{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:03:33Z","timestamp":1791378213582,"version":"4.3.2"},"reference-count":177,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018735","name":"Fondo de Financiamiento de Centros de Investigaci\u00f3n en \u00c1reas Prioritarias","doi-asserted-by":"publisher","award":["Project [15130011 and 1523A0008]"],"award-info":[{"award-number":["Project [15130011 and 1523A0008]"]}],"id":[{"id":"10.13039\/501100018735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["projects FONDECYT Regular [1231154] ANID\/PIA\/ACT240058"],"award-info":[{"award-number":["projects FONDECYT Regular [1231154] ANID\/PIA\/ACT240058"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Drug Deliv."],"abstract":"<jats:p>Oral cancer, particularly oral squamous cell carcinoma (OSCC), poses significant challenges due to its aggressiveness, high metastatic potential, and resistance to conventional therapies. Recent advancements in drug delivery systems (DDS), including nanotechnology, intelligent hydrogels, lipid nanoparticles, and photodynamic therapy (PDT), offer innovative solutions for targeted treatment. These DDS utilize tumor-specific stimuli, such as pH variations, reactive oxygen species (ROS), and enzymatic activity, to achieve precise drug release while minimizing systemic toxicity. Cutting-edge technologies, such as microelectromechanical systems (MEMS) and artificial intelligence (AI), are enhancing the precision and personalization of DDS. Combination therapies integrating chemotherapy, PDT, and immunotherapy show promise in overcoming current limitations. Despite significant progress, challenges remain in scalability, patient-specific customization, and safety assessments. This review synthesizes the state-of-the-art in DDS for OSCC, highlighting future directions and the need for interdisciplinary collaboration to improve therapeutic outcomes and patient quality of life.<\/jats:p>","DOI":"10.3389\/fddev.2025.1596964","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T06:31:16Z","timestamp":1751005876000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Advanced drug delivery systems for oral squamous cell carcinoma: a comprehensive review of nanotechnology-based and other innovative approaches"],"prefix":"10.3389","volume":"5","author":[{"given":"Alain","family":"Herrada C\u00e9spedes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier O.","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-07849-x","article-title":"Following cytotoxic nanoconjugates from injection to halting the cell cycle machinery and its therapeutic implications in oral cancer","volume":"170","author":"Abdel Hamid","year":"2021","journal-title":"BMC Cancer"},{"key":"B1","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.1016\/j.matpr.2021.07.088","article-title":"By artificial intelligence algorithms and machine learning models to diagnosis cancer","volume":"80","author":"Agarwal","year":"2023","journal-title":"Mater. Today Proc."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/j.ijbiomac.2021.10.028","article-title":"Dose dependent safety implications and acute intravenous toxicity of aminocellulose-grafted-polycaprolactone coated gelatin nanoparticles in mice","volume":"192","author":"Ahmad","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.oraloncology.2017.07.004","article-title":"Dual peptide-mediated targeted delivery of bioactive siRNAs to oral cancer cells in vivo","volume":"72","author":"Alexander-Bryant","year":"2017","journal-title":"Oral Oncol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"19360","DOI":"10.1038\/s41598-024-70003-7","article-title":"An in vitro study for reducing the cytotoxicity and dose dumping risk of remdesivir via entrapment in nanostructured lipid carriers","volume":"14","author":"Amiri","year":"2024","journal-title":"Sci. Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.21608\/adjalexu.2019.57569","article-title":"Therapeutic effect of paclitaxel loaded on gold nanoparticles in treatment of induced oral squamous cell carcinoma","volume":"44","author":"Asar","year":"2019","journal-title":"Alexandria Dent. J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"28480","DOI":"10.1021\/acsnano.4c06369","article-title":"Immune implications of cholesterol-containing lipid nanoparticles","volume":"18","author":"Back","year":"2024","journal-title":"ACS Nano"},{"key":"B7","doi-asserted-by":"publisher","first-page":"118369","DOI":"10.1016\/j.lfs.2020.118369","article-title":"Targeted doxorubicin-loaded mesenchymal stem cells-derived exosomes as a versatile platform for fighting against colorectal cancer","volume":"261","author":"Bagheri","year":"2020","journal-title":"Life Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"055012","DOI":"10.1088\/1748-605X\/ace8de","article-title":"Delivery of chemotherapeutic drug targeting folate receptor to oral cancer cells using functionalized carbon nanospheres","volume":"18","author":"Bhattacharya","year":"2023","journal-title":"Biomed. Mater."},{"key":"B9","doi-asserted-by":"crossref","DOI":"10.5772\/intechopen.100181","article-title":"Way to cure oral squamous cell carcinoma with theranostics and nanoparticular approaches","volume-title":"Oral cancer - current concepts and future perspectives","author":"Bhattacharya","year":"2022"},{"key":"B10","doi-asserted-by":"publisher","first-page":"105127","DOI":"10.1016\/j.jddst.2023.105127","article-title":"Elecrospun nanofibers: the versatile platform as a drug delivery system in healthcare","volume":"90","author":"Bishnoi","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.2217\/nnm-2019-0130","article-title":"Cost\u2013effectiveness of nanomedicine: estimating the real size of nano-costs","volume":"14","author":"Bosetti","year":"2019","journal-title":"Nanomedicine"},{"key":"B12","doi-asserted-by":"publisher","first-page":"100017","DOI":"10.1016\/j.oor.2023.100017","article-title":"Salivary exosomes as biomarkers for early diagnosis of oral squamous cell carcinoma","volume":"6","author":"Bozyk","year":"2023","journal-title":"Oral Oncol. Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"32045","DOI":"10.1021\/acsnano.4c10381","article-title":"Extracellular matrix limits nanoparticle diffusion and cellular uptake in a tissue-specific manner","volume":"18","author":"Cahn","year":"2024","journal-title":"ACS Nano"},{"key":"B14","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.2147\/IJN.S377816","article-title":"Personalized targeted therapeutic strategies against oral squamous cell carcinoma. An evidence-based review of literature","volume":"17","author":"Cao","year":"2022","journal-title":"Int. J. Nanomedicine"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1007\/s13346-020-00801-9","article-title":"Development of DNA polymer films as a drug delivery system for the treatment of oral cancer","volume":"10","author":"Ceron Jayme","year":"2020","journal-title":"Drug Deliv. Transl. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.37349\/etat.2024.00272","article-title":"Exploring the therapeutic potential of lipid-based nanoparticles in the management of oral squamous cell carcinoma","volume":"5","author":"Chaudhary","year":"2024","journal-title":"Explor. Target. Anti-tumor Ther."},{"key":"B17","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-97634-1","volume-title":"Dental applications of nanotechnology","author":"Chaughule","year":"2018"},{"key":"B18","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12943-023-01865-0","article-title":"Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation","volume":"22","author":"Chehelgerdi","year":"2023","journal-title":"Mol. Cancer"},{"key":"B19","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3389\/fchem.2020.00251","article-title":"Injectable hydrogel for NIR-II photo-thermal tumor therapy and dihydroartemisinin-mediated chemodynamic therapy","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3659","DOI":"10.3390\/polym15183659","article-title":"Mesoporous titanium dioxide nanoparticles\u2014poly(N-isopropylacrylamide) hydrogel prepared by electron beam irradiation inhibits the proliferation and migration of oral squamous cell carcinoma cells","volume":"15","author":"Chen","year":"2023","journal-title":"Polymers"},{"key":"B21","doi-asserted-by":"publisher","first-page":"22673","DOI":"10.1021\/acsami.0c05724","article-title":"Response of pH-sensitive doxorubicin nanoparticles on complex tumor microenvironments by tailoring multiple physicochemical properties","volume":"12","author":"Chen","year":"2020","journal-title":"ACS Appl. Mater. and Interfaces"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1021\/acs.molpharmaceut.2c00947","article-title":"Targeted nanodrugs to destroy the tumor extracellular matrix barrier for improving drug delivery and cancer therapeutic efficacy","volume":"20","author":"Chen","year":"2023","journal-title":"Mol. Pharm."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40364-023-00551-z","article-title":"Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy","volume":"12","author":"Chen","year":"2024","journal-title":"Biomark. Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"120964","DOI":"10.1016\/j.biomaterials.2021.120964","article-title":"Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy","volume":"275","author":"Cheng","year":"2021","journal-title":"Biomaterials"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1251583","DOI":"10.3389\/fbioe.2023.1251583","article-title":"Drug-loaded mucoadhesive microneedle patch for the treatment of oral submucous fibrosis","volume":"11","author":"Cheng","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3390\/mi13020164","article-title":"Microelectromechanical systems (MEMS) for biomedical applications","volume":"13","author":"Chircov","year":"2022","journal-title":"Micromachines"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e81800","DOI":"10.7759\/cureus.81800","article-title":"Role of artificial intelligence in the diagnosis of oral squamous cell carcinoma: a systematic review","volume":"17","author":"Chowdhury","year":"2025","journal-title":"Cureus"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1505833","DOI":"10.3389\/froh.2024.1505833","article-title":"Current trends on prevalence, risk factors and prevention of oral cancer","volume":"5","author":"Coletta","year":"2024","journal-title":"Front. Oral Health"},{"key":"B29","doi-asserted-by":"publisher","first-page":"S254","DOI":"10.1016\/S0959-8049(12)71663-5","article-title":"1052 polymersomes \u2013 a novel drug delivery system for the delivery of chemotherapeutic agents to oral cancer cells","volume":"48","author":"Colley","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"B30","doi-asserted-by":"publisher","first-page":"39228","DOI":"10.1021\/acsami.9b15817","article-title":"High-strength, self-adhesive, and strain-sensitive chitosan\/poly(acrylic acid) double-network nanocomposite hydrogels fabricated by salt-soaking strategy for flexible sensors","volume":"11","author":"Cui","year":"2019","journal-title":"ACS Appl. Mater. and Interfaces"},{"key":"B31","doi-asserted-by":"publisher","first-page":"24487","DOI":"10.1039\/D1RA03322K","article-title":"Active targeting of cancer cells by CD44 binding peptide-functionalized oil core-based nanocapsules","volume":"11","author":"De Capua","year":"2021","journal-title":"RSC Adv."},{"key":"B32","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12989-015-0109-1","article-title":"Advanced computational modeling for in vitro nanomaterial dosimetry","volume":"12","author":"DeLoid","year":"2015","journal-title":"Part. Fibre Toxicol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"6595","DOI":"10.1016\/j.biomaterials.2014.04.038","article-title":"The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles","volume":"35","author":"Deng","year":"2014","journal-title":"Biomaterials"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.21275\/SR24219203948","article-title":"Artificial intelligence (AI): it?s role in drug discovery and novel drug delivery system","volume":"13","author":"Deori Leena Hujuri","year":"2024","journal-title":"Int. J. Sci. Res. (IJSR)"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1007\/s11095-011-0489-3","article-title":"Development and in vitro-in vivo evaluation of fenretinide-loaded oral mucoadhesive patches for site-specific chemoprevention of oral cancer","volume":"28","author":"Desai","year":"2011","journal-title":"Pharm. Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"6162","DOI":"10.1021\/acs.molpharmaceut.3c00555","article-title":"Multiphysics-informed pharmacokinetic modeling of systemic exposure of intramuscularly injected LNPs","volume":"20","author":"Di","year":"2023","journal-title":"Mol. Pharm."},{"key":"B37","doi-asserted-by":"publisher","first-page":"40873","DOI":"10.1039\/c9ra08202f","article-title":"CD44-targeted hyaluronic acid\u2013curcumin reverses chemotherapeutics resistance by inhibiting P-gp and anti-apoptotic pathways","volume":"9","author":"Diao","year":"2019","journal-title":"RSC Adv."},{"key":"B38","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3390\/polym12040823","article-title":"Investigating novel syntheses of a series of unique hybrid PLGA-chitosan polymers for potential therapeutic delivery applications","volume":"12","author":"Duskey","year":"2020","journal-title":"Polymers"},{"key":"B39","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.sbi.2020.06.023","article-title":"Multiscale modeling of protein membrane interactions for nanoparticle targeting in drug delivery","volume":"64","author":"Eckmann","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.2147\/IJN.S75474","article-title":"Layered nanoemulsions as mucoadhesive buccal systems for controlled delivery of oral cancer therapeutics","volume":"10","author":"Elbayoumi","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"B41","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3389\/fbioe.2019.00363","article-title":"Synthesis, functionalization, and bioapplications of two-dimensional boron nitride nanomaterials","volume":"7","author":"Emanet","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/cas.12079","article-title":"Tumor\u2010targeted chemotherapy with the nanopolymer\u2010based drug NC \u20106004 for oral squamous cell carcinoma","volume":"104","author":"Endo","year":"2013","journal-title":"Cancer Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/odi.13551","article-title":"Function of gold nanoparticles in oral cancer beyond drug delivery: implications in cell apoptosis","volume":"27","author":"Essawy","year":"2021","journal-title":"Oral Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-019-03545-4","article-title":"Exosomes: cell-created drug delivery systems","volume":"459","author":"Familtseva","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"831","DOI":"10.3390\/pharmaceutics15030831","article-title":"Solid lipid nanoparticles: multitasking nano-carriers for cancer treatment","volume":"15","author":"German-Cort\u00e9s","year":"2023","journal-title":"Pharmaceutics"},{"key":"B46","doi-asserted-by":"publisher","first-page":"4829","DOI":"10.1038\/s41467-022-31859-3","article-title":"A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer","volume":"13","author":"Goldberg","year":"2022","journal-title":"Nat. Commun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"644","DOI":"10.7150\/jca.7093","article-title":"A target-specific oral formulation of doxorubicin-protein nanoparticles: efficacy and safety in hepatocellular cancer","volume":"4","author":"Golla","year":"2013","journal-title":"J. Cancer"},{"key":"B48","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12951-020-00649-8","article-title":"Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy","volume":"18","author":"Gong","year":"2020","journal-title":"J. Nanobiotechnology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1039\/D1LC00192B","article-title":"Quantifying nanotherapeutic penetration using a hydrogel-based microsystem as a new 3D in vitro platform","volume":"21","author":"Goodarzi","year":"2021","journal-title":"Lab a Chip"},{"key":"B50","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2147\/IJN.S124995","article-title":"Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer","volume":"13","author":"Gupta","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"B52","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1158\/1940-6207.CAPR-14-0418","article-title":"Fenretinide perturbs focal adhesion kinase in premalignant and malignant human oral keratinocytes. Fenretinide\u2019s chemopreventive mechanisms include ECM interactions","volume":"8","author":"Han","year":"2015","journal-title":"Cancer Prev. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"102068","DOI":"10.1016\/j.rechem.2025.102068","article-title":"Nanoparticle-based drug delivery system for Oral Cancer: mechanism, challenges, and therapeutic potential","volume":"14","author":"Hasan","year":"2025","journal-title":"Results Chem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.addr.2019.05.001","article-title":"The significance of artificial intelligence in drug delivery system design","author":"Hassanzadeh","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B55","doi-asserted-by":"publisher","first-page":"19896","DOI":"10.1038\/s41598-021-99180-5","article-title":"Cytosolic protein delivery using pH-responsive, charge-reversible lipid nanoparticles","volume":"11","author":"Hirai","year":"2021","journal-title":"Sci. Rep."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1093\/carcin\/bgs122","article-title":"Evaluation of a mucoadhesive fenretinide patch for local intraoral delivery: a strategy to reintroduce fenretinide for oral cancer chemoprevention","volume":"33","author":"Holpuch","year":"2012","journal-title":"Carcinogenesis"},{"key":"B57","doi-asserted-by":"publisher","first-page":"2000394","DOI":"10.1002\/marc.202000394","article-title":"Direct polymerization approach to synthesize acid\u2010degradable block copolymers bearing imine pendants for tunable pH\u2010sensitivity and enhanced release","volume":"41","author":"Hu","year":"2020","journal-title":"Macromol. Rapid Commun."},{"key":"B58","doi-asserted-by":"publisher","first-page":"10973","DOI":"10.7150\/thno.49670","article-title":"Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues","volume":"10","author":"Ingram","year":"2020","journal-title":"Theranostics"},{"key":"B59","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1093\/jmicro\/dfac007","article-title":"Inhibition of retinoid X receptor improved the morphology, localization of desmosomal proteins and paracellular permeability in three-dimensional cultures of mouse keratinocytes","volume":"71","author":"Ishikawa","year":"2022","journal-title":"Microscopy"},{"key":"B60","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3390\/jfb14090437","article-title":"Lipid\u2013polymer hybrid nanosystems: a rational fusion for advanced therapeutic delivery","volume":"14","author":"Jain","year":"2023","journal-title":"J. Funct. Biomaterials"},{"key":"B61","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ejps.2017.09.049","article-title":"Evaluation of the digestibility of solid lipid nanoparticles of glyceryl dibehenate produced by two techniques: ultrasonication and spray-flash evaporation","volume":"111","author":"Jannin","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e6800","DOI":"10.1002\/cam4.6800","article-title":"RGD peptide in cancer targeting: benefits, challenges, solutions, and possible integrin\u2013RGD interactions","volume":"13","author":"Javid","year":"2024","journal-title":"Cancer Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"29","DOI":"10.18332\/tid\/105844","article-title":"Tobacco and oral squamous cell carcinoma: a review ofcarcinogenic pathways","volume":"17","author":"Jiang","year":"2019","journal-title":"Tob. Induc. Dis."},{"key":"B64","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12951-018-0362-1","article-title":"Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells","volume":"16","author":"Kalimuthu","year":"2018","journal-title":"J. Nanobiotechnology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1901223","DOI":"10.1002\/adhm.201901223","article-title":"Size\u2010dependent EPR effect of polymeric nanoparticles on tumor targeting","volume":"9","author":"Kang","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.17179\/EXCLI2024-7253","article-title":"AI illuminates paths in oral cancer: transformative insights, diagnostic precision, and personalized strategies","volume":"23","author":"Kapoor","year":"2024","journal-title":"EXCLI J."},{"key":"B67","doi-asserted-by":"publisher","first-page":"119386","DOI":"10.1016\/j.ijpharm.2020.119386","article-title":"Fabrication and in vivo evaluation of ligand appended paclitaxel and artemether loaded lipid nanoparticulate systems for the treatment of NSCLC: a nanoparticle assisted combination oncotherapy","volume":"583","author":"Khatri","year":"2020","journal-title":"Int. J. Pharm."},{"key":"B68","doi-asserted-by":"publisher","first-page":"112063","DOI":"10.1016\/j.matdes.2023.112063","article-title":"Flash dissolving nanofiber membranes for chemo\/cascade chemodynamic therapy of oral cancer","volume":"231","author":"Kim","year":"2023","journal-title":"Mater. and Des."},{"key":"B69","doi-asserted-by":"publisher","first-page":"100129","DOI":"10.1016\/j.nxnano.2024.100129","article-title":"Nanomedicine: how nanomaterials are transforming drug delivery, bio-imaging, and diagnosis","volume":"7","author":"Kurul","year":"2025","journal-title":"Next Nanotechnol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"107795","DOI":"10.1016\/j.pharmthera.2020.107795","article-title":"Nanomedicine: photo-activated nanostructured titanium dioxide, as a promising anticancer agent","volume":"222","author":"Lagopati","year":"2021","journal-title":"Pharmacol. and Ther."},{"key":"B71","doi-asserted-by":"publisher","first-page":"4774","DOI":"10.3390\/ijms21134774","article-title":"Reproducible large-scale isolation of exosomes from adipose tissue-derived mesenchymal stem\/stromal cells and their application in acute kidney injury","volume":"21","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"e33860","DOI":"10.1371\/journal.pone.0033860","article-title":"Biodegradable thermosensitive hydrogel for SAHA and DDP delivery: therapeutic effects on oral squamous cell carcinoma xenografts","volume":"7","author":"Li","year":"2012","journal-title":"PLoS ONE"},{"key":"B73","doi-asserted-by":"publisher","first-page":"930920","DOI":"10.3389\/fonc.2022.930920","article-title":"pH-responsive graphene oxide loaded with targeted peptide and anticancer drug for OSCC therapy","volume":"12","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.2147\/IJN.S402249","article-title":"A targeted and pH-responsive nano-graphene oxide nanoparticle loaded with doxorubicin for synergetic chemo-photothermal therapy of oral squamous cell carcinoma","volume":"18","author":"Li","year":"2023","journal-title":"Int. J. Nanomedicine"},{"key":"B75","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1208\/s12248-015-9828-3","article-title":"Thermosensitive hydrogel Co-loaded with gold nanoparticles and doxorubicin for effective chemoradiotherapy","volume":"18","author":"Li","year":"2016","journal-title":"AAPS J."},{"key":"B76","doi-asserted-by":"publisher","first-page":"31264","DOI":"10.1039\/C9RA04343H","article-title":"MMP-responsive in situ forming hydrogel loaded with doxorubicin-encapsulated biodegradable micelles for local chemotherapy of oral squamous cell carcinoma","volume":"9","author":"Li","year":"2019","journal-title":"RSC Adv."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2002188","DOI":"10.1002\/smll.202002188","article-title":"Dual pH\/ROS\u2010responsive nanoplatform with deep tumor penetration and self\u2010amplified drug release for enhancing tumor chemotherapeutic efficacy","volume":"16","author":"Li","year":"2020","journal-title":"Small"},{"key":"B78","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1080\/10717544.2021.1876182","article-title":"Stimuli-responsive drug delivery systems for head and neck cancer therapy","volume":"28","author":"Liang","year":"2021","journal-title":"Drug Deliv."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1002\/hed.26619","article-title":"Chemoradiation therapy changes oral microbiome and metabolomic profiles in patients with oral cavity cancer and oropharyngeal cancer","volume":"43","author":"Lim","year":"2021","journal-title":"Head and Neck"},{"key":"B80","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1021\/acs.nanolett.0c04833","article-title":"Bifunctional janus particles as multivalent synthetic nanoparticle antibodies (SNAbs) for selective depletion of target cells","volume":"21","author":"Liu","year":"2021","journal-title":"Nano Lett."},{"key":"B81","doi-asserted-by":"publisher","first-page":"2201561","DOI":"10.1002\/smll.202201561","article-title":"Designing a mucoadhesive ChemoPatch to ablate oral dysplasia for cancer prevention","volume":"18","author":"Liu","year":"","journal-title":"Small"},{"key":"B82","doi-asserted-by":"publisher","first-page":"115178","DOI":"10.1016\/j.physe.2022.115178","article-title":"Synthesis of monodispersed calcium ferrite (CaFe2O4) nanocubes with hydrophilic surface for pH-induced drug release and tongue squamous cell carcinoma treatment","volume":"140","author":"Liu","year":"","journal-title":"Phys. E Low-dimensional Syst. Nanostructures"},{"key":"B83","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.actbio.2017.11.010","article-title":"Dual pH-responsive multifunctional nanoparticles for targeted treatment of breast cancer by combining immunotherapy and chemotherapy","volume":"66","author":"Liu","year":"2018","journal-title":"Acta Biomater."},{"key":"B84","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/jfb13040167","article-title":"On-demand release of fucoidan from a multilayered nanofiber patch for the killing of oral squamous cancer cells and promotion of epithelial regeneration","volume":"13","author":"Liu","year":"2022","journal-title":"J. Funct. Biomaterials"},{"key":"B85","doi-asserted-by":"publisher","first-page":"e28148","DOI":"10.1016\/j.heliyon.2024.e28148","article-title":"Role of exosomes in the communication and treatment between OSCC and normal cells","volume":"10","author":"Ma","year":"2024","journal-title":"Heliyon"},{"key":"B86","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ejpb.2022.12.003","article-title":"Novel mucoadhesive celecoxib-loaded cubosomal sponges: anticancer potential and regulation of myeloid-derived suppressor cells in oral squamous cell carcinoma","volume":"182","author":"Mabrouk","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"B87","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1111\/j.1600-0714.2009.00759.x","article-title":"Targeted drug delivery system for oral cancer therapy using sonoporation","volume":"38","author":"Maeda","year":"2009","journal-title":"J. Oral Pathology and Med."},{"key":"B88","doi-asserted-by":"publisher","first-page":"2302969","DOI":"10.1002\/adhm.202302969","article-title":"Soft and flexible bioelectronic micro\u2010systems for electronically controlled drug delivery","volume":"13","author":"Mariello","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"B89","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s11033-023-09146-1","article-title":"Marine-derived \u03ba-carrageenan-coated zinc oxide nanoparticles for targeted drug delivery and apoptosis induction in oral cancer","volume":"51","author":"Marunganathan","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.21873\/invivo.13251","article-title":"Efficacy of antineoplastic nanocarriers on 3D oral cancer spheroids","volume":"37","author":"Mendoza-Martinez","year":"2023","journal-title":"Vivo"},{"key":"B91","doi-asserted-by":"publisher","first-page":"104551","DOI":"10.1016\/j.oraloncology.2019.104551","article-title":"Global patterns and trends in cancers of the lip, tongue and mouth","volume":"102","author":"Miranda-Filho","year":"2020","journal-title":"Oral Oncol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.jconrel.2021.05.032","article-title":"Solid lipid nanoparticles for hydrophilic drugs","volume":"335","author":"Mirchandani","year":"2021","journal-title":"J. Control. Release"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1569567","DOI":"10.3389\/froh.2025.1569567","article-title":"Artificial intelligence and the diagnosis of oral cavity cancer and oral potentially malignant disorders from clinical photographs: a narrative review","volume":"6","author":"Mirfendereski","year":"2025","journal-title":"Front. Oral Health"},{"key":"B94","doi-asserted-by":"publisher","first-page":"101458","DOI":"10.1016\/j.jddst.2019.101458","article-title":"Solid lipid nanoparticles and nanostructured lipid carriers in oral cancer drug delivery","volume":"55","author":"Nasirizadeh","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"B95","first-page":"2497","article-title":"Role of extracellular matrix assembly in interstitial transport in solid tumors","volume":"60","author":"Netti","year":"2000","journal-title":"Cancer Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"595","DOI":"10.4155\/tde.15.5","article-title":"Advanced drug delivery systems for local treatment of the oral cavity","volume":"6","author":"Nguyen","year":"2015","journal-title":"Ther. Deliv."},{"key":"B97","doi-asserted-by":"publisher","first-page":"25575","DOI":"10.1021\/acsami.0c22883","article-title":"Safe and targeted sonodynamic cancer therapy using biocompatible exosome-based nanosonosensitizers","volume":"13","author":"Nguyen Cao","year":"2021","journal-title":"ACS Appl. Mater. and Interfaces"},{"key":"B98","doi-asserted-by":"publisher","first-page":"5072","DOI":"10.3390\/ijms22105072","article-title":"Modified gold nanoparticles for efficient delivery of betulinic acid to cancer cell mitochondria","volume":"22","author":"Oladimeji","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0378-5173(02)00035-2","article-title":"Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)\u2014effect of surfactants, storage time and crystallinity","volume":"237","author":"Olbrich","year":"2002","journal-title":"Int. J. Pharm."},{"key":"B100","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jconrel.2018.08.039","article-title":"Encapsulation of thermo-responsive gel in pH-sensitive polymersomes as dual-responsive smart carriers for controlled release of doxorubicin","volume":"288","author":"Oroojalian","year":"2018","journal-title":"J. Control. Release"},{"key":"B101","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1016\/S0959-8049(20)31164-3","article-title":"Phase IIa\/IIb clinical trial of NC-6004 (Nanoparticle Cisplatin) plus Pembrolizumab in patients with head and neck cancer (HNSCC) who have failed platinum or a platinum-containing regimen","volume":"138","author":"Osada","year":"2020","journal-title":"Eur. J. Cancer"},{"key":"B102","doi-asserted-by":"publisher","first-page":"708765","DOI":"10.3389\/fonc.2021.708765","article-title":"Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications","volume":"11","author":"Otmani","year":"2021","journal-title":"Front. Oncol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1039\/c6mb00786d","article-title":"Cancerous perturbations within the ERK, PI3K\/Akt, and Wnt\/\u03b2-catenin signaling network constitutively activate inter-pathway positive feedback loops","volume":"13","author":"Padala","year":"2017","journal-title":"Mol. Biosyst."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.7150\/thno.68756","article-title":"A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy","volume":"12","author":"Peng","year":"2022","journal-title":"Theranostics"},{"key":"B105","doi-asserted-by":"publisher","first-page":"119680","DOI":"10.1016\/j.biomaterials.2019.119680","article-title":"Biodegradable zwitterionic polymer membrane coating endowing nanoparticles with ultra-long circulation and enhanced tumor photothermal therapy","volume":"231","author":"Peng","year":"2020","journal-title":"Biomaterials"},{"key":"B106","doi-asserted-by":"publisher","first-page":"111279","DOI":"10.1016\/j.colsurfb.2020.111279","article-title":"Catechol-modified chitosan\/hyaluronic acid nanoparticles as a new avenue for local delivery of doxorubicin to oral cancer cells","volume":"196","author":"Pornpitchanarong","year":"2020","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"B107","doi-asserted-by":"publisher","first-page":"101870","DOI":"10.1016\/j.jsps.2023.101870","article-title":"Exploring LIPIDs for their potential to improves bioavailability of lipophilic drugs candidates: a review","volume":"31","author":"Preeti","year":"2023","journal-title":"Saudi Pharm. J."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.51542\/ijscia.v3i3.4","article-title":"Ssociation analysis of TP53 mutations in codon R175 and G245 with histopathological grading outcomes in OSCC patients","volume":"3","author":"Puteri","year":"2022","journal-title":"Int. J. Of Sci. Adv."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1016\/j.bbamem.2016.02.028","article-title":"Computational and experimental approaches for investigating nanoparticle-based drug delivery systems","volume":"1858","author":"Ramezanpour","year":"2016","journal-title":"Biochimica Biophysica Acta (BBA) - Biomembr."},{"key":"B110","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41699-021-00231-2","article-title":"2D boron nitride nanosheets for polymer composite materials","volume":"5","author":"Rasul","year":"2021","journal-title":"npj 2D Mater. Appl."},{"key":"B111","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.3390\/pharmaceutics14122573","article-title":"An alternative device for the topical treatment of oral cancer: development and ex-vivo evaluation of imiquimod-loaded polysaccharides formulations","volume":"14","author":"Remiro","year":"2022","journal-title":"Pharmaceutics"},{"key":"B112","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.3390\/polym16162320","article-title":"Computational methodologies in synthesis, preparation and application of antimicrobial polymers, biomolecules, and nanocomposites","volume":"16","author":"Rezi\u0107","year":"2024","journal-title":"Polymers"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3390\/pharmaceutics12111095","article-title":"Manufacturing considerations for the development of lipid nanoparticles using microfluidics","volume":"12","author":"Roces","year":"2020","journal-title":"Pharmaceutics"},{"key":"B114","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1080\/21691401.2017.1373284","article-title":"Application of nanocarrier-based drug delivery system in treatment of oral cancer","volume":"46","author":"Sah","year":"2018","journal-title":"Artif. Cells, Nanomedicine, Biotechnol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3390\/inorganics12110292","article-title":"Inorganic-based nanoparticles and biomaterials as biocompatible scaffolds for regenerative medicine and tissue engineering: current advances and trends of development","volume":"12","author":"Saikia","year":"2024","journal-title":"Inorganics"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1021\/mp5000423","article-title":"Sequential release of autophagy inhibitor and chemotherapeutic drug with polymeric delivery system for oral squamous cell carcinoma therapy","volume":"11","author":"Saiyin","year":"2014","journal-title":"Mol. Pharm."},{"key":"B177","article-title":"DDS for oral cancer treatment","author":"Sanchez","year":"2025"},{"key":"B117","doi-asserted-by":"publisher","first-page":"4400","DOI":"10.3390\/polym13244400","article-title":"Polymeric nanoparticles: exploring the current drug development and therapeutic insight of breast cancer treatment and recommendations","volume":"13","author":"Sartaj","year":"2021","journal-title":"Polymers"},{"key":"B118","doi-asserted-by":"publisher","first-page":"29S","DOI":"10.1177\/0022034514527969","article-title":"Human papillomavirus (HPV)-associated oral cancers and treatment strategies","volume":"93","author":"Sathish","year":"2014","journal-title":"J. Dent. Res."},{"key":"B119","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1021\/acs.molpharmaceut.1c00213","article-title":"MiR-155 inhibitor-laden exosomes reverse resistance to cisplatin in a 3D tumor spheroid and xenograft model of oral cancer","volume":"18","author":"Sayyed","year":"2021","journal-title":"Mol. Pharm."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.3390\/pharmaceutics16101328","article-title":"Artificial intelligence (AI) applications in drug discovery and drug delivery: revolutionizing personalized medicine","volume":"16","author":"Serrano","year":"2024","journal-title":"Pharmaceutics"},{"key":"B121","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3892\/ijo.2021.5252","article-title":"Stromal cells in the tumor microenvironment promote the progression of oral squamous cell carcinoma","volume":"59","author":"Shan","year":"2021","journal-title":"Int. J. Oncol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"815606","DOI":"10.3389\/froh.2021.815606","article-title":"Salvage surgery in recurrent oral squamous cell carcinoma","volume":"2","author":"Shetty","year":"2022","journal-title":"Front. Oral Health"},{"key":"B123","doi-asserted-by":"publisher","first-page":"8988","DOI":"10.1021\/acsanm.4c00421","article-title":"Cancer cell membrane-coated nanoparticles for treatment of oral tongue squamous cell carcinoma by combining photothermal\/photodynamic therapy and autophagy inhibition","volume":"7","author":"Shi","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"key":"B124","doi-asserted-by":"publisher","first-page":"29260","DOI":"10.1021\/acsami.8b08269","article-title":"Reactive oxygen species-responsive nanoparticles based on PEGlated prodrug for targeted treatment of oral tongue squamous cell carcinoma by combining photodynamic therapy and chemotherapy","volume":"10","author":"Shi","year":"2018","journal-title":"ACS Appl. Mater. and Interfaces"},{"key":"B125","doi-asserted-by":"publisher","first-page":"e006666","DOI":"10.1136\/jitc-2023-006666","article-title":"TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma","volume":"11","author":"Shi","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"B126","doi-asserted-by":"publisher","first-page":"7921","DOI":"10.7150\/thno.49577","article-title":"The EPR effect and beyond: strategies to improve tumor targeting and cancer nanomedicine treatment efficacy","volume":"10","author":"Shi","year":"2020","journal-title":"Theranostics"},{"key":"B127","doi-asserted-by":"publisher","first-page":"390518","DOI":"10.1155\/2013\/390518","article-title":"In vivo biocompatibility of PLGA-polyhexylthiophene nanofiber scaffolds in a rat model","volume":"2013","author":"Subramanian","year":"2013","journal-title":"BioMed Res. Int."},{"key":"B128","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","article-title":"PEGylation as a strategy for improving nanoparticle-based drug and gene delivery","volume":"99","author":"Suk","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B129","doi-asserted-by":"publisher","first-page":"e202208732","DOI":"10.1002\/anie.202208732","article-title":"Responsive peptide nanofibers with theranostic and prognostic capacity","volume":"61","author":"Sun","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"B130","doi-asserted-by":"publisher","first-page":"53646","DOI":"10.1021\/acsami.1c17642","article-title":"Intelligent tumor microenvironment-activated multifunctional nanoplatform coupled with turn-on and always-on fluorescence probes for imaging-guided cancer treatment","volume":"13","author":"Sun","year":"2021","journal-title":"ACS Appl. Mater. and Interfaces"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.37349\/ei.2021.00013","article-title":"Immunosuppressive microenvironment in oral cancer: implications for cancer immunotherapy","author":"SureshBabu","year":"2021","journal-title":"Explor. Immunol"},{"key":"B132","doi-asserted-by":"publisher","first-page":"18071","DOI":"10.1038\/s41598-022-23013-2","article-title":"Development of lipid nanoparticles and liposomes reference materials (II): cytotoxic profiles","volume":"12","author":"Syama","year":"2022","journal-title":"Sci. Rep."},{"key":"B133","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1515\/ntrev-2022-0154","article-title":"Biosynthesis of ZnO NPs from pumpkin seeds\u2019 extract and elucidation of its anticancer potential against breast cancer","volume":"11","author":"Tabrez","year":"2022","journal-title":"Nanotechnol. Rev."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1249349","DOI":"10.3389\/fbioe.2023.1249349","article-title":"Preparation of honokiol-loaded titanium dioxide nanotube drug delivery system and its effect on CAL-27 cells","volume":"11","author":"Tang","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"101817","DOI":"10.1016\/j.jddst.2020.101817","article-title":"Thermosensitive injectable hydrogel containing carboplatin loaded nanoparticles: a dual approach for sustained and localized delivery with improved safety and therapeutic efficacy","volume":"58","author":"Thakur","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"18419","DOI":"10.1021\/jacs.2c06877","article-title":"Engineering poly(ethylene glycol) nanoparticles for accelerated blood clearance inhibition and targeted drug delivery","volume":"144","author":"Tian","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"B137","doi-asserted-by":"publisher","first-page":"615","DOI":"10.3390\/mi3040615","article-title":"Approaches and challenges of engineering implantable microelectromechanical systems (MEMS) drug delivery systems for in vitro and in vivo applications","volume":"3","author":"Tng","year":"2012","journal-title":"Micromachines"},{"key":"B138","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.21817\/ijet\/2017\/v9i2\/170902284","article-title":"Current trends in MEMS drug delivery techniques","volume":"9","author":"Ullah","year":"2017","journal-title":"Int. J. Eng. Technol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.3390\/app15063189","article-title":"Enhancement of EPR effect for passive tumor targeting: current status and future perspectives","volume":"15","author":"Vagena","year":"2025","journal-title":"Appl. Sci."},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1101\/2020.01.16.907394","article-title":"Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery","author":"Van Der Meel","year":"2020","journal-title":"Bioengineering"},{"key":"B141","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3389\/fbioe.2020.00827","article-title":"Recent advances in micro-electro-mechanical devices for controlled drug release applications","volume":"8","author":"Villarruel Mendoza","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3390\/diagnostics15030280","article-title":"Artificial intelligence in oral cancer: a comprehensive scoping review of diagnostic and prognostic applications","volume":"15","author":"Vinay","year":"2025","journal-title":"Diagnostics"},{"key":"B143","doi-asserted-by":"publisher","first-page":"24919","DOI":"10.1021\/acsnano.3c06599","article-title":"Pulmonary toxicity of boron nitride nanomaterials is aspect ratio dependent","volume":"17","author":"Visani De Luna","year":"2023","journal-title":"ACS Nano"},{"key":"B144","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.3390\/pharmaceutics15071916","article-title":"Artificial intelligence in pharmaceutical technology and drug delivery design","volume":"15","author":"Vora","year":"2023","journal-title":"Pharmaceutics"},{"key":"B145","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1093\/carcin\/bgac070","article-title":"Fenretinide combines perturbation of signaling kinases, cell\u2013extracellular matrix interactions and matrix metalloproteinase activation to inhibit invasion in oral squamous cell carcinoma cells","volume":"43","author":"Wang","year":"2022","journal-title":"Carcinogenesis"},{"key":"B146","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2147\/IJN.S150610","article-title":"Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment","volume":"13","author":"Wang","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"B147","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.2147\/IJN.S165699","article-title":"Zinc oxide nanoparticles induce toxicity in CAL 27 oral cancer cell lines by activating PINK1\/Parkin-mediated mitophagy","volume":"13","author":"Wang","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"B148","doi-asserted-by":"publisher","first-page":"18327","DOI":"10.1021\/acsnano.1c07587","article-title":"A microfluidics-based scalable approach to generate extracellular vesicles with enhanced therapeutic MicroRNA loading for intranasal delivery to mouse glioblastomas","volume":"15","author":"Wang","year":"2021","journal-title":"ACS Nano"},{"key":"B149","doi-asserted-by":"publisher","first-page":"116508","DOI":"10.1016\/j.ejmech.2024.116508","article-title":"Nanomaterials-based advanced systems for photothermal\/photodynamic therapy of oral cancer","volume":"272","author":"Wang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"B150","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12951-015-0116-2","article-title":"A cell-targeted chemotherapeutic nanomedicine strategy for oral squamous cell carcinoma therapy","volume":"13","author":"Wang","year":"2015","journal-title":"J. Nanobiotechnology"},{"key":"B151","doi-asserted-by":"publisher","first-page":"17699","DOI":"10.1039\/D4NR01780C","article-title":"Immunomodulatory nanoparticles activate cytotoxic T cells for enhancement of the effect of cancer immunotherapy","volume":"16","author":"Wells","year":"2024","journal-title":"Nanoscale"},{"key":"B152","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0378-5173(02)00220-X","article-title":"The influence of the crystallinity of lipid nanoparticles on their occlusive properties","volume":"242","author":"Wissing","year":"2002","journal-title":"Int. J. Pharm."},{"key":"B153","doi-asserted-by":"publisher","first-page":"17168","DOI":"10.1039\/D1NR04625J","article-title":"Near-infrared light-responsive hybrid hydrogels for the synergistic chemo-photothermal therapy of oral cancer","volume":"13","author":"Wu","year":"2021","journal-title":"Nanoscale"},{"key":"B154","doi-asserted-by":"publisher","first-page":"154653","DOI":"10.1016\/j.cej.2024.154653","article-title":"Bioorthogonal surface-edited exosomes for targeted multimodal imaging and synergic chemophototherapy of oral cancer","volume":"497","author":"Wu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"B155","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1080\/10717544.2020.1785581","article-title":"Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect","volume":"27","author":"Xu","year":"2020","journal-title":"Drug Deliv."},{"key":"B156","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1002\/bit.28462","article-title":"Dual\u2010targeting multifunctional hyaluronic acid ligand\u2010capped gold nanorods with enhanced endo\u2010lysosomal escape ability for synergetic photodynamic\u2013photothermal therapy of cancer","volume":"120","author":"Xu","year":"2023","journal-title":"Biotechnol. Bioeng."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.3390\/biom10091335","article-title":"Natural compounds modulate drug transporter mediated oral cancer treatment","volume":"10","author":"Yang","year":"2020","journal-title":"Biomolecules"},{"key":"B158","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.3390\/pharmaceutics14122682","article-title":"Recent advances in lipid nanoparticles for delivery of mRNA","volume":"14","author":"Yang","year":"2022","journal-title":"Pharmaceutics"},{"key":"B159","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1186\/s12951-022-01738-6","article-title":"Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer","volume":"20","author":"Yang","year":"2022","journal-title":"J. Nanobiotechnology"},{"key":"B160","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1186\/s12885-023-10948-6","article-title":"Joint effect of human papillomavirus exposure, smoking and alcohol on risk of oral squamous cell carcinoma","volume":"23","author":"Yang","year":"2023","journal-title":"BMC Cancer"},{"key":"B161","doi-asserted-by":"publisher","first-page":"20214","DOI":"10.1021\/acsami.0c03022","article-title":"Mild acid-responsive \u201cnanoenzyme capsule\u201d remodeling of the tumor microenvironment to increase tumor penetration","volume":"12","author":"Yao","year":"2020","journal-title":"ACS Appl. Mater. and Interfaces"},{"key":"B162","doi-asserted-by":"publisher","first-page":"1174014","DOI":"10.3389\/fbioe.2023.1174014","article-title":"Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo\/photothermal therapy of oral cancer","volume":"11","author":"Yin","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"9662","DOI":"10.1021\/acsnano.0c00910","article-title":"Hollow magnetic nanocatalysts drive starvation\u2013chemodynamic\u2013hyperthermia synergistic therapy for tumor","volume":"14","author":"Ying","year":"2020","journal-title":"ACS Nano"},{"key":"B164","doi-asserted-by":"publisher","first-page":"735","DOI":"10.2147\/IJN.S231448","article-title":"Antitumor activity of thermosensitive hydrogels packaging gambogic acid nanoparticles and tumor-penetrating peptide iRGD against gastric cancer","volume":"15","author":"Zhang","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"B165","doi-asserted-by":"publisher","first-page":"6294","DOI":"10.1021\/acsabm.1c00569","article-title":"pH\/ROS dual-responsive polymer\u2013drug-based nanocarriers: click-reaction preparation and fluorescence imaging-guided chemotherapy and photodynamic therapy","volume":"4","author":"Zhang","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"B166","doi-asserted-by":"publisher","first-page":"100333","DOI":"10.1016\/j.mtbio.2022.100333","article-title":"Gold nanomaterials for oral cancer diagnosis and therapy: advances, challenges, and prospects","volume":"15","author":"Zhang","year":"2022","journal-title":"Mater. Today Bio"},{"key":"B167","doi-asserted-by":"publisher","first-page":"2102004","DOI":"10.1002\/adfm.202102004","article-title":"Bioengineered dual\u2010targeting protein nanocage for stereoscopical loading of synergistic hydrophilic\/hydrophobic drugs to enhance anticancer efficacy","volume":"31","author":"Zhang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"B168","doi-asserted-by":"publisher","first-page":"10699","DOI":"10.2147\/IJN.S481901","article-title":"Photodynamic therapy for oral squamous cell carcinoma: current status, challenges, and prospects","volume":"19","author":"Zhang","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"B169","doi-asserted-by":"publisher","first-page":"5680","DOI":"10.1021\/acsami.9b23325","article-title":"Self-delivered and self-monitored chemo-photodynamic nanoparticles with light-triggered synergistic antitumor therapies by downregulation of HIF-1\u03b1 and depletion of GSH","volume":"12","author":"Zhang","year":"2020","journal-title":"ACS Appl. Mater. and Interfaces"},{"key":"B170","doi-asserted-by":"publisher","first-page":"741","DOI":"10.3390\/gels8110741","article-title":"Developments on the smart hydrogel-based drug delivery system for oral tumor therapy","volume":"8","author":"Zhao","year":"2022","journal-title":"Gels"},{"key":"B171","doi-asserted-by":"publisher","first-page":"109006","DOI":"10.1016\/j.biopha.2019.109006","article-title":"Improving breast cancer therapy using doxorubicin loaded solid lipid nanoparticles: synthesis of a novel arginine-glycine-aspartic tripeptide conjugated, pH sensitive lipid and evaluation of the nanomedicine in vitro and in vivo","volume":"116","author":"Zheng","year":"2019","journal-title":"Biomed. and Pharmacother."},{"key":"B172","doi-asserted-by":"publisher","first-page":"44007","DOI":"10.1021\/acsami.9b19546","article-title":"Water-soluble, zwitterionic poly-photosensitizers as carrier-free, photosensitizer-self-delivery system for in vivo photodynamic therapy","volume":"11","author":"Zheng","year":"2019","journal-title":"ACS Appl. Mater. and Interfaces"},{"key":"B173","doi-asserted-by":"publisher","first-page":"102003","DOI":"10.1016\/j.nantod.2023.102003","article-title":"Toll-like receptor-targeted nanoparticles: a powerful combination for tumor immunotherapy","volume":"53","author":"Zhi","year":"2023","journal-title":"Nano Today"},{"key":"B174","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1021\/acs.nanolett.7b05087","article-title":"Peptide-functionalized phase-transformation nanoparticles for low intensity focused ultrasound-assisted tumor imaging and therapy","volume":"18","author":"Zhu","year":"2018","journal-title":"Nano Lett."},{"key":"B175","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1021\/acs.biomac.9b00428","article-title":"Cancer-selective bioreductive chemotherapy mediated by dual hypoxia-responsive nanomedicine upon photodynamic therapy-induced hypoxia aggravation","volume":"20","author":"Zhu","year":"2019","journal-title":"Biomacromolecules"},{"key":"B176","doi-asserted-by":"publisher","first-page":"9084","DOI":"10.1039\/D0TB01089H","article-title":"Photonic hyperthermal and sonodynamic nanotherapy targeting oral squamous cell carcinoma","volume":"8","author":"Zuo","year":"2020","journal-title":"J. Mater. Chem. B"}],"container-title":["Frontiers in Drug Delivery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fddev.2025.1596964\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T06:31:18Z","timestamp":1751005878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fddev.2025.1596964\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":177,"alternative-id":["10.3389\/fddev.2025.1596964"],"URL":"https:\/\/doi.org\/10.3389\/fddev.2025.1596964","relation":{},"ISSN":["2674-0850"],"issn-type":[{"value":"2674-0850","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,27]]},"article-number":"1596964"}}