{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:58:42Z","timestamp":1793948322795,"version":"4.8.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Dent. Med."],"abstract":"Objectives<\/jats:title>A detailed meta-analysis and systematic search was conducted to assess the histologic and radiographic efficacy of autologous peripheral venous blood concentrates (APVBCs) for the socket preservation.<\/jats:p><\/jats:sec>Design<\/jats:title>Electronic databases were searched until 31 January 2025. Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) in English were identified. Alveolar bone reconstruction was assessed through histologic and radiographic evaluation after tooth extraction. Data were analyzed using Revman5.3, and the risk of bias was evaluated with the Cochrane Collaboration tool.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 16 studies (12 RCTs and 4 CCTs) involving 619 sites was included in our meta-analysis. The results indicated that the APVBCs application significantly reduced the vertical bone resorption in the buccal ridge (standardized mean difference [SMD]: \u22120.30; 95% confidence interval [CI]: \u22120.54 to \u22120.06; p<\/jats:italic>\u2009=\u20090.02, I<\/jats:italic>2<\/jats:sup>\u2009=\u20095%) and palatal\/lingual ridge (SMD:\u22120.30, 95% CI: \u22120.54 to \u22120.06; p<\/jats:italic>\u2009=\u20090.02, I<\/jats:italic>2<\/jats:sup>\u2009=\u20090%) by radiographic analysis. In addition, the vertical resorption of the buccal and palatal\/lingual alveolar ridge was significantly reduced by using materials combined with APVBCs as the filling material for extraction sockets. The newly formed bone percentage showed a statistically significant increase in APVBC presence during socket preservation (SMD: 1.27, 95% CI: 0.65\u20131.89; p<\/jats:italic>\u2009&lt;\u20090.0001, I<\/jats:italic>2<\/jats:sup>\u2009=\u200971%) and APVBC\u2009+\u2009material groups (SMD: 0.85, 95% CI: 0.35\u20131.35; p<\/jats:italic>\u2009=\u20090.0009, I<\/jats:italic>2<\/jats:sup>\u2009=\u20090%). However, APVBCs\u2009+\u2009materials did not show significant effects on the remaining graft particles.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>APVBCs in socket preservation can reduce vertical bone resorption and enhance new bone formation. Meanwhile, APVBCs may improve osteogenic efficiency with bone graft material.<\/jats:p><\/jats:sec>Systematic Review Registration<\/jats:title>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420250653020<\/jats:uri>, identifier CRD420250653020.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fdmed.2025.1602738","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T05:24:26Z","timestamp":1752211466000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The histological and radiological evaluation of autologous peripheral venous blood concentrates in socket preservation: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"6","author":[{"given":"Yusheng","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7046","DOI":"10.3390\/jcm12227046","article-title":"Osseodensification: an alternative to conventional osteotomy in implant site preparation: a systematic review","volume":"12","author":"Fontes Pereira","year":"2023","journal-title":"J Clin Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/s41415-022-4967-2","article-title":"Is there clinical evidence to support alveolar ridge preservation over extraction alone? A review of recent literature and case reports of late graft failure","volume":"233","author":"Adams","year":"2022","journal-title":"Br Dent J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"6229","DOI":"10.3390\/jcm13206229","article-title":"Quality of life after microvascular alveolar ridge reconstruction with subsequent dental rehabilitation","volume":"13","author":"Zeman-Kuhnert","year":"2024","journal-title":"J Clin Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.3390\/molecules26103007","article-title":"Bone grafts and substitutes in dentistry: a review of current trends and developments","volume":"26","author":"Zhao","year":"2021","journal-title":"Molecules (Basel, Switzerland)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/prd.12555","article-title":"Essential principles for blood centrifugation","volume":"97","author":"Quirynen","year":"2025","journal-title":"Periodontol 2000"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4571","DOI":"10.3390\/jcm13154571","article-title":"Systematic review of platelet-rich plasma in medical and surgical specialties: quality, evaluation, evidence, and enforcement","volume":"13","author":"Rahman","year":"2024","journal-title":"J Clin Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"22808000241299588","DOI":"10.1177\/22808000241299588","article-title":"Platelet-rich fibrin in dentistry","volume":"22","author":"Song","year":"2024","journal-title":"J Appl Biomater Funct Mater"},{"key":"B8","doi-asserted-by":"publisher","first-page":"6644366","DOI":"10.1155\/2021\/6644366","article-title":"Cgf membrane promotes periodontal tissue regeneration mediated by hucmscs through upregulating taz and osteogenic differentiation genes","volume":"2021","author":"Li","year":"2021","journal-title":"Stem Cells Int"},{"key":"B9","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1186\/s12903-023-03357-5","article-title":"Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis","volume":"23","author":"Chen","year":"2023","journal-title":"BMC Oral Health"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e28072","DOI":"10.7759\/cureus.28072","article-title":"Third-generation platelet concentrates in periodontal regeneration: gaining ground in the field of regeneration","volume":"14","author":"Shirbhate","year":"2022","journal-title":"Cureus"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e12887","DOI":"10.1111\/dth.12887","article-title":"Utility of platelet rich fibrin gel therapy in nonhealing ulcer secondary to ecthyma gangrenosum","volume":"32","author":"Rajan","year":"2019","journal-title":"Dermatol Ther"},{"key":"B12","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/s13770-022-00456-2","article-title":"Distinctive roles of wnt signaling in chondrogenic differentiation of bmscs under coupling of pressure and platelet-rich fibrin","volume":"19","author":"Cheng","year":"2022","journal-title":"Tissue Eng Regen Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"105162","DOI":"10.1016\/j.archoralbio.2021.105162","article-title":"The platelet derived growth factor bb promotes osteogenic differentiation of periodontal ligament stem cells via the wnt\/\u03b2-catenin signaling pathway","volume":"129","author":"Deng","year":"2021","journal-title":"Arch Oral Biol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1515\/med-2021-0259","article-title":"Platelet-rich fibrin: basics of biological actions and protocol modifications","volume":"16","author":"Pavlovic","year":"2021","journal-title":"Open Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"B16","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1111\/cid.13208","article-title":"Efficacy of the application of leukocyte and platelet-rich fibrin (l-prf) on alveolar ridge preservation. A randomized controlled clinical trial","volume":"25","author":"Abad","year":"2023","journal-title":"Clin Implant Dent Relat Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/cid.13289","article-title":"Injectable platelet rich fibrin versus hyaluronic acid with bovine derived xenograft for alveolar ridge preservation. A randomized controlled clinical trial with histomorphometric analysis","volume":"26","author":"Abaza","year":"2023","journal-title":"Clin Implant Dent Relat Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/clr.14372","article-title":"Does injectable platelet-rich fibrin combined with autogenous demineralized dentine enhance alveolar ridge preservation? A randomized controlled trial","volume":"36","author":"Amer","year":"2025","journal-title":"Clin Oral Implants Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1111\/cid.12846","article-title":"Platelet-rich fibrin to preserve alveolar bone sockets following tooth extraction: a randomized controlled trial","volume":"21","author":"Areewong","year":"2019","journal-title":"Clin Implant Dent Relat Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jcms.2019.11.006","article-title":"Tomographic and histomorphometric evaluation of socket healing after tooth extraction using leukocyte- and platelet-rich fibrin: a randomized, single-blind, controlled clinical trial","volume":"48","author":"Canellas","year":"2020","journal-title":"J Cranio-Maxillofac Surg"},{"key":"B21","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1111\/jcpe.13463","article-title":"Effect of different platelet-rich fibrin matrices for ridge preservation in multiple tooth extractions: a split-mouth randomized controlled clinical trial","volume":"48","author":"Castro","year":"2021","journal-title":"J Clin Periodontol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/JPER.17-0466","article-title":"Advanced platelet-rich fibrin and freeze-dried bone allograft for ridge preservation: a randomized controlled clinical trial","volume":"89","author":"Clark","year":"2018","journal-title":"J Periodontol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s10006-018-0680-3","article-title":"To assess the efficacy of socket plug technique using platelet rich fibrin with or without the use of bone substitute in alveolar ridge preservation: a prospective randomised controlled study","volume":"22","author":"Girish Kumar","year":"2018","journal-title":"Oral Maxillofac Surg"},{"key":"B24","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12903-022-02091-8","article-title":"Clinical application of concentrate growth factors combined with bone substitute in alveolar ridge preservation of anterior teeth","volume":"22","author":"Keranmu","year":"2022","journal-title":"BMC Oral Health"},{"key":"B25","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s40729-021-00396-x","article-title":"Clinical applications of concentrated growth factors combined with bone substitutes for alveolar ridge preservation in maxillary molar area: a randomized controlled trial","volume":"7","author":"Lin","year":"2021","journal-title":"Int J Implant Dent"},{"key":"B26","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s40729-022-00448-w","article-title":"Clinical applications of concentrated growth factors membrane for sealing the socket in alveolar ridge preservation: a randomized controlled trial","volume":"8","author":"Liu","year":"2022","journal-title":"Int J Implant Dent"},{"key":"B27","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s10006-023-01190-2","article-title":"Comparison of histologic and radiographic changes of sockets grafted with lprf and sockets without intervention after tooth extraction","volume":"28","author":"Mousavi","year":"2024","journal-title":"Oral Maxillofac Surg"},{"key":"B28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/cid.12950","article-title":"Three-dimensional analysis of dimensional changes after alveolar ridge preservation with bone substitutes or plasma rich in growth factors: randomized and controlled clinical trial","volume":"23","author":"Stumbras","year":"2020","journal-title":"Clin Implant Dent Relat Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1111\/jcpe.12612","article-title":"The use of leucocyte and platelet-rich fibrin in socket management and ridge preservation: a split-mouth, randomized, controlled clinical trial","volume":"43","author":"Temmerman","year":"2016","journal-title":"J Clin Periodontol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1111\/jcpe.13688","article-title":"Increased local concentrations of growth factors from leucocyte- and platelet-rich fibrin do not translate into improved alveolar ridge preservation: an intra-individual mechanistic randomized controlled trial","volume":"49","author":"Wang","year":"2022","journal-title":"J Clin Periodontol"},{"key":"B31","first-page":"2277","article-title":"Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction","volume":"15","author":"Zhang","year":"2018","journal-title":"Exp Ther Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1111\/jcpe.13345","article-title":"Short-term comparison of two non-surgical treatment modalities of peri-implantitis: clinical and microbiological outcomes in a two-factorial randomized controlled trial","volume":"47","author":"Merli","year":"2020","journal-title":"J Clin Periodontol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/j.joms.2017.02.009","article-title":"Healing of postextraction sockets preserved with autologous platelet concentrates. A systematic review and meta-analysis","volume":"75","author":"Del Fabbro","year":"2017","journal-title":"J Oral Maxillofac Surg"},{"key":"B34","doi-asserted-by":"publisher","first-page":"6686857","DOI":"10.1155\/2021\/6686857","article-title":"The effectiveness of advanced platelet-rich fibrin in comparison with leukocyte-platelet-rich fibrin on outcome after dentoalveolar surgery","volume":"2021","author":"Makki","year":"2021","journal-title":"Int J Dent"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e55","DOI":"10.1016\/j.oooo.2021.01.012","article-title":"Ridge preservation using collacone compared with an empty socket: a pilot study","volume":"132","author":"Anderud","year":"2021","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1093\/stcltm\/szac052","article-title":"Preclinical study of human bone marrow-derived mesenchymal stem cells using a 3-dimensional manufacturing setting for enhancing spinal fusion","volume":"11","author":"Cho","year":"2022","journal-title":"Stem Cells Transl Med"},{"key":"B37","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41368-021-00120-w","article-title":"Individualized plasticity autograft mimic with efficient bioactivity inducing osteogenesis","volume":"13","author":"Wei","year":"2021","journal-title":"Int J Oral Sci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jcm11030894","article-title":"Guided bone regeneration in the edentulous atrophic maxilla using deproteinized bovine bone mineral (dbbm) combined with platelet-rich fibrin (prf) \u2013 a prospective study","volume":"11","author":"Caram\u00eas","year":"2022","journal-title":"J Clin Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.fmre.2021.08.003","article-title":"Preparation, characterization and biological properties of a novel bone block composed of platelet rich fibrin and a deproteinized bovine bone mineral","volume":"2","author":"Feng","year":"2022","journal-title":"Fundam Res"},{"key":"B40","first-page":"319","article-title":"Bone regeneration in maxillary sinus augmentation using advanced platelet-rich fibrin (A-PRF) and plasma rich in growth factors (PRGF): a pilot randomized controlled trial","volume":"43","author":"Dragonas","year":"2023","journal-title":"Int J Periodontics Restor Dent"},{"key":"B41","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s12903-025-05698-9","article-title":"Efficacy of different forms of concentrated growth factors combined with deproteinized bovine bone minerals in guided bone regeneration: a randomized clinical trial","volume":"25","author":"Zhu","year":"2025","journal-title":"BMC Oral Health"},{"key":"B42","doi-asserted-by":"publisher","first-page":"7451","DOI":"10.3390\/ijerph18147451","article-title":"Comparison study of the histomorphometric results after socket preservation with PRF and allograft used for socket preservation-randomized controlled trials","volume":"18","author":"Ivanova","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"B43","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jobcr.2020.07.018","article-title":"A neoteric procedure for alveolar ridge preservation using autogenous fresh mineralized tooth graft prepared at chair side","volume":"10","author":"Dwivedi","year":"2020","journal-title":"J Oral Biol Craniofac Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.3390\/ma13051153","article-title":"Alveolar socket preservation with different autologous graft materials: preliminary results of a multicenter pilot study in human","volume":"13","author":"Minetti","year":"2020","journal-title":"Materials (Basel, Switzerland)"},{"key":"B45","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1186\/s12903-023-03400-5","article-title":"The effect of recurrent application of concentrated platelet-rich fibrin inside the extraction socket on the hard and soft tissues. A randomized controlled trial","volume":"23","author":"Lahham","year":"2023","journal-title":"BMC Oral Health"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1007\/s12663-021-01651-9","article-title":"Soft and hard tissue changes subsequent to spontaneous healing of the extraction sockets using cone-beam computed tomography: a cross-sectional study","volume":"21","author":"Safi","year":"2022","journal-title":"J Maxillofac Oral Surg"},{"key":"B47","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ijom.2022.04.018","article-title":"Autogenous tooth bone graft material prepared chairside and its clinical applications: a systematic review","volume":"52","author":"Mahardawi","year":"2023","journal-title":"Int J Oral Maxillofac Surg"},{"key":"B48","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s13770-022-00438-4","article-title":"Demineralized dentin matrix for dental and alveolar bone tissues regeneration: an innovative scope review","volume":"19","author":"Grawish","year":"2022","journal-title":"Tissue Eng Regen Med"},{"key":"B49","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40729-022-00421-7","article-title":"Horizontal augmentation techniques in the mandible: a systematic review","volume":"8","author":"Smeets","year":"2022","journal-title":"Int J Implant Dent"},{"key":"B50","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s13770-022-00445-5","article-title":"Clinical reference strategy for the selection of treatment materials for maxillofacial bone transplantation: a systematic review and network meta-analysis","volume":"19","author":"Zhang","year":"2022","journal-title":"Tissue Eng Regen Med"}],"container-title":["Frontiers in Dental Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fdmed.2025.1602738\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T05:24:27Z","timestamp":1752211467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fdmed.2025.1602738\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":50,"alternative-id":["10.3389\/fdmed.2025.1602738"],"URL":"https:\/\/doi.org\/10.3389\/fdmed.2025.1602738","relation":{},"ISSN":["2673-4915"],"issn-type":[{"value":"2673-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,11]]},"article-number":"1602738"}}