{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:13:13Z","timestamp":1784905993919,"version":"3.55.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Digit. Health"],"abstract":"<jats:p>In the high-stakes environment of intensive care units (ICUs), managing transpulmonary pressure is crucial for providing breathing assistance to intubated patients, particularly when combining this intervention with respiratory therapy, such as high-frequency chest compression (HFCC). Despite the complexity of lung tissues, a computed tomography-based finite element model (CT-FEM), guided by Biot's theory, can be employed to numerically predict their vibroacoustic behavior at low frequencies, where the properties of the lungs align with the theory's principles. In this work, one aims to develop an analytical model of the lungs for two different levels of transpulmonary pressure\u201410\u2005cm H<jats:sub>2<\/jats:sub>O (inflated lungs) and 20\u2005cm H<jats:sub>2<\/jats:sub>O (healthy lungs)\u2014to examine the poroviscoelastic behavior of the lungs and evaluate the generated analytical model using a CT-FEM of the human thorax like a digital twin of the human thorax. Biot's theory was utilized to predict the complex-valued shear wave speed, as well as the fast and slow compression wave speeds, across a frequency range between 5 and 100\u2005Hz. The analytically computed values were tested using a previously validated CT-FEM of the human thorax to compare respiratory therapy outcomes for intubated patients under different transpulmonary pressure levels. Besides the frequency response function of the thorax, the kinetic energy density and the strain energy density were compared for these pressure levels. The CT-FEM demonstrated that all peak points fall within the range of 20\u201345\u2005Hz; therefore, this range might be considered in ICUs settings. Kinetic energy density was nearly 2.2 times higher, and strain energy density was 1.46\u20131.26 times higher at the first and last peaks, respectively; therefore, inflated lungs experienced greater effects than healthy ones under the same respiratory therapy conditions. Overall, this study highlights how different transpulmonary pressures affect HFCC therapy, offering insights into gentle and effective conditions for intubated patients in ICUs while revealing the lungs\u2019 3D responses by integrating analytically predicted shear wave speed, fast and slow compression wave speeds.<\/jats:p>","DOI":"10.3389\/fdgth.2025.1434578","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T17:55:27Z","timestamp":1743789327000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of the transpulmonary pressure on the lungs\u2019 vibroacoustic response: a first numerical perspective"],"prefix":"10.3389","volume":"7","author":[{"given":"Arife","family":"Uzundurukan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Poncet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria Camilla","family":"Boffito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Micheau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"441","DOI":"10.12968\/hmed.2019.80.8.441","article-title":"Upper airway tract complications of endotracheal intubation","volume":"80","author":"Tikka","year":"2019","journal-title":"Br J Hosp Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1001\/jama.2021.1727","article-title":"Intubation practices and adverse peri-intubation events in critically ill patients from 29 countries","volume":"325","author":"Russotto","year":"2021","journal-title":"J Am Med Assoc"},{"key":"B3","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.cmpb.2010.05.005","article-title":"Dynamic functional residual capacity can be estimated using a stress\u2013strain approach","volume":"101","author":"Sundaresan","year":"2011","journal-title":"Comput Methods Programs Biomed"},{"key":"B4","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1097\/PCC.0000000000001923","article-title":"Adverse tracheal intubation-associated events in pediatric patients at nonspecialist centers: a multicenter prospective observational study","volume":"20","author":"Matettore","year":"2019","journal-title":"Pediatr Crit Care Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1007\/s00134-016-4400-x","article-title":"Esophageal and transpulmonary pressure in the clinical setting: meaning, usefulness and perspectives","volume":"42","author":"Mauri","year":"2016","journal-title":"Intensive Care Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"114","DOI":"10.5152\/TurkThoracJ.2018.18107","article-title":"Physiotherapy and rehabilitation implementation in intensive care units: a survey study","volume":"20","author":"Cakmak","year":"2019","journal-title":"Turk Thorac J"},{"key":"B7","doi-asserted-by":"publisher","first-page":"100134","DOI":"10.1016\/j.bea.2024.100134","article-title":"Acoustic airway clearance devices: a systematic review of experimental and numerical studies","volume":"8","author":"Uzundurukan","year":"","journal-title":"Biomed Eng Adv"},{"key":"B8","doi-asserted-by":"publisher","first-page":"E44","DOI":"10.21037\/jtd.2017.01.32","article-title":"Chest physiotherapy in mechanically ventilated patients without pneumonia\u2014a narrative review","volume":"9","author":"Spapen","year":"2017","journal-title":"J Thorac Dis"},{"key":"B9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/978-3-031-23953-3_34","article-title":"Biphasic cuirass ventilation for airway secretions","volume-title":"Humidification in the Intensive Care Unit: The Essentials","author":"Mefford","year":"2023"},{"key":"B10","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.rmed.2019.04.011","article-title":"Influence of frequency and amplitude on the mucus viscoelasticity of the novel mechano-acoustic FrequencerTM","volume":"153","author":"Schieppati","year":"2019","journal-title":"Respir Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"108062","DOI":"10.1016\/j.cmpb.2024.108062","article-title":"CT-FEM of the human thorax: frequency response function and 3D harmonic analysis at resonance","volume":"246","author":"Uzundurukan","year":"","journal-title":"Comput Methods Programs Biomed"},{"key":"B12","doi-asserted-by":"publisher","first-page":"rs.3.rs","DOI":"10.21203\/rs.3.rs-4165729\/v1","article-title":"Effects of high frequency chest wall oscillation (HFCWO) on clinical symptoms in COPD","author":"Bruner","year":"2024","journal-title":"Res. 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