{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T12:12:31Z","timestamp":1762776751481,"version":"build-2065373602"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Dent. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dental trauma can jeopardize the long-term success of previous endodontic treatments, especially in teeth affected by orthodontically induced inflammatory root resorption (OIIRR). This case presents the first documented association between secondary trauma-induced acidity and degradation of ProRoot mineral trioxide aggregate (MTA) in such compromised teeth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 20-year-old male with a history of orthodontic treatment and severe apical root resorption sustained a subluxation injury to tooth 22, leading to pulp necrosis and apical pathosis. Initial endodontic management with ProRoot MTA achieved favorable outcomes at 6- and 18-month follow-ups. Two-and-a-half years later, secondary trauma occurred. Over the following 18 months, the tooth developed acute symptoms, a periapical lesion, and radiographic signs of MTA disintegration. Endodontic retreatment with Biodentine resolved the symptoms and achieved complete periapical healing, confirmed at 3, 6, and 18 months, and 4 years post-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights MTA's susceptibility to acidic degradation in compromised conditions and supports Biodentine as a potentially more pH-resistant alternative. Clinicians should be vigilant when treating traumatized, orthodontically compromised teeth and prioritize restorative materials with high stability in hostile environments to minimize treatment failure risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fdmed.2025.1686600","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:21:48Z","timestamp":1762410108000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: ProRoot MTA degradation in a compromised tooth: secondary trauma and acidic microenvironment leading to retreatment with Biodentine"],"prefix":"10.3389","volume":"6","author":[{"given":"Saulius","family":"Drukteinis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goda","family":"Bilvinait\u0117","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Galler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1111\/j.1600-9657.2008.00696.x","article-title":"Epidemiology of traumatic dental injuries \u2013 a 12-year review","volume":"24","author":"Glendor","year":"2008","journal-title":"Dent Traumatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1034\/j.1600-9657.2002.00153.x","article-title":"Traumatic injuries in the primary and permanent dentition","volume":"18","author":"Flores","year":"2002","journal-title":"Dent Traumatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/s0031-3955(05)70258-3","article-title":"Diagnosis and management of dental injuries in children","volume":"47","author":"McTigue","year":"2000","journal-title":"Pediatr Clin North Am"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/iej.13672","article-title":"Present status and future directions: endodontic management of traumatic injuries to permanent teeth","volume":"55","author":"Krastl","year":"2022","journal-title":"Int Endod J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/j.1600-9657.2011.01102.x","article-title":"Combination injuries 1. The risk of pulp necrosis in permanent teeth with concussion injuries and concomitant crown fractures","volume":"28","author":"Lauridsen","year":"2012","journal-title":"Dent Traumatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41368-024-00321-z","article-title":"Experts consensus on management of tooth luxation and avulsion","volume":"16","author":"Huang","year":"2024","journal-title":"Int J Oral Sci"},{"key":"B7","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.ajodo.2009.06.021","article-title":"Root resorption associated with orthodontic tooth movement: a systematic review","volume":"37","author":"Weltman","year":"2010","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"B8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1034\/j.1601-1546.2002.10106.x","article-title":"Root resorption due to dental trauma","volume":"1","author":"Trope","year":"2002","journal-title":"Endod Topics"},{"key":"B9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/adj.12395","article-title":"Epidemiology and outcomes of traumatic dental injuries: a review of the literature","volume":"61","author":"Lam","year":"2016","journal-title":"Aust Dent J"},{"key":"B10","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/s41415-023-6564-4","article-title":"Contemporary issues in the management of dental trauma","volume":"235","author":"Alani","year":"2023","journal-title":"Br Dent J"},{"key":"B11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/edt.12449","article-title":"The relationship of previous dental trauma with new cases of dental trauma. A systematic review and meta-analysis","volume":"35","author":"Magno","year":"2019","journal-title":"Dent Traumatol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"5569313","DOI":"10.1155\/2021\/5569313","article-title":"Minimal intervention in dentistry: a literature review on biodentine as a bioactive pulp capping material","volume":"2021","author":"Arandi","year":"2021","journal-title":"Biomed Res Int"},{"key":"B13","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3390\/ma11010123","article-title":"Effect of exposed surface area, volume and environmental pH on the calcium Ion release of three commercially available tricalcium silicate based dental cements","volume":"11","author":"Rajasekharan","year":"2018","journal-title":"Materials"},{"key":"B14","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1186\/s12903-023-03211-8","article-title":"The effect of acidity on the physicochemical properties of two hydraulic calcium silicate-based cements and two calcium phosphate silicate-based cements","volume":"23","author":"Yang","year":"2023","journal-title":"BMC Oral Health"},{"key":"B15","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1186\/s12903-020-01325-x","article-title":"Comparative evaluation of volumetric changes of three different retrograde calcium silicate materials placed under different pH condititions","volume":"20","author":"Kwon","year":"2020","journal-title":"BMC Oral Health"},{"key":"B16","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1007\/s00784-024-06067-6","article-title":"A laboratory study to assess the physico-chemical properties of BioRoot RCS and BioRoot flow exposed to citric acid and EDTA irrigating solutions","volume":"28","author":"Bilvinait\u0117","year":"2024","journal-title":"Clin Oral Investig"},{"key":"B17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cemconres.2017.09.002","article-title":"Role of pH on the structure, composition and morphology of C-S-H\u2013PCE nanocomposites and their effect on early strength development of Portland cement","volume":"1021","author":"Kanchanason","year":"2017","journal-title":"Cement Concr Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"104524","DOI":"10.1016\/j.cemconcomp.2022.104524","article-title":"Sulfuric acid and citric acid attack of calcium sulfoaluminate-based binders","volume":"130","author":"Damion","year":"2022","journal-title":"Cem Concr Compos"},{"key":"B19","doi-asserted-by":"publisher","first-page":"107000","DOI":"10.1016\/j.cemconres.2022.107000","article-title":"Evaluating acid resistance of Portland cement, calcium aluminate cement, and calcium sulfoaluminate based cement using acid neutralisation","volume":"162","author":"Damion","year":"2022","journal-title":"Cement Concr Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00784-018-2394-1","article-title":"Microstructure and chemical analysis of four calcium silicate-based cements in different environmental conditions","volume":"23","author":"Ashofteh Yazdi","year":"2019","journal-title":"Clin Oral Investig"},{"key":"B21","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ejwf.2021.09.003","article-title":"Orthodontic root resorption","volume":"10","author":"Sameshima","year":"2021","journal-title":"J World Fed Orthod"}],"container-title":["Frontiers in Dental Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fdmed.2025.1686600\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T12:09:01Z","timestamp":1762776541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fdmed.2025.1686600\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":21,"alternative-id":["10.3389\/fdmed.2025.1686600"],"URL":"https:\/\/doi.org\/10.3389\/fdmed.2025.1686600","relation":{},"ISSN":["2673-4915"],"issn-type":[{"type":"electronic","value":"2673-4915"}],"subject":[],"published":{"date-parts":[[2025,11,6]]},"article-number":"1686600"}}