{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:22:01Z","timestamp":1789078921057,"version":"build-2803163510"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2018.00027","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T23:15:54Z","timestamp":1518131754000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":52,"title":["The Natural History of Metabolic Comorbidities in Turner Syndrome from Childhood to Early Adulthood: Comparison between 45,X Monosomy and Other Karyotypes"],"prefix":"10.3389","volume":"9","author":[{"given":"Yael","family":"Lebenthal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigal","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat","family":"Sofrin-Drucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nessia","family":"Nagelberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Weintrob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Shalitin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Tenenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Phillip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liora","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/BF01213097","article-title":"Chromosome abnormalities found among 34,910 newborn children: results from a 13-year incidence study in Arhus, Denmark","volume":"87","author":"Nielsen","year":"1991","journal-title":"Hum Genet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1056\/NEJMra030360","article-title":"Turner\u2019s syndrome","volume":"351","author":"Sybert","year":"2004","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1210\/jc.2006-1374","article-title":"Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group","volume":"92","author":"Bondy","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"B4","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/cen.13394","article-title":"The Turner syndrome life course project: karyotype-phenotype analyses across the lifespan","volume":"87","author":"Cameron-Pimblett","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1089\/thy.2005.15.1061","article-title":"Prevalence of thyroid dysfunction in Turner\u2019s syndrome: a long-term follow-up study and brief literature review","volume":"15","author":"Livadas","year":"2005","journal-title":"Thyroid"},{"key":"B6","doi-asserted-by":"publisher","first-page":"5495","DOI":"10.1210\/jc.2002-020855","article-title":"Prevalence and clinical picture of celiac disease in Turner syndrome","volume":"87","author":"Bonamico","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"B7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1530\/eje.1.02267","article-title":"Body composition is distinctly altered in Turner syndrome: relations to glucose metabolism, circulating adipokines, and endothelial adhesion molecules","volume":"155","author":"Gravholt","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.1210\/jc.2004-0122","article-title":"Impaired insulin secretion in the Turner metabolic syndrome","volume":"89","author":"Bakalov","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1210\/jc.2006-0503","article-title":"Monosomy for the X-chromosome is associated with an atherogenic lipid profile","volume":"91","author":"Van","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"B10","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S0002-9343(03)00364-4","article-title":"Bone mineral density and fractures in Turner syndrome","volume":"115","author":"Bakalov","year":"2003","journal-title":"Am J Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"62","DOI":"10.4008\/jcrpe.v1i2.9","article-title":"Atherogenic lipid profile and systolic blood pressure are associated with carotid artery intima-media thickness in children with Turner syndrome","volume":"1","author":"Pirgon","year":"2008","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1111\/cen.12079","article-title":"An evaluation of early cardiometabolic risk factors in children and adolescents with Turner syndrome","volume":"78","author":"O\u2019Gorman","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B13","first-page":"1","article-title":"2000 CDC Growth Charts for the United States: methods and development","volume":"246","author":"Kuczmarski","year":"2002","journal-title":"Vital Health Stat 11"},{"key":"B14","first-page":"1","article-title":"Anthropometric reference data for children and adults: United States, 2003\u20132006","volume":"10","author":"McDowell","year":"2008","journal-title":"Natl Health Stat Report"},{"key":"B15","first-page":"1","article-title":"Changes in terminology for childhood overweight and obesity","volume":"25","author":"Ogden","year":"2010","journal-title":"Natl Health Stat Report"},{"key":"B16","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1542\/peds.114.2.S2.555","article-title":"The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents","volume":"114","year":"2005","journal-title":"Pediatrics"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","article-title":"The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report","volume":"289","author":"Chobanian","year":"2003","journal-title":"JAMA"},{"key":"B18","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"B19","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1542\/peds.2008-1349","article-title":"Lipid screening and cardiovascular health in childhood","volume":"122","author":"Daniels","year":"2008","journal-title":"Pediatrics"},{"key":"B20","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1210\/edrv.23.1.0457","article-title":"Turner\u2019s syndrome in adulthood","volume":"23","author":"Elsheikh","year":"2002","journal-title":"Endocr Rev"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3897","DOI":"10.1210\/jc.2006-0558","article-title":"Prevalence, incidence, diagnostic delay, and mortality in Turner syndrome","volume":"91","author":"Stochholm","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"B22","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1136\/adc.2003.035907","article-title":"Optimizing management in Turner syndrome: from infancy to adult transfer","volume":"91","author":"Donaldson","year":"2006","journal-title":"Arch Dis Child"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1210\/jc.2009-0926","article-title":"Approach to the patient with Turner syndrome","volume":"95","author":"Davenport","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"B24","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/BF00441818","article-title":"Differences in carbohydrate tolerance in Turner syndrome depending on age and karyotype","volume":"148","author":"Cicognani","year":"1988","journal-title":"Eur J Pediatr"},{"key":"B25","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/S0022-3476(95)70551-1","article-title":"Lipid abnormalities in Turner syndrome","volume":"126","author":"Ross","year":"1995","journal-title":"J Pediatr"},{"key":"B26","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1046\/j.1365-2265.2000.00960.x","article-title":"Blood pressure and Turner syndrome","volume":"52","author":"Nathwani","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1161\/HYPERTENSIONAHA.115.07065","article-title":"Pilot study of blood pressure in girls with Turner syndrome: an awareness gap, clinical associations, and new hypotheses","volume":"68","author":"Los","year":"2016","journal-title":"Hypertension"},{"key":"B28","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/j.1365-2265.2007.02807.x","article-title":"Chromosomal mosaicism mitigates stigmata and cardiovascular risk factors in Turner syndrome","volume":"66","author":"El-Mansoury","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1210\/jc.2009-0384","article-title":"X-chromosome gene dosage and the risk of diabetes in Turner syndrome","volume":"94","author":"Bakalov","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"B30","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3109\/09513590.2013.872236","article-title":"The influence of hormonal replacement and growth hormone treatment on the lipids in Turner syndrome","volume":"30","author":"Irzyniec","year":"2014","journal-title":"Gynecol Endocrinol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1210\/jc.2006-0158","article-title":"Clinical significance of the parental origin of the X chromosome in turner syndrome","volume":"92","author":"Sagi","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"B32","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/j.1365-2265.2006.02483.x","article-title":"Physiological and catecholamine response to sympathetic stimulation in turner syndrome","volume":"64","author":"Zuckerman-Levin","year":"2006","journal-title":"Clin Endocrinol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1093\/ajcn\/59.4.810","article-title":"The predictive value of childhood body mass index values for overweight at age 35 y","volume":"59","author":"Guo","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"B34","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1111\/j.1651-2227.1997.tb15174.x","article-title":"Reference values for height, height velocity and weight in Turner\u2019s syndrome","volume":"86","author":"Rongen-Westerlaken","year":"1997","journal-title":"Acta Paediatr"},{"key":"B35","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/sj.ijo.0801119","article-title":"Body mass index (BMI) in Turner syndrome before and during growth hormone (GH) therapy","volume":"24","author":"Blackett","year":"2000","journal-title":"Int J Obes Relat Metab Disord"},{"key":"B36","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/cen.13044","article-title":"Weight gain in Turner syndrome: association to puberty induction? Longitudinal analysis of KIGS data","volume":"85","author":"Reinehr","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B37","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.1210\/jc.2007-0671","article-title":"Metabolic effects of oral versus transdermal estrogen in growth hormone-treated girls with turner syndrome","volume":"92","author":"Mauras","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.1210\/jc.2012-4243","article-title":"Metabolic effects of oral versus transdermal 17\u03b2-estradiol (E2): a randomized clinical trial in girls with Turner syndrome","volume":"98","author":"Torres-Santiago","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"B39","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1111\/cen.12464","article-title":"Is growth hormone treatment in children associated with weight gain? Longitudinal analysis of KIGS data","volume":"81","author":"Reinehr","year":"2014","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fendo.2018.00027\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T08:20:44Z","timestamp":1526372444000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fendo.2018.00027\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":39,"alternative-id":["10.3389\/fendo.2018.00027"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2018.00027","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,9]]},"article-number":"27"}}