HDAC6 alleviates ventricular remodeling in experimental dilated cardiomyopathy via inhibition of NLRP3 inflammasome activation and promotion of cardiomyocyte autophagy","volume":"39","author":"Pang","year":"2023","journal-title":"Cell Biol Toxicol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1530\/JOE-19-0518","article-title":"JAK2\/STAT3 Regulates estrogen-related senescence of bone marrow stem cells","volume":"245","author":"Wu","year":"2020","journal-title":"J Endocrinol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1368765","DOI":"10.3389\/fphar.2024.1368765","article-title":"Potential mechanisms of formononetin against inflammation and oxidative stress: a review","volume":"15","author":"Ding","year":"2024","journal-title":"Front Pharmacol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s11011-023-01302-7","article-title":"Mechanistic interplay of different mediators involved in mediating the anti-depressant effect of isoflavones","volume":"39","author":"Diksha","year":"2024","journal-title":"Metab Brain Dis"},{"key":"B54","doi-asserted-by":"publisher","first-page":"147844","DOI":"10.1016\/j.brainres.2022.147844","article-title":"The antidepressant-like effect of formononetin on chronic corticosterone-treated mice","volume":"1783","author":"Zhang","year":"2022","journal-title":"Brain Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"113549","DOI":"10.1016\/j.jep.2020.113549","article-title":"Integrating hippocampal metabolomics and network pharmacology deciphers the antidepressant mechanisms of Xiaoyaosan","volume":"268","author":"Liu","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"B56","first-page":"610","article-title":"Formononetin improves cognitive behavior in aging rats with chronic unpredictable mild in hippocampal tissue stress by blocking the NF-\u03baB pathway and inhibiting the release of inflammatory factors","volume":"39","author":"Zhang","year":"2023","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1865656\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:53:45Z","timestamp":1791348825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1865656\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":56,"alternative-id":["10.3389\/fcvm.2026.1865656"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2026.1865656","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"article-number":"1865656"}}