{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:32:58Z","timestamp":1790415178524,"version":"4.1.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In patients with heart failure with preserved ejection fraction (HFpEF), further investigation of the safety and long-term efficacy of combined radiofrequency catheter ablation and left atrial appendage closure (RF\u2009+\u2009LAAC) in patients with HFpEF is warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective study, we aimed to evaluate the outcome of RF\u2009+\u2009LAAC in patients with AF and HFpEF, compared to radiofrequency catheter ablation (RF) alone. 331 patients with AF and chronic HFpEF were divided into two groups: RF\u2009+\u2009LAAC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009196) and RF (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009135). After 1:1 propensity score matching (PSM), 96 matched pairs were enrolled in further analysis. HF rehospitalization, ischemic stroke\/transient ischemic attack (TIA), and major bleeding events were assessed over 24 months. Kaplan\u2013Meier analyses were used to compare outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The RF\u2009+\u2009LAAC group demonstrated comparable procedural complication rates to RF alone (5.2% vs. 4.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.733). The risks of ischemic stroke\/TIA (ARR=4.95%, HR\u2009=\u20090.096, 95%CI:0.012\u20130.753,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026) and major bleeding events (ARR=3.91%, HR\u2009=\u20090.120, 95%CI: 0.015\u20130.957,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) were significantly lower in RF\u2009+\u2009LAAC group vs. RF alone, while HF rehospitalization was similar between the two groups (ARR=\u22120.56%, HR\u2009=\u20091.356, 95%CI: 0.303\u20136.059,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.690).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with AF and HFpEF, combined RF\u2009+\u2009LAAC was associated with lower risks of ischemic stroke\/TIA and major bleeding, without an observed increase in HF rehospitalization, compared with RF alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1871243","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:33:55Z","timestamp":1782102835000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Long-term outcome of patients with atrial fibrillation and heart failure with preserved ejection fraction after combined radiofrequency catheter ablation and left atrial appendage closure"],"prefix":"10.3389","volume":"13","author":[{"given":"Qian-ji","family":"Che","sequence":"first","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-cheng","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun-Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Pai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jchf.2017.05.001","article-title":"Atrial fibrillation in heart failure with preserved, mid-range, and reduced ejection fraction","volume":"5","author":"Sartipy","year":"2017","journal-title":"JACC Heart Fail"},{"key":"B2","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.1093\/eurheartj\/ehy626","article-title":"Prognostic implications of atrial fibrillation in heart failure with reduced, mid-range, and preserved ejection fraction: a report from 14964 patients in the European 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