{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:01:59Z","timestamp":1791237719449,"version":"4.1.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Dent. Med."],"abstract":"<jats:p>Growing evidence links chronic systemic inflammation, particularly from periodontitis, to neurodegenerative processes, which have been reported to share common pathways. Early detection of neurodegenerative diseases such as Alzheimer's disease is crucial, given that underlying neuropathological processes evolve silently for decades before diagnosis. The gingival crevicular fluid (GCF), a serum-derived exudate from the gingival sulcus, mirrors both local periodontal inflammation and systemic conditions. Its molecular composition\u2014rich in cytokines, enzymes, oxidative stress markers, and microbial metabolites\u2014makes it a potential source of biomarkers reflecting neuroinflammatory pathways. This review discusses the biological rationale and emerging evidence supporting the use of GCF as a functionalized biofluid for early detection of dementia or asymptomatic neurodegeneration. By integrating advances in biosensing and lab-on-a-chip technologies, GCF analysis could become a minimally invasive, point-of-care approach to identify individuals at risk of neurodegenerative diseases. Exploring this oral\u2013brain connection may open new perspectives in preventive medicine and personalized diagnostics.<\/jats:p>","DOI":"10.3389\/fdmed.2025.1738635","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:28:03Z","timestamp":1768458483000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Gingival crevicular fluid as a functionalized point of care for the early detection of dementia or the asymptomatic phase of neurodegeneration"],"prefix":"10.3389","volume":"6","author":[{"given":"Ylenia","family":"Leanza","sequence":"first","affiliation":[{"name":"Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania","place":["Catania, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Belmonte","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania","place":["Catania, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Polizzi","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania","place":["Catania, Italy"]},{"name":"International Research Center on Periodontal and Systemic Health \u201cPerioHealth\u201d, University of Catania","place":["Catania, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, University of Milan","place":["Milan, Italy"]},{"name":"Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca 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