{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:12:17Z","timestamp":1788415937736,"version":"build-2803163510"},"reference-count":104,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Dent. Med."],"abstract":"<jats:p>Curcumin, the active polyphenol in turmeric (Curcuma longa), is well-known for its anti-inflammatory, antioxidant, and antimicrobial properties, making it a promising therapeutic agent for a range of diseases, including neuroinflammatory conditions and periodontal disease. Periodontitis, a prevalent oral disease, is associated with chronic inflammation and bacterial infection. Curcumin has demonstrated antibacterial effects against periodontal pathogens such as Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia when applied locally as a sub-gingival gel in conjunction with scaling and root planning (SRP). Furthermore, curcumin's ability to produce reactive oxygen species (ROS) under visible light exposure enhances its effects through photodynamic therapy (PDT) and potentiates its antibacterial and anti-inflammatory actions. Curcumin demonstrates promising potential as an adjunctive therapy for periodontitis, indicating that it may serve as a valuable adjuvant strategy for improving periodontal management. Nonetheless, additional well-designed clinical and translational studies are warranted to confirm these benefits.<\/jats:p>","DOI":"10.3389\/fdmed.2026.1861025","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:13:45Z","timestamp":1788412425000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcumin as an adjunct in periodontal therapy: local effects, delivery systems, and clinical perspectives"],"prefix":"10.3389","volume":"7","author":[{"given":"Ana Carolina Aparecida","family":"Rivas","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Traumatology, and Periodontology, School of Dentistry of Ribeir\u00e3o Preto \u2013 University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto - Sp, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Mario","family":"Taba","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Traumatology, and Periodontology, School of Dentistry of Ribeir\u00e3o Preto \u2013 University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto - Sp, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Gomes","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Traumatology, and Periodontology, School of Dentistry of Ribeir\u00e3o Preto \u2013 University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto - Sp, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","first-page":"44","article-title":"Turmeric and curcumin: biological actions and medicinal applications","volume":"87","author":"Chattopadhyay","year":"2004","journal-title":"Curr Sci"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1002\/cber.191004302168","article-title":"Zur kenntnis des curcumins","volume":"43","author":"Milobedzka","year":"1910","journal-title":"Ber Dtsch Chem Ges"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1002\/cber.19130460214","article-title":"Aromatische telluretin-verbindungen. 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