{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:43:30Z","timestamp":1789505010792,"version":"build-2803163510"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Dent. Med"],"abstract":"<jats:p>The goal of this perspective article is to use multiple idiopathic cervical root resorption (MICRR) as a model to demonstrate the need for transdisciplinary collaborations, from basic science to treatment planning, to improve the quality of health care for all. This is not a review of the literature on the current state of MICRR. Tooth root resorption is a normal physiological process required for resorption and exfoliation of primary teeth; however, root resorption of adult teeth is largely pathological. MICRR is an aggressive form of external root resorption, which occurs near the cemento-enamel junction (CEJ). The cause of MICRR remains elusive, however, it is mediated primarily by osteoclasts\/odontoclasts. Accumulating case studies and experiments in animal models have provided insights into defining the etiologies and pathophysiological mechanisms for MICRR, which include: systemic conditions and syndromes, inherited genetic variants affecting osteoclast\/odontoclast activity, altered periodontal structures, drug-induced root resorption and rebound effects after cessation of anti-resorptive treatment, chemotherapy, exposure to pets or viral infections, and other factors such as inflammatory conditions or trauma. To determine the causative factors for MICRR, as well as other oral-dental conditions, at minimum, a comprehensive health history should be collected for all patients by dental care providers, discussed with other health care providers and appropriate collaborations established. The examples highlighted in this perspective emphasize the need for transdisciplinary research collaborations coupled with integrated management strategies between medicine and dentistry in order to identify cause(s) early and improve clinical outcomes.<\/jats:p>","DOI":"10.3389\/fdmed.2021.652605","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T07:01:41Z","timestamp":1616742101000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Multiple Idiopathic Cervical Root Resorption: A Challenge for a Transdisciplinary Medical-Dental Team"],"prefix":"10.3389","volume":"2","author":[{"given":"Emily Y.","family":"Chu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina Golob","family":"Deeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evlambia","family":"Hajishengallis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha J.","family":"Somerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Thumbigere-Math","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1001\/jama.2017.19777","article-title":"The importance of oral health in comprehensive health care","volume":"320","author":"Lee","year":"2018","journal-title":"JAMA."},{"key":"B2","volume-title":"The Concise Oral Exam.","year":"2018"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2334\/josnusd.49.1","article-title":"Physiologic root resorption in primary teeth: molecular and histological events","volume":"49","author":"Harokopakis-Hajishengallis","year":"2007","journal-title":"J Oral Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/j.1600-0722.1970.tb02074.x","article-title":"Luxation of permanent teeth due to trauma. A clinical and radiographic follow-up study of 189 injured teeth","volume":"78","author":"Andreasen","year":"1970","journal-title":"Scand J Dent Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1034\/j.1600-9657.2003.00192.x","article-title":"Root resorption\u2013diagnosis, classification and treatment choices based on stimulation factors","volume":"19","author":"Fuss","year":"2003","journal-title":"Dent Traumatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/sj.bdj.2013.431","article-title":"Resorption: part 1. Pathology, classification and aetiology","volume":"214","author":"Darcey","year":"2013","journal-title":"Br Dent J."},{"key":"B7","first-page":"9","article-title":"Tooth resorption","volume":"30","author":"Ne","year":"1999","journal-title":"Quintessence Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1182\/blood-2010-12-326355","article-title":"Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets","volume":"118","author":"Wong","year":"2011","journal-title":"Blood."},{"key":"B9","first-page":"62","article-title":"Multiple external root resorption in a pediatric patient with familial expansile osteolysis","volume":"42","author":"Macaraeg","year":"2020","journal-title":"Pediatr Dent."},{"key":"B10","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1902\/jop.2015.150536","article-title":"A familial pattern of multiple idiopathic cervical root resorption with a 30-year follow-up","volume":"87","author":"Neely","year":"2016","journal-title":"J Periodontol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1177\/0022034512469026","article-title":"Deficiency in acellular cementum and periodontal attachment in bsp null mice","volume":"92","author":"Foster","year":"2013","journal-title":"J Dent Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.joen.2019.02.013","article-title":"Discontinuation of denosumab as a potential cause of generalized external cervical root resorption: a case report","volume":"45","author":"Deeb","year":"2019","journal-title":"J Endodont."},{"key":"B13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1365-2591.2010.01820.x","article-title":"Multiple idiopathic cervical resorption: case report and discussion of management options","volume":"44","author":"Yu","year":"2011","journal-title":"Int Endodont J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/iej.12440","article-title":"Multiple idiopathic cervical root resorption: a case report","volume":"49","author":"Wu","year":"2016","journal-title":"Int Endod J."},{"key":"B15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/sj.bdj.4808213","article-title":"Multiple idiopathic cervical root resorption in a male","volume":"175","author":"Beckett","year":"1993","journal-title":"Br Dent J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1259\/dmfr\/12925020","article-title":"Multiple idiopathic cervical root resorption: systematic review and report of four cases","volume":"32","author":"Liang","year":"2003","journal-title":"Dento Maxillo Facial Radiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1902\/jop.2007.060155","article-title":"A familial pattern of multiple idiopathic cervical root resorption in a father and son: a 22-year follow-up","volume":"78","author":"Neely","year":"2007","journal-title":"J Periodontol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.joen.2017.10.001","article-title":"Impact of cone-beam computed tomography on treatment planning for external cervical resorption and a novel axial slice-based classification system","volume":"44","author":"Goodell","year":"2018","journal-title":"J Endod."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1002\/jbmr.3690","article-title":"Inactivating mutation in IRF8 promotes osteoclast transcriptional programs and increases susceptibility to tooth root resorption","volume":"34","author":"Thumbigere-Math","year":"2019","journal-title":"J Bone Miner Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"326","DOI":"10.14219\/jada.archive.1930.0051","article-title":"Laboratory studies of an unusual case of resorption","volume":"17","author":"Mueller","year":"1930","journal-title":"J Am Dent Assoc."},{"key":"B21","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/S0096-6347(42)90327-2","article-title":"Root resorptions and their relation to pathologic bone formation: Part II. Classification, degrees, prognosis and frequency","volume":"28","author":"Becks","year":"1942","journal-title":"Am J Orthodont Oral Surg."},{"key":"B22","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/0030-4220(82)90199-2","article-title":"Root Resorption - Review And Discussion","volume":"54","author":"Goultschin","year":"1982","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"B23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.4103\/0970-9290.114917","article-title":"Multiple internal resorption in permanent teeth associated with hyperparathyroidism","volume":"24","author":"Nagaraj","year":"2013","journal-title":"Indian J Dent Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1016\/j.joen.2017.03.040","article-title":"External cervical resorption: a new oral manifestation of systemic sclerosis","volume":"43","author":"Arroyo-Bote","year":"2017","journal-title":"J Endodont."},{"key":"B25","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/S1079-2104(96)80440-9","article-title":"Dental observations in Gaucher's disease: review of the literature and two case reports with 13- and 60-year follow-ups","volume":"82","author":"Bender","year":"1996","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"B26","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.tripleo.2005.02.069","article-title":"External cervical root resorption involving multiple maxillary teeth in a patient with hereditary hemorrhagic telangiectasia","volume":"100","author":"Edwards","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"B27","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/0030-4220(78)90199-8","article-title":"Monostotic Paget's disease of the mandible presenting with progressive resorption of the teeth","volume":"46","author":"Smith","year":"1978","journal-title":"Oral Surg Oral Med Oral Pathol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1752-248X.2007.00011.x","article-title":"Multiple root resorption as a presenting sign of Paget's disease of bone","volume":"1","author":"Monteiro","year":"2008","journal-title":"Oral Surg."},{"key":"B29","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/sj.bdj.4800826","article-title":"Dental and oral lesions in two patients with focal dermal hypoplasia (Goltz syndrome)","volume":"189","author":"Baxter","year":"2000","journal-title":"Br Dent J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/000163599428814","article-title":"Root resorption and signs of repair in Papillon-Lefevre syndrome. A case study","volume":"57","author":"Rudiger","year":"1999","journal-title":"Acta Odontol Scand."},{"key":"B31","doi-asserted-by":"publisher","first-page":"453","DOI":"10.14219\/jada.archive.1989.0182","article-title":"Multiple external root resorption","volume":"118","author":"Yusof","year":"1989","journal-title":"J Am Dent Assoc."},{"key":"B32","first-page":"363","article-title":"Tooth root resorption associated with a familial bone dysplasia affecting mother and daughter","volume":"21","author":"Olsen","year":"1999","journal-title":"Pediatr Dent."},{"key":"B33","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0030-4220(90)90145-I","article-title":"Dental abnormalities associated with familial expansile osteolysis: a clinical and radiographic study","volume":"70","author":"Mitchell","year":"1990","journal-title":"Oral Surg Oral Med Oral Pathol."},{"key":"B34","first-page":"530","article-title":"Hypophosphatasia: a case report and literature review","volume":"72","author":"Tangney","year":"1979","journal-title":"Irish Med J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/j.1600-0714.1996.tb00274.x","article-title":"Hypophosphatasia affecting the permanent dentition","volume":"25","author":"Olsson","year":"1996","journal-title":"J Oral Pathol Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.bone.2015.05.007","article-title":"Mineralization defects in cementum and craniofacial bone from loss of bone sialoprotein","volume":"78","author":"Foster","year":"2015","journal-title":"Bone."},{"key":"B37","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.tripleo.2004.11.047","article-title":"A case of multiple idiopathic external root resorption: a 6-year follow-up study","volume":"100","author":"Iwamatsu-Kobayashi","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodont."},{"key":"B38","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/edt.12316","article-title":"Effect of bisphosphonates on root resorption after tooth replantation - a systematic review","volume":"33","author":"Najeeb","year":"2017","journal-title":"Dent Traumatol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.joen.2018.12.012","article-title":"Multiple cervical root resorption in a young adult female previously treated with chemotherapy: a case report","volume":"45","author":"Llavayol","year":"2019","journal-title":"J Endodont."},{"key":"B40","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.joen.2009.03.044","article-title":"Human and feline invasive cervical resorptions: the missing link?\u2013Presentation of four cases","volume":"35","author":"von Arx","year":"2009","journal-title":"J Endodont."},{"key":"B41","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/j.1600-0765.2008.01123.x","article-title":"Identifying early osteoclastic resorptive lesions in feline teeth: a model for understanding the origin of multiple idiopathic root resorption","volume":"44","author":"DeLaurier","year":"2009","journal-title":"J Periodont Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1034\/j.1600-051X.2002.290615.x","article-title":"Cervical external root resorption in vital teeth","volume":"29","author":"Bergmans","year":"2002","journal-title":"J Clin Periodontol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1177\/154411130301400406","article-title":"Tooth bleaching\u2013a critical review of the biological aspects","volume":"14","author":"Dahl","year":"2003","journal-title":"Crit Rev Oral Biol Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1902\/jop.1967.38.6_part1.534","article-title":"Clinical and histological aspects of peripheral cervical resorption","volume":"38","author":"Southam","year":"1967","journal-title":"J Periodontol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/S0099-2399(86)80157-1","article-title":"Herpes zoster revisited: implicated in root resorption","volume":"12","author":"Solomon","year":"1986","journal-title":"J Endodont."},{"key":"B46","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.bjoms.2005.05.008","article-title":"Herpes zoster associated with tooth resorption and periapical lesions","volume":"45","author":"Ramchandani","year":"2007","journal-title":"Br J Oral Maxillofac Surg."},{"key":"B47","first-page":"83","article-title":"Invasive cervical resorption: an analysis of potential predisposing factors","volume":"30","author":"Heithersay","year":"1999","journal-title":"Quintessence Int."},{"key":"B48","first-page":"27","article-title":"Clinical, radiologic, and histopathologic features of invasive cervical resorption","volume":"30","author":"Heithersay","year":"1999","journal-title":"Quintessence Int."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1016\/j.joen.2017.05.026","article-title":"descriptive analysis of factors associated with external cervical resorption","volume":"43","author":"Mavridou","year":"2017","journal-title":"J Endodont."},{"key":"B50","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1155\/2013\/812323","article-title":"Invasive cervical resorption: a review","volume":"5","author":"Kandalgaonkar","year":"2013","journal-title":"J Int Oral Health."},{"key":"B51","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1080\/19424396.2000.12223135","article-title":"Luxation injuries and external root resorption\u2013etiology, treatment, and prognosis","volume":"28","author":"Trope","year":"2000","journal-title":"J Calif Dent Assoc."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1111\/iej.12942","article-title":"External cervical resorption-part 1: histopathology, distribution and presentation","volume":"51","author":"Patel","year":"2018","journal-title":"Int Endodont J."},{"key":"B53","doi-asserted-by":"publisher","first-page":"726.e1","DOI":"10.1016\/j.ajodo.2009.11.009","article-title":"Systematic review of self-ligating brackets","volume":"137","author":"Chen","year":"2010","journal-title":"Am J Orthodont Dentofacial Orthop."},{"key":"B54","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1365-2591.2010.01822.x","article-title":"Playing wind instruments as a potential aetiologic cofactor in external cervical resorption: two case reports","volume":"44","author":"Gunst","year":"2011","journal-title":"Int Endodont J."},{"key":"B55","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/0002-9416(86)90108-9","article-title":"Idiopathic resorption of teeth. A report of three cases","volume":"89","author":"George","year":"1986","journal-title":"Am J Orthodont."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1016\/j.joen.2016.06.007","article-title":"Understanding external cervical resorption in vital teeth","volume":"42","author":"Mavridou","year":"2016","journal-title":"J Endodont."},{"key":"B57","first-page":"195","article-title":"Die diffuse atrophie des alveoarknochens. Weitere beitra ge zur kenntnis des alveolarschwundes und dessen wiedergutmachung durch zementwachstum","volume":"21","author":"Gottlieb","year":"1923","journal-title":"Z Stomatol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1902\/jop.1946.17.1.7","article-title":"The new concept of periodontoclasia","volume":"17","author":"Gottlieb","year":"1946","journal-title":"J Periodontol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1902\/jop.2014.140202","article-title":"A ninety-year history of periodontosis: the legacy of Professor Bernhard Gottlieb","volume":"86","author":"Fine","year":"2015","journal-title":"J Periodontol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1902\/jop.1985.56.12.748","article-title":"A new look at the etiology and pathogenesis of early-onset periodontitis. Cementopathia revisited","volume":"56","author":"Page","year":"1985","journal-title":"J Periodontol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/j.1600-0757.2006.00157.x","article-title":"Biology and principles of periodontal wound healing\/regeneration","volume":"41","author":"Polimeni","year":"2006","journal-title":"Periodontol 2000."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/jcp.10321","article-title":"Hypoxia is a major stimulator of osteoclast formation and bone resorption","volume":"196","author":"Arnett","year":"2003","journal-title":"J Cell Physiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/71667","article-title":"Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis","volume":"24","author":"Hughes","year":"2000","journal-title":"Nat Genet."},{"key":"B64","doi-asserted-by":"publisher","first-page":"E67","DOI":"10.1136\/jmg.39.10.e67","article-title":"Familial expansile osteolysis in a large Spanish kindred resulting from an insertion mutation in the TNFRSF11A gene","volume":"39","author":"Palenzuela","year":"2002","journal-title":"J Med Genet."},{"key":"B65","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/8756-3282(91)90019-F","article-title":"Familial expansile osteolysis: a morphological, histomorphometric and serological study","volume":"12","author":"Dickson","year":"1991","journal-title":"Bone."},{"key":"B66","doi-asserted-by":"publisher","first-page":"e54493","DOI":"10.7554\/eLife.54493","article-title":"Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1","volume":"9","author":"Madel","year":"2020","journal-title":"Elife."},{"key":"B67","first-page":"161","article-title":"Spontaneous resorption of the roots of all permanent teeth as a familial disease","volume":"19","author":"Pinska","year":"1966","journal-title":"Czas Stomatol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1016\/j.joen.2016.07.008","article-title":"Osteoprotegerin-Knockout mice developed early onset root resorption","volume":"42","author":"Liu","year":"2016","journal-title":"J Endodont."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/er.2013-1009","article-title":"The rachitic tooth","volume":"35","author":"Foster","year":"2014","journal-title":"Endocr Rev."},{"key":"B70","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nrendo.2016.14","article-title":"Hypophosphatasia - aetiology, nosology, pathogenesis, diagnosis and treatment","volume":"12","author":"Whyte","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.bone.2017.02.011","article-title":"Hypophosphatasia: an overview for 2017","volume":"102","author":"Whyte","year":"2017","journal-title":"Bone."},{"key":"B72","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.1600-0714.1991.tb00419.x","article-title":"On the mechanism of drug-induced gingival hyperplasia","volume":"20","author":"Brown","year":"1991","journal-title":"J Oral Pathol Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1600-051X.1996.tb02072.x","article-title":"The pathogenesis of drug-induced gingival overgrowth","volume":"23","author":"Seymour","year":"1996","journal-title":"J Clin Periodontol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.1741-2358.2003.00064.x","article-title":"Xerostomia: clinical aspects and treatment","volume":"20","author":"Cassolato","year":"2003","journal-title":"Gerodontology."},{"key":"B75","doi-asserted-by":"publisher","first-page":"61","DOI":"10.14219\/jada.archive.2003.0018","article-title":"Xerostomia: etiology, recognition and treatment","volume":"134","author":"Guggenheimer","year":"2003","journal-title":"J Am Dent Assoc."},{"key":"B76","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1210\/jc.2010-1502","article-title":"Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass","volume":"96","author":"Bone","year":"2011","journal-title":"J Clin Endocrinol Metab."},{"key":"B77","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/jbmr.251","article-title":"Effects of denosumab on bone turnover markers in postmenopausal osteoporosis","volume":"26","author":"Eastell","year":"2011","journal-title":"J Bone Miner Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41413-020-0088-1","article-title":"Mitigating osteonecrosis of the jaw (ONJ) through preventive dental care and understanding of risk factors","volume":"8","author":"Wan","year":"2020","journal-title":"Bone Res."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520972945.","article-title":"Bisphosphonates as supplement to dental treatment: a network meta-analysis","author":"Zymperdikas","year":"2020","journal-title":"J Dent Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1902\/jop.2013.130017","article-title":"Periodontal disease as a risk factor for bisphosphonate-related osteonecrosis of the jaw","volume":"85","author":"Thumbigere-Math","year":"2014","journal-title":"J Periodontol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1097\/COC.0b013e3182155fcb","article-title":"A retrospective study evaluating frequency and risk factors of osteonecrosis of the jaw in 576 cancer patients receiving intravenous bisphosphonates","volume":"35","author":"Thumbigere-Math","year":"2012","journal-title":"Am J Clin Oncol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1748-5827.2001.tb02497.x","article-title":"Prevalence of odontoclastic resorptive lesions in a population of clinically healthy cats","volume":"42","author":"Ingham","year":"2001","journal-title":"J Small Anim Pract."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.2460\/javma.2000.217.1866","article-title":"Prevalence of odontoclastic resorption lesions and periapical radiographic lucencies in cats: 265 cases (1995-1998)","volume":"217","author":"Lommer","year":"2000","journal-title":"J Am Vet Med Assoc."},{"key":"B84","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2460\/javma.1998.212.03.392","article-title":"Prevalence and risk factors for odontoclastic resorptive lesions in cats","volume":"212","author":"Lund","year":"1998","journal-title":"J Am Vet Med Assoc."},{"key":"B85","doi-asserted-by":"publisher","first-page":"188","DOI":"10.5326\/15473317-35-3-188","article-title":"Risk factors for odontoclastic resorptive lesions in cats","volume":"35","author":"Scarlett","year":"1999","journal-title":"J Am Anim Hosp Assoc."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1177\/00220345960750090601","article-title":"Expression of adhesion molecules during tooth resorption in feline teeth: a model system for aggressive osteoclastic activity","volume":"75","author":"Shigeyama","year":"1996","journal-title":"J Dent Res."},{"key":"B87","first-page":"213","article-title":"Acute phase reaction following bisphosphonates","volume":"27","author":"Tsurukami","year":"2017","journal-title":"Clin Calcium."},{"key":"B88","doi-asserted-by":"publisher","first-page":"4380","DOI":"10.1210\/jc.2010-0597","article-title":"Characterization of and risk factors for the acute-phase response after zoledronic acid","volume":"95","author":"Reid","year":"2010","journal-title":"J Clin Endocrinol Metab."}],"container-title":["Frontiers in Dental Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fdmed.2021.652605\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T21:51:03Z","timestamp":1724709063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fdmed.2021.652605\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,26]]},"references-count":88,"alternative-id":["10.3389\/fdmed.2021.652605"],"URL":"https:\/\/doi.org\/10.3389\/fdmed.2021.652605","relation":{},"ISSN":["2673-4915"],"issn-type":[{"value":"2673-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,26]]},"article-number":"652605"}}