{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:55:53Z","timestamp":1753890953573,"version":"3.41.2"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Dent. Med"],"abstract":"<jats:p>This Special Issue was initiated in response to the call for improved research by the National Academies of Sciences, Engineering, and Medicine (NASEM) (United States) Consensus Study Report on Temporomandibular Disorders (TMDs), a set of putatively localized musculoskeletal conditions. In this Special Issue, the importance of systems biology for TMDs emerges from each of three separate publications. The importance of systems biology to patients is anchored in two domains\u2014laboratory research and clinical observation. The three publications fully speak to the underlying goals in the NASEM recommendations for initiatives: that research on TMDs needs to broaden, that integration between basic and clinical science needs to improve, and that while better evidence is needed, clinicians need to utilize the evidence that already exists. All three of these initiatives, taken together, would lead to better understanding of these complex diseases and to better care of patients with these diseases.<\/jats:p>","DOI":"10.3389\/fdmed.2024.1374883","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T04:34:12Z","timestamp":1715834052000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Perspective: Advancing the science regarding temporomandibular disorders"],"prefix":"10.3389","volume":"5","author":[{"given":"Richard","family":"Ohrbach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre F.","family":"DaSilva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mildred C.","family":"Embree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Kusiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"volume-title":"Temporomandibular Disorders: Priorities for Research and Care","year":"2020","key":"B1"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fdmed.2022.1004942","article-title":"NG2\/CSPG4 Regulates cartilage degeneration during TMJ osteoarthritis","volume":"3","author":"Reed","year":"2022","journal-title":"Front Dent Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fdmed.2022.1007011","article-title":"Quantitative bone imaging biomarkers and joint space analysis of the articular Fossa in temporomandibular joint osteoarthritis using artificial intelligence models","volume":"3","author":"Mackie","year":"2022","journal-title":"Front Dent Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"100060","DOI":"10.1016\/j.ynpai.2021.100060","article-title":"Parabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connection","volume":"9","author":"Uddin","year":"2021","journal-title":"Neurobiol Pain"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1038\/s41593-017-0012-1","article-title":"A craniofacial-specific monosynaptic circuit enables heightened affective pain","volume":"20","author":"Rodriguez","year":"2017","journal-title":"Nat Neurosci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1177\/0022034512470832","article-title":"Masseter motor unit recruitment is altered in experimental jaw muscle pain","volume":"92","author":"Minami","year":"2013","journal-title":"J Dent Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fdmed.2023.1183327","article-title":"Creating patients: how technology and measurement approaches are misused in diagnosis and convert healthy individuals into TMD patients","volume":"4","author":"Greene","year":"2023","journal-title":"Front Dent Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jcm12206623","article-title":"Proprioception and mechanoreceptors in osteoarthritis: a systematic literature review","volume":"12","author":"Salamanna","year":"2023","journal-title":"J Clin Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.bja.2019.06.017","article-title":"Modulatory effects of different exercise modalities on the functional connectivity of the periaqueductal grey and ventral tegmental area in patients with knee osteoarthritis: a randomised multimodal magnetic resonance imaging study","volume":"123","author":"Liu","year":"2019","journal-title":"Br J Anaesth"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jcm12206635","article-title":"Active neurodynamics at home in patients with knee osteoarthritis: a feasibility study","volume":"12","author":"Serrano-Garc\u00eda","year":"2023","journal-title":"J Clin Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1016\/j.apmr.2014.05.016","article-title":"Comparison of mirror, raw video, and real-time visual biofeedback for training toe-out gait in individuals with knee osteoarthritis","volume":"95","author":"Hunt","year":"2014","journal-title":"Arch Phys Med Rehab"},{"key":"B12","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1111\/joor.12422","article-title":"Self-management in temporomandibular disorders: a systematic review of behavioural components","volume":"43","author":"Story","year":"2016","journal-title":"J Oral Rehabil"},{"key":"B13","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1111\/joor.12448","article-title":"Self-management programmes in temporomandibular disorders: results from an international Delphi process","volume":"43","author":"Durham","year":"2016","journal-title":"J Oral Rehabil"},{"key":"B14","doi-asserted-by":"publisher","first-page":"s57","DOI":"10.11607\/ofph.2582","article-title":"Attributes germane to temporomandibular disorders and their associations with five chronic overlapping pain conditions","volume":"34","author":"Sharma","year":"2020","journal-title":"J Oral Facial Pain Headache"},{"key":"B15","first-page":"197","article-title":"Pain, affect, nonlinear dynamical systems, and chronic pain: bringing order to disorder","volume-title":"Causality of Psychological Injury: Presenting Evidence in Court","author":"Young","year":"2010"},{"key":"B16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1093\/ije\/dyp296","article-title":"Causal thinking and complex system approaches in epidemiology","volume":"39","author":"Galea","year":"2009","journal-title":"Int J Epidemiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jpain.2007.09.006","article-title":"Pain and stress in a systems perspective: reciprocal neural, endocrine, and immune interactions","volume":"9","author":"Chapman","year":"2008","journal-title":"J Pain"},{"volume-title":"Pain and Suffering","year":"1998","author":"Livingston","key":"B18"},{"key":"B19","doi-asserted-by":"publisher","first-page":"107","DOI":"10.11607\/ofph.2016","article-title":"Shared genetics of temporomandibular disorder pain and neck pain: results of a twin study","volume":"32","author":"Visscher","year":"2018","journal-title":"J Oral Facial Pain Headache"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2633556521999509","DOI":"10.1177\/2633556521999509","article-title":"Glimpsing the raging seas that stop swans: a qualitative look at living with multimorbidity and pain in patients from a tertiary care service","volume":"11","author":"Favarato","year":"2021","journal-title":"J Multimorb Comorb"},{"key":"B21","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.semarthrit.2020.10.006","article-title":"The prevalence of psychiatric and chronic pain comorbidities in fibromyalgia: an ACTTION systematic review","volume":"51","author":"Kleykamp","year":"2021","journal-title":"Semin Arthritis Rheu"},{"key":"B22","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s11916-022-01054-6","article-title":"Interplay of oral, mandibular, and facial disorders and migraine","volume":"26","author":"Teruel","year":"2022","journal-title":"Curr Pain Headache Rep"},{"key":"B23","doi-asserted-by":"publisher","first-page":"T27","DOI":"10.1016\/j.jpain.2011.09.001","article-title":"Clinical findings and pain symptoms as potential risk factors for chronic TMD: descriptive data and empirically identified domains from the OPPERA case-control study","volume":"12","author":"Ohrbach","year":"2011","journal-title":"J Pain"},{"key":"B24","doi-asserted-by":"publisher","first-page":"T51","DOI":"10.1016\/j.jpain.2013.06.001","article-title":"General health status and incidence of first-onset temporomandibular disorder: the OPPERA prospective cohort study","volume":"14","author":"Sanders","year":"2013","journal-title":"J Pain"},{"key":"B25","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.adaj.2021.08.008","article-title":"The prevalence of comorbid chronic pain conditions among patients with temporomandibular disorders: a systematic review","volume":"153","author":"Kleykamp","year":"2021","journal-title":"J Am Dent Assoc"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3233\/BMR-210244","article-title":"The impact of nociplastic pain features on the response to physical therapy in patients with primary myofascial pain","volume":"35","author":"Kohns","year":"2022","journal-title":"J Back Musculoskelet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1097\/AJP.0000000000000300","article-title":"Chronic widespread back pain is distinct from chronic local back pain: evidence from quantitative sensory testing, pain drawings, and psychometrics","volume":"32","author":"Gerhardt","year":"2016","journal-title":"Clin J Pain"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1177\/0022034516657070","article-title":"Pain mechanisms and centralized pain in temporomandibular disorders","volume":"95","author":"Harper","year":"2016","journal-title":"J Dent Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"34","DOI":"10.11607\/ofph.1557","article-title":"Prolonged jaw opening promotes nociception and enhanced cytokine expression","volume":"30","author":"Hawkins","year":"2016","journal-title":"J Oral Facial Pain Headache"},{"key":"B30","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1123\/jsr.2015-0018","article-title":"Athletes\u2019 expectations about sport-injury rehabilitation: a cross-cultural study","volume":"25","author":"Arvinen-Barrow","year":"2016","journal-title":"J Sport Rehabil"},{"key":"B31","doi-asserted-by":"publisher","first-page":"797","DOI":"10.2522\/ptj.20150229","article-title":"How well do you expect to recover, and what does recovery mean, anyway? Qualitative study of expectations after a musculoskeletal injury","volume":"96","author":"Carroll","year":"2016","journal-title":"Phys Ther"},{"key":"B32","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.pmr.2014.06.011","article-title":"Psychosocial factors in sports injury rehabilitation and return to play","volume":"25","author":"Podlog","year":"2014","journal-title":"Phys Med Rehabil Clin N Am"},{"key":"B33","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.neuron.2007.05.019","article-title":"Brain states: top-down influences in sensory processing","volume":"54","author":"Gilbert","year":"2007","journal-title":"Neuron"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e1006","DOI":"10.1097\/PR9.0000000000001006","article-title":"Patient perspectives of pain and function after knee replacement: a systematic review and meta-synthesis of qualitative studies","volume":"7","author":"Taylor","year":"2022","journal-title":"Pain Rep"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e47834","DOI":"10.2196\/47834","article-title":"Guideline-adherent physiotherapy for patients with hip and knee osteoarthritis in Germany: protocol for an implementation research project using the theoretical domains framework and the behavior change wheel","volume":"12","author":"Bahns","year":"2023","journal-title":"JMIR Res Protoc"},{"key":"B36","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/joor.12067","article-title":"Diagnosis and treatment of temporomandibular disorders: an ethical analysis of current practices","volume":"40","author":"Reid","year":"2013","journal-title":"J Oral Rehabil"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fdgth.2023.1132446","article-title":"Building the foundation for a modern patient-partnered infrastructure to study temporomandibular disorders","volume":"5","author":"Gressler","year":"2023","journal-title":"Front Dig Health"},{"key":"B38","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s40271-023-00618-x","article-title":"Focus groups to inform the development of a patient-reported outcome measure (PROM) for temporomandibular joint disorders (TMDs)","volume":"16","author":"Elstad","year":"2023","journal-title":"Patient"},{"key":"B39","doi-asserted-by":"publisher","first-page":"16s","DOI":"10.1177\/23800844221116850","article-title":"The forefront of dentistry-promising tech-innovations and new treatments","volume":"7","author":"DaSilva","year":"2022","journal-title":"JDR Clin Trans Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e17754","DOI":"10.2196\/17754","article-title":"Sensory-discriminative three-dimensional body pain mobile app measures versus traditional pain measurement with a visual analog scale: validation study","volume":"8","author":"Kaciroti","year":"2020","journal-title":"JMIR Mhealth Uhealth"},{"key":"B41","first-page":"1","volume-title":"The Science of Self-Report: Implications for Research and Practice","author":"Stone","year":"2000"},{"key":"B42","doi-asserted-by":"publisher","first-page":"107","DOI":"10.11607\/ofph.1592","article-title":"Self-report of waking-state oral parafunctional behaviors in the natural environment","volume":"30","author":"Kaplan","year":"2016","journal-title":"J Oral Facial Pain Headache"},{"key":"B43","doi-asserted-by":"publisher","first-page":"4329","DOI":"10.2147\/JPR.S435830","article-title":"Chronic pain and time\u2014a theoretical analysis","volume":"16","author":"B\u00e4ckryd","year":"2023","journal-title":"J Pain Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nc\/niad021","article-title":"Lifeworlds in pain: a principled method for investigation and intervention","volume":"2023","author":"Tabor","year":"2023","journal-title":"Neurosci Conscious"},{"key":"B45","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/joor.12871","article-title":"Challenges in the clinical implementation of a biopsychosocial model for assessment and management of orofacial pain","volume":"47","author":"Sharma","year":"2019","journal-title":"J Oral Rehabil"},{"key":"B46","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/s41415-022-4501-6","article-title":"A commentary on temporomandibular disorders: priorities for research and care\u2014bridging from the US to the UK","volume":"233","author":"Durham","year":"2022","journal-title":"Brit Dent J"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/adj.12940","article-title":"Lessons for Australia\u2014commentary on \u201ctemporomandibular disorders: priorities for research and care\u201d","volume":"68","author":"Peck","year":"2023","journal-title":"Aust Dent J"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5867\/medwave.2023.01.2648","article-title":"Observaciones sobre trastornos temporomandibulares:prioridades de investigaci\u00f3n y atenci\u00f3n: \u00bfc\u00f3mo avanzar\u00e1 Chile?","volume":"23","author":"Oyarzo","year":"2023","journal-title":"Medwave"}],"container-title":["Frontiers in Dental Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fdmed.2024.1374883\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T04:34:18Z","timestamp":1715834058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fdmed.2024.1374883\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,16]]},"references-count":48,"alternative-id":["10.3389\/fdmed.2024.1374883"],"URL":"https:\/\/doi.org\/10.3389\/fdmed.2024.1374883","relation":{},"ISSN":["2673-4915"],"issn-type":[{"type":"electronic","value":"2673-4915"}],"subject":[],"published":{"date-parts":[[2024,5,16]]},"article-number":"1374883"}}