{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:18:53Z","timestamp":1783491533349,"version":"3.55.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Parathyroid hormone (PTH) influences calcium handling in cardiomyocytes and sympathetic cardiac signaling. It has been linked to arterial hypertension and cardiovascular mortality. We hypothesized that PTH is independently associated with atrial fibrillation (AF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from 3,201 patients (mean age 63\u2009\u00b1\u200913 years, 25.8% female) enrolled in the LUdwigshafen RIsk and Cardiovascular health (LURIC) study. We defined AF based on medical history or current ECG. Multivariable binary logistic regression was used to assess the association between PTH and AF, adjusting for established AF risk factors, parameters of mineral metabolism, kidney function, and concomitant medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      AF was present in 389 patients (12.2%). PTH was significantly associated with AF in the primary multivariable model [OR 3.96 (2.32\u20136.76),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001]. In the fully adjusted model including mineral metabolism and medication variables, the association remained significant [OR 2.32 (1.24\u20134.35),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009]. The association remained significant after additional adjustment for markers of cardiac dysfunction, including invasive hemodynamic parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated PTH was associated with prevalent AF in patients referred for coronary angiography after adjustment for common confounders. The association persisted after adjustment for structural, neurohumoral and invasive hemodynamic markers, suggesting that elevated PTH is not merely a surrogate of cardiac dysfunction but may represent an independent correlate of AF. Prospective studies are needed to clarify the temporal and causal relationship between PTH and AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1885117","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:57:46Z","timestamp":1783490266000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of parathyroid hormone and atrial fibrillation: epidemiological insights from the LURIC study"],"prefix":"10.3389","volume":"13","author":[{"given":"L.","family":"K\u00f6nig","sequence":"first","affiliation":[{"name":"Medical University of Vienna","place":["Vienna, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Gr\u00fcbler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine with Cardiology, Nephrology and Intensive Care Medicine, Universitaetsklinikum Wiener Neustadt","place":["Wiener Neustadt, Austria"]},{"name":"Medical Faculty, Sigmund Freud University","place":["Vienna, Austria"]},{"name":"Department of Medicine, Faculty of Medicine and Dentistry, Danube Private University","place":["Krems, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Verheyen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University Graz","place":["Graz, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kolesnik","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University Graz","place":["Graz, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wallner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University Graz","place":["Graz, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"van Ballegooijen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, Vanderbilt University Medical Centre","place":["Amsterdam, Netherlands"]},{"name":"Department of Health Sciences and the EMGO Institute, Vanderbilt University Amsterdam , Amsterdam","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"von Lewinski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University Graz","place":["Graz, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pilz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz , 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