{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:25:31Z","timestamp":1787034331102,"version":"build-2736575974"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>\n                    Left atrial (LA) myopathy plays a critical role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). This study aimed to evaluate LA function in a murine model of hypertension-induced HFpEF, with and without obesity, by analyzing left ventricular (LV) pressure signals to quantify the contribution of LA systole to total LV volume. HFpEF was induced in C57BL\/6J mice using the SAUNA model, which involves uninephrectomy, chronic aldosterone infusion, and high-salt drinking water for four weeks. To model obesity-associated HFpEF, a high-fat diet (HFD) was added to the SAUNA protocol. Invasive hemodynamic measurements were obtained, and a novel method was developed to assess atrial systole using the second-order derivative of the LV pressure signal during diastolic filling. SAUNA HFpEF mice exhibited preserved LVEF, moderate hypertension, pulmonary congestion, and diastolic dysfunction as evidenced by a prolonged time constant of relaxation (Tau). In sham control mice, atrial systole accounted for 23.0\u2009\u00b1\u20092.4% of LV volume, whereas this contribution was significantly reduced to 13.9\u2009\u00b1\u20092.3% in SAUNA HFpEF mice (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&amp;lt;\u20090.01). In obese sham controls, atrial systole contributed 53.1\u2009\u00b1\u20092.2%, which was markedly decreased to 36.8\u2009\u00b1\u20093.6% in obese-SAUNA HFpEF mice (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&amp;lt;\u20090.003). This novel method enables precise quantification of LA systolic contribution to LV filling in mice and highlights the pathophysiological effects of hypertension and obesity on LA function in HFpEF.\n                  <\/jats:p>","DOI":"10.3389\/fcvm.2026.1919465","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:38:13Z","timestamp":1787031493000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing left atrial systolic contribution via pressure-volume loops in murine HFpEF"],"prefix":"10.3389","volume":"13","author":[{"given":"Hana E.","family":"Baker","sequence":"first","affiliation":[{"name":"Eli Lilly and Company","place":["Indianapolis, IN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Belle-Oladeji","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company","place":["Indianapolis, IN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialuisa","family":"Andreasson","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company","place":["Indianapolis, IN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Christie","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company","place":["Indianapolis, IN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karissa J.","family":"Hyatt","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company","place":["Indianapolis, IN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Wang","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company","place":["Indianapolis, IN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry A.","family":"Borlaug","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic","place":["Rochester, MN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Sam","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company","place":["Indianapolis, IN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: a comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1161\/CIRCHEARTFAILURE.114.001667","article-title":"Left atrial remodeling and function in advanced heart failure with preserved or reduced ejection fraction","volume":"8","author":"Melenovsky","year":"2015","journal-title":"Circ Heart 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