{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:24:31Z","timestamp":1785821071839,"version":"3.56.0"},"reference-count":95,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Dent. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This paper examined the clinical applications of \u201cbioactive\u201d dental materials within a framework of minimum intervention dentistry, ranging from non-invasive to invasive procedures for managing carious lesions. Modern approaches to caries management emphasise personalised care, caries risk assessment, and lesion activity evaluation, combined with the strategic use of ion-releasing biomaterials (IRB). These materials, which can release ions such as calcium, phosphate, fluoride and other ions, may support dental remineralization, stabilize collagen, buffer pH, and deter bacterial growth, thus promoting long-term oral health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The Bioactive Dental Concept finds a great ally with the new generation ABRAM (Advanced Bioactive Restorative Adhesive Material) and available materials; it is structured to guide clinicians to select bioactive options when clinically appropriate. Interventions are categorised as non-invasive (home care and professional applications), micro-invasive (sealants, resin infiltration, peptides), and invasive. Diagnostic tools like fluorescence and infrared imaging improve early detection, enabling minimally invasive, targeted treatments. Early lesions are sealed and remineralised; moderate ones need selective excavation and cavity conditioning. Extensive lesions require durable bioactive restorations, with new materials like \u201calkasite\u201d and dual-cure bioactive composites. Integrating evidence-based dentistry (EBD) principles remains essential, though reliance on strict hierarchies of evidence may limit the adoption of innovative approaches. Practical clinical experience and biological acceptability must also inform decision-making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The article emphasises the need for a balanced approach that combines the rigor of EBD with clinical pragmatism. Even though no restorative material is yet biologically ideal, bioactive and ion-releasing materials significantly improve the management of carious lesions, supporting the aim of preserving natural tooth structures and promoting oral eubiosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fdmed.2026.1739208","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:33:04Z","timestamp":1775626384000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Bioactive and Ion-releasing materials in minimum intervention dentistry: a clinical pathway from prevention to restorative treatment"],"prefix":"10.3389","volume":"7","author":[{"given":"Herv\u00e9","family":"Tassery","sequence":"first","affiliation":[{"name":"Ecole de Me\u0301decine Dentaire de Marseille, Universite\u0301 d'Aix-Marseille","place":["Marseille, France"]},{"name":"Institut Hospitalo-Universitaire M\u00e9diterran\u00e9e-Infection, Aix-Marseille Univ, IRD, MEPHI, AP-HM","place":["Marseille, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Sauro","sequence":"additional","affiliation":[{"name":"Dental Biomaterials and Minimally Invasive Dentistry, Department of Dentistry, Cardenal Herrera-CEU University, CEU Universities","place":["Valencia, Spain"]},{"name":"Department of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amel","family":"Slimani","sequence":"additional","affiliation":[{"name":"LBN, Univ Montpellier, Faculty of Dentistry","place":["Montpellier, France"]},{"name":"CSD Madeleine-Fran\u00e7oise Calais, CHU Montpellier","place":["Montpellier, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4042","DOI":"10.3390\/ma15124042","article-title":"Long-Term assessment of contemporary Ion-releasing restorative dental materials","volume":"15","author":"Marovic","year":"2022","journal-title":"Materials"},{"key":"B2","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.dental.2018.03.001","article-title":"Bioactive dental materials\u2014do they exist and what does bioactivity mean?","volume":"34","author":"Vallittu","year":"2018","journal-title":"Dent Mater"},{"key":"B3","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1007\/s10856-006-0432-z","article-title":"The story of bioglass\u00ae","volume":"17","author":"Hench","year":"2006","journal-title":"J Mater Sci Mater Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s00784-024-05525-5","article-title":"Bonding performance and interfacial adaptation of modern bulk-fill restorative composites after aging in artificial saliva: an in vitro study","volume":"28","author":"Pires","year":"2024","journal-title":"Clin Oral Investig"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12903-021-01674-1","article-title":"Cariescare international adapted for the pandemic in children: caries OUT multicentre single-group interventional study protocol","volume":"21","author":"Martignon","year":"2021","journal-title":"BMC oral Health"},{"key":"B6","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1080\/19424396.2011.12221948","article-title":"Validation of the CDA CAMBRA caries risk assessment\u2013a six-year retrospective study","volume":"39","author":"Dom\u00e9jean","year":"2011","journal-title":"J Calif Dent Assoc"},{"key":"B7","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41415-019-0678-8","article-title":"Cariescare practice guide: consensus on evidence into practice","volume":"227","author":"Martignon","year":"2019","journal-title":"Br Dent J"},{"key":"B8","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/s41415-020-2116-3","article-title":"Carious lesion detection technologies: factual clinical approaches","volume":"229","author":"Slimani","year":"2020","journal-title":"Br Dent J"},{"key":"B9","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/j.1600-0528.2007.00347.x","article-title":"The international caries detection and assessment system (ICDAS): an integrated system for measuring dental caries","volume":"35","author":"Ismail","year":"2007","journal-title":"Community Dent Oral Epidemiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1111\/cdoe.12025","article-title":"International caries detection and assessment system (ICDAS) and its international caries classification and management system (ICCMS) - methods for staging of the caries process and enabling dentists to manage caries","volume":"41","author":"Pitts","year":"2013","journal-title":"Community Dent Oral Epidemiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/adj.12049","article-title":"Use of new minimum intervention dentistry technologies in caries management","volume":"58","author":"Tassery","year":"2013","journal-title":"Aust Dent J"},{"key":"B12","doi-asserted-by":"publisher","first-page":"155","DOI":"10.5005\/jcdp-9-2-155","article-title":"Minimally invasive dentistry using sonic and ultra-sonic devices in ultraconservative class 2 restorations","volume":"9","author":"Koubi","year":"2008","journal-title":"J Contemp Dent Pract"},{"key":"B13","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jiph.2018.10.074","article-title":"Infection control in the dental clinics: probiotic-based cleaning as an alternative to chemical disinfection","volume":"12","author":"Al Marzooq","year":"2019","journal-title":"J Infect Public Health"},{"key":"B14","doi-asserted-by":"publisher","first-page":"558","DOI":"10.12016\/j.issn.2096-1456.2016.09.013","article-title":"Application of probiotics for dental caries prevention in children","volume":"24","author":"Chun","year":"2016","journal-title":"\u53e3\u8154\u75be\u75c5\u9632\u6cbb"},{"key":"B15","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.1007\/s00784-020-03431-0","article-title":"How to intervene in the caries process in adults: proximal and secondary caries? 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