{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:23:32Z","timestamp":1787300612000,"version":"build-2736575974"},"reference-count":259,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402079"],"award-info":[{"award-number":["82402079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300461"],"award-info":[{"award-number":["82300461"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Epigenetics modulates gene expression and plays a pivotal role in numerous immune disorders. Over the past two decades, increasing evidence has indicated that epigenetic regulation contributes to transplant rejection and immune tolerance. Four primary epigenetic mechanisms\u2014DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs (ncRNAs)\u2014exert distinct effects on rejection after transplantation. Therefore, understanding the epigenetic mechanisms of rejection provides novel avenues for inducing immune tolerance and developing strategies to prolong graft survival and patient longevity. This review outlines the history of epigenetics and highlights landmark events since the term was coined. Furthermore, we summarize epigenetic research methodologies and describe the four primary general mechanisms of epigenetic regulation. We subsequently focus on recent studies supporting the role of epigenetic regulation in distinct pathological processes of solid organ transplantation (namely, ischemia\u2012reperfusion injury, acute rejection, and chronic rejection) and graft-vs.-host disease following hematopoietic stem cell transplantation. Finally, we discuss the clinical applications of epigenetics in transplant rejection, including predictive diagnostics and the induction of immune tolerance, to guide the future development of improved rejection suppression therapies.<\/jats:p>","DOI":"10.3389\/fcvm.2026.1878170","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:34:03Z","timestamp":1787297643000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic regulation in transplant rejection and tolerance: mechanisms and therapeutic prospects"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuhao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Center for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuan","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Center for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiang","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Center for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiKai","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Center for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"NHC Key Laboratory of Organ Transplantation, Ministry of Education, Chinese Academy of Medical Sciences","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"B1","year":""},{"key":"B2","doi-asserted-by":"publisher","first-page":"Cd005161","DOI":"10.1002\/14651858.CD005161.pub2","article-title":"Cyclosporin versus tacrolimus for liver transplanted patients","volume":"2006","author":"Haddad","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1053\/j.ajkd.2023.10.016","article-title":"Infections following kidney transplantation after exposure to immunosuppression for treatment of glomerulonephritis","volume":"83","author":"Massicotte-Azarniouch","year":"2024","journal-title":"Am J Kidney Dis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.jaci.2018.07.014","article-title":"Epigenetic mechanisms regulating T-cell responses","volume":"142","author":"Schmidl","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/ni0703-616","article-title":"An epigenetic view of helper T cell differentiation","volume":"4","author":"Ansel","year":"2003","journal-title":"Nat Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/nri.2017.146","article-title":"Epigenetic control of CD8(+) T cell differentiation","volume":"18","author":"Henning","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/s41590-022-01224-z","article-title":"Epigenetic regulation of T cell exhaustion","volume":"23","author":"Belk","year":"2022","journal-title":"Nat Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7150\/ijbs.11218","article-title":"DNA methylation, its mediators and genome integrity","volume":"11","author":"Meng","year":"2015","journal-title":"Int J Biol Sci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/s41392-024-01918-w","article-title":"Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases","volume":"9","author":"Yao","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B10","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat Rev Genet"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1016\/j.healun.2020.09.012","article-title":"MicroRNA-206 antagomiR-enriched extracellular vesicles attenuate lung ischemia-reperfusion injury through CXCL1 regulation in alveolar epithelial cells","volume":"39","author":"Cai","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"B12","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ijcard.2021.07.042","article-title":"LncRNA HCP5 in hBMSC-derived exosomes alleviates myocardial ischemia reperfusion injury by sponging miR-497 to activate IGF1\/PI3K\/AKT pathway","volume":"342","author":"Li","year":"2021","journal-title":"Int J Cardiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.1182\/bloodadvances.2019000531","article-title":"Vitamin C stabilizes CD8+ iTregs and enhances their therapeutic potential in controlling murine GVHD and leukemia relapse","volume":"3","author":"Iamsawat","year":"2019","journal-title":"Blood Adv"},{"key":"B14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1093\/ije\/dyr184","article-title":"The epigenotype","volume":"41","author":"Waddington","year":"2012","journal-title":"Int J Epidemiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/S0021-9258(18)57261-6","article-title":"The quantitative separation of purines, pyrimidines, and nucleosides by paper chromatography","volume":"175","author":"Hotchkiss","year":"1948","journal-title":"J Biol Chem"},{"key":"B16","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1126\/science.6254144","article-title":"DNA methylation and gene function","volume":"210","author":"Razin","year":"1980","journal-title":"Science"},{"key":"B17","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1073\/pnas.51.5.786","article-title":"Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis","volume":"51","author":"Allfrey","year":"1964","journal-title":"Proc Natl Acad Sci USA"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3852","DOI":"10.1073\/pnas.73.11.3852","article-title":"Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures","volume":"73","author":"Sanger","year":"1976","journal-title":"Proc Natl Acad Sci USA"},{"key":"B19","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1128\/mcb.10.1.28-36.1990","article-title":"The product of the H19 gene may function as an RNA","volume":"10","author":"Brannan","year":"1990","journal-title":"Mol Cell Biol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"B21","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/s1074-7613(00)80642-1","article-title":"Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation","volume":"9","author":"Agarwal","year":"1998","journal-title":"Immunity"},{"key":"B22","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/s1074-7613(00)80605-6","article-title":"Helper T cell differentiation is controlled by the cell cycle","volume":"9","author":"Bird","year":"1998","journal-title":"Immunity"},{"key":"B23","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/s1074-7613(01)00227-8","article-title":"A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival","volume":"15","author":"Lee","year":"2001","journal-title":"Immunity"},{"key":"B24","doi-asserted-by":"publisher","first-page":"4253","DOI":"10.4049\/jimmunol.169.8.4253","article-title":"Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells","volume":"169","author":"Santourlidis","year":"2002","journal-title":"J Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1084\/jem.20021127","article-title":"DNA Methylation maintains allele-specific KIR gene expression in human natural killer cells","volume":"197","author":"Chan","year":"2003","journal-title":"J Exp Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"3363","DOI":"10.1182\/blood-2006-02-005520","article-title":"Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell response","volume":"108","author":"Fann","year":"2006","journal-title":"Blood"},{"key":"B27","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/ni1455","article-title":"Foxp3 in control of the regulatory T cell lineage","volume":"8","author":"Zheng","year":"2007","journal-title":"Nat Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/nri2474","article-title":"Epigenetic control of Foxp3 expression: the key to a stable regulatory T-cell lineage?","volume":"9","author":"Huehn","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1182\/blood-2009-05-219584","article-title":"Epigenetic mechanisms of regulation of Foxp3 expression","volume":"114","author":"Lal","year":"2009","journal-title":"Blood"},{"key":"B30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1371\/journal.pbio.0050038","article-title":"Epigenetic control of the Foxp3 locus in regulatory T cells","volume":"5","author":"Floess","year":"2007","journal-title":"PLoS Biol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.cell.2007.08.019","article-title":"The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing","volume":"130","author":"De Santa","year":"2007","journal-title":"Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1038\/nm1652","article-title":"Deacetylase inhibition promotes the generation and function of regulatory T cells","volume":"13","author":"Tao","year":"2007","journal-title":"Nat Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.1093\/eurheartj\/ehu346","article-title":"MicroRNAs as non-invasive biomarkers of heart transplant rejection","volume":"35","author":"Duong Van Huyen","year":"2014","journal-title":"Eur Heart J"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1182\/blood-2014-08-598037","article-title":"BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice","volume":"125","author":"Sun","year":"2015","journal-title":"Blood"},{"key":"B35","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1111\/ajt.16183","article-title":"DNA methylation modulates allograft survival and acute rejection after renal transplantation by regulating the mTOR pathway","volume":"21","author":"Zhu","year":"2021","journal-title":"Am J Transplant"},{"key":"B36","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.immuni.2022.01.011","article-title":"Interferon-\u03b2 acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation","volume":"55","author":"Fueyo-Gonz\u00e1lez","year":"2022","journal-title":"Immunity"},{"key":"B37","doi-asserted-by":"publisher","first-page":"4534","DOI":"10.1038\/s41467-025-58841-z","article-title":"Targeting Setdb1 in T cells induces transplant tolerance without compromising antitumor immunity","volume":"16","author":"Tan","year":"2025","journal-title":"Nat Commun"},{"key":"B38","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1126\/science.1169786","article-title":"The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain","volume":"324","author":"Kriaucionis","year":"2009","journal-title":"Science"},{"key":"B39","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"key":"B40","doi-asserted-by":"publisher","first-page":"35334","DOI":"10.1074\/jbc.C111.284620","article-title":"Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites","volume":"286","author":"Maiti","year":"2011","journal-title":"J Biol Chem"},{"key":"B41","doi-asserted-by":"publisher","first-page":"48350","DOI":"10.1074\/jbc.M403427200","article-title":"The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites","volume":"279","author":"Hermann","year":"2004","journal-title":"J Biol Chem"},{"key":"B42","first-page":"135","article-title":"Role of mammalian DNA methyltransferases in development","volume-title":"Annual Review of Biochemistry","author":"Chen","year":"2020"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1126\/science.1210597","article-title":"Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine","volume":"333","author":"Ito","year":"2011","journal-title":"Science"},{"key":"B44","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.cell.2011.03.022","article-title":"Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain","volume":"145","author":"Guo","year":"2011","journal-title":"Cell"},{"key":"B45","doi-asserted-by":"publisher","first-page":"4886","DOI":"10.1093\/nar\/21.21.4886","article-title":"Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2","volume":"21","author":"Nan","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"6538","DOI":"10.1128\/mcb.18.11.6538","article-title":"Identification and characterization of a family of mammalian methyl-CpG binding proteins","volume":"18","author":"Hendrich","year":"1998","journal-title":"Mol Cell Biol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1126\/science.1147939","article-title":"UHRF1 plays a role in maintaining DNA methylation in mammalian cells","volume":"317","author":"Bostick","year":"2007","journal-title":"Science"},{"key":"B48","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1038\/sj.onc.1210855","article-title":"The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression","volume":"27","author":"Achour","year":"2008","journal-title":"Oncogene"},{"key":"B49","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1128\/mcb.26.1.169-181.2006","article-title":"A family of human zinc finger proteins that bind methylated DNA and repress transcription","volume":"26","author":"Filion","year":"2006","journal-title":"Mol Cell Biol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1126\/science.162.3853.579","article-title":"Histone phosphorylation: stimulation by adenosine 3\u2032,5\u2032-monophosphate","volume":"162","author":"Langan","year":"1968","journal-title":"Science"},{"key":"B51","doi-asserted-by":"publisher","first-page":"4671","DOI":"10.1093\/nar\/8.20.4671","article-title":"Histone 2B can be modified by the attachment of ubiquitin","volume":"8","author":"West","year":"1980","journal-title":"Nucleic Acids Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"5528","DOI":"10.1038\/sj.onc.1210619","article-title":"Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design","volume":"26","author":"Hodawadekar","year":"2007","journal-title":"Oncogene"},{"key":"B53","doi-asserted-by":"publisher","first-page":"a018762","DOI":"10.1101\/cshperspect.a018762","article-title":"Writers and readers of histone acetylation: structure, mechanism, and inhibition","volume":"6","author":"Marmorstein","year":"2014","journal-title":"Cold Spring Harbor Perspect Biol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"a018713","DOI":"10.1101\/cshperspect.a018713","article-title":"Erasers of histone acetylation: the histone deacetylase enzymes","volume":"6","author":"Seto","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s00018-008-8303-z","article-title":"Dynamic protein methylation in chromatin biology","volume":"66","author":"Ng","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molcel.2008.12.013","article-title":"Protein arginine methylation in mammals: who, what, and why","volume":"33","author":"Bedford","year":"2009","journal-title":"Mol Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nature01080","article-title":"Active genes are tri-methylated at K4 of histone H3","volume":"419","author":"Santos-Rosa","year":"2002","journal-title":"Nature"},{"key":"B58","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nrm3274","article-title":"Understanding the language of Lys36 methylation at histone H3","volume":"13","author":"Wagner","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1016\/j.celrep.2017.08.088","article-title":"Histone H3 methylated at arginine 17 is essential for reprogramming the paternal genome in zygotes","volume":"20","author":"Hatanaka","year":"2017","journal-title":"Cell Rep"},{"key":"B60","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/s41580-022-00483-w","article-title":"Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance","volume":"23","author":"Padeken","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.molcel.2019.03.011","article-title":"Molecular mechanisms directing PRC2 recruitment and H3K27 methylation","volume":"74","author":"Laugesen","year":"2019","journal-title":"Mol Cell"},{"key":"B62","doi-asserted-by":"publisher","first-page":"12152","DOI":"10.1093\/nar\/gkab1068","article-title":"Chromatin loading of MCM hexamers is associated with di-\/tri-methylation of histone H4K20 toward S phase entry","volume":"49","author":"Hayashi-Takanaka","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B63","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.sbi.2019.10.007","article-title":"Transcription through the nucleosome","volume":"61","author":"Kujirai","year":"2020","journal-title":"Curr Opin Struct Biol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/cr.2011.32","article-title":"ATP-dependent chromatin remodeling: genetics, genomics and mechanisms","volume":"21","author":"Hargreaves","year":"2011","journal-title":"Cell Res"},{"key":"B65","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1146\/annurev.biochem.77.062706.153223","article-title":"The biology of chromatin remodeling complexes","volume":"78","author":"Clapier","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"B66","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.cell.2013.07.011","article-title":"Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes","volume":"154","author":"Narlikar","year":"2013","journal-title":"Cell"},{"key":"B67","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41586-020-2087-1","article-title":"Cryo-EM structure of SWI\/SNF Complex bound to a nucleosome","volume":"579","author":"Han","year":"2020","journal-title":"Nature"},{"key":"B68","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1186\/s13046-021-02151-x","article-title":"The emerging role of ISWI chromatin remodeling complexes in cancer","volume":"40","author":"Li","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"B69","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.tibs.2008.10.010","article-title":"The INO80 chromatin remodeling complex in transcription, replication and repair","volume":"34","author":"Conaway","year":"2009","journal-title":"Trends Biochem Sci"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1093\/emboj\/cdg179","article-title":"Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes","volume":"22","author":"Simic","year":"2003","journal-title":"EMBO J"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1002\/1873-3468.13182","article-title":"Noncoding RNAs in disease","volume":"592","author":"Lekka","year":"2018","journal-title":"FEBS Lett"},{"key":"B72","doi-asserted-by":"publisher","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An overview of microRNAs: biology, functions, therapeutics, and analysis methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"J Cell Physiol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"B74","doi-asserted-by":"publisher","first-page":"047662","DOI":"10.1242\/dmm.047662","article-title":"MiRNA interplay: mechanisms and consequences in cancer","volume":"14","author":"Hill","year":"2021","journal-title":"Dis Model Mech"},{"key":"B75","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/s41574-019-0260-0","article-title":"The clinical potential of circulating microRNAs in obesity","volume":"15","author":"Ji","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/s41581-022-00608-6","article-title":"MicroRNAs in kidney injury and disease","volume":"18","author":"Mahtal","year":"2022","journal-title":"Nat Rev Nephrol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nrg.2015.10","article-title":"Unique features of long non-coding RNA biogenesis and function","volume":"17","author":"Quinn","year":"2016","journal-title":"Nat Rev Genet"},{"key":"B78","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3892\/or.2016.5236","article-title":"Non-coding RNAs as regulators in epigenetics","volume":"37","author":"Wei","year":"2017","journal-title":"Oncol Rep"},{"key":"B79","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.canlet.2021.02.004","article-title":"CircRNA in cancer: fundamental mechanism and clinical potential","volume":"505","author":"Chen","year":"2021","journal-title":"Cancer Lett"},{"key":"B80","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat Rev Genet"},{"key":"B81","doi-asserted-by":"publisher","first-page":"677","DOI":"10.2217\/epi-2023-0141","article-title":"CircRNA: a promising all-around star in the future","volume":"15","author":"Li","year":"2023","journal-title":"Epigenomics"},{"key":"B82","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12943-019-1125-9","article-title":"Roles of circRNAs in the tumour microenvironment","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol Cancer"},{"key":"B83","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12943-021-01446-z","article-title":"Circular RNAs in acute myeloid leukemia","volume":"20","author":"Singh","year":"2021","journal-title":"Mol Cancer"},{"key":"B84","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00439-021-02409-6","article-title":"Differential fates of introns in gene expression due to global alternative splicing","volume":"141","author":"Kumari","year":"2022","journal-title":"Hum Genet"},{"key":"B85","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ebiom.2018.01.025","article-title":"Ischemia-reperfusion injury reduces long term renal graft survival: mechanism and beyond","volume":"28","author":"Zhao","year":"2018","journal-title":"EBioMedicine"},{"key":"B86","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev.pathol.3.121806.151449","article-title":"Graft vascular disease: immune response meets the vessel wall","volume":"4","author":"Mitchell","year":"2009","journal-title":"Annu Rev Pathol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/ki.1997.183","article-title":"The nature of renal cell injury","volume":"51","author":"Edelstein","year":"1997","journal-title":"Kidney Int"},{"key":"B88","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s00540-020-02823-6","article-title":"Review 2: primary graft dysfunction after lung transplant-pathophysiology, clinical considerations and therapeutic targets","volume":"34","author":"Jin","year":"2020","journal-title":"J Anesth"},{"key":"B89","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1097\/mot.0000000000000234","article-title":"Update on ischemia-reperfusion injury in lung transplantation","volume":"20","author":"Chen","year":"2015","journal-title":"Curr Opin Organ Transplant"},{"key":"B90","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1164\/rccm.200207-670SO","article-title":"Ischemia-reperfusion-induced lung injury","volume":"167","author":"De Perrot","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"B91","doi-asserted-by":"publisher","first-page":"L668","DOI":"10.1152\/ajplung.00198.2014","article-title":"Shear stress-related mechanosignaling with lung ischemia: lessons from basic research can inform lung transplantation","volume":"307","author":"Chatterjee","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nrm.2016.149","article-title":"Necroptosis in development, inflammation and disease","volume":"18","author":"Weinlich","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"52","DOI":"10.5500\/wjt.v5.i2.52","article-title":"Update on ischemia-reperfusion injury in kidney transplantation: pathogenesis and treatment","volume":"5","author":"Salvadori","year":"2015","journal-title":"World J Transplant"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s00467-018-3984-5","article-title":"Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury","volume":"34","author":"Martin","year":"2019","journal-title":"Pediatr Nephrol"},{"key":"B95","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/bmb\/ldh025","article-title":"Vascular ischaemia and reperfusion injury","volume":"70","author":"Eltzschig","year":"2004","journal-title":"Br Med Bull"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1097\/00000542-200106000-00030","article-title":"Pathophysiology clinical manifestations, and prevention of ischemia-reperfusion injury","volume":"94","author":"Collard","year":"2001","journal-title":"Anesthesiology"},{"key":"B97","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1681\/asn.2017010079","article-title":"Complement recognition pathways in renal transplantation","volume":"28","author":"Nauser","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/j.jcmgh.2023.03.003","article-title":"Mechanistic insight and clinical implications of ischemia\/reperfusion injury post liver transplantation","volume":"15","author":"Liu","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.3389\/fimmu.2018.02548","article-title":"T cell allorecognition pathways in solid organ transplantation","volume":"9","author":"Siu","year":"2018","journal-title":"Front Immunol"},{"key":"B100","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1097\/00007890-199301000-00033","article-title":"Mediation of acute but not chronic rejection of MHC-incompatible rat kidney grafts by alloreactive CD4T cells activated by the direct pathway of sensitization","volume":"55","author":"Braun","year":"1993","journal-title":"Transplantation"},{"key":"B101","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1034\/j.1600-6143.2003.00142.x","article-title":"A role for indirect allorecognition in lung transplant recipients with obliterative bronchiolitis","volume":"3","author":"Stanford","year":"2003","journal-title":"Am J Transplant"},{"key":"B102","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","article-title":"Differentiation of effector CD4T cell populations (*)","volume":"28","author":"Zhu","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"B103","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/imr.12038","article-title":"CD4(+) T-cell subsets in transplantation","volume":"252","author":"Liu","year":"2013","journal-title":"Immunol Rev"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1038\/ki.1997.256","article-title":"Predominant Th1 cell infiltration in acute rejection episodes of human kidney grafts","volume":"51","author":"D'elios","year":"1997","journal-title":"Kidney Int"},{"key":"B105","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/75029","article-title":"The axis of interleukin 12 and gamma interferon regulates acute vascular Xenogeneic rejection","volume":"6","author":"Wang","year":"2000","journal-title":"Nat Med"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1097\/00007890-200012150-00017","article-title":"Islet allograft rejection can be mediated by CD4+, alloantigen experienced, direct pathway T cells of TH1 and TH2 cytokine phenotype","volume":"70","author":"Barbara","year":"2000","journal-title":"Transplantation"},{"key":"B107","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1097\/00007890-199703150-00001","article-title":"Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival?","volume":"63","author":"Piccotti","year":"1997","journal-title":"Transplantation"},{"key":"B108","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1084\/jem.183.2.699","article-title":"Two levels of help for B cell alloantibody production","volume":"183","author":"Steele","year":"1996","journal-title":"J Exp Med"},{"key":"B109","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1084\/jem.20081937","article-title":"A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy","volume":"205","author":"Yuan","year":"2008","journal-title":"J Exp Med"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.2353\/ajpath.2010.091106","article-title":"Interleukin-17 promotes early allograft inflammation","volume":"177","author":"Gorbacheva","year":"2010","journal-title":"Am J Pathol"},{"key":"B111","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/30989","article-title":"A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell","volume":"393","author":"Ridge","year":"1998","journal-title":"Nature"},{"key":"B112","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nri819","article-title":"Cytotoxic T lymphocytes: all roads lead to death","volume":"2","author":"Barry","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"B113","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev.immunol.20.100201.131730","article-title":"Lymphocyte-mediated cytotoxicity","volume":"20","author":"Russell","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1016\/j.healun.2005.03.019","article-title":"Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection","volume":"24","author":"Stewart","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"B115","first-page":"S142","article-title":"Cardiac allograft vasculopathy: the central pathogenetic role of ischemia-induced endothelial cell injury","volume":"14","author":"Day","year":"1995","journal-title":"J Heart Lung Transplant"},{"key":"B116","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.athoracsur.2010.03.043","article-title":"Donor age is associated with chronic allograft vasculopathy after adult heart transplantation: implications for donor allocation","volume":"90","author":"Nagji","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"B117","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.molmed.2015.02.004","article-title":"The perfect storm: HLA antibodies, complement, Fc\u03b3Rs, and endothelium in transplant rejection","volume":"21","author":"Thomas","year":"2015","journal-title":"Trends Mol Med"},{"key":"B118","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/nrneph.2012.212","article-title":"The role of complement in antibody-mediated rejection in kidney transplantation","volume":"8","author":"Stegall","year":"2012","journal-title":"Nat Rev Nephrol"},{"key":"B119","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/s1074-7613(01)00117-0","article-title":"Innate immune responses to transplants: a significant variable with cadaver donors","volume":"14","author":"Baldwin","year":"2001","journal-title":"Immunity"},{"key":"B120","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/s0952-7915(03)00100-6","article-title":"Role of the complement system in rejection","volume":"15","author":"Sacks","year":"2003","journal-title":"Curr Opin Immunol"},{"key":"B121","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1600-6143.2011.03836.x","article-title":"A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody","volume":"12","author":"Hirohashi","year":"2012","journal-title":"Am J Transplant"},{"key":"B122","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1111\/j.1600-6143.2009.02819.x","article-title":"Effect of antibodies on endothelium","volume":"9","author":"Zhang","year":"2009","journal-title":"Am J Transplant"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1111\/j.1600-6143.2005.00843.x","article-title":"Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis","volume":"5","author":"Vongwiwatana","year":"2005","journal-title":"Am J Transplant"},{"key":"B124","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1097\/01.tp.0000151644.85832.b5","article-title":"Inhibition of matrix metalloproteinases during chronic allograft nephropathy in rats","volume":"79","author":"Lutz","year":"2005","journal-title":"Transplantation"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1093\/eurheartj\/ehs375","article-title":"Matricellular proteins and matrix metalloproteinases mark the inflammatory and fibrotic response in human cardiac allograft rejection","volume":"34","author":"Vanhoutte","year":"2013","journal-title":"Eur Heart J"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1523-1755.2005.00376.x","article-title":"Chronic renal allograft rejection: pathophysiologic considerations","volume":"68","author":"Joosten","year":"2005","journal-title":"Kidney Int"},{"key":"B127","doi-asserted-by":"publisher","first-page":"607030","DOI":"10.3389\/fimmu.2020.607030","article-title":"Current preventions and treatments of aGVHD: from pharmacological prophylaxis to innovative therapies","volume":"11","author":"Naserian","year":"2020","journal-title":"Front Immunol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s40257-017-0306-9","article-title":"Cutaneous graft-versus-host disease: diagnosis and treatment","volume":"19","author":"Strong Rodrigues","year":"2018","journal-title":"Am J Clin Dermatol"},{"key":"B129","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/nrgastro.2017.126","article-title":"Acute graft-versus-host disease of the gut: considerations for the gastroenterologist","volume":"14","author":"Naymagon","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.immuni.2019.08.011","article-title":"MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota","volume":"51","author":"Koyama","year":"2019","journal-title":"Immunity"},{"key":"B131","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1172\/jci4285","article-title":"Tumor necrosis factor- alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease","volume":"102","author":"Cooke","year":"1998","journal-title":"J Clin Invest"},{"key":"B132","doi-asserted-by":"publisher","first-page":"3014","DOI":"10.1182\/blood-2014-12-615781","article-title":"\u03b1-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice","volume":"125","author":"Uryu","year":"2015","journal-title":"Blood"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1172\/jci136139","article-title":"One-two punch injury to tolerance mechanisms in graft-versus-host disease","volume":"130","author":"Carrington","year":"2020","journal-title":"J Clin Invest"},{"key":"B134","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1002\/cncr.20613","article-title":"Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management","volume":"101","author":"Couriel","year":"2004","journal-title":"Cancer"},{"key":"B135","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","article-title":"National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 diagnosis and staging working group report","volume":"21","author":"Jagasia","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"B136","doi-asserted-by":"publisher","first-page":"3344","DOI":"10.1016\/j.transproceed.2006.10.112","article-title":"Ischemic epigenetics and the transplanted kidney","volume":"38","author":"Pratt","year":"2006","journal-title":"Transplant Proc"},{"key":"B137","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.ajt.2024.11.003","article-title":"Severe ischemia-reperfusion injury induces epigenetic inactivation of LHX1 in kidney progenitor cells after kidney transplantation","volume":"25","author":"Cruzado","year":"2025","journal-title":"Am J Transplant"},{"key":"B138","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1038\/onc.2011.596","article-title":"RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells","volume":"31","author":"Lin","year":"2012","journal-title":"Oncogene"},{"key":"B139","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nri3198","article-title":"Regulation and function of mtor signalling in T cell fate decisions","volume":"12","author":"Chi","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"B140","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1600-065X.2012.01152.x","article-title":"Mtor, metabolism, and the regulation of T-cell differentiation and function","volume":"249","author":"Waickman","year":"2012","journal-title":"Immunol Rev"},{"key":"B141","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1161\/circulationaha.120.050553","article-title":"TET2 protects against vascular smooth muscle cell apoptosis and intimal thickening in transplant vasculopathy","volume":"144","author":"Ostriker","year":"2021","journal-title":"Circulation"},{"key":"B142","doi-asserted-by":"publisher","first-page":"3060","DOI":"10.1111\/ajt.14372","article-title":"Effects of DNA methylation on progression to interstitial fibrosis and tubular atrophy in renal allograft biopsies: a multi-omics approach","volume":"17","author":"Bontha","year":"2017","journal-title":"Am J Transplant"},{"key":"B143","doi-asserted-by":"publisher","first-page":"709164","DOI":"10.3389\/fimmu.2021.709164","article-title":"Defining a methylation signature associated with operational tolerance in kidney transplant recipients","volume":"12","author":"Rodriguez","year":"2021","journal-title":"Front Immunol"},{"key":"B144","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.clim.2015.08.012","article-title":"Role of HMGS1 in regulation of STAT3 expression in CD4+ T cells from patients with aGVHD after allogeneic hematopoietic stem cell transplantation","volume":"161","author":"Xu","year":"2015","journal-title":"Clin Immunol"},{"key":"B145","doi-asserted-by":"publisher","first-page":"7165230","DOI":"10.1155\/2020\/7165230","article-title":"HMGB1 recruits TET2\/AID\/TDG to induce DNA demethylation in STAT3 promoter in CD4(+) T cells from aGVHD patients","volume":"2020","author":"Xu","year":"2020","journal-title":"J Immunol Res"},{"key":"B146","doi-asserted-by":"publisher","first-page":"669","DOI":"10.3389\/fimmu.2018.00669","article-title":"Intestinal microbiota at engraftment influence acute graft-versus-host disease via the Treg\/Th17 balance in Allo-HSCT recipients","volume":"9","author":"Han","year":"2018","journal-title":"Front Immunol"},{"key":"B147","first-page":"7565","article-title":"Correlation between histone H3K4 trimethylation and DNA methylation and evaluation of the metabolomic features in acute rejection after kidney transplantation","volume":"12","author":"Zhang","year":"2020","journal-title":"Am J Transl Res"},{"key":"B148","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12865-016-0179-3","article-title":"Inhibition of histone methyltransferase EZH2 ameliorates early acute renal allograft rejection in rats","volume":"17","author":"Li","year":"2016","journal-title":"BMC Immunol"},{"key":"B149","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13045-020-00937-8","article-title":"EZH2: a novel target for cancer treatment","volume":"13","author":"Duan","year":"2020","journal-title":"J Hematol Oncol"},{"key":"B150","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/s41586-021-03520-4","article-title":"Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity","volume":"595","author":"Griffin","year":"2021","journal-title":"Nature"},{"key":"B151","doi-asserted-by":"publisher","first-page":"107051","DOI":"10.1016\/j.phrs.2023.107051","article-title":"NSD2 modulates Drp1-mediated mitochondrial fission in chronic renal allograft interstitial fibrosis by methylating STAT1","volume":"200","author":"Zhang","year":"2024","journal-title":"Pharmacol Res"},{"key":"B152","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1038\/s41388-021-01747-z","article-title":"NSD2 promotes tumor angiogenesis through methylating and activating STAT3 protein","volume":"40","author":"Song","year":"2021","journal-title":"Oncogene"},{"key":"B153","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/s13059-024-03415-3","article-title":"Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation","volume":"25","author":"Shipman","year":"2024","journal-title":"Genome Biol"},{"key":"B154","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1097\/TP.0b013e3182a1931f","article-title":"Modulation of allogeneic CD8+ T-cell response by DZNep controls GVHD while preserving hematopoietic chimerism","volume":"96","author":"Wang","year":"2013","journal-title":"Transplantation"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1182\/blood-2011-06-364422","article-title":"Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells","volume":"119","author":"He","year":"2012","journal-title":"Blood"},{"key":"B156","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.1182\/blood-2013-05-505180","article-title":"The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease","volume":"122","author":"He","year":"2013","journal-title":"Blood"},{"key":"B157","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/ajt.13106","article-title":"Class-specific histone\/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation","volume":"15","author":"Levine","year":"2015","journal-title":"Am J Transplant"},{"key":"B158","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1042\/cs20210823","article-title":"Inhibition of HDAC3 protects against kidney cold storage\/transplantation injury and allograft dysfunction","volume":"136","author":"Xiang","year":"2022","journal-title":"Clin Sci (Lond)"},{"key":"B159","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1681\/asn.2007091040","article-title":"Epigenetic regulation of BMP7 in the regenerative response to ischemia","volume":"19","author":"Marumo","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"B160","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/sj.ki.5001731","article-title":"Modulator of bone morphogenetic protein activity in the progression of kidney diseases","volume":"70","author":"Yanagita","year":"2006","journal-title":"Kidney Int"},{"key":"B161","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.molmed.2005.09.007","article-title":"BMP7 signaling in renal development and disease","volume":"11","author":"Patel","year":"2005","journal-title":"Trends Mol Med"},{"key":"B162","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.trim.2018.02.006","article-title":"Expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction","volume":"48","author":"Xia","year":"2018","journal-title":"Transpl Immunol"},{"key":"B163","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.kint.2015.12.051","article-title":"Targeting Sirtuin-1 prolongs murine renal allograft survival and function","volume":"89","author":"Levine","year":"2016","journal-title":"Kidney Int"},{"key":"B164","doi-asserted-by":"publisher","first-page":"ra45","DOI":"10.1126\/scisignal.2002873","article-title":"Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms","volume":"5","author":"Beier","year":"2012","journal-title":"Sci Signal"},{"key":"B165","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1182\/blood-2009-02-207118","article-title":"Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization","volume":"115","author":"van Loosdregt","year":"2010","journal-title":"Blood"},{"key":"B166","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/resp.12933","article-title":"Histone deacetylase 2 is decreased in peripheral blood pro-inflammatory CD8+ T and NKT-like lymphocytes following lung transplant","volume":"22","author":"Hodge","year":"2017","journal-title":"Respirology"},{"key":"B167","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41420-023-01574-z","article-title":"Disruption of RCAN1.4 expression mediated by YY1\/HDAC2 modulates chronic renal allograft interstitial fibrosis","volume":"9","author":"Zhang","year":"2023","journal-title":"Cell Death Discov"},{"key":"B168","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/s41420-021-00713-8","article-title":"RCAN1.4 attenuates renal fibrosis through inhibiting calcineurin-mediated nuclear translocation of NFAT2","volume":"7","author":"Zhang","year":"2021","journal-title":"Cell Death Discov"},{"key":"B169","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.gene.2017.11.059","article-title":"Role of tumor necrosis factor-\u03b1 in epithelial-to-mesenchymal transition in transplanted kidney cells in recipients with chronic allograft dysfunction","volume":"642","author":"Zhao","year":"2018","journal-title":"Gene"},{"key":"B170","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1182\/blood-2016-08-731505","article-title":"T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model","volume":"130","author":"Woods","year":"2017","journal-title":"Blood"},{"key":"B171","doi-asserted-by":"publisher","first-page":"3078","DOI":"10.3389\/fimmu.2018.03078","article-title":"A possible reason to induce acute graft-vs.-host disease after hematopoietic stem cell transplantation: lack of sirtuin-1 in CD4(+) T cells","volume":"9","author":"Xu","year":"2018","journal-title":"Front Immunol"},{"key":"B172","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nature06880","article-title":"Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor","volume":"453","author":"Quintana","year":"2008","journal-title":"Nature"},{"key":"B173","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3389\/fimmu.2012.00223","article-title":"Aryl hydrocarbon receptor-mediated perturbations in gene expression during early stages of CD4(+) T-cell differentiation","volume":"3","author":"Rohlman","year":"2012","journal-title":"Front Immunol"},{"key":"B174","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13148-022-01330-7","article-title":"The absence of AhR in CD4(+) T cells in patients with acute graft-versus-host disease may be related to insufficient CTCF expression","volume":"14","author":"Zeng","year":"2022","journal-title":"Clin Epigenetics"},{"key":"B175","doi-asserted-by":"publisher","first-page":"568637","DOI":"10.3389\/fimmu.2020.568637","article-title":"Downregulation of P53 by insufficient CTCF in CD4(+) T cells is an important factor inducing acute graft-versus-host disease","volume":"11","author":"Hua","year":"2020","journal-title":"Front Immunol"},{"key":"B176","doi-asserted-by":"publisher","first-page":"F910","DOI":"10.1152\/ajprenal.00409.2023","article-title":"mir-199a-5p aggravates renal ischemia-reperfusion and transplant injury by targeting AKAP1 to disrupt mitochondrial dynamics","volume":"327","author":"Shi","year":"2024","journal-title":"Am J Physiol Renal Physiol"},{"key":"B177","doi-asserted-by":"publisher","first-page":"16367","DOI":"10.1002\/jcp.28305","article-title":"MicroRNA-449b-5p targets HMGB1 to attenuate hepatocyte injury in liver ischemia and reperfusion","volume":"234","author":"Zhang","year":"2019","journal-title":"J Cell Physiol"},{"key":"B178","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1177\/1753425920928449","article-title":"Inhibition of microRNA-128-3p alleviates liver ischaemia-reperfusion injury in mice through repressing the Rnd3\/NF-\u03baB axis","volume":"26","author":"Mou","year":"2020","journal-title":"Innate Immun"},{"key":"B179","doi-asserted-by":"publisher","first-page":"110783","DOI":"10.1016\/j.cellsig.2023.110783","article-title":"MicroRNA let-7a mediates posttranscriptional inhibition of Nr4a1 and exacerbates cardiac allograft rejection","volume":"109","author":"Ding","year":"2023","journal-title":"Cell Signal"},{"key":"B180","doi-asserted-by":"publisher","first-page":"108521","DOI":"10.1016\/j.intimp.2022.108521","article-title":"Cytosporone B (Csn-B), an NR4A1 agonist, attenuates acute cardiac allograft rejection by inducing differential apoptosis of CD4+T cells","volume":"104","author":"Ding","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"B181","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.yexcr.2015.01.018","article-title":"MicroRNA-10b downregulation mediates acute rejection of renal allografts by derepressing BCL2L11","volume":"333","author":"Liu","year":"2015","journal-title":"Exp Cell Res"},{"key":"B182","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.3724\/abbs.2022100","article-title":"Mir-505-5p alleviates acute rejection of liver transplantation by inhibiting Myd88 and inducing M2 polarization of Kupffer cells","volume":"54","author":"Chai","year":"2022","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"B183","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.kint.2018.10.041","article-title":"M2 macrophages in kidney disease: biology, therapies, and perspectives","volume":"95","author":"Chen","year":"2019","journal-title":"Kidney Int"},{"key":"B184","doi-asserted-by":"publisher","first-page":"101320","DOI":"10.1016\/j.trim.2020.101320","article-title":"Mir-669b-3p regulates CD4+ T cell function by down-regulating indoleamine-2, 3-dioxygenase","volume":"62","author":"Li","year":"2020","journal-title":"Transpl Immunol"},{"key":"B185","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.healun.2016.04.018","article-title":"Knockout of microRNA-155 ameliorates the Th1\/Th17 immune response and tissue injury in chronic rejection","volume":"36","author":"Zhang","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"B186","doi-asserted-by":"publisher","first-page":"12253","DOI":"10.3390\/ijms232012253","article-title":"Association between circulating microRNAs (miR-21-5p, miR-20a-5p, miR-29b-3p, miR-126-3p and miR-101-3p) and chronic allograft dysfunction in renal transplant recipients","volume":"23","author":"Chen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B187","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1097\/TP.0b013e3182751efd","article-title":"MicroRNA sequence profiles of human kidney allografts with or without tubulointerstitial fibrosis","volume":"94","author":"Ben-Dov","year":"2012","journal-title":"Transplantation"},{"key":"B188","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1084\/jem.20100035","article-title":"Mir-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis","volume":"207","author":"Liu","year":"2010","journal-title":"J Exp Med"},{"key":"B189","doi-asserted-by":"publisher","first-page":"121ra18","DOI":"10.1126\/scitranslmed.3003205","article-title":"MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways","volume":"4","author":"Chau","year":"2012","journal-title":"Sci Transl Med"},{"key":"B190","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.7150\/ijbs.7.1056","article-title":"Diverse roles of TGB-\u03b2\/Smads in renal fibrosis and inflammation","volume":"7","author":"Lan","year":"2011","journal-title":"Int J Biol Sci"},{"key":"B191","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1111\/ajt.16581","article-title":"Mir-21 antagonism reprograms macrophage metabolism and abrogates chronic allograft vasculopathy","volume":"21","author":"Usuelli","year":"2021","journal-title":"Am J Transplant"},{"key":"B192","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1111\/ajt.13185","article-title":"Dysregulated microRNA expression and chronic lung allograft rejection in recipients with antibodies to donor HLA","volume":"15","author":"Xu","year":"2015","journal-title":"Am J Transplant"},{"key":"B193","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/j.healun.2015.03.021","article-title":"MicroRNA-144 dysregulates the transforming growth factor-\u03b2 signaling cascade and contributes to the development of bronchiolitis obliterans syndrome after human lung transplantation","volume":"34","author":"Xu","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"B194","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.4049\/jimmunol.1601778","article-title":"Serum miR-29a is upregulated in acute graft-versus-host disease and activates dendritic cells through TLR binding","volume":"198","author":"Ranganathan","year":"2017","journal-title":"J Immunol"},{"key":"B195","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1182\/blood-2015-02-627356","article-title":"MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice","volume":"126","author":"Wu","year":"2015","journal-title":"Blood"},{"key":"B196","doi-asserted-by":"publisher","first-page":"3036","DOI":"10.1182\/bloodadvances.2021005103","article-title":"MicroRNA-31 regulates T-cell metabolism via HIF1\u03b1 and promotes chronic GVHD pathogenesis in mice","volume":"6","author":"Wu","year":"2022","journal-title":"Blood Adv"},{"key":"B197","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1038\/s41418-023-01198-x","article-title":"Small extracellular vesicles delivering lncRNA WAC-AS1 aggravate renal allograft ischemia-reperfusion injury by inducing ferroptosis propagation","volume":"30","author":"Li","year":"2023","journal-title":"Cell Death Differ"},{"key":"B198","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.omtn.2019.05.009","article-title":"Silencing of lncRNA MALAT1 prevents inflammatory injury after lung transplant ischemia-reperfusion by downregulation of IL-8 via p300","volume":"18","author":"Wei","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"B199","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/tp.0000000000001463","article-title":"Differential expression of long noncoding RNAs during cardiac allograft rejection","volume":"101","author":"Gu","year":"2017","journal-title":"Transplantation"},{"key":"B200","doi-asserted-by":"publisher","first-page":"104400","DOI":"10.1016\/j.cellimm.2021.104400","article-title":"The lncRNA PVT1 regulates autophagy in regulatory T cells to suppress heart transplant rejection in mice by targeting miR-146a","volume":"367","author":"Lu","year":"2021","journal-title":"Cell Immunol"},{"key":"B201","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/nep.12851","article-title":"Transforming growth factor-\u03b2 activated long non-coding RNA ATB plays an important role in acute rejection of renal allografts and may impacts the postoperative pharmaceutical immunosuppression therapy","volume":"22","author":"Qiu","year":"2017","journal-title":"Nephrology"},{"key":"B202","doi-asserted-by":"publisher","first-page":"C395","DOI":"10.1152\/ajpcell.00323.2022","article-title":"Long noncoding RNA LINC01882 ameliorates aGVHD via skewing CD4 1T cell differentiation toward Treg cells","volume":"324","author":"Teng","year":"2023","journal-title":"Am J Physiol Cell Physiol"},{"key":"B203","doi-asserted-by":"publisher","first-page":"573","DOI":"10.26355\/eurrev_202201_27884","article-title":"Lnc-AC145676.2.1-6-3 can influence STX3-induced abnormal autophagy by sponging hsa-miR-1292-3p in intestinal aGVHD","volume":"26","author":"Sun","year":"2022","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B204","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1111\/ijlh.13852","article-title":"Lnc-AC145676.2.1-6-3 plays an important role in intestinal acute graft-versus-host disease through the regulation of interleukin-1\u03b2","volume":"44","author":"Sun","year":"2022","journal-title":"Int J Lab Hematol"},{"key":"B205","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1111\/ajt.16475","article-title":"Circular RNA Foxo3 in cardiac ischemia-reperfusion injury in heart transplantation: a new regulator and target","volume":"21","author":"Su","year":"2021","journal-title":"Am J Transplant"},{"key":"B206","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.1038\/onc.2015.460","article-title":"Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis","volume":"35","author":"Yang","year":"2016","journal-title":"Oncogene"},{"key":"B207","doi-asserted-by":"publisher","first-page":"622","DOI":"10.7150\/ijbs.24223","article-title":"miR-433 inhibits breast cancer cell growth via the MAPK signaling pathway by targeting Rap1a","volume":"14","author":"Zhang","year":"2018","journal-title":"Int J Biol Sci"},{"key":"B208","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.biopha.2017.07.053","article-title":"MiR-136 controls neurocytes apoptosis by regulating tissue inhibitor of metalloproteinases-3 in spinal cord ischemic injury","volume":"94","author":"Jin","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"B209","doi-asserted-by":"publisher","first-page":"5330","DOI":"10.1073\/pnas.0813121106","article-title":"MicroRNA expression profiles predictive of human renal allograft status","volume":"106","author":"Anglicheau","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B210","doi-asserted-by":"publisher","first-page":"e60702","DOI":"10.1371\/journal.pone.0060702","article-title":"Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejection","volume":"8","author":"Danger","year":"2013","journal-title":"PLoS One"},{"key":"B211","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1182\/blood-2013-06-510586","article-title":"Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease","volume":"122","author":"Xiao","year":"2013","journal-title":"Blood"},{"key":"B212","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1097\/tp.0000000000004622","article-title":"Combining serum miR-144-3p and miR-652-3p as potential biomarkers for the early diagnosis and stratification of acute cellular rejection in heart transplantation patients","volume":"107","author":"P\u00e9rez-Carrillo","year":"2023","journal-title":"Transplantation"},{"key":"B213","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1007\/s00277-021-04573-1","article-title":"Circulating miR-455-3p, miR-5787, and miR-548a-3p as potential noninvasive biomarkers in the diagnosis of acute graft-versus-host disease: a validation study","volume":"100","author":"Motaei","year":"2021","journal-title":"Ann Hematol"},{"key":"B214","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.3390\/jcm10132748","article-title":"MicroRNA expression changes in kidney transplant: diagnostic efficacy of miR-150-5p as potential rejection biomarker, pilot study","volume":"10","author":"Alfaro","year":"2021","journal-title":"J Clin Med"},{"key":"B215","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1016\/j.transproceed.2015.04.094","article-title":"Serum microRNA-99a helps detect acute rejection in renal transplantation","volume":"47","author":"Tao","year":"2015","journal-title":"Transplant Proc"},{"key":"B216","doi-asserted-by":"publisher","first-page":"5295","DOI":"10.1182\/bloodadvances.2021005930","article-title":"MicroRNA serum profiles and chronic graft-versus-host disease","volume":"6","author":"Reikvam","year":"2022","journal-title":"Blood Adv"},{"key":"B217","doi-asserted-by":"publisher","first-page":"155689","DOI":"10.1016\/j.cyto.2021.155689","article-title":"miR-199a-3p may be an early warning marker for acute rejection after liver transplantation in rats","volume":"148","author":"Mo","year":"2021","journal-title":"Cytokine"},{"key":"B218","doi-asserted-by":"publisher","first-page":"2415374","DOI":"10.1155\/2020\/2415374","article-title":"Identifying 4 novel lncRNAs as potential biomarkers for acute rejection and graft loss of renal allograft","volume":"2020","author":"Zhang","year":"2020","journal-title":"J Immunol Res"},{"key":"B219","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1007\/s12010-019-03082-2","article-title":"Long non-coding RNA expression profiling in biopsy to identify renal allograft at risk of chronic damage and future graft loss","volume":"190","author":"Xu","year":"2020","journal-title":"Appl Biochem Biotechnol"},{"key":"B220","doi-asserted-by":"publisher","first-page":"103307","DOI":"10.1016\/j.retram.2021.103307","article-title":"IFNG-AS1 and MAF4 long non-coding RNAs are upregulated in acute leukemia patients who underwent bone marrow transplantation","volume":"69","author":"Jafari","year":"2021","journal-title":"Curr Res Transl Med"},{"key":"B221","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1373\/clinchem.2019.305854","article-title":"Circular RNAs in urine of kidney transplant patients with acute T cell-mediated allograft rejection","volume":"65","author":"K\u00f6lling","year":"2019","journal-title":"Clin Chem"},{"key":"B222","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1089\/omi.2016.0164","article-title":"Hepatic miR-301a as a liver transplant rejection biomarker? And its role for interleukin-6 production in hepatocytes","volume":"21","author":"Nakano","year":"2017","journal-title":"OMICS"},{"key":"B223","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1159\/000485451","article-title":"A molecular signature of two long non-coding RNAs in peripheral blood predicts acute renal allograft rejection","volume":"44","author":"Ge","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"B224","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1182\/blood-2018-07-863233","article-title":"Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice","volume":"133","author":"Daenthanasanmak","year":"2019","journal-title":"Blood"},{"key":"B225","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/intimm\/dxx060","article-title":"Generation of allo-antigen-specific induced Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model","volume":"29","author":"Kasahara","year":"2017","journal-title":"Int Immunol"},{"key":"B226","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1182\/blood-2016-05-714535","article-title":"miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency","volume":"128","author":"Lu","year":"2016","journal-title":"Blood"},{"key":"B227","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.4049\/jimmunol.1700196","article-title":"A cellular microRNA facilitates regulatory T lymphocyte development by targeting the Foxp3 promoter TATA-Box Motif","volume":"200","author":"Zhang","year":"2018","journal-title":"J Immunol"},{"key":"B228","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.7150\/thno.33178","article-title":"Knockdown of NEAT1 induces tolerogenic phenotype in dendritic cells by inhibiting activation of NLRP3 inflammasome","volume":"9","author":"Zhang","year":"2019","journal-title":"Theranostics"},{"key":"B229","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.healun.2021.03.025","article-title":"Preventing alloimmune rejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation","volume":"40","author":"Wang","year":"2021","journal-title":"J Heart Lung Transplant"},{"key":"B230","doi-asserted-by":"publisher","first-page":"10615","DOI":"10.1002\/btm2.10615","article-title":"Circular RNA MAP2K2-modified immunosuppressive dendritic cells for preventing alloimmune rejection in organ transplantation","volume":"9","author":"Li","year":"2024","journal-title":"Bioeng Transl Med"},{"key":"B231","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.3389\/fimmu.2018.02407","article-title":"GDF15 regulates Malat-1 circular RNA and inactivates Nf\u03ba\u03b2 signaling leading to immune tolerogenic DCs for preventing alloimmune rejection in heart transplantation","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Immunol"},{"key":"B232","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/gt.2016.39","article-title":"Exposure to hypomethylating agent, 5-azacytidine, may improve iCasp9 suicide gene therapy for treating GvHD in allografts","volume":"23","author":"B\u00f4le-Richard","year":"2016","journal-title":"Gene Ther"},{"key":"B233","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/imm.12343","article-title":"\u2018Default\u2019 generated neonatal regulatory T cells are hypomethylated at conserved non-coding sequence 2 and promote long-term cardiac allograft survival","volume":"143","author":"Cheng","year":"2014","journal-title":"Immunology"},{"key":"B234","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.trim.2013.10.001","article-title":"Inhibiting cardiac allograft rejection with interleukin-35 therapy combined with decitabine treatment in mice","volume":"29","author":"Guo","year":"2013","journal-title":"Transpl Immunol"},{"key":"B235","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.1073\/pnas.0400380101","article-title":"Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect","volume":"101","author":"Reddy","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B236","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/ni.3400","article-title":"Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease","volume":"17","author":"Mathewson","year":"2016","journal-title":"Nat Immunol"},{"key":"B237","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1097\/tp.0000000000001345","article-title":"Absence of miR-182 augments cardiac allograft survival","volume":"101","author":"Wei","year":"2017","journal-title":"Transplantation"},{"key":"B238","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.3389\/fimmu.2018.01847","article-title":"The long noncoding RNA MALAT1 induces tolerogenic dendritic cells and regulatory T cells via miR155\/dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin\/IL10 axis","volume":"9","author":"Wu","year":"2018","journal-title":"Front Immunol"},{"key":"B239","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cellimm.2016.05.007","article-title":"MicroRNA-150 negatively regulates the function of CD4(+) T cells through AKT3\/Bim signaling pathway","volume":"306","author":"Sang","year":"2016","journal-title":"Cell Immunol"},{"key":"B240","doi-asserted-by":"publisher","first-page":"E3432","DOI":"10.1073\/pnas.1408780111","article-title":"Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions","volume":"111","author":"Lu","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"B241","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.14670\/hh-18-818","article-title":"DNMT1 silencing induces KIR2DL1\/2\/3 expression via methylation to alleviate graft-versus-host disease after allogeneic hematopoietic stem cell transplantation","volume":"40","author":"Zhang","year":"2025","journal-title":"Histol Histopathol"},{"key":"B242","doi-asserted-by":"publisher","first-page":"13227","DOI":"10.3389\/ti.2024.13227","article-title":"Assessment of the therapeutic potential of enhancer of zeste homolog 2 inhibition in a murine model of bronchiolitis obliterans syndrome","volume":"37","author":"Matsudo","year":"2024","journal-title":"Transpl Int"},{"key":"B243","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s13287-026-04997-4","article-title":"Immune-evasive stem cells: engineering tolerance and reprogramming microenvironments for regenerative therapy","volume":"17","author":"Wu","year":"2026","journal-title":"Stem Cell Res Ther"},{"key":"B244","doi-asserted-by":"publisher","first-page":"e00035","DOI":"10.1002\/ggn2.202500035","article-title":"3D genome architecture in stem cell lineage commitment: from structural organization to precision regulation","volume":"6","author":"He","year":"2025","journal-title":"Adv Genet (Hoboken)"},{"key":"B245","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/s2213-2600(23)00293-x","article-title":"Effect of once-per-day tacrolimus versus twice-per-day ciclosporin on 3-year incidence of chronic lung allograft dysfunction after lung transplantation in Scandinavia (ScanCLAD): a multicentre randomised controlled trial","volume":"12","author":"Dellgren","year":"2024","journal-title":"Lancet Respir Med"},{"key":"B246","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.jhep.2023.01.030","article-title":"Liver transplantation immunology: immunosuppression, rejection, and immunomodulation","volume":"78","author":"Montano-Loza","year":"2023","journal-title":"J Hepatol"},{"key":"B247","doi-asserted-by":"publisher","first-page":"4294","DOI":"10.1182\/bloodadvances.2023010973","article-title":"High-dose alemtuzumab and cyclosporine vs tacrolimus, methotrexate, and sirolimus for chronic graft-versus-host disease prevention","volume":"8","author":"Holtzman","year":"2024","journal-title":"Blood Adv"},{"key":"B248","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1634\/theoncologist.10-3-176","article-title":"FDA drug approval summary: azacitidine (5-azacytidine, Vidaza) for injectable suspension","volume":"10","author":"Kaminskas","year":"2005","journal-title":"Oncologist"},{"key":"B249","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1634\/theoncologist.12-10-1247","article-title":"FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma","volume":"12","author":"Mann","year":"2007","journal-title":"Oncologist"},{"key":"B250","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.tips.2010.08.001","article-title":"Targeting DNA methylation for epigenetic therapy","volume":"31","author":"Yang","year":"2010","journal-title":"Trends Pharmacol Sci"},{"key":"B251","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3389\/fonc.2018.00092","article-title":"Combination therapy with histone deacetylase inhibitors (HDACi) for the treatment of cancer: achieving the full therapeutic potential of HDACi","volume":"8","author":"Suraweera","year":"2018","journal-title":"Front Oncol"},{"key":"B252","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/tp.0000000000000878","article-title":"Epigenetics in kidney transplantation: current evidence, predictions, and future research directions","volume":"100","author":"Mas","year":"2016","journal-title":"Transplantation"},{"key":"B253","doi-asserted-by":"publisher","first-page":"100609","DOI":"10.1016\/j.trre.2021.100609","article-title":"Clinical epigenetics and acute\/chronic rejection in solid organ transplantation: an update","volume":"35","author":"Vasco","year":"2021","journal-title":"Transplant Rev"},{"key":"B254","doi-asserted-by":"publisher","first-page":"861498","DOI":"10.3389\/fimmu.2022.861498","article-title":"Epigenetic regulation in kidney transplantation","volume":"13","author":"Xiang","year":"2022","journal-title":"Front Immunol"},{"key":"B255","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1111\/ajt.13585","article-title":"The emerging role of DNA methylation in kidney transplantation: a perspective","volume":"16","author":"Heylen","year":"2016","journal-title":"Am J Transplant"},{"key":"B256","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.3324\/haematol.2019.240291","article-title":"New insights into the basic biology of acute graft-versus-host-disease","volume":"105","author":"Li","year":"2020","journal-title":"Haematologica"},{"key":"B257","doi-asserted-by":"publisher","first-page":"4281","DOI":"10.3390\/ijms21124281","article-title":"Targeting histone deacetylases to modulate graft-versus-host disease and graft-versus-leukemia","volume":"21","author":"Kim","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B258","doi-asserted-by":"publisher","first-page":"e14306","DOI":"10.1111\/ctr.14306","article-title":"Epigenetic-based therapy in allogenic hematopoietic stem cell transplantation: novel opportunities for personalized treatment","volume":"35","author":"Benincasa","year":"2021","journal-title":"Clin Transplant"},{"key":"B259","doi-asserted-by":"publisher","first-page":"1188853","DOI":"10.3389\/fimmu.2023.1188853","article-title":"The impact of epigenetic modifications on allogeneic hematopoietic stem cell transplantation","volume":"14","author":"Ktena","year":"2023","journal-title":"Front Immunol"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1878170\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:34:06Z","timestamp":1787297646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1878170\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":259,"alternative-id":["10.3389\/fcvm.2026.1878170"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2026.1878170","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]},"article-number":"1878170"}}