{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:30:40Z","timestamp":1787725840554,"version":"build-2784847793"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multisystem inflammatory syndrome in adults (MIS-A) is a rare, post-infectious hyperinflammatory condition characterized by multiorgan involvement and substantial cardiovascular morbidity. This study aimed to characterize the cardiovascular phenotype and clinical outcomes of adults with MIS-A and to compare findings between ICU and non-ICU patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective case series of 22 hospitalized patients with a MIS-A phenotype across two university-affiliated clinical bases in Almaty, Kazakhstan (City Hospital No. 1 and City Hospital No. 7). Data were retrospectively abstracted from completed inpatient medical records after discharge or in-hospital death. Demographics, clinical manifestations documented during hospital days 0\u22123, baseline laboratory markers (first 24\u2005h), treatments, and outcomes were extracted from medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age was 43 years (IQR, 29\u221263; range 19\u221286), and 13\/22 patients were female (59.1%). Fever (\u226538\u2005\u00b0C) was documented on 18\/22 (81.8%). Mucocutaneous findings included rash in 12\/22 (54.5%), enanthema in 10\/22 (45.5%), and non-purulent conjunctivitis in 5\/22 (22.7%). Echocardiography was available for 17\/22 (77.3%); LVEF &amp;lt;50% was observed in 6\/17 (35.3%). Gastrointestinal symptoms occurred in 7\/22 (31.8%), neurologic manifestations in 8\/22 (36.4%), and respiratory manifestations in 16\/22 (72.7%). Inflammatory markers were markedly elevated, including C-reactive protein (median 181\u2005mg\/L, IQR, 95.4\u2013245.0) and D-dimer (median 6.4\u2005\u00b5g\/mL FEU, IQR, 4.0\u201310.0). Leukocytosis occurred in 15\/22 (68.2%), thrombocytopenia in 11\/22 (50.0%), and lymphopenia in 8\/22 (36.4%). Systemic corticosteroids were used on 14\/22 (63.6%); ICU admission occurred on 11\/22 (50.0%). In-hospital mortality was 5\/22 (22.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hospitalized patients with a MIS-A phenotype demonstrated severe hyperinflammation with frequent multiorgan involvement and meaningful in-hospital mortality. Early recognition and standardized assessment of organ dysfunction, particularly cardiovascular involvement, are essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1893335","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:03:22Z","timestamp":1787724202000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multisystem inflammatory syndrome in adults (MIS-A): cardiovascular manifestations and in-hospital outcomes from two tertiary centers"],"prefix":"10.3389","volume":"13","author":[{"given":"Nazima","family":"Zarubekova","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaukhar","family":"Kurmanova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almira","family":"Akparova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira","family":"Melis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almagul","family":"Kurmanova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Abdrakhmanova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sholpan","family":"Sadykova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademi","family":"Samadin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Shin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhamilya","family":"Zhankina","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Natural Sciences, Friedrich-Alexander University, Erlangen-N\u00fcrnberg","place":["Erlangen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"B1","year":""},{"key":"B2","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3390\/biomed3010016","article-title":"Multisystem inflammatory syndrome in adults (MIS-A) and SARS-CoV2: an evolving relationship","volume":"3","author":"Worku","year":"2023","journal-title":"BioMed"},{"key":"B3","doi-asserted-by":"publisher","first-page":"272","DOI":"10.53854\/liim-3203-2","article-title":"Multisystem inflammatory syndrome of adults (MIS-A): the undercover threat for young adults. 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