{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:02:13Z","timestamp":1790744533716,"version":"4.1.0"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coronary artery disease is a common heart disease worldwide, and the morbidity and mortality rates among Chinese residents continue to rise. Percutaneous coronary intervention (PCI) can improve survival rates, but long-term management is required after the procedure. Traditional interventions have shortcomings such as dependence on medical institutions and the lack of personalized treatment plans. This study aims to evaluate the effectiveness of the Artificial Intelligence-based Health Education Precision Linkage System (AI-HEALS) in improving self-health management among young and middle-aged patients after PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      This is a single-center, randomized, single-blind, parallel-group controlled trial. Eligible patients aged 18\u201359 years from Xuanwu Hospital, Capital Medical University, will be randomly allocated at a 1:1 ratio to receive either standard care plus the AI-HEALS intervention (intervention group) or standard care alone (control group). The primary outcome is the change in self-management ability from baseline to the 3-month intervention endpoint, assessed using the Coronary Heart Disease Self-Management Behavior Scale (CSMS). Secondary outcomes include medication adherence, dietary behavior, exercise frequency, and psychological indicators. Assuming an effect size of\n                      <jats:italic>d<\/jats:italic>\n                      \u2009=\u20090.69, 80% statistical power, and a two-sided significance level of\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.05, with an anticipated 20% dropout rate, the required sample size was calculated as 86 participants (43 per group). Primary analyses will follow the intention-to-treat principle. Generalized linear mixed models will be used for repeated measures outcomes, and multiple imputation by chained equations will handle missing data. Quantitative findings will be integrated with qualitative data from structured interviews conducted among intervention group participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study has been approved by the Ethics Committee of Xuanwu Hospital, Capital Medical University (Approval No.[2024] 409-002). Written informed consent will be obtained from all participants. Results will be disseminated through peer-reviewed publications and academic conferences.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial Registration<\/jats:bold>\n                      :\n                      <jats:ext-link>http:\/\/www.chictr.org.cn\/<\/jats:ext-link>\n                      , identifier ChiCTR2500100519.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1879287","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:50:28Z","timestamp":1790743828000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of an artificial intelligence health education accurately linking system on self-management in young and middle-aged patients after percutaneous coronary intervention: a protocol"],"prefix":"10.3389","volume":"13","author":[{"given":"Yueli","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, Xuanwu Hospital Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengke","family":"Shan","sequence":"additional","affiliation":[{"name":"School of Nursing, Henan University of Science and Technology","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xuanwu Hospital Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xuanwu Hospital Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xuanwu Hospital Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xuanwu Hospital Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xuanwu Hospital Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhua","family":"Li","sequence":"additional","affiliation":[{"name":"School of Education, Chengdu College of Arts and Sciences","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.suc.2022.01.007","article-title":"Epidemiology of coronary artery disease","volume":"102","author":"Duggan","year":"2022","journal-title":"Surg Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"949","DOI":"10.3967\/bes2024.162","article-title":"Report on cardiovascular health and diseases in China 2023: an updated summary","volume":"37","year":"2024","journal-title":"Biomed Environ Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.12114\/j.issn.1007-9572.2025.0221","article-title":"Expert consensus on early screening and prevention of coronary artery disease in young people","volume":"29","year":"2026","journal-title":"Chin Gen Pract"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e023207","DOI":"10.1161\/JAHA.121.023207","article-title":"Prevalence of coronary microvascular disease and coronary vasospasm in patients with nonobstructive coronary artery disease","volume":"11","author":"Mileva","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"B5","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1001\/jamacardio.2021.5613","article-title":"Prevalence and trends of coronary heart disease in the United States, 2011 to 2018","volume":"7","author":"Lee","year":"2022","journal-title":"JAMA Cardiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1001\/jamacardio.2022.3926","article-title":"Fundamental pathobiology of coronary atherosclerosis and clinical implications for chronic ischemic heart disease management-the plaque hypothesis: a narrative review","volume":"8","author":"Stone","year":"2023","journal-title":"JAMA Cardiol"},{"key":"B7","first-page":"211","volume-title":"Pathophysiology of Coronary artery Disease. 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