{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:00:16Z","timestamp":1790240416244,"version":"4.1.0"},"reference-count":121,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric pulmonary hypertension (PH) is traditionally managed under a strict hemodynamic paradigm, often overlooking systemic metabolic and nutritional drivers. This review introduces the \u201cCellular Deprivation Model\u201d to evaluate how specific micronutrient deficiencies and metabolic blocks accelerate pulmonary vasculopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic, PRISMA-compliant search was conducted in PubMed\/MEDLINE for literature published between January 2000 and April 2026. Keywords intersected pediatric PH with malnutrition, avitaminosis, iron deficiency, and inborn errors of metabolism. Out of 401 unique records, 115 articles were synthesized across clinical and mechanistic tracks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acquired deficiencies (including ascorbic acid, thiamine, iron, folate, and cobalamin deficiencies) and inherited disorders of vitamin metabolism (such as Cobalamin C deficiency and folate metabolism disorders) converge on common pathophysiological pathways: the hypoxia-inducible factor (HIF) axis, causing normoxic pseudo-hypoxia, and endothelial nitric oxide synthase (eNOS) uncoupling via tetrahydrobiopterin depletion. In low- and middle-income countries (LMICs), these cellular blocks form a positive socio-hemodynamic feedback loop with congenital heart disease, accelerating vascular media hypertrophy and reducing surgical operability. Strikingly, these nutrition-driven vascular phenotypes demonstrate rapid, complete reversibility upon metabolic rescue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Standardized biochemical testing for micronutrients faces severe economic and cold-chain barriers in resource-limited settings. We propose a pragmatic shift toward universal empirical metabolic pre-conditioning\u2014utilizing standardized, low-cost iron, vitamin C, thiamine, and folate regimens\u2014for at-risk pediatric populations. This strategy aims to bypass advanced diagnostic delays, expand surgical operability windows, and mitigate perioperative mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1900356","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:08:33Z","timestamp":1790237313000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Addressing micronutrient deficiencies and vitamin metabolism disorders in pediatric pulmonary hypertension: a strategic proposal for low- and middle-income countries"],"prefix":"10.3389","volume":"13","author":[{"given":"Mattia","family":"Pasquinucci","sequence":"first","affiliation":[{"name":"Department of Pediatrics, AULSS 7 Pedemontana, San Bassiano Hospital","place":["Bassano del Grappa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Scaglione","sequence":"additional","affiliation":[{"name":"Department of Pediatric Metabolic Diseases, H\u00f4pital Universitaire Necker-Enfants Malades, AP-HP, Universit\u00e9 Paris Cit\u00e9","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Mezzalira","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, AULSS 7 Pedemontana, San Bassiano Hospital","place":["Bassano del Grappa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Bonsembiante","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, AULSS 7 Pedemontana, San Bassiano Hospital","place":["Bassano del Grappa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariaelena","family":"Zaffina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Women\u2019s Health, 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