{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:28:24Z","timestamp":1782883704013,"version":"3.54.5"},"reference-count":155,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001516","name":"National Heart Foundation of New Zealand","doi-asserted-by":"publisher","award":["1600, 1698"],"award-info":[{"award-number":["1600, 1698"]}],"id":[{"id":"10.13039\/501100001516","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001509","name":"Royal Society of New Zealand","doi-asserted-by":"publisher","award":["CSG-U001601"],"award-info":[{"award-number":["CSG-U001601"]}],"id":[{"id":"10.13039\/501100001509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2017.00350","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T04:57:39Z","timestamp":1513141059000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Ghrelin, MicroRNAs, and Critical Limb Ischemia: Hungering for a Novel Treatment Option"],"prefix":"10.3389","volume":"8","author":[{"given":"Joshua P. H.","family":"Neale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Katare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl O.","family":"Schwenke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,12,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nrcardio.2013.70","article-title":"Therapeutic angiogenesis for critical limb ischaemia","volume":"7","author":"Annex","year":"2013","journal-title":"Nat Rev Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/S0140-6736(13)61249-0","article-title":"Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis","volume":"382","author":"Fowkes","year":"2013","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/hr.2015.134","article-title":"Current therapies and investigational drugs for peripheral arterial disease","volume":"39","author":"Suzuki","year":"2016","journal-title":"Hypertens Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/s12877-016-0389-9","article-title":"Prevalent peripheral arterial disease and inflammatory burden","volume":"16","author":"Cauley","year":"2016","journal-title":"BMC Geriatr"},{"key":"B5","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/joim.12102","article-title":"Medical management of critical limb ischaemia: where do we stand today?","volume":"4","author":"Lambert","year":"2013","journal-title":"J Intern Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1161\/CIRCRESAHA.116.303849","article-title":"Epidemiology of peripheral artery disease","volume":"9","author":"Criqui","year":"2015","journal-title":"Circ Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/1753-0407.12328","article-title":"International diabetes federation world diabetes congress 2015","volume":"3","author":"Gao","year":"2016","journal-title":"J Diabetes"},{"key":"B8","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/nature06516","article-title":"The coming acceleration of global population ageing","volume":"7179","author":"Lutz","year":"2008","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.jvs.2014.03.290","article-title":"Epidemiology of peripheral arterial disease and critical limb ischemia in an insured national population","volume":"3","author":"Nehler","year":"2014","journal-title":"J Vasc Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.jvs.2006.12.037","article-title":"Inter-Society Consensus for the management of peripheral arterial disease (TASC II)","volume":"1","author":"Norgren","year":"2007","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/0741-5214(92)90417-7","article-title":"Assessment of quality of life of patients with severe ischemia as a result of infrainguinal arterial occlusive disease","volume":"1","author":"Albers","year":"1992","journal-title":"J Vasc Surg"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e000697","DOI":"10.1161\/jaha.113.000697","article-title":"Adherence to guideline-recommended therapy is associated with decreased major adverse cardiovascular events and major adverse limb events among patients with peripheral arterial disease","volume":"3","author":"Armstrong","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"B13","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1177\/1358863X08091485","article-title":"Critical limb ischemia: medical and surgical management","volume":"3","author":"Slovut","year":"2008","journal-title":"Vasc Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.jvs.2012.02.069","article-title":"Cost-effectiveness in the contemporary management of critical limb ischemia with tissue loss","volume":"4","author":"Barshes","year":"2012","journal-title":"J Vasc Surg"},{"key":"B15","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jvs.2006.03.026","article-title":"Natural history of limbs with arterial insufficiency and chronic ulceration treated without revascularization","volume":"1","author":"Marston","year":"2006","journal-title":"J Vasc Surg"},{"key":"B16","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1093\/eurheartj\/ehv006","article-title":"Peripheral arterial disease and critical limb ischaemia: still poor outcomes and lack of guideline adherence","volume":"15","author":"Reinecke","year":"2015","journal-title":"Eur Heart J"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1093\/eurheartj\/ehw547","article-title":"Angiogenic gene therapy in cardiovascular diseases: dream or vision?","volume":"18","author":"Yl\u00e4-Herttuala","year":"2017","journal-title":"Eur Heart J"},{"key":"B18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12967-017-1153-4","article-title":"Therapeutic strategies for cell-based neovascularization in critical limb ischemia","volume":"1","author":"Samura","year":"2017","journal-title":"J Transl Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.ejvs.2015.08.018","article-title":"Bone marrow derived cell therapy in critical limb ischemia: a meta-analysis of randomized placebo controlled trials","volume":"6","author":"Weem","year":"2015","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B20","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1024\/0301-1526\/a000298","article-title":"Gene therapy for therapeutic angiogenesis in peripheral arterial disease \u2013 a systematic review and meta-analysis of randomized, controlled trials","volume":"5","author":"Hammer","year":"2013","journal-title":"Vasa"},{"key":"B21","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"6762","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1210\/en.2015-1799","article-title":"Ghrelin promotes functional angiogenesis in a mouse model of critical limb ischemia through activation of proangiogenic microRNAs","volume":"2","author":"Katare","year":"2015","journal-title":"Endocrinology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4172\/1747-0862.1000108","article-title":"Unacylated ghrelin (UnAG): a new treatment option for peripheral arterial disease?","volume":"8","author":"Togliatto","year":"2014","journal-title":"J Mol Genet Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.2337\/db14-1825","article-title":"Unacylated ghrelin: a gut-limb connection","volume":"4","author":"Chakrabarti","year":"2015","journal-title":"Diabetes"},{"key":"B25","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.cardiores.2005.09.001","article-title":"Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man","volume":"1","author":"Kleinz","year":"2006","journal-title":"Cardiovasc Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.1210\/jcem.87.6.8739","article-title":"The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans","volume":"6","author":"Gnanapavan","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"B27","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14797\/mdcj-8-4-10","article-title":"Critical limb ischemia: epidemiology","volume":"4","author":"Davies","year":"2012","journal-title":"Methodist DeBakey Cardiovasc J"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e463","DOI":"10.1161\/CIRCULATIONAHA.106.174526","article-title":"ACC\/AHA 2005 practice guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic)","volume":"11","author":"Hirsch","year":"2006","journal-title":"Circulation"},{"key":"B29","doi-asserted-by":"publisher","first-page":"H1044","DOI":"10.1152\/ajpheart.00773.2004","article-title":"Marriage of resistance and conduit arteries breeds critical limb ischemia","volume":"3","author":"Coats","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1001\/jamasurg.2016.2018","article-title":"The current state of critical limb ischemia","volume":"11","author":"Farber","year":"2016","journal-title":"JAMA Surg"},{"key":"B31","first-page":"1182","article-title":"Tumor angiogenesis: therapeutic implications","volume":"21","author":"Folkman","year":"1971","journal-title":"N Engl J Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/386671a0","article-title":"Mechanisms of angiogenesis","volume":"6626","author":"Risau","year":"1997","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"7347","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3937","DOI":"10.1161\/CIRCULATIONAHA.105.543124","article-title":"Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis","volume":"25","author":"Rissanen","year":"2005","journal-title":"Circulation"},{"key":"B35","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s10456-009-9129-5","article-title":"Intussusceptive angiogenesis and its role in vascular morphogenesis, patterning, and remodeling","volume":"2","author":"Makanya","year":"2009","journal-title":"Angiogenesis"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1161\/01.CIR.0000159345.00591.8F","article-title":"Angiogenesis: where do we stand now?","volume":"12","author":"Simons","year":"2005","journal-title":"Circulation"},{"key":"B37","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00395-008-0760-x","article-title":"Collateral circulation. Past and present","volume":"1","author":"Schaper","year":"2009","journal-title":"Basic Res Cardiol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/labinvest.3780252","article-title":"In vitro models of vasculogenesis and angiogenesis","volume":"4","author":"Vailh\u00e9","year":"2001","journal-title":"Lab Invest"},{"key":"B39","doi-asserted-by":"publisher","first-page":"15006","DOI":"10.1038\/natrevmats.2015.6","article-title":"Design principles for therapeutic angiogenic materials","volume":"1","author":"Briquez","year":"2016","journal-title":"Nat Rev Mater"},{"key":"B40","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1177\/1074248415574336","article-title":"pCMV-vegf165 intramuscular gene transfer is an effective method of treatment for patients with chronic lower limb ischemia","volume":"5","author":"Deev","year":"2015","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"B41","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1242\/dmm.010413","article-title":"Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success","volume":"2","author":"Dragneva","year":"2013","journal-title":"Dis Model Mech"},{"key":"B42","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/nature04478","article-title":"Angiogenesis in life, disease and medicine","volume":"7070","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e002938","DOI":"10.1161\/JAHA.115.002938","article-title":"Critical limb ischemia: current trends and future directions","volume":"2","author":"Teraa","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"B44","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1161\/CIRCULATIONAHA.114.012913","article-title":"Effect of repetitive intra-arterial infusion of bone marrow mononuclear cells in patients with no-option limb ischemia: the randomized, double-blind, placebo-controlled JUVENTAS trial","volume":"10","author":"Teraa","year":"2015","journal-title":"Circulation"},{"key":"B45","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/1479-5876-11-143","article-title":"A double blind randomized placebo controlled phase I\/II study assessing the safety and efficacy of allogeneic bone marrow derived mesenchymal stem cell in critical limb ischemia","volume":"1","author":"Gupta","year":"2013","journal-title":"J Transl Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/j.jcyt.2013.05.017","article-title":"Peripheral blood-derived autologous stem cell therapy for the treatment of patients with late-stage peripheral artery disease-results of the short- and long-term follow-up","volume":"10","author":"Szabo","year":"2013","journal-title":"Cytotherapy"},{"key":"B47","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.avsg.2009.10.012","article-title":"Safety and efficacy of therapeutic angiogenesis as a novel treatment in patients with critical limb ischemia","volume":"2","author":"Lara-Hernandez","year":"2010","journal-title":"Ann Vasc Surg"},{"key":"B48","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.atherosclerosis.2012.07.031","article-title":"Long-term clinical outcome after intramuscular transplantation of granulocyte colony stimulating factor-mobilized CD34 positive cells in patients with critical limb ischemia","volume":"2","author":"Kinoshita","year":"2012","journal-title":"Atherosclerosis"},{"key":"B49","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1089\/hum.2006.17.683","article-title":"Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double-blind randomized trial","volume":"6","author":"Kusumanto","year":"2006","journal-title":"Hum Gene Ther"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/S0140-6736(11)60394-2","article-title":"Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia","volume":"9781","author":"Belch","year":"2011","journal-title":"Lancet"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1038\/gt.2010.51","article-title":"Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia","volume":"9","author":"Shigematsu","year":"2010","journal-title":"Gene Ther"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1161\/CIRCULATIONAHA.106.607994","article-title":"Use of a constitutively active hypoxia-inducible factor-1\u03b1 transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience","volume":"10","author":"Rajagopalan","year":"2007","journal-title":"Circulation"},{"key":"B53","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.cell.2008.01.017","article-title":"Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone","volume":"3","author":"Yang","year":"2008","journal-title":"Cell"},{"key":"B54","doi-asserted-by":"publisher","first-page":"253","DOI":"10.11909\/j.issn.1671-5411.2014.03.007","article-title":"The cardiovascular action of hexarelin","volume":"3","author":"Mao","year":"2014","journal-title":"J Geriatr Cardiol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1097\/CRD.0000000000000113","article-title":"Ghrelin and the cardiovascular system","volume":"6","author":"Lilleness","year":"2016","journal-title":"Cardiol Rev"},{"key":"B56","doi-asserted-by":"publisher","first-page":"62","DOI":"10.2174\/157340310790231662","article-title":"Ghrelin and cardiovascular diseases","volume":"1","author":"Zhang","year":"2010","journal-title":"Curr Cardiol Rev"},{"key":"B57","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2174\/1381612822666151119144458","article-title":"Human ghrelin: a gastric hormone with cardiovascular properties ghrelin","volume":"1","author":"Virdis","year":"2016","journal-title":"Curr Pharm Des"},{"key":"B58","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jjcc.2011.11.002","article-title":"Ghrelin and cardiovascular diseases","volume":"1","author":"Kishimoto","year":"2012","journal-title":"J Cardiol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"798","DOI":"10.3390\/ijms18040798","article-title":"Therapeutic potential of targeting the ghrelin pathway","volume":"4","author":"Colld\u00e9n","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B60","doi-asserted-by":"publisher","first-page":"59929","DOI":"10.18632\/oncotarget.18349","article-title":"Preclinical evidence of ghrelin as a therapeutic target in epilepsy","volume":"35","author":"Ge","year":"2017","journal-title":"Oncotarget"},{"key":"B61","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.peptides.2011.11.001","article-title":"Ghrelin stimulates angiogenesis via GHSR1a-dependent MEK\/ERK and PI3K\/Akt signal pathways in rat cardiac microvascular endothelial cells","volume":"1","author":"Wang","year":"2012","journal-title":"Peptides"},{"key":"B62","first-page":"29","article-title":"Reduced ghrelin in endothelial cells plays important mechanistic role in aging-related impairment of angiogenesis","volume":"2","author":"Ahluwalia","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.bbrc.2006.11.144","article-title":"Ghrelin stimulates angiogenesis in human microvascular endothelial cells: implications beyond GH release","volume":"2","author":"Li","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"B64","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.regpep.2012.08.013","article-title":"Myocardial angiogenesis after chronic ghrelin treatment in a rat myocardial infarction model","author":"Yuan","year":"2012","journal-title":"Regul Pept"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1016\/j.peptides.2004.08.011","article-title":"Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo","volume":"12","author":"Conconi","year":"2004","journal-title":"Peptides"},{"key":"B66","doi-asserted-by":"publisher","first-page":"35","DOI":"10.4149\/BLL_2015_007","article-title":"Systemic administration of ghrelin did not restore angiogenesis in hindlimb ischemia in control and diet-induced obese mice","volume":"1","author":"Tahergorabi","year":"2015","journal-title":"Bratislavsk Lek Listy"},{"key":"B67","doi-asserted-by":"publisher","first-page":"849","DOI":"10.3892\/ijmm.14.5.849","article-title":"Ghrelin inhibits in vitro angiogenic activity of rat brain microvascular endothelial cells","volume":"5","author":"Baiguera","year":"2004","journal-title":"Int J Mol Med"},{"key":"B68","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0092-8674(02)01083-8","article-title":"PKB binding proteins: getting in on the Akt","volume":"3","author":"Brazil","year":"2002","journal-title":"Cell"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e000376","DOI":"10.1161\/JAHA.113.000376","article-title":"Unacylated ghrelin promotes skeletal muscle regeneration following hindlimb ischemia via SOD-2-mediated miR-221\/222 expression","volume":"6","author":"Togliatto","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"B70","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.1182\/blood-2006-01-012369","article-title":"MicroRNAs modulate the angiogenic properties of HUVECs","volume":"9","author":"Poliseno","year":"2006","journal-title":"Blood"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.2337\/db14-0991","article-title":"Unacylated ghrelin induces oxidative stress resistance in a glucose intolerance and peripheral artery disease mouse model by restoring endothelial cell miR-126 expression","volume":"4","author":"Togliatto","year":"2015","journal-title":"Diabetes"},{"key":"B72","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/j.1532-5415.2007.01092.x","article-title":"Lower extremity ischemia, calf skeletal muscle characteristics, and functional impairment in peripheral arterial disease","volume":"3","author":"McDermott","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"B73","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s12603-015-0550-8","article-title":"Relationship between plasma ghrelin levels and sarcopenia in elderly subjects: a cross-sectional study","volume":"6","author":"Serra-Prat","year":"2015","journal-title":"J Nutr Health Aging"},{"key":"B74","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1172\/JCI39920","article-title":"Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice","volume":"2","author":"Porporato","year":"2013","journal-title":"J Clin Invest"},{"key":"B75","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1177\/14746514040040040401","article-title":"Intermittent claudication in the patient with diabetes","volume":"4","author":"Jude","year":"2004","journal-title":"Br J Diabetes Vasc Dis"},{"key":"B76","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ejphar.2013.01.035","article-title":"Ghrelin prevents the development of experimental diabetic neuropathy in rodents","author":"Tsuchimochi","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.bbrc.2009.08.171","article-title":"Ghrelin reverses experimental diabetic neuropathy in mice","volume":"3","author":"Kyoraku","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"B78","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1507\/endocrj.64.S53","article-title":"Clinical application of ghrelin for diabetic peripheral neuropathy","volume":"64","author":"Ueno","year":"2017","journal-title":"Endocr J"},{"key":"B79","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1177\/1538574408315995","article-title":"The myopathy of peripheral arterial occlusive disease: part 2. Oxidative stress, neuropathy, and shift in muscle fiber type","volume":"2","author":"Pipinos","year":"2009","journal-title":"Vasc Endovascular Surg"},{"key":"B80","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1677\/JOE-08-0160","article-title":"Phosphatidylinositol-3-kinase\/Akt\/glycogen synthase kinase-3\u03b2 and ERK1\/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells","volume":"3","author":"Chung","year":"2008","journal-title":"J Endocrinol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1161\/01.CIR.0000127956.43874.F2","article-title":"Ghrelin inhibits proinflammatory responses and nuclear factor-kappa B activation in human endothelial cells","volume":"18","author":"Li","year":"2004","journal-title":"Circulation"},{"key":"B82","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.bbrc.2007.08.021","article-title":"Effect of ghrelin on human endothelial cells apoptosis induced by high glucose","volume":"3","author":"Zhao","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"B83","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/cbf.1736","article-title":"Ghrelin inhibits AGEs-induced apoptosis in human endothelial cells involving ERK1\/2 and PI3K\/Akt pathways","volume":"2","author":"Xiang","year":"2011","journal-title":"Cell Biochem Funct"},{"key":"B84","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.amjhyper.2006.01.022","article-title":"Ghrelin inhibits vascular superoxide production in spontaneously hypertensive rats","volume":"7","author":"Kawczynska-Drozdz","year":"2006","journal-title":"Am J Hypertens"},{"key":"B85","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.metabol.2013.12.011","article-title":"Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway","volume":"4","author":"Shimada","year":"2014","journal-title":"Metabolism"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.2337\/db09-0858","article-title":"Unacylated ghrelin rescues endothelial progenitor cell function in individuals with type 2 diabetes","volume":"4","author":"Togliatto","year":"2010","journal-title":"Diabetes"},{"key":"B87","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1021\/jm201223m","article-title":"Des-acyl ghrelin fragments and analogues promote survival of pancreatic B-cells and human pancreatic islets and prevent diabetes in streptozotocin-treated rats","volume":"6","author":"Granata","year":"2012","journal-title":"J Med Chem"},{"key":"B88","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.trsl.2010.01.004","article-title":"Serum levels of apelin and ghrelin in patients with acute coronary syndromes and established coronary artery disease-KOZANI STUDY","volume":"5","author":"Kadoglou","year":"2010","journal-title":"Transl Res"},{"key":"B89","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/ajh\/hpt232","article-title":"Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients","volume":"5","author":"Yano","year":"2014","journal-title":"Am J Hypertens"},{"key":"B90","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.peptides.2014.09.012","article-title":"High plasma ghrelin protects from coronary heart disease and Leu72Leu polymorphism of ghrelin gene from cancer in healthy adults during the 19 years follow-up study","volume":"61","author":"Laurila","year":"2014","journal-title":"Peptides"},{"key":"B91","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.regpep.2013.08.003","article-title":"Regulatory peptides characterization of pericardial and plasma ghrelin levels in patients with ischemic and non-ischemic heart disease","volume":"186","author":"Sax","year":"2013","journal-title":"Regul Pept"},{"key":"B92","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.peptides.2014.04.008","article-title":"Serum levels of novel adipokines in patients with acute ischemic stroke: potential contribution to diagnosis and prognosis","volume":"57","author":"Kadoglou","year":"2014","journal-title":"Peptides"},{"key":"B93","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/fcp.12251","article-title":"Ghrelin ameliorates atherosclerosis by inhibiting endoplasmic reticulum stress","volume":"2","author":"Ai","year":"2016","journal-title":"Fundam Clin Pharmacol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.peptides.2017.01.013","article-title":"Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model","volume":"90","author":"Wang","year":"2017","journal-title":"Peptides"},{"key":"B95","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1097\/MOL.0000000000000183","article-title":"Ghrelin and atherosclerosis","volume":"4","author":"Ukkola","year":"2015","journal-title":"Curr Opin Lipidol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.amjcard.2007.08.032","article-title":"Prediction of intermittent claudication, ischemic stroke, and other cardiovascular disease by detection of abdominal aortic calcific deposits by plain lumbar radiographs","volume":"3","author":"Levitzky","year":"2008","journal-title":"Am J Cardiol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.biopha.2017.05.031","article-title":"Ghrelin attenuates vascular calcification in diabetic patients with amputation","volume":"91","author":"Xu","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"B98","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.regpep.2005.02.015","article-title":"Ghrelin blunted vascular calcification in vivo and in vitro in rats","volume":"129","author":"Li","year":"2005","journal-title":"Regul Pept"},{"key":"B99","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.lfs.2016.11.025","article-title":"Ghrelin improves vascular autophagy in rats with vascular calcification","volume":"179","author":"Xu","year":"2016","journal-title":"Life Sci"},{"key":"B100","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"2","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"B101","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"7006","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"B102","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNA target recognition and regulatory functions","volume":"2","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"B103","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"5","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"B104","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans","volume":"5","author":"Wightman","year":"1993","journal-title":"Cell"},{"key":"B105","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1475-2840-13-44","article-title":"Cardiovascular microRNAs: as modulators and diagnostic biomarkers of diabetic heart disease","volume":"1","author":"Rawal","year":"2014","journal-title":"Cardiovasc Diabetol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.vph.2011.06.006","article-title":"MicroRNA regulation in angiogenesis","volume":"4","author":"Caporali","year":"2011","journal-title":"Vascul Pharmacol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"6","author":"Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"B108","doi-asserted-by":"publisher","first-page":"e11803","DOI":"10.1371\/journal.pone.0011803","article-title":"Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs","volume":"7","author":"Collino","year":"2010","journal-title":"PLoS One"},{"key":"B109","doi-asserted-by":"publisher","first-page":"BSR20160502","DOI":"10.1042\/BSR20160502","article-title":"Circulating mircoRNA-21 as a predictor for vascular restenosis after interventional therapy in patients with lower extremity arterial occlusive disease","volume":"2","author":"Zhang","year":"2017","journal-title":"Biosci Rep"},{"key":"B110","doi-asserted-by":"publisher","first-page":"42916","DOI":"10.1038\/srep42916","article-title":"Circulating miR-155, miR-145 and let-7c as diagnostic biomarkers of the coronary artery disease","volume":"7","author":"Faccini","year":"2017","journal-title":"Sci Rep"},{"key":"B111","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1024\/0301-1526\/a000345","article-title":"miRNAs in peripheral artery disease \u2013 something gripping this way comes","volume":"3","author":"Kloos","year":"2014","journal-title":"Vasa"},{"key":"B112","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1161\/CIRCRESAHA.111.247452","article-title":"Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?","volume":"3","author":"Creemers","year":"2012","journal-title":"Circ Res"},{"key":"B113","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1161\/CIRCGENETICS.113.000053","article-title":"Differential microRNA expression profiles in peripheral arterial disease","volume":"5","author":"Stather","year":"2013","journal-title":"Circulation"},{"key":"B114","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1177\/0003319716638242","article-title":"Circulating miR-130a, miR-27b, and miR-210 in patients with peripheral artery disease and their potential relationship with oxidative stress","volume":"10","author":"Signorelli","year":"2016","journal-title":"Angiology"},{"key":"B115","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1161\/CIRCRESAHA.111.300418","article-title":"MicroRNA-15a and MicroRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia","volume":"2","author":"Spinetti","year":"2013","journal-title":"Circ Res"},{"key":"B116","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.ejvs.2016.07.061","article-title":"Upregulation of 14q32 microRNAs in human subcutaneous adipose tissue of patients with critical limb ischemia at risk of major amputation","volume":"3","author":"Welten","year":"2016","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1073\/pnas.0707493105","article-title":"MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1","volume":"5","author":"Harris","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B118","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.devcel.2008.07.008","article-title":"miR-126 regulates angiogenic signaling and vascular integrity","volume":"2","author":"Fish","year":"2008","journal-title":"Dev Cell"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1111\/j.1582-4934.2008.00613.x","article-title":"Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis","author":"Van Solingen","year":"2009","journal-title":"J Cell Mol Med"},{"key":"B120","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.devcel.2008.07.002","article-title":"The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis","volume":"2","author":"Wang","year":"2008","journal-title":"Dev Cell"},{"key":"B121","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/nm.2186","article-title":"MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis","volume":"8","author":"Anand","year":"2010","journal-title":"Nat Med"},{"key":"B122","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1038\/ncomms3829","article-title":"miR-1 and miR-206 target different genes to have opposing roles during angiogenesis in zebrafish embryos","volume":"4","author":"Lin","year":"2013","journal-title":"Nat Commun"},{"key":"B123","doi-asserted-by":"publisher","first-page":"4356","DOI":"10.1242\/dev.083774","article-title":"miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish","volume":"23","author":"Stahlhut","year":"2012","journal-title":"Development"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1126\/science.1174381","article-title":"MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice","volume":"5935","author":"Bonauer","year":"2009","journal-title":"Science"},{"key":"B125","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1101\/gad.435107","article-title":"SIRT1 controls endothelial angiogenic functions during vascular growth","volume":"20","author":"Potente","year":"2007","journal-title":"Genes Dev"},{"key":"B126","doi-asserted-by":"publisher","first-page":"e7607","DOI":"10.1371\/journal.pone.0007607","article-title":"MicroRNA-221 and microrna-222 modulate differentiation and maturation of skeletal muscle cells","volume":"4","author":"Cardinalli","year":"2009","journal-title":"PLoS One"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1007\/s00125-011-2125-5","article-title":"MIR221\/MIR222-driven post-transcriptional regulation of P27KIP1 and P57KIP2 is crucial for high-glucose- and AGE-mediated vascular cell damage","volume":"7","author":"Togliatto","year":"2011","journal-title":"Diabetologia"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1038\/s41598-017-01320-3","article-title":"MicroRNA-30a regulation of epithelial-mesenchymal transition in diabetic cataracts through targeting SNAI1","volume":"1","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"B129","first-page":"15527","article-title":"MiR-30a regulates the atrial fibrillation-induced myocardial fibrosis by targeting snail 1","volume":"8","author":"Yuan","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.ajpath.2013.05.019","article-title":"miR-30a negatively regulates TGF-\u03b21-induced epithelial-mesenchymal transition and peritoneal fibrosis by targeting snai1","volume":"3","author":"Zhou","year":"2013","journal-title":"Am J Pathol"},{"key":"B131","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/nature07511","article-title":"MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts","volume":"7224","author":"Thum","year":"2008","journal-title":"Nature"},{"key":"B132","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/cvr\/cvp015","article-title":"MicroRNA expression in response to murine myocardial infarction: MiR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue","volume":"1","author":"Roy","year":"2009","journal-title":"Cardiovasc Res"},{"key":"B133","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1093\/cvr\/cvw039","article-title":"The multifactorial nature of microRNAs in vascular remodelling","volume":"1","author":"Welten","year":"2016","journal-title":"Cardiovasc Res"},{"key":"B134","doi-asserted-by":"publisher","first-page":"3989","DOI":"10.1242\/dev.029736","article-title":"Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126","volume":"24","author":"Kuhnert","year":"2008","journal-title":"Development"},{"key":"B135","doi-asserted-by":"publisher","first-page":"3883","DOI":"10.1038\/srep03883","article-title":"Systemic delivery of miR-126 by miRNA-loaded Bubble liposomes for the treatment of hindlimb ischemia","volume":"1","author":"Endo-Takahashi","year":"2014","journal-title":"Sci Rep"},{"key":"B136","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1681\/ASN.2013060640","article-title":"Hematopoietic microRNA-126 protects against renal ischemia\/reperfusion injury by promoting vascular integrity","volume":"8","author":"Bijkerk","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"B137","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.yjmcc.2016.05.007","article-title":"The role of miR-126 in embryonic angiogenesis, adult vascular homeostasis, and vascular repair and its alterations in atherosclerotic disease","volume":"97","author":"Chistiakov","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1161\/CIRCRESAHA.111.243592","article-title":"Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction","volume":"6","author":"Zhou","year":"2011","journal-title":"Circ Res"},{"key":"B139","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1161\/CIRCRESAHA.111.251546","article-title":"Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132","volume":"8","author":"Katare","year":"2011","journal-title":"Circ Res"},{"key":"B140","doi-asserted-by":"publisher","first-page":"e46808","DOI":"10.1371\/journal.pone.0046808","article-title":"miR-206 regulates pulmonary artery smooth muscle cell proliferation and differentiation","volume":"10","author":"Jalali","year":"2012","journal-title":"PLoS One"},{"key":"B141","doi-asserted-by":"publisher","first-page":"4944","DOI":"10.1182\/blood-2010-01-264812","article-title":"Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells","volume":"23","author":"Doebele","year":"2010","journal-title":"Blood"},{"key":"B142","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/cvr\/cvu162","article-title":"Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury","volume":"4","author":"Daniel","year":"2014","journal-title":"Cardiovasc Res"},{"key":"B143","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1161\/CIRCULATIONAHA.113.001904","article-title":"Inhibition of microRNA-92a protects against ischemia\/reperfusion injury in a large-animal model","volume":"10","author":"Hinkel","year":"2013","journal-title":"Circulation"},{"key":"B144","doi-asserted-by":"publisher","first-page":"4451","DOI":"10.1242\/dev.071381","article-title":"Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis","volume":"20","author":"Stenzel","year":"2011","journal-title":"Development"},{"key":"B145","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nrd.2016.253","article-title":"From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors","volume":"4","author":"Ashkenazi","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"B146","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nature09917","article-title":"Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase","volume":"7346","author":"Guarani","year":"2011","journal-title":"Nature"},{"key":"B147","doi-asserted-by":"publisher","first-page":"40","DOI":"10.2174\/1570161114666160914175149","article-title":"The mir-221\/222 cluster is a key player in vascular biology via the fine-tuning of endothelial cell physiology","volume":"1","author":"Celic","year":"2016","journal-title":"Curr Vasc Pharmacol"},{"key":"B148","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1101\/gr.2722704","article-title":"Identification of mammalian microRNA host genes and transcription units","author":"Rodriguez","year":"2004","journal-title":"Genome Res"},{"key":"B149","doi-asserted-by":"publisher","first-page":"3679","DOI":"10.1111\/jcmm.13278","article-title":"MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1-mediated autophagy","volume":"21","author":"Chen","year":"2017","journal-title":"J Cell Mol Med"},{"key":"B150","doi-asserted-by":"publisher","first-page":"121ra18","DOI":"10.1126\/scitranslmed.3003205","article-title":"MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways","volume":"121","author":"Chau","year":"2012","journal-title":"Sci Transl Med"},{"key":"B151","doi-asserted-by":"publisher","first-page":"706","DOI":"10.4161\/rna.8.5.16154","article-title":"Regulation and function of miRNA-21 in health and disease","volume":"5","author":"Kumarswamy","year":"2011","journal-title":"RNA Biol"},{"key":"B152","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/JND-140058","article-title":"Skeletal muscle microRNAs: their diagnostic and therapeutic potentiadl in human muscle disease","volume":"1","author":"Alexander","year":"2015","journal-title":"J Neuromuscul Dis"},{"key":"B153","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.2174\/1381612820666141226095701","article-title":"MicroRNA-21: a central regulator of fibrotic diseases via various targets","volume":"17","author":"Huang","year":"2015","journal-title":"Curr Pharm Des"},{"key":"B154","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1161\/ATVBAHA.111.234286","article-title":"Transforming growth factor-\u03b2-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21","volume":"2","author":"Kumarswamy","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1210\/jc.2012-4247","article-title":"The human experience with ghrelin administration","volume":"5","author":"Garin","year":"2013","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fendo.2017.00350\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T04:57:45Z","timestamp":1513141065000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fendo.2017.00350\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,13]]},"references-count":155,"alternative-id":["10.3389\/fendo.2017.00350"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2017.00350","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,13]]},"article-number":"350"}}