{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:59:15Z","timestamp":1785308355372,"version":"3.55.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Dent. Med."],"abstract":"\n Objectives<\/jats:title>\n To compare 12-month marginal bone loss (MBL) between immediate implant placement (IIP) and early implant placement (EIP) in the anterior region. Secondary objectives included the evaluation of implant stability (ISQ), esthetic outcomes (PES\u2013WES), and peri-implant health (probing depth and bleeding index) when using customized healing abutments.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A prospective, randomized, split-mouth clinical trial was conducted involving 12 patients, with a total of 24 implant sites. The protocol was approved by the institutional review board (IRB2023-H0113D-P-0494), registered at\n ClinicalTrials.gov<\/jats:ext-link>\n (NCT0698551). Each patient received one IIP and one contralateral EIP via fully guided surgery. Chairside-fabricated customized healing abutments were utilized, and definitive restorations were delivered at 3 months. Outcomes were recorded at 3, 6, and 12 months. MBL was assessed via standardized CBCT, implant stability via resonance-frequency analysis, and esthetics through Pink\/White Esthetic Scores. Mixed-effects models were used for statistical analysis (\n \u03b1<\/jats:italic>\n \u2009=\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n IIP demonstrated significantly lower early MBL at 3 months (mean difference: \u22120.30\u2005mm, 95% CI: \u22120.52 to \u22120.08;\n p<\/jats:italic>\n \u2009=\u20090.012) and 6 months (mean difference: \u22120.22\u2005mm, 95% CI: \u22120.39 to \u22120.05;\n p<\/jats:italic>\n \u2009=\u20090.016), and higher ISQ at 3 months (mean difference: 2.49, 95% CI: 0.49\u20134.49;\n p<\/jats:italic>\n \u2009=\u20090.017) compared to EIP. However, no significant differences were observed in MBL (mean difference: \u22120.01\u2005mm, 95% CI: \u22120.08 to 0.06;\n p<\/jats:italic>\n \u2009=\u20090.618) or ISQ (mean difference: 0.20, 95% CI: \u22121.62 to 2.02;\n p<\/jats:italic>\n \u2009=\u20090.823) at the 12-month primary endpoint. Regarding esthetics, total PES favored IIP at 6 months (mean difference: 2.09, 95% CI: 1.48\u20132.70;\n p<\/jats:italic>\n \u2009&lt;\u20090.001) and 12 months (mean difference: 1.50, 95% CI: 0.92\u20132.08;\n p<\/jats:italic>\n \u2009&lt;\u20090.001). WES was similar at 6 months (mean difference: 0.42, 95% CI: \u22120.31 to 1.15;\n p<\/jats:italic>\n \u2009=\u20090.234) but favored IIP at 12 months (mean difference: 1.00, 95% CI: 0.50\u20131.50;\n p<\/jats:italic>\n \u2009=\u20090.002). Peri-implant health parameters improved over time in both groups with no implant losses.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n When combined with guided protocols and customized healing abutments, IIP and EIP yield comparable 12-month marginal bone outcomes. IIP provides an advantage in accelerated early stability and superior soft-tissue esthetic scores (PES) compared to EIP. The clinically meaningful esthetic advantages of IIP support its preferential use in the anterior zone when anatomical conditions permit.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fdmed.2026.1884486","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:02:16Z","timestamp":1785304936000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A prospective randomized split-mouth trial comparing immediate versus early anterior implant placement with customized healing abutments: 12-month marginal bone loss, stability, and esthetic outcome"],"prefix":"10.3389","volume":"7","author":[{"given":"Sara N.","family":"El Touliani","sequence":"first","affiliation":[{"name":"Oral Rehabilitation Sciences Department, Faculty of Dentistry, Beirut Arab University","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Abdelhamid","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada M. H.","family":"Fahmy","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Arab Academy for Science, Technology and Maritime Transport","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser M.","family":"Aly","sequence":"additional","affiliation":[{"name":"Oral Rehabilitation Sciences Department, Faculty of Dentistry, Beirut Arab University","place":["Beirut, Lebanon"]},{"name":"Faculty of Dentistry, Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1111\/jopr.14011","article-title":"Peri-implant tissue definition and registration with a 3D-printed emergence profile former on titanium stock healing abutment: a dental technique and clinical report","volume":"35","author":"Azpiazu-Flores","year":"2026","journal-title":"J Prosthodont"},{"key":"B2","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/jerd.12512","article-title":"Peri-implant tissue management after immediate implant placement using a customized healing abutment","volume":"31","author":"Ruales-Carrera","year":"2019","journal-title":"J Esthet Restor Dent"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.3390\/ma12183041","article-title":"Peri-implant soft tissue conditioning by means of customized healing abutment: a randomized controlled clinical trial","volume":"12","author":"Beretta","year":"2019","journal-title":"Materials"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/clr.14195","article-title":"Radiographic alveolar bone assessment in correlation with primary implant stability: a systematic review and meta-analysis","volume":"35","author":"Putra","year":"2024","journal-title":"Clin Oral Implants Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/s41432-023-00902-7","article-title":"Comparing clinical outcomes of immediate implant placement with early implant placement in healthy adult patients requiring single-tooth replacement in the aesthetic zone: a systematic review and meta-analysis of randomised controlled trials","volume":"24","author":"Asghar","year":"2023","journal-title":"Evid Based Dent"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.3390\/jcm12082783","article-title":"Immediate implant and customized healing abutment for a periodontally compromised socket: 1-year follow-up retrospective evaluation","volume":"12","author":"Menchini-Fabris","year":"2023","journal-title":"J Clin Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3390\/ma13030511","article-title":"Correlation between buccal bone thickness at implant placement in healed sites and buccal soft tissue maturation pattern: a prospective three-year study","volume":"13","author":"Farronato","year":"2020","journal-title":"Materials"},{"key":"B8","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1097\/ID.0000000000000666","article-title":"Immediate early and delayed implants: a 2-year prospective cohort study of 131 transmucosal flapless implants placed in sites with different Pre-extractive endodontic infections","volume":"26","author":"Prati","year":"2017","journal-title":"Implant Dent"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000259","article-title":"Three-dimensional evaluation of alveolar bone and soft tissue dimensions of maxillary central incisors for immediate implant placement: a cone-beam computed tomography assisted analysis","volume":"24","author":"Kheur","year":"2015","journal-title":"Implant Dent"},{"key":"B10","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1111\/clr.13924","article-title":"Immediate implant placement vs. early implant treatment in the esthetic area. 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