{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:39:15Z","timestamp":1786451955243,"version":"build-2736575974"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate factors associated with anxiety, depressive symptoms, and cognitive impairment in individuals with hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A multicenter, large-sample cross-sectional study was conducted on 1,915 essential hypertension patients from multiple hospitals in Shandong Province (May 2022\u2013July 2024). They were divided into four groups by Mini-Mental State Examination, Hamilton Anxiety and Depression Scales: hypertension alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091,350), with cognitive impairment (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009191), with anxiety\/depression (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009309), and with all three conditions (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200965). Demographics, clinical indices, lifestyle, sleep quality, and treatment information were collected. Univariate analysis, binary logistic regression, and ROC curves were used to examine these factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Independent risk factors for hypertension patients with anxiety\/depression included waist circumference (OR=1.06), heart rate (1.02), education level, alcohol cessation (3.1), usual systolic blood pressure (1.02) and poor sleep; protective factors included age (0.94), height (0.96), occasional drinking (0.25), hypertension family history (0.15) and lower LDL-C (0.73). For hypertension patients with all three conditions, risk factors were waist circumference (1.07) and poor sleep. Lower LDL-C (0.62) was a protective factor. ROC curves showed good discriminative capacity (AUC=0.895, 0.887).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among individuals with hypertension, comorbid anxiety, depression, and cognitive impairment are associated with poorer sleep quality and elevated waist circumference. Lower LDL-C and appropriate lipid management may have protective effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1888483","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:13:01Z","timestamp":1786450381000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors associated with anxiety, depression, and cognitive impairment in individuals with hypertension: a cross-sectional study based on a Chinese population"],"prefix":"10.3389","volume":"13","author":[{"given":"Xinxin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Feicheng City Traditional Chinese Medicine Hospital","place":["Feicheng, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhong","sequence":"additional","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health, 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