{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:46:39Z","timestamp":1771634799849,"version":"3.50.1"},"reference-count":52,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100000858","name":"University of Sheffield","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2016.00141","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T03:12:31Z","timestamp":1477537951000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["A Candidate Gene Association Study of Bone Mineral Density in an Iranian Population"],"prefix":"10.3389","volume":"7","author":[{"given":"Seyed Alireza","family":"Dastgheib","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Gartland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Mohammad Bagher","family":"Tabei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamhossein Ranjbar","family":"Omrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion Dawn","family":"Teare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"key":"B1","volume-title":"Harrison\u2019s Principles of Internal Medicine","author":"Fauci","year":"2008","edition":"17th ed"},{"issue":"10","key":"B2","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/nrendo.2014.125","article-title":"Fracture mortality: associations with epidemiology and osteoporosis treatment","volume":"10","author":"Sattui","year":"2014","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"B3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s11926-008-0017-6","article-title":"Osteoporosis epidemiology update","volume":"10","author":"Cole","year":"2008","journal-title":"Curr Rheumatol Rep"},{"issue":"6","key":"B4","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.berh.2014.03.003","article-title":"Hip fracture as the tracer condition","volume":"27","author":"Kassim Javaid","year":"2013","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"9319","key":"B5","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1016\/S0140-6736(02)08662-2","article-title":"Osteoporosis \u2013 the disease of the 21st century?","volume":"359","author":"Clark","year":"2002","journal-title":"Lancet"},{"issue":"3","key":"B6","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00198-004-1811-2","article-title":"Requirements for DXA for the management of osteoporosis in Europe","volume":"16","author":"Kanis","year":"2005","journal-title":"Osteoporos Int"},{"issue":"9","key":"B7","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nrrheum.2010.106","article-title":"Genetic epidemiology of age-related osteoporosis and its clinical applications","volume":"6","author":"Cheung","year":"2010","journal-title":"Nat Rev Rheumatol"},{"issue":"12","key":"B8","doi-asserted-by":"publisher","first-page":"936","DOI":"10.7326\/0003-4819-145-4-200608150-00005","article-title":"The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis (vol 145, pg 255, 2006)","volume":"145","author":"Uitterlinden","year":"2006","journal-title":"Ann Intern Med"},{"issue":"3","key":"B9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11914-005-0019-5","article-title":"Genetic epidemiology of osteoporosis: past, present, and future","volume":"3","author":"Zmuda","year":"2005","journal-title":"Curr Osteoporos Rep"},{"issue":"8","key":"B10","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/nrg3228","article-title":"Genetics of osteoporosis from genome-wide association studies: advances and challenges","volume":"13","author":"Richards","year":"2012","journal-title":"Nat Rev Genet"},{"key":"B11","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fendo.2015.00024","article-title":"Ethnic differences in bone health","volume":"6","author":"Zengin","year":"2015","journal-title":"Front Endocrinol"},{"issue":"9623","key":"B12","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/S0140-6736(08)60599-1","article-title":"Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study","volume":"371","author":"Richards","year":"2008","journal-title":"Lancet"},{"issue":"8","key":"B13","doi-asserted-by":"publisher","first-page":"528","DOI":"10.7326\/0003-4819-151-8-200910200-00006","article-title":"Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture","volume":"151","author":"Richards","year":"2009","journal-title":"Ann Intern Med"},{"issue":"11","key":"B14","doi-asserted-by":"publisher","first-page":"e1001217","DOI":"10.1371\/journal.pgen.1001217","article-title":"Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone","volume":"6","author":"Paternoster","year":"2010","journal-title":"PLoS Genet"},{"issue":"11","key":"B15","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1038\/ng.446","article-title":"Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies","volume":"41","author":"Rivadeneira","year":"2009","journal-title":"Nat Genet"},{"issue":"22","key":"B16","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1056\/NEJMoa0801197","article-title":"Multiple genetic loci for bone mineral density and fractures","volume":"358","author":"Styrkarsdottir","year":"2008","journal-title":"N Engl J Med"},{"issue":"1","key":"B17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/ng.284","article-title":"New sequence variants associated with bone mineral density","volume":"41","author":"Styrkarsdottir","year":"2009","journal-title":"Nat Genet"},{"issue":"5","key":"B18","doi-asserted-by":"publisher","first-page":"826","DOI":"10.4158\/EP.17.5.826","article-title":"Association of the FokI polymorphism in the vitamin D receptor gene with vertebral fracture in Iranian postmenopausal women","volume":"17","author":"Hossein-nezhad","year":"2011","journal-title":"Endocr Pract"},{"issue":"1","key":"B19","first-page":"75","article-title":"Association between vitamin D receptor gene BsmI polymorphism and bone mineral density in a population of 146 Iranian women","volume":"15","author":"Pouresmaeili","year":"2013","journal-title":"Cell J"},{"issue":"7","key":"B20","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1097\/FPC.0b013e3280951625","article-title":"Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect estrogen treatment","volume":"17","author":"Ohlendorff","year":"2007","journal-title":"Pharmacogenet Genomics"},{"issue":"5","key":"B21","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/ejhg.2011.245","article-title":"Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women","volume":"20","author":"Gartland","year":"2012","journal-title":"Eur J Hum Genet"},{"issue":"23","key":"B22","doi-asserted-by":"publisher","first-page":"9362","DOI":"10.1073\/pnas.0903103106","article-title":"Potential etiologic and functional implications of genome-wide association loci for human diseases and traits","volume":"106","author":"Hindorff","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"B23","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/S0001-2998(97)80025-6","article-title":"Technical principles of dual energy x-ray absorptiometry","volume":"27","author":"Blake","year":"1997","journal-title":"Semin Nucl Med"},{"issue":"5","key":"B24","first-page":"582","article-title":"Complications occurring from diagnostic venipuncture","volume":"34","author":"Galena","year":"1992","journal-title":"J Fam Pract"},{"issue":"3","key":"B25","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1378\/chest.114.3.748","article-title":"The safety of brachial artery puncture for arterial blood sampling","volume":"114","author":"Okeson","year":"1998","journal-title":"Chest"},{"issue":"9","key":"B26","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1038\/nprot.2010.116","article-title":"Data quality control in genetic case-control association studies","volume":"5","author":"Anderson","year":"2010","journal-title":"Nat Protoc"},{"key":"B27","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/1471-2458-6-158","article-title":"Obesity and hypertension in an Iranian cohort study; Iranian women experience higher rates of obesity and hypertension than American women","volume":"6","author":"Bahrami","year":"2006","journal-title":"BMC Public Health"},{"issue":"3","key":"B28","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jocd.2006.05.001","article-title":"Peak bone mass of Iranian population: the Iranian Multicenter Osteoporosis Study","volume":"9","author":"Larijani","year":"2006","journal-title":"J Clin Densitom"},{"issue":"1\u20132","key":"B29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s11657-006-0005-2","article-title":"Bone mineral density in the normal Iranian population: a comparison with American reference data","volume":"1","author":"Omrani","year":"2006","journal-title":"Arch Osteoporos"},{"issue":"10","key":"B30","doi-asserted-by":"publisher","first-page":"e13217","DOI":"10.1371\/journal.pone.0013217","article-title":"European bone mineral density loci are also associated with BMD in East-Asian populations","volume":"5","author":"Styrkarsdottir","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"B31","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s002239900663","article-title":"Bone density of the spine and femur in adult white females","volume":"65","author":"Mazess","year":"1999","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"B32","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.bone.2006.09.029","article-title":"Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men","volume":"40","author":"Kiel","year":"2007","journal-title":"Bone"},{"issue":"15","key":"B33","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.clinbiochem.2013.03.011","article-title":"Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women","volume":"46","author":"Shang","year":"2013","journal-title":"Clin Biochem"},{"issue":"12","key":"B34","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1056\/NEJM199503233321202","article-title":"Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group","volume":"332","author":"Cummings","year":"1995","journal-title":"N Engl J Med"},{"issue":"5","key":"B35","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/jbmr.5650080507","article-title":"Effects of weight and body mass index on bone mineral density in men and women: the Framingham study","volume":"8","author":"Felson","year":"1993","journal-title":"J Bone Miner Res"},{"issue":"9","key":"B36","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1359\/jbmr.1999.14.9.1622","article-title":"Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early Postmenopausal Intervention Cohort (EPIC) study group","volume":"14","author":"Ravn","year":"1999","journal-title":"J Bone Miner Res"},{"issue":"2","key":"B37","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1359\/jbmr.2000.15.2.322","article-title":"Osteoporosis in elderly men and women: effects of dietary calcium, physical activity, and body mass index","volume":"15","author":"Nguyen","year":"2000","journal-title":"J Bone Miner Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"205963","DOI":"10.1155\/2013\/205963","article-title":"Relationship between weight, body mass index, and bone mineral density in men referred for dual-energy X-ray absorptiometry scan in Isfahan, Iran","volume":"2013","author":"Salamat","year":"2013","journal-title":"J Osteoporos"},{"key":"B39","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1749-6632.2009.05317.x","article-title":"Genetics of osteoporosis","volume":"1192","author":"Ralston","year":"2010","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"B40","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00439-009-0773-z","article-title":"Genetics of osteoporosis: accelerating pace in gene identification and validation","volume":"127","author":"Li","year":"2010","journal-title":"Hum Genet"},{"issue":"5","key":"B41","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/ng.2249","article-title":"Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture","volume":"44","author":"Estrada","year":"2012","journal-title":"Nat Genet"},{"issue":"4","key":"B42","doi-asserted-by":"publisher","first-page":"e1001372","DOI":"10.1371\/journal.pgen.1001372","article-title":"Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk","volume":"7","author":"Duncan","year":"2011","journal-title":"PLoS Genet"},{"issue":"3","key":"B43","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.maturitas.2011.02.010","article-title":"TNFRSF11B gene polymorphisms 1181G > C and 245T > G as well as haplotype CT influence bone mineral density in postmenopausal women","volume":"69","author":"Mencej-Bedra\u010d","year":"2011","journal-title":"Maturitas"},{"issue":"4","key":"B44","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1007\/s00198-012-2059-x","article-title":"Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients","volume":"24","author":"Wesselius","year":"2013","journal-title":"Osteoporos Int"},{"issue":"8955","key":"B45","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/S0140-6736(95)90740-8","article-title":"Vitamin-D-receptor-gene polymorphism and bone loss","volume":"345","author":"Keen","year":"1995","journal-title":"Lancet"},{"issue":"6991","key":"B46","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1136\/bmj.310.6991.1357","article-title":"Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: a twin study in Britain","volume":"310","author":"Spector","year":"1995","journal-title":"BMJ"},{"issue":"8947","key":"B47","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S0140-6736(95)90404-2","article-title":"Vitamin-D-receptor-gene polymorphisms and change in lumbar-spine bone mineral density","volume":"345","author":"Ferrari","year":"1995","journal-title":"Lancet"},{"issue":"7009","key":"B48","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1136\/bmj.311.7009.874a","article-title":"Vitamin-D-receptor genotype and bone mineral density. Evidence conflicts on link","volume":"311","author":"Peacock","year":"1995","journal-title":"BMJ"},{"issue":"4","key":"B49","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.bone.2006.04.016","article-title":"Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis","volume":"39","author":"Fang","year":"2006","journal-title":"Bone"},{"issue":"1","key":"B50","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s11033-012-2086-x","article-title":"Association of vitamin D receptor BsmI gene polymorphism with risk of osteoporosis: a meta-analysis of 41 studies","volume":"40","author":"Qin","year":"2013","journal-title":"Mol Biol Rep"},{"issue":"3","key":"B51","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.4238\/2014.September.26.17","article-title":"Association of vitamin D receptor BsmI gene polymorphism with risk of low bone mineral density in post-menopausal women: a meta-analysis","volume":"13","author":"Ma","year":"2014","journal-title":"Genet Mol Res"},{"issue":"4","key":"B52","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/jbmr.5650110414","article-title":"The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins","volume":"11","author":"Arden","year":"1996","journal-title":"J Bone Miner Res"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fendo.2016.00141\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T22:11:47Z","timestamp":1498342307000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fendo.2016.00141\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,27]]},"references-count":52,"URL":"https:\/\/doi.org\/10.3389\/fendo.2016.00141","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,27]]}}}