{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:09:35Z","timestamp":1789016975597,"version":"build-2803163510"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This investigation sought to assess the prognostic significance of the hemoglobin-to-serum creatinine (Hb\/SCr) ratio for long-term survival among patients with coexisting coronary artery disease (CAD) and reduced kidney function after percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study encompassed 2,310 patients who underwent PCI and had concomitant CAD and reduced kidney function. The cohort median Hb\/SCr value of 1.60 was used as a pragmatic reference threshold to classify patients into low (&amp;lt;1.60) and high (\u22651.60) Hb\/SCr groups. The predictive significance of the Hb\/SCr ratio regarding cardiac-cause mortality (CCM) and all-cause mortality (ACM) over a follow-up period of up to 60 months was evaluated employing Kaplan\u2013Meier analysis and multivariable Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During 60 months of follow-up, 56 cardiac-cause deaths (2.4%) and 87 all-cause deaths (3.8%) occurred. Kaplan\u2013Meier analysis showed significantly higher cumulative mortality in the low Hb\/SCr group for both CCM (log-rank\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002263) and ACM (log-rank\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002349). The Hb\/SCr ratio showed modest discrimination for CCM (AUC 0.663, 95% CI 0.585\u20130.742) and ACM (AUC 0.614, 95% CI 0.548\u20130.680). Compared with Hb\/SCr\u2009&amp;lt;\u20091.60, Hb\/SCr\u2009\u2265\u20091.60 was associated with lower adjusted risks of CCM (HR 0.49, 95% CI 0.27\u20130.90;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.021) and ACM (HR 0.59, 95% CI 0.37\u20130.94;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.028). Similar associations were observed when the ratio was analysed as a continuous variable (CCM: HR 0.28, 95% CI 0.14\u20130.57; ACM: HR 0.42, 95% CI 0.23\u20130.77).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A lower Hb\/SCr ratio independently predicts increased long-term risks of CCM and ACM in patients with CAD and reduced kidney function after PCI. Given its modest discriminative ability, this readily available ratio may serve as a complementary marker for risk stratification rather than a standalone predictive tool, potentially helping to identify patients who warrant closer post-procedural surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1868952","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:28:47Z","timestamp":1789014527000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of hemoglobin-to-serum creatinine ratio in patients with coronary artery disease and reduced kidney function following percutaneous coronary intervention"],"prefix":"10.3389","volume":"13","author":[{"given":"Sini","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical 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