{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:05:12Z","timestamp":1789621512006,"version":"build-2803163510"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac myxoma is the most common primary benign cardiac tumor and a known cause of cerebral embolism due to tumor fragment embolization. However, long-term intracranial imaging findings following surgical resection of cardiac myxoma are rarely documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>We report a 56-year-old female with a history of intracranial aneurysm intervention, hospitalized for acute cerebral infarction. Transthoracic echocardiography (TTE) revealed a cardiac mass, which was resected and pathologically confirmed as benign cardiac myxoma. Ten months postoperatively, she developed limb convulsive seizures meeting criteria for acute symptomatic seizures. Cranial MRI with DWI showed new-onset multiple nodular hemorrhagic lesions, and PET-CT suggested myxoma recurrence with metastatic infiltration. The case was discussed at a multidisciplinary team (MDT) meeting involving neuro-oncology, neurosurgery, interventional radiology, and cardiology, At 16 months postoperatively, imaging revealed increased number and size of intracranial metastases, with worsening edema and midline shift. After full counseling, the patient and her family declined radiotherapy and biopsy. Thus, the diagnosis was based on imaging and clinical correlation, without pathological confirmation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the diagnostic challenges in differentiating intracranial lesions following cardiac myxoma resection and underscores the importance of long-term cranial imaging surveillance. Even after complete tumor resection, clinicians should remain vigilant for potential myxoma-related complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1908269","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:50:54Z","timestamp":1789620654000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Delayed intracranial lesions following cardiac myxoma resection in a patient with concurrent cerebral embolism: a diagnostic challenge in the absence of pathological evidence"],"prefix":"10.3389","volume":"13","author":[{"given":"Minjie","family":"Shao","sequence":"first","affiliation":[{"name":"Neurology Department, Wenling First People\u2019s Hospital","place":["Taizhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Hong","sequence":"additional","affiliation":[{"name":"Neurology Department, Wenling First People\u2019s Hospital","place":["Taizhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongming","family":"Ying","sequence":"additional","affiliation":[{"name":"Neurology Department, Taizhou Hospital of Chinese Traditional and Western Medicine","place":["Taizhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Cai","sequence":"additional","affiliation":[{"name":"Neurology Department, Wenling First People\u2019s Hospital","place":["Taizhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.3390\/cancers17101621","article-title":"Rain metastases from primary cardiac tumors: a systematic review of diagnosis, treatment, and prognosis","volume":"17","author":"Marrone","year":"2025","journal-title":"Cancers (Basel)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1046441","DOI":"10.3389\/fneur.2022.1046441","article-title":"Case report: Multiple brain metastases of atrial myxoma: Clinical experience and literature review","volume":"13","author":"Ma","year":"2023","journal-title":"Front Neurol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1605692","DOI":"10.3389\/fonc.2025.1605692","article-title":"Case report: cardiac myxomas and carney complex: a case of recurrent embolic strokes and intracranial tumor growth","volume":"15","author":"Kuhn","year":"2025","journal-title":"Front Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e40599","DOI":"10.7759\/cureus.40599","article-title":"Trial myxoma: an unusual etiology of ischemic stroke in an adult patient","volume":"15","author":"Sadia","year":"2023","journal-title":"Cureus"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1016\/j.radcr.2020.08.043","article-title":"Brain 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Magn Reson Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"112396","DOI":"10.4330\/wjc.v17.i12.112396","article-title":"Cardiac myxoma and its implications for cardioembolic stroke","volume":"17","author":"Cai","year":"2025","journal-title":"World J Cardiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e1581","DOI":"10.1002\/ctm2.1581","article-title":"Resolving the heterogeneous tumour microenvironment in cardiac myxoma through single-cell and spatial transcriptomics","volume":"14","author":"Liu","year":"2024","journal-title":"Clin Transl Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-024-01912-2","article-title":"Revealing the crucial roles of suppressive immune microenvironment in cardiac myxoma progression","volume":"9","author":"Jiang","year":"2024","journal-title":"Signal Transduct Target Ther"}],"container-title":["Frontiers in Cardiovascular 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