{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T23:59:02Z","timestamp":1786751942504,"version":"build-2736575974"},"reference-count":56,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2016.00150","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T14:10:17Z","timestamp":1485180617000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":48,"title":["Autoimmune\/Inflammatory Syndrome Induced by Adjuvants and Thyroid Autoimmunity"],"prefix":"10.3389","volume":"7","author":[{"given":"Abdulla","family":"Watad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stav","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2013.10.004","article-title":"Autoimmune\/inflammatory syndrome induced by adjuvants (ASIA) 2013: unveiling the pathogenic, clinical and diagnostic aspects","volume":"47","author":"Perricone","year":"2013","journal-title":"J Autoimmun"},{"key":"B2","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1177\/0961203311429317","article-title":"Human adjuvant disease induced by foreign substances: a new model of ASIA (Shoenfeld\u2019s syndrome)","volume":"21","author":"Vera-Lastra","year":"2012","journal-title":"Lupus"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2010.10.004","article-title":"Autoimmune or auto-inflammatory syndrome induced by adjuvants (ASIA): old truths and a new syndrome?","volume":"36","author":"Meroni","year":"2011","journal-title":"J Autoimmun"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-016-8811-0","article-title":"Severe manifestations of autoimmune syndrome induced by adjuvants (Shoenfeld\u2019s syndrome)","author":"Jara","year":"2016","journal-title":"Immunol Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s10165-010-0380-9","article-title":"The sick building syndrome as a part of the autoimmune (auto-inflammatory) syndrome induced by adjuvants","volume":"21","author":"Israeli","year":"2011","journal-title":"Mod Rheumatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.jaut.2010.07.003","article-title":"\u201cASIA\u201d \u2013 autoimmune\/inflammatory syndrome induced by adjuvants","volume":"36","author":"Shoenfeld","year":"2011","journal-title":"J Autoimmun"},{"key":"B7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s12016-010-8212-4","article-title":"Macrophagic myofaciitis a vaccine (alum) autoimmune-related disease","volume":"41","author":"Israeli","year":"2011","journal-title":"Clin Rev Allergy Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12026-016-8817-7","article-title":"HLA-DRB1 the notorious gene in the mosaic of autoimmunity","author":"Arango","year":"2016","journal-title":"Immunol Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1177\/0961203311429316","article-title":"The spectrum of ASIA: \u201cautoimmune (auto-inflammatory) Syndrome induced by adjuvants\u201d","volume":"21","author":"Agmon-Levin","year":"2012","journal-title":"Lupus"},{"key":"B10","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1586\/eci.13.2","article-title":"Autoimmune\/inflammatory syndrome induced by adjuvants (Shoenfeld\u2019s syndrome): clinical and immunological spectrum","volume":"9","author":"Vera-Lastra","year":"2013","journal-title":"Expert Rev Clin Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"S0264-410X(16)00016-5","DOI":"10.1016\/j.vaccine.2015.12.067","article-title":"Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil","volume":"pii","author":"Inbar","year":"2016","journal-title":"Vaccine"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-016-8821-y","article-title":"Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature","author":"Colaris","year":"2016","journal-title":"Immunol Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1097\/00006534-200202000-00049","article-title":"The silicone gel-filled breast implant controversy: an update","volume":"109","author":"Muzaffar","year":"2002","journal-title":"Plast Reconstr Surg"},{"key":"B14","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1006\/jaut.1995.0020","article-title":"Multiple autoantibodies in patients with silicone breast implants","volume":"8","author":"Bar-Meir","year":"1995","journal-title":"J Autoimmun"},{"key":"B15","first-page":"534","article-title":"Women with silicone breast implants and unexplained systemic symptoms: a descriptive cohort study","volume":"71","author":"Maijers","year":"2013","journal-title":"Neth J Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.autrev.2016.02.017","article-title":"Type 1 diabetes associated autoimmunity","volume":"15","author":"Kahaly","year":"2016","journal-title":"Autoimmun Rev"},{"key":"B17","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/0092-8674(87)90507-1","article-title":"Molecular mimicry and autoimmune disease","volume":"50","author":"Oldstone","year":"1987","journal-title":"Cell"},{"key":"B18","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1210\/er.2002-0020","article-title":"Current perspective on the pathogenesis of Graves\u2019 disease and ophthalmopathy","volume":"24","author":"Prabhakar","year":"2003","journal-title":"Endocr Rev"},{"key":"B19","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","article-title":"Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)","volume":"87","author":"Hollowell","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1056\/NEJM199411243312107","article-title":"The pathogenesis of insulin-dependent diabetes mellitus","volume":"331","author":"Atkinson","year":"1994","journal-title":"N Engl J Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/aji.12151","article-title":"Human papilloma virus vaccine and primary ovarian failure: another facet of the autoimmune\/inflammatory syndrome induced by adjuvants","volume":"70","author":"Colafrancesco","year":"2013","journal-title":"Am J Reprod Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1136\/bcr-2012-006879","article-title":"Premature ovarian failure 3 years after menarche in a 16-year-old girl following human papillomavirus vaccination","volume":"2012","author":"Little","year":"2012","journal-title":"BMJ Case Rep"},{"key":"B23","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1097\/GCO.0000000000000183","article-title":"A link between human papilloma virus vaccination and primary ovarian insufficiency: current analysis","volume":"27","author":"Gruber","year":"2015","journal-title":"Curr Opin Obstet Gynecol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1097\/GCO.0000000000000240","article-title":"Human papillomavirus vaccination and primary ovarian insufficiency: an association based on ideology rather than evidence","volume":"28","author":"Hawkes","year":"2016","journal-title":"Curr Opin Obstet Gynecol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2324709614556129","DOI":"10.1177\/2324709614556129","article-title":"Adolescent premature ovarian insufficiency following human papillomavirus vaccination: a case series seen in general practice","volume":"2","author":"Little","year":"2014","journal-title":"J Investig Med High Impact Case Rep"},{"key":"B26","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1056\/NEJMcp0808697","article-title":"Clinical practice. Primary ovarian insufficiency","volume":"360","author":"Nelson","year":"2009","journal-title":"N Engl J Med"},{"key":"B27","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jri.2005.02.003","article-title":"Circulating auto-antibodies against the zona pellucida and thyroid microsomal antigen in women with premature ovarian failure","volume":"66","author":"Kelkar","year":"2005","journal-title":"J Reprod Immunol"},{"key":"B28","first-page":"254","article-title":"Antiovarian antibody in premature ovarian failure","volume":"53","author":"Chattopadhyay","year":"1999","journal-title":"Indian J Med Sci"},{"key":"B29","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.rbmo.2011.06.013","article-title":"Identification and validation of candidate biomarkers involved in human ovarian autoimmunity","volume":"23","author":"Mande","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"B30","doi-asserted-by":"publisher","first-page":"A471","DOI":"10.1016\/j.autrev.2011.11.010","article-title":"Ovarian failure and polycystic ovary syndrome","volume":"11","author":"Petrikova","year":"2012","journal-title":"Autoimmun Rev"},{"key":"B31","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1210\/er.18.1.107","article-title":"Premature ovarian failure and ovarian autoimmunity","volume":"18","author":"Hoek","year":"1997","journal-title":"Endocr Rev"},{"key":"B32","doi-asserted-by":"publisher","first-page":"3690","DOI":"10.1016\/j.vaccine.2009.04.004","article-title":"Immune thrombocytopenic purpura following human papillomavirus vaccination","volume":"27","author":"Pugnet","year":"2009","journal-title":"Vaccine"},{"key":"B33","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.vaccine.2010.09.020","article-title":"Guillain-Barr\u00e9 syndrome after Gardasil vaccination: data from Vaccine Adverse Event Reporting System 2006-2009","volume":"29","author":"Souayah","year":"2011","journal-title":"Vaccine"},{"key":"B34","first-page":"472","article-title":"[Demyelinating disease and vaccination of the human papillomavirus]","volume":"52","author":"Alvarez-Soria","year":"2011","journal-title":"Rev Neurol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1093\/rheumatology\/kes168","article-title":"Vasculitis following HPV immunization","volume":"52","author":"Gomes","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s10067-013-2266-7","article-title":"Human papillomavirus vaccine and systemic lupus erythematosus","volume":"32","author":"Gatto","year":"2013","journal-title":"Clin Rheumatol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1177\/1352458508096868","article-title":"CNS demyelination and quadrivalent HPV vaccination","volume":"15","author":"Sutton","year":"2009","journal-title":"Mult Scler"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1177\/0961203309345724","article-title":"Adjuvants and autoimmunity","volume":"18","author":"Israeli","year":"2009","journal-title":"Lupus"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1016\/j.jinorgbio.2009.08.005","article-title":"Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction","volume":"103","author":"Couette","year":"2009","journal-title":"J Inorg Biochem"},{"key":"B40","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1212\/01.wnl.0000335762.42177.07","article-title":"Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood","volume":"72","author":"Mikaeloff","year":"2009","journal-title":"Neurology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1111\/j.1365-2990.2012.01293.x","article-title":"Macrophagic myofasciitis: a report of second case from UK","volume":"38","author":"Shivane","year":"2012","journal-title":"Neuropathol Appl Neurobiol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0165-5728(82)90016-9","article-title":"Late onset of Guillain-Barr\u00e9 syndrome","volume":"3","author":"Poser","year":"1982","journal-title":"J Neuroimmunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1177\/0961203311429557","article-title":"Macrophagic myofasciitis: characterization and pathophysiology","volume":"21","author":"Gherardi","year":"2012","journal-title":"Lupus"},{"key":"B44","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1177\/0961203311429318","article-title":"Autoimmunity following hepatitis B vaccine as part of the spectrum of \u201cautoimmune (auto-inflammatory) syndrome induced by adjuvants\u201d (ASIA): analysis of 93 cases","volume":"21","author":"Zafrir","year":"2012","journal-title":"Lupus"},{"key":"B45","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/joim.12155","article-title":"Autoimmune disorders and quadrivalent human papillomavirus vaccination of young female subjects","volume":"275","author":"Grimaldi-Bensouda","year":"2014","journal-title":"J Intern Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1196\/annals.1288.068","article-title":"Vaccinations may induce diabetes-related autoantibodies in one-year-old children","volume":"1005","author":"Wahlberg","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.2337\/diab.46.11.1701","article-title":"Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers","volume":"46","author":"Bingley","year":"1997","journal-title":"Diabetes"},{"key":"B48","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0168-8227(00)00199-6","article-title":"Islet autoantibodies in the prediction of diabetes in school children","volume":"51","author":"Samuelsson","year":"2001","journal-title":"Diabetes Res Clin Pract"},{"key":"B49","first-page":"48","article-title":"Subacute thyroiditis and dyserythropoesis after influenza vaccination suggesting immune dysregulation","volume":"103","author":"Hern\u00e1n Martinez","year":"2011","journal-title":"Bol Asoc Med P R"},{"key":"B50","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S1607-551X(09)70315-8","article-title":"Subacute thyroiditis following influenza vaccine (Vaxigrip) in a young female","volume":"22","author":"Hsiao","year":"2006","journal-title":"Kaohsiung J Med Sci"},{"key":"B51","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1007\/BF03346633","article-title":"Subacute thyroiditis following the H1N1 vaccine","volume":"33","author":"Girgis","year":"2010","journal-title":"J Endocrinol Invest"},{"key":"B52","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1385\/EP:13:3:239","article-title":"Is granulomatous thyroiditis a complication of breast implants?","volume":"13","author":"Prebtani","year":"2002","journal-title":"Endocr Pathol"},{"key":"B53","first-page":"198","article-title":"[Hashimoto\u2019s thyroiditis and silicone breast implants: 2 cases]","volume":"22","author":"Vayssairat","year":"1997","journal-title":"J Mal Vasc"},{"key":"B54","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1163\/156856295X00643","article-title":"The effect of silicone-gel on the immune response","volume":"7","author":"Naim","year":"1995","journal-title":"J Biomater Sci Polym Ed"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/21645515.2016.1199308","article-title":"Risk of new onset autoimmune disease in 9- to 25-year-old women exposed to human papillomavirus-16\/18 AS04-adjuvanted vaccine in the United Kingdom","volume":"18","author":"Willame","year":"2016","journal-title":"Hum Vaccin Immunother"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1006\/bbrc.1994.1332","article-title":"Induction of thyrotropin receptor (TSH-R) autoantibodies and thyroiditis in mice immunised with the recombinant TSH-R","volume":"199","author":"Costagliola","year":"1994","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fendo.2016.00150\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T14:10:17Z","timestamp":1485180617000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fendo.2016.00150\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,24]]},"references-count":56,"URL":"https:\/\/doi.org\/10.3389\/fendo.2016.00150","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,24]]}}}