{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:31:26Z","timestamp":1771399886475,"version":"3.50.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Dent. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      This\n                      <jats:italic>in vitro<\/jats:italic>\n                      study aimed to develop a novel choline-based ionic liquid-incorporated silicone denture base soft liners (SDBSLs) with improved antifungal potential and compliance in standard properties.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Choline borate (CB) ionic liquid was synthesized, characterized, and blended with a silicone liner (Molloplast-B) in concentrations of 1%, 2%, and 5% w\/w to form the experimental group, CB, with three subgroups (CB1%, CB2%, and CB5%, respectively). Commercial silicone liners served as the negative control, while silicone liners blended with the antifungal drug itraconazole (1.25% wt\/wt) were the positive control. The antifungal potential against\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      was evaluated via a direct-contact assay, with growth inhibition quantified by measuring the culture turbidity (OD600). The tear strength was determined using the type A test and the Shore A hardness was measured using a durometer. A physical parameter, percent mass change (%), was tested using the immersion method (at 1 week and 6 weeks). The Alamar Blue assay was performed to assess the biocompatibility of the samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data were statistically analyzed using SPSS 25, with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&amp;lt;0.001. The results showed that CB1% had the most significant inhibitory effect on\n                      <jats:italic>C. albicans<\/jats:italic>\n                      growth (83.71%). The drug- incorporated liners gained the most weight (5.00\u2009\u00b1\u20090.11%). The liners in CB5% were the toughest, with a tear strength of 5.31\u2009\u00b1\u20091.84 kN\/m. The liners in the negative control group (Molloplast-B) were the softest (Shore A\u2009=\u200960.16\u2009\u00b1\u20091.07), followed by those in CB5% (51.33\u2009\u00b1\u20091.40). The biocompatibility of the ionic liquid-modified samples was better than that of the positive controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The novel choline borate in silicone liners enhanced the antifungal potential and met the standard criteria of physical and mechanical compliance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fdmed.2026.1734528","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:57:00Z","timestamp":1771397820000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of a novel antifungal ionic liquid-mediated silicone denture base soft liner"],"prefix":"10.3389","volume":"7","author":[{"given":"Nadia","family":"Munir","sequence":"first","affiliation":[{"name":"Department of Dental Materials, Lahore Medical and Dental College, University of Biological and Applied Sciences (UBAS)","place":["Lahore, Pakistan"]},{"name":"School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian","place":["Kelantan, Malaysia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja Azman Raja","family":"Awang","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dental Sciences, Health Campus, Universiti Sains Malaysia","place":["Kubang Kerian, Kelantan, Malaysia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveed","family":"Inayat","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Azra Naheed Dental College, Superior University","place":["Lahore, Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazala","family":"Suleman","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, King Khalid University College of Dentistry, Abha","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawshad","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Dental Materials, Institute of Basic Medical Sciences, Khyber Medical University","place":["Peshawar, Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor Huda","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, School of Dental Sciences, Health Campus, Universiti Sains Malaysia","place":["Kubang Kerian, Kelantan, Malaysia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Sohail","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Dentistry, Ajman University","place":["Ajman, United Arab Emirates"]},{"name":"Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates"},{"name":"School of Dentistry, University of Jordan","place":["Amman, Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Zeeshan","family":"Munir","sequence":"additional","affiliation":[{"name":"Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia","place":["Penang, Malaysia"]},{"name":"Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences","place":["Lahore, Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Samad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University","place":["Dammam, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"279","DOI":"10.5543\/tkda.2016.83451","article-title":"Association between vitamin D and arterial stiffness","volume":"44","author":"Aydo\u011fdu","year":"2016","journal-title":"Turk Kardiyol Dern Ars"},{"key":"B2","doi-asserted-by":"publisher","first-page":"419","DOI":"10.15311\/selcukdentj.1156304","article-title":"A systematic review of denture stomatitis: predisposing factors, clinical features, etiology, and global Candida sp 27. 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