{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:18:06Z","timestamp":1787811486239,"version":"build-2784847793"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Double-chambered left ventricle (DCLV) is an extremely rare congenital anomaly characterized by an aberrant muscular or fibromuscular septum dividing the left ventricular cavity. Most cases present in childhood or adolescence. Adult presentations are exceptional, particularly when complicated by severe valvular dysfunction and advanced heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A 50-year-old male with longstanding atrial fibrillation presented with one month of exertional chest tightness and progressive dyspnea, including paroxysmal nocturnal dyspnea. Physical examination revealed a displaced apex and a grade 5\/6 holosystolic murmur consistent with severe mitral regurgitation. Electrocardiography showed permanent atrial fibrillation with an extremely high premature ventricular complex burden (52.9%). Transthoracic echocardiography was diagnostic, demonstrating a hypertrophied muscular septum dividing the mid-to-distal left ventricle into a basal and an apical chamber (peak gradient 7 mmHg), severe mitral regurgitation due to restrictive leaflet closure, left ventricular non-compaction, and severe biventricular systolic dysfunction (left ventricular ejection fraction 29.4%). Despite optimization of guideline-directed medical therapy for heart failure with reduced ejection fraction, the patient's symptoms and functional capacity showed no improvement over one month of follow-up. Given the surgically complex anatomy, diffuse myocardial disease, and refractory biventricular failure, the multidisciplinary heart team recommended referral for orthotopic heart transplantation evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights that double-chambered left ventricle (DCLV), though typically a pediatric diagnosis, can rarely present in adulthood with severe mitral regurgitation and refractory heart failure, adding to the limited reports of this presentation. In such cases where structural repair is not feasible due to complex anatomy and low intraventricular gradient, heart transplantation evaluation may represent the most appropriate therapeutic strategy, although the long-term response to medical therapy remains to be determined.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1895634","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:33:45Z","timestamp":1787808825000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Double-chambered left ventricle with advanced biventricular failure: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Guiping","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Ultrasonic and Jiujiang City Key Laboratory of Cell Therapy, Jiujiang NO. 1 People\u2019s Hospital","place":["Jiujiang, Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Jiujiang City Key Laboratory of Cell Therapy, Jiujiang NO. 1 People\u2019s Hospital","place":["Jiujiang, Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Jiujiang Sixth People\u2019s Hospital","place":["Jiujiang, Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and Jiujiang City Key Laboratory of Cell Therapy, Jiujiang NO. 1 People\u2019s Hospital","place":["Jiujiang, Jiangxi, China"]},{"name":"Chronic Disease Management Center, Jiujiang NO. 1 People\u2019s Hospital","place":["Jiujiang, Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jccase.2026.01.003","article-title":"An infant case of double-chambered left ventricle with extensive non-compaction revealed by intraoperative endoscopy","volume":"33","author":"Ifuku","year":"2026","journal-title":"J Cardiol Cases"},{"key":"B2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s43044-023-00341-w","article-title":"Double-chambered left ventricle: diagnosis by CMR and review of the literature","volume":"75","author":"Saadia","year":"2023","journal-title":"Egypt Heart J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"ytad173","DOI":"10.1093\/ehjcr\/ytad173","article-title":"A case series of double-chambered left ventricle detected by cardiovascular magnetic resonance","volume":"7","author":"Meier","year":"2023","journal-title":"Eur Heart J Case Rep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"104942","DOI":"10.1016\/j.jaccas.2025.104942","article-title":"Double-Chambered left ventricle: how cardiac magnetic resonance overturned the diagnosis","volume":"30","author":"Pomiato","year":"2025","journal-title":"JACC Case Rep"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e33524","DOI":"10.1097\/MD.0000000000033524","article-title":"An asymptomatic double-chambered left ventricle diagnosed by contrast-enhanced ultrasound imaging: a case report","volume":"102","author":"Tian","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"B6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cjcpc.2021.10.001","article-title":"Rare case of an adult with double-chambered left ventricle","volume":"1","author":"Frick","year":"2022","journal-title":"CJC Pediatr Congenit Heart Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.xjtc.2024.09.024","article-title":"Successful surgical correction of double-chambered left ventricle: a case report","volume":"29","author":"Zuo","year":"2024","journal-title":"JTCVS Tech"},{"key":"B8","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/echo.14939","article-title":"Diagnosis of double-chambered left ventricle of superior-inferior type by echocardiography: a retrospective study of 9 subjects across two heart centers","volume":"38","author":"Bao","year":"2020","journal-title":"Echocardiography"},{"key":"B9","doi-asserted-by":"publisher","first-page":"522","DOI":"10.2459\/JCM.0000000000000264","article-title":"Left ventricular noncompaction presenting like a double-chambered left ventricle","volume":"16","author":"Novo","year":"2015","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1093\/ehjci\/jes185","article-title":"Double-chambered left ventricle plus left ventricular non-compaction: report of an abnormal association","volume":"14","author":"Correia","year":"2012","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"B11","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.jchf.2020.04.008","article-title":"Effect of dapagliflozin in patients with HFrEF treated with sacubitril\/valsartan: the DAPA-HF trial","volume":"8","author":"Solomon","year":"2020","journal-title":"JACC Heart Fail"},{"key":"B12","doi-asserted-by":"publisher","first-page":"E198","DOI":"10.1532\/HSF98.20041011","article-title":"Successful surgical management of a double-chambered left ventricle in a 13-year-old girl: a report of a rare case","volume":"7","author":"Dogan","year":"2004","journal-title":"Heart Surg Forum"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e44431","DOI":"10.1097\/MD.0000000000044431","article-title":"Multimodality CMR diagnosis of double-chambered left ventricle in a child: a case report","volume":"104","author":"Anser","year":"2025","journal-title":"Medicine (Baltimore)"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1895634\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:33:45Z","timestamp":1787808825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1895634\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":13,"alternative-id":["10.3389\/fcvm.2026.1895634"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2026.1895634","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"article-number":"1895634"}}