{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:50:46Z","timestamp":1791687046363,"version":"4.3.4"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100025294","name":"Research Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100025294","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Drug Deliv."],"abstract":"<jats:p>\n                    Osteoarthritis (OA) is the major cause of pain and disability worldwide, particularly affecting the knee joint. Although intra-articular (IA) treatments including corticosteroids and hyaluronic acid (HA), are commonly used to manage symptoms, their therapeutic effects are often short-lived, necessitating repeated injections. In this study, HA-coated solid lipid nanoparticles (HA-DXP-SLNs) entrapping with the glucocorticoid prodrug, dexamethasone palmitate (DXP) was developed as dual-function nanocarrier system for IA delivery. Using a scalable microfluidics platform, monodisperse SLNs of \u223c90\u00a0nm in diameter were produced with high DXP encapsulation efficiency (88%) and loading capacity (6% w\/w). In phosphate buffered saline (PBS), DXP-SLNs exhibited a biphasic release profile with an initial burst followed by sustained release of DXP, which was further moderated by HA surface coating. HA coatings of the SLNs enhanced particle stability, shifted particle surface charge from positive to negative, and enabled uptake by patient-derived primary osteoarthritic chondrocytes (hOAAC). Incubation in murine plasma demonstrated enzymatic conversion of DXP to dexamethasone (DEX), which accumulated in plasma over 72\u00a0h. HA-DXP-SLNs suppressed prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    production by LPS-stimulated THP-1 monocytes and by hOAAC more effectively than uncoated DXP-SLNs, while maintaining cell viability. These findings indicate that the HA coating of SLNs contributes to\n                    <jats:italic>in vitro<\/jats:italic>\n                    therapeutic efficacy of the overall SLNs, as well as to particle stabilisation. HA-DXP-SLNs therefore represent a promising nanocarrier for prolonged IA corticosteroid delivery in knee OA, with the potential to reduce the frequency of current IA corticosteroid and HA administration.\n                  <\/jats:p>","DOI":"10.3389\/fddev.2026.1809275","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:28:57Z","timestamp":1788499737000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis, characterisation, and in vitro assessment of hyaluronic acid-coated solid lipid nanoparticles entrapping dexamethasone palmitate designed for intra-articular administration"],"prefix":"10.3389","volume":"6","author":[{"given":"Jinxin","family":"Zhang","sequence":"first","affiliation":[{"name":"UCD School of Veterinary Medicine, University College Dublin","place":["Dublin, Ireland"]},{"name":"UCD Conway Institute, University College Dublin","place":["Dublin, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumi","family":"Khandelia","sequence":"additional","affiliation":[{"name":"UCD School of Veterinary Medicine, University College Dublin","place":["Dublin, Ireland"]},{"name":"UCD Conway Institute, University College Dublin","place":["Dublin, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Hogg","sequence":"additional","affiliation":[{"name":"UCD School of Veterinary Medicine, University College Dublin","place":["Dublin, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Z.","family":"Bahlool","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biomolecular Science, Royal College of Surgeons in Ireland","place":["Dublin, Ireland"]},{"name":"Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan","place":["Amman, Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Hodgkinson","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland","place":["Dublin, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally-Ann","family":"Cryan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biomolecular Science, Royal College of Surgeons in Ireland","place":["Dublin, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"O\u2019Byrne","sequence":"additional","affiliation":[{"name":"National Orthopaedics Hospital Cappagh","place":["Dublin, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Brayden","sequence":"additional","affiliation":[{"name":"UCD School of Veterinary Medicine, University College Dublin","place":["Dublin, Ireland"]},{"name":"UCD Conway Institute, University College Dublin","place":["Dublin, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/ar2655","article-title":"Developments in the scientific understanding of OA","volume":"11","author":"Abramson","year":"2009","journal-title":"Arthritis Res. and Ther."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3566","DOI":"10.1021\/acsabm.1c00732","article-title":"Microfluidics for development of lipid nanoparticles: paving the way for nucleic acids to the clinic","volume":"6","author":"Ali","year":"2021","journal-title":"ACS Appl. 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