{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:56:29Z","timestamp":1790866589236,"version":"4.1.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Catheter-based renal denervation (RDN) is an interventional therapy for patients with resistant or uncontrolled arterial hypertension after the exclusion of secondary causes. This study aimed to evaluate the effects of the SPYRAL\u2122 catheter system on systolic (SBP) and diastolic blood pressure (DBP) in a real-world clinical setting. Additionally, we explored whether the number of ablation points was associated with the magnitude of blood pressure (BP) reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective, single-center study including patients aged \u226518 years with predominantly resistant hypertension with preserved renal function (eGFR \u226540\u2005mL\/min\/1.73 m2) and no evidence of secondary hypertension. Ambulatory blood pressure monitoring (ABPM) and renal function were assessed at baseline and three months after RDN. Patients were stratified into subgroups based on the number of ablation points (\u226420 vs. &amp;gt;20). A two-tailed\n                      <jats:italic>p<\/jats:italic>\n                      -value &amp;lt;0.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from eleven patients (mean age 64.4\u2009\u00b1\u20098.1, 45.5% were male) were analyzed. At three months, eGFR remained stable (mean decrease \u22124.6\u2005mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      , CI 95% \u221215.8\u20136.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.37). Mean ambulatory SBP and DBP decreased significantly following RDN (\n                      <jats:italic>\u0394<\/jats:italic>\n                      \u221219.4mmHg, CI 95% \u22129.2 to \u221229.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002;\n                      <jats:italic>\u0394<\/jats:italic>\n                      \u22128.6 mmHg, CI 95% \u22123.9 to \u221213.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002; for SBP and DBP respectively). Subgroup analysis revealed that patients with more ablation points experienced a greater reduction in SBP (\n                      <jats:italic>\u0394<\/jats:italic>\n                      \u221217.7 mmHg, CI 95% 0.1\u201335.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) and a numerically greater reduction in DBP (\n                      <jats:italic>\u0394<\/jats:italic>\n                      \u22124.8 mmHg, CI 95% 4.5\u201312,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.27) than those with fewer abation points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this small retrospective cohort, reductions in SBP and DBP were observed following RDN using the SPYRAL\u2122 multi-electrode system, with no excess of adverse renal events. These preliminary findings require confirmation in larger, adequately powered patient cohorts before firm conclusions can be established.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1934448","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:14:41Z","timestamp":1790864081000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Early blood pressure outcomes after SPYRAL\u2122 renal denervation: an exploratory small cohort analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Sasho","family":"Stanisavljevikj","sequence":"first","affiliation":[{"name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","place":["Erlangen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Anwar","sequence":"additional","affiliation":[{"name":"Die MSH Medical School Hamburg\u2013University of Applied Sciences and Medical University","place":["Hamburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abu Rumman","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology and Angiology, Helios Clinics Schwerin","place":["Schwerin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hristijan","family":"Alagjozovski","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology and Angiology, Helios Clinics Schwerin","place":["Schwerin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladyslav","family":"Kavalerchyk","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology and Angiology, Helios Clinics Schwerin","place":["Schwerin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivica","family":"Bojovski","sequence":"additional","affiliation":[{"name":"University Clinic of Cardiology","place":["Skopje, North Macedonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davor","family":"Vukadinovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III\u2013Cardiology, Angiology, and Internal Intensive Care, Saarland University Medical Center","place":["Homburg, Saarland, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Weil","sequence":"additional","affiliation":[{"name":"Med. Klinik II-Kardiologie und Angiologie, Sana Kliniken","place":["L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Staudt","sequence":"additional","affiliation":[{"name":"Die MSH Medical School Hamburg\u2013University of Applied Sciences and Medical University","place":["Hamburg, Germany"]},{"name":"Clinic for Cardiology and Angiology, Helios Clinics Schwerin","place":["Schwerin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","article-title":"Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/S0140-6736(21)01330-1","article-title":"Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019","volume":"398","author":"Zhou","year":"2021","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1161\/HYP.0000000000000084","article-title":"Resistant hypertension: detection, evaluation, and management: a scientific statement from the American Heart Association","volume":"72","author":"Carey","year":"2018","journal-title":"Hypertension"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur. 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