{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:01:27Z","timestamp":1791576087296,"version":"4.3.4"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Dent. Med"],"abstract":"<jats:p>Dental pulp is a mesenchymal connective tissue located inside the rigid encasement of the dentin. When bacteria or bacterial products invade the dental pulp, inflammation known as pulpitis is induced in this tissue. Various mediators produced during the course of pulpitis profoundly modify the pathophysiology of the inflammation. Typical mediators include cytokines, chemokines, nitric oxide, reactive oxygen species, matrix metalloproteinases, proteases, neutrophil extracellular traps, neuropeptides, and eicosanoids. Controlling these mediators may potentially lead to the healing of pulpitis and the preservation of pulp tissue. This review discusses these mediators and further explores the possibility of controlling them.<\/jats:p>","DOI":"10.3389\/fdmed.2024.1426887","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T04:31:48Z","timestamp":1722918708000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Characteristics of inflammatory mediators in dental pulp inflammation and the potential for their control"],"prefix":"10.3389","volume":"5","author":[{"given":"Nobuyuki","family":"Kawashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Okiji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/cga.12169","article-title":"Odontoblasts: specialized hard-tissue-forming cells in the dentin-pulp complex","volume":"56","author":"Kawashima","year":"2016","journal-title":"Congenit Anom (Kyoto)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/j.archoralbio.2012.08.010","article-title":"Characterisation of dental pulp stem cells: a new horizon for tissue regeneration?","volume":"57","author":"Kawashima","year":"2012","journal-title":"Arch Oral Biol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1177\/00220345920710051201","article-title":"An immunohistochemical study of the distribution of immunocompetent cells, especially macrophages and Ia antigen-expressing cells of heterogeneous populations, in normal rat molar pulp","volume":"71","author":"Okiji","year":"1992","journal-title":"J Dent Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1093\/intimm\/dxl070","article-title":"The existence of CD11c+ sentinel and F4\/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties","volume":"18","author":"Zhang","year":"2006","journal-title":"Int Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"5176","DOI":"10.1038\/s41598-022-08987-3","article-title":"Kinetics of LYVE-1-positive M2-like macrophages in developing and repairing dental pulp in vivo and their pro-angiogenic activity in vitro","volume":"12","author":"Kieu","year":"2022","journal-title":"Sci Rep"},{"key":"B6","article-title":"Endodontic Diagnosis","year":"2013"},{"key":"B7","doi-asserted-by":"publisher","first-page":"230251","DOI":"10.1155\/2015\/230251","article-title":"Dental pulp defence and repair mechanisms in dental caries","volume":"2015","author":"Farges","year":"2015","journal-title":"Mediat Inflamm"},{"key":"B8","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1177\/10454411990100030501","article-title":"Interstitial fluid pressure in normal and inflamed pulp","volume":"10","author":"Heyeraas","year":"1999","journal-title":"Crit Rev Oral Biol Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.bbrc.2019.11.032","article-title":"HIF1\u03b1 inhibits LPS-mediated induction of IL-6 synthesis via SOCS3-dependent CEBP\u03b2 suppression in human dental pulp cells","volume":"522","author":"Fujii","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"B10","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1111\/iej.13264","article-title":"Hypoxia-inducible factor 1\u03b1 promotes interleukin 1\u03b2 and tumour necrosis factor \u03b1 expression in lipopolysaccharide-stimulated human dental pulp cells","volume":"53","author":"Fujii","year":"2020","journal-title":"Int Endod J"},{"key":"B11","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.3390\/ijms24055001","article-title":"Molecular mechanisms of neurogenic inflammation of the skin","volume":"24","author":"Marek-Jozefowicz","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B12","doi-asserted-by":"publisher","first-page":"323","DOI":"10.37358\/RC.17.2.5445","article-title":"Detection and assessment of interleukin 6 in irreversible pulp inflamation","volume":"68","author":"Giuroiu","year":"2017","journal-title":"Rev Chim-Bucharest"},{"key":"B13","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/iej.12030","article-title":"Cytokines as diagnostic markers of pulpal inflammation","volume":"46","author":"Elsalhy","year":"2013","journal-title":"Int Endod J"},{"key":"B14","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0099-2399(06)80438-3","article-title":"Quantitative analysis of immunoglobulins and inflammatory factors in human pulpal blood from exposed pulps","volume":"21","author":"Nakanishi","year":"1995","journal-title":"J Endod"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1111\/iej.13343","article-title":"Inflammatory biomarkers in dentinal fluid as an approach to molecular diagnostics in pulpitis","volume":"53","author":"Brizuela","year":"2020","journal-title":"Int Endod J"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1111\/iej.13950","article-title":"Molecular biomarkers for objective assessment of symptomatic pulpitis: a systematic review and meta-analysis","volume":"56","author":"Karrar","year":"2023","journal-title":"Int Endod J"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/960321","article-title":"Dental pulp: correspondences and contradictions between clinical and histological diagnosis","volume":"2015","author":"Giuroiu","year":"2015","journal-title":"BioMed Res Int"},{"key":"B18","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S0099-2399(89)80093-7","article-title":"A study of T and B cells in pulpal pathosis","volume":"15","author":"Hahn","year":"1989","journal-title":"J Endod"},{"key":"B19","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/imm.12399","article-title":"Human Th1 dichotomy: origin, phenotype and biologic activities","volume":"144","author":"Annunziato","year":"2014","journal-title":"Immunology"},{"key":"B20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/B978-1-4160-0246-8.50009-7","article-title":"Chapter 3\u2014the immune system and the inflammatory response","volume-title":"Textbook of Pediatric Rheumatology (Fifth Edition)","author":"Gattorno","year":"2005"},{"key":"B21","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1203\/PDR.0b013e31819e76c7","article-title":"The Treg\/Th17 cell balance: a new paradigm for autoimmunity","volume":"65","author":"Eisenstein","year":"2009","journal-title":"Pediatr Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.archoralbio.2019.05.003","article-title":"Interleukin-17 plays a role in pulp inflammation partly by WNT5A protein induction","volume":"103","author":"Liu","year":"2019","journal-title":"Arch Oral Biol"},{"key":"B23","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/B978-1-4557-4801-3.00006-0","article-title":"6-Cell-mediated defense against infection","volume-title":"Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases (Eighth Edition)","author":"Hohl","year":"2015"},{"key":"B24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","article-title":"Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease","volume":"32","author":"Iyer","year":"2012","journal-title":"Crit Rev Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/imr.12218","article-title":"Macrophage phenotypes in atherosclerosis","volume":"262","author":"Colin","year":"2014","journal-title":"Immunol Rev"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1111\/febs.14466","article-title":"A guide to chemokines and their receptors","volume":"285","author":"Hughes","year":"2018","journal-title":"FEBS J"},{"key":"B27","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1590\/S1678-77572009000500031","article-title":"Interleukin-1 beta and interleukin-8 in healthy and inflamed dental pulps","volume":"17","author":"Silva","year":"2009","journal-title":"J Appl Oral Sci"},{"key":"B29","doi-asserted-by":"publisher","first-page":"155846","DOI":"10.1016\/j.cyto.2022.155846","article-title":"The detection of pro-inflammatory cytokines in exudates from dental pulp tissues","volume":"153","author":"Wu","year":"2022","journal-title":"Cytokine"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1111\/iej.13547","article-title":"Identification and validation of novel biomarkers and therapeutics for pulpitis using connectivity mapping","volume":"54","author":"Al-Natour","year":"2021","journal-title":"Int Endod J"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.joen.2020.07.013","article-title":"Comparison of neurokinin A, substance P, interleukin 8, and matrix metalloproteinase-8 changes in pulp tissue and gingival crevicular fluid samples of healthy and symptomatic irreversible pulpitis teeth","volume":"46","author":"Dincer G","year":"2020","journal-title":"J Endod."},{"key":"B32","first-page":"586","article-title":"Kinetics of chemokine mRNA expression in experimentally-induced rat pulitis","volume":"48","author":"Kawashima","year":"2005","journal-title":"Jpn J Conserv Dent"},{"key":"B33","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1152\/physrev.00036.2017","article-title":"Sources of vascular nitric oxide and reactive oxygen species and their regulation","volume":"99","author":"Tejero","year":"2019","journal-title":"Physiol Rev"},{"key":"B34","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.micron.2008.01.018","article-title":"Action of nitric oxide on healthy and inflamed human dental pulp tissue","volume":"39","author":"da Silva","year":"2008","journal-title":"Micron (Oxford, England: 1993)"},{"key":"B35","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/BF03401781","article-title":"Inducible nitric oxide synthase and inflammatory diseases","volume":"6","author":"Zamora","year":"2000","journal-title":"Mol Med"},{"key":"B36","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1177\/154405910408300408","article-title":"Nitric oxide synthase in healthy and inflamed human dental pulp","volume":"83","author":"Di Nardo Di Maio","year":"2004","journal-title":"J Dent Res"},{"key":"B37","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1152\/physrev.00037.2016","article-title":"Arginase: a multifaceted enzyme important in health and disease","volume":"98","author":"Caldwell","year":"2018","journal-title":"Physiol Rev"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1038\/cdd.2009.49","article-title":"Superoxide is the major reactive oxygen species regulating autophagy","volume":"16","author":"Chen","year":"2009","journal-title":"Cell Death Differ"},{"key":"B40","first-page":"241","article-title":"Chapter eight\u2014matrix metalloproteinases, vascular remodeling, and vascular disease","volume-title":"Advances in Pharmacology","author":"Wang","year":"2018"},{"key":"B41","doi-asserted-by":"publisher","first-page":"9739","DOI":"10.3390\/ijms21249739","article-title":"The roles of matrix metalloproteinases and their inhibitors in human diseases","volume":"21","author":"Cabral-Pacheco","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B42","first-page":"191","article-title":"Concentration of collagenases (MMP-1, -8, -13) in patients with chronically inflamed dental pulp tissue","volume":"33","author":"Evrosimovska","year":"2012","journal-title":"Prilozi"},{"key":"B43","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1177\/00220345211046874","article-title":"MMP-9 levels and NaOCl lavage in randomized trial on direct pulp capping","volume":"101","author":"Ballal","year":"2022","journal-title":"J Dent Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e52523","DOI":"10.1371\/journal.pone.0052523","article-title":"The anti-inflammatory effects of matrix metalloproteinase-3 on irreversible pulpitis of mature erupted teeth","volume":"7","author":"Eba","year":"2012","journal-title":"PloS one"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1016\/j.joen.2014.04.001","article-title":"Down-regulation of inflammatory mediator synthesis and infiltration of inflammatory cells by MMP-3 in experimentally induced rat pulpitis","volume":"40","author":"Takimoto","year":"2014","journal-title":"J Endod"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.biocel.2007.11.008","article-title":"Neutrophil serine proteases fine-tune the inflammatory response","volume":"40","author":"Pham","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.4049\/jimmunol.1201719","article-title":"Neutrophil extracellular traps: double-edged swords of innate immunity","volume":"189","author":"Kaplan","year":"2012","journal-title":"J Immunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.joen.2019.02.014","article-title":"Neutrophil extracellular traps exert potential cytotoxic and proinflammatory effects in the dental pulp","volume":"45","author":"Holder","year":"2019","journal-title":"J Endod"},{"key":"B49","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/j.1365-2591.2006.01093.x","article-title":"Quantification of neuropeptides (calcitonin gene-related peptide, substance P, neurokinin A, neuropeptide Y and vasoactive intestinal polypeptide) expressed in healthy and inflamed human dental pulp","volume":"39","author":"Caviedes-Bucheli","year":"2006","journal-title":"Int Endod J"},{"key":"B50","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.joen.2008.10.010","article-title":"Substance P expression by human dental pulp fibroblasts: a potential role in neurogenic inflammation","volume":"35","author":"Killough","year":"2009","journal-title":"J Endod"},{"key":"B51","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00540-018-2579-4","article-title":"Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain","volume":"33","author":"Matsuda","year":"2019","journal-title":"J Anesth"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.997403","article-title":"Eicosanoids in inflammation in the blood and the vessel","volume":"13","author":"Yamaguchi","year":"2022","journal-title":"Front Pharmacol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/0003-9969(87)90116-6","article-title":"Arachidonic-acid metabolism in normal and experimentally-inflamed rat dental pulp","volume":"32","author":"Okiji","year":"1987","journal-title":"Arch Oral Biol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1177\/00220345910700010501","article-title":"The role of leukotriene B4 in neutrophil infiltration in experimentally-induced inflammation of rat tooth pulp","volume":"70","author":"Okiji","year":"1991","journal-title":"J Dent Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1177\/039463201202500118","article-title":"Prostaglandin E2 to diagnose between reversible and irreversible pulpitis","volume":"25","author":"Petrini","year":"2012","journal-title":"Int J Immunopathol Pharmacol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"311","DOI":"10.2174\/156802607779941314","article-title":"Eicosanoids in inflammation: biosynthesis, pharmacology, and therapeutic frontiers","volume":"7","author":"Khanapure","year":"2007","journal-title":"Curr Top Med Chem"},{"key":"B57","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1590\/0103-6440201902542","article-title":"Prostaglandin E2 induces expression of mineralization genes by undifferentiated dental pulp cells","volume":"30","author":"Lorencetti-Silva","year":"2019","journal-title":"Braz Dent J"},{"key":"B58","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.joen.2015.12.011","article-title":"Prostaglandin E2 stimulates EP2, adenylate cyclase, phospholipase C, and intracellular calcium release to mediate cyclic adenosine monophosphate production in dental pulp cells","volume":"42","author":"Chang","year":"2016","journal-title":"J Endod"},{"key":"B59","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.joen.2023.01.009","article-title":"Prostaglandin E(2)-transporting pathway and its roles via EP2\/EP4 in cultured human dental pulp","volume":"49","author":"Ohkura","year":"2023","journal-title":"J Endod"},{"key":"B60","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.joen.2019.03.020","article-title":"Prostacyclin analog promotes human dental pulp cell migration via a matrix metalloproteinase 9-related pathway","volume":"45","author":"Seang","year":"2019","journal-title":"J Endod"},{"key":"B61","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12903-022-02083-8","article-title":"Leukotriene B(4) loaded in microspheres regulate the expression of genes related to odontoblastic differentiation and biomineralization by dental pulp stem cells","volume":"22","author":"da Silva","year":"2022","journal-title":"BMC Oral Health"},{"key":"B62","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13287-021-02141-y","article-title":"Resolvin E1 accelerates pulp repair by regulating inflammation and stimulating dentin regeneration in dental pulp stem cells","volume":"12","author":"Chen","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"B63","doi-asserted-by":"publisher","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep"},{"key":"B64","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3389\/fphys.2018.00419","article-title":"The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes","volume":"9","author":"Krzyszczyk","year":"2018","journal-title":"Front Physiol"},{"key":"B65","first-page":"1812","article-title":"Involvement of M1\/M2 macrophage polarization in reparative dentin formation","volume":"12","author":"Kadowaki","year":"2022","journal-title":"Life (Basel)"},{"key":"B66","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.joen.2016.11.003","article-title":"The effects of M1 and M2 macrophages on odontogenic differentiation of human dental pulp cells","volume":"43","author":"Park","year":"2017","journal-title":"J Endod"},{"key":"B67","doi-asserted-by":"publisher","first-page":"108043","DOI":"10.1016\/j.isci.2023.108043","article-title":"Dental pulp stem cells accelerate wound healing through CCL2-induced M2 macrophages polarization","volume":"26","author":"Yang","year":"2023","journal-title":"iScience"},{"key":"B68","doi-asserted-by":"publisher","first-page":"20216","DOI":"10.1038\/s41598-020-77161-4","article-title":"Macrophage modulation of dental pulp stem cell activity during tertiary dentinogenesis","volume":"10","author":"Neves","year":"2020","journal-title":"Sci Rep"},{"key":"B69","doi-asserted-by":"publisher","first-page":"213883","DOI":"10.1016\/j.bioadv.2024.213883","article-title":"An injectable dental pulp-derived decellularized matrix hydrogel promotes dentin repair through modulation of macrophage response","volume":"161","author":"Yi","year":"2024","journal-title":"Biomater Adv"},{"key":"B70","doi-asserted-by":"publisher","first-page":"2656784","DOI":"10.1155\/2022\/2656784","article-title":"The immunomodulatory and regenerative effect of biodentine on human THP-1 cells and dental pulp stem cells: In vitro study","volume":"2022","author":"Abuarqoub","year":"2022","journal-title":"Biomed Res Int"},{"key":"B71","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.joen.2013.11.011","article-title":"M2 macrophages participate in the biological tissue healing reaction to mineral trioxide aggregate","volume":"40","author":"Ito","year":"2014","journal-title":"J Endod"},{"key":"B72","doi-asserted-by":"publisher","first-page":"229","DOI":"10.4103\/0973-029X.140762","article-title":"MicroRNAs\u2014biology and clinical applications","volume":"18","author":"Ranganathan","year":"2014","journal-title":"J Oral Maxillofac Pathol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"7433","DOI":"10.3390\/ijms24087433","article-title":"MicroRNA-146b-5p suppresses pro-inflammatory mediator synthesis via targeting TRAF6, IRAK1, and RELA in lipopolysaccharide-stimulated human dental pulp cells","volume":"24","author":"Han","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B74","doi-asserted-by":"publisher","first-page":"21331","DOI":"10.1002\/jcp.28737","article-title":"Anti-inflammatory roles of microRNA 21 in lipopolysaccharide-stimulated human dental pulp cells","volume":"234","author":"Nara","year":"2019","journal-title":"J Cell Physiol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.3390\/cells10082142","article-title":"The role of microRNAs in pulp inflammation","volume":"10","author":"Mu\u00f1oz-Carrillo","year":"2021","journal-title":"Cells"},{"key":"B76","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2012.00056","article-title":"Exosomal miRNAs: biological properties and therapeutic potential","volume":"3","author":"Hu","year":"2012","journal-title":"Front Genet"},{"key":"B77","doi-asserted-by":"publisher","first-page":"e0167289","DOI":"10.1371\/journal.pone.0167289","article-title":"Biological markers for pulpal inflammation: a systematic review","volume":"11","author":"Rechenberg","year":"2016","journal-title":"PLoS One"},{"key":"B78","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1177\/154405910508400815","article-title":"Effect of NOS inhibitor on cytokine and COX2 expression in rat pulpitis","volume":"84","author":"Kawashima","year":"2005","journal-title":"J Dent Res"},{"key":"B79","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/j.1600-0722.2004.00139.x","article-title":"Effects of an inducible nitric oxide synthase inhibitor on experimentally induced rat pulpitis","volume":"112","author":"Kawanishi","year":"2004","journal-title":"Eur J Oral Sci"},{"key":"B80","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3390\/jcm9020434","article-title":"Pulp-dentin tissue healing response: a discussion of current biomedical approaches","volume":"9","author":"Shah","year":"2020","journal-title":"J Clin Med"}],"container-title":["Frontiers in Dental Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fdmed.2024.1426887\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T04:31:53Z","timestamp":1722918713000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fdmed.2024.1426887\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,6]]},"references-count":80,"alternative-id":["10.3389\/fdmed.2024.1426887"],"URL":"https:\/\/doi.org\/10.3389\/fdmed.2024.1426887","relation":{},"ISSN":["2673-4915"],"issn-type":[{"value":"2673-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,6]]},"article-number":"1426887"}}