{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:19:50Z","timestamp":1783059590760,"version":"3.54.6"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Dent. Med."],"abstract":"\n Introduction<\/jats:title>\n Pulpotomy is a common vital pulp therapy in primary molars aimed at preserving radicular pulp vitality until exfoliation. Concerns regarding the cytotoxicity and systemic effects of formocresol have prompted interest in biocompatible alternatives such as Aloe vera, which possesses anti-inflammatory, antimicrobial, and regenerative properties.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To evaluate the clinical and radiographic success of Aloe vera as a pulpotomy medicament in primary molars compared to conventional agents.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A systematic search of PubMed, Scopus and Web of Science was conducted in accordance with PRISMA guidelines. Randomized controlled trials evaluating Aloe vera as a pulpotomy medicament in primary molars were included. Risk of bias was assessed using the Cochrane RoB2 tool, and the certainty of evidence for primary outcomes was evaluated using the GRADE approach.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Clinical success at 3\u20136 months was high (90%\u2013100%) and comparable between groups. However, radiographic success was highly inconsistent; two major trials reported significantly lower success for Aloe vera (21.1% and 54.8%) compared to formocresol at 6\u201312 months.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Aloe vera demonstrates promising short-term clinical performance, but it showed less predictable radiographic outcomes and was inferior to standard comparators in some trials. Due to the Very Low certainty of evidence and high risk of bias in major studies, herbal agents cannot currently be recommended as definitive substitutes for formocresol or MTA.<\/jats:p>\n <\/jats:sec>\n \n Systematic Review Registration<\/jats:title>\n \n https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420251230179<\/jats:ext-link>\n , PROSPERO, identifier CRD420251230179.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fdmed.2026.1845683","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:39:16Z","timestamp":1783057156000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and radiographic outcomes of Aloe vera as a pulpotomy medicament in primary teeth: a systematic review"],"prefix":"10.3389","volume":"7","author":[{"given":"Samiksha","family":"Uchil","sequence":"first","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, AB Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University)","place":["Mangalore, Karnataka, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"R","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, AB Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University)","place":["Mangalore, Karnataka, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna","family":"Bhandary","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, AB Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University)","place":["Mangalore, Karnataka, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadhvi","family":"B","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, AB Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University)","place":["Mangalore, Karnataka, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urvashi","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, AB Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University)","place":["Mangalore, Karnataka, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1016\/j.joen.2008.02.031","article-title":"Vital pulp therapy with new materials for primary teeth: new directions and treatment perspectives","volume":"34","author":"Fuks","year":"2008","journal-title":"J Endod"},{"key":"B2","volume-title":"The Reference Manual of Pediatric Dentistry","year":"2019"},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-55157-4","volume-title":"Mineral Trioxide aggregate in Dentistry: From Preparation to 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