{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T10:36:22Z","timestamp":1776940582176,"version":"3.51.4"},"reference-count":123,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T00:00:00Z","timestamp":1521417600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2018.00090","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T15:49:54Z","timestamp":1521474594000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Presence and Effects of Pituitary Adenylate Cyclase Activating Polypeptide Under Physiological and Pathological Conditions in the Stomach"],"prefix":"10.3389","volume":"9","author":[{"given":"Dora","family":"Reglodi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Illes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balazs","family":"Opper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Schafer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Tamas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.2174\/156802606775270288","article-title":"Neuropeptide mimetics and antagonists in the treatment of inflammatory disease: focus on VIP and PACAP","volume":"6","author":"Abad","year":"2006","journal-title":"Curr Top Med Chem"},{"key":"B2","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.npep.2017.07.002","article-title":"Effects of pituitary adenylate cyclase activating polypeptide on small intestinal INT 407 cells","volume":"65","author":"Illes","year":"2017","journal-title":"Neuropeptides"},{"key":"B3","doi-asserted-by":"publisher","first-page":"435","DOI":"10.4196\/kjpp.2015.19.5.435","article-title":"Pituitary adenylate cyclase-activating polypeptide inhibits pacemaker activity of colonic interstitial cells of Cajal","volume":"19","author":"Wu","year":"2015","journal-title":"Korean J Physiol Pharmacol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e108389","DOI":"10.1371\/journal.pone.0108389","article-title":"Pituitary adenylate cyclase-activating polypeptide ameliorates experimental acute ileitis and extra-intestinal sequelae","volume":"9","author":"Heimesaat","year":"2014","journal-title":"PLoS One"},{"key":"B5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/jcp.21381","article-title":"PACAP provides colonic protection against dextran sodium sulfate induced colitis","volume":"216","author":"Azuma","year":"2008","journal-title":"J Cell Physiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1002\/ijc.23308","article-title":"Induction of colitis and rapid development of colorectal tumors in mice deficient in the neuropeptide PACAP","volume":"122","author":"Nemetz","year":"2008","journal-title":"Int J Cancer"},{"key":"B7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-3-319-35135-3_16","article-title":"PACAP regulation of gastrointestinal function and obesity","volume-title":"Current Topics of Neurotoxicity 11 Pituitary Adenylate Cyclase Activating Polypeptide-PACAP","author":"Vu","year":"2016"},{"key":"B8","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s12031-015-0688-1","article-title":"The role of neuropeptides in mouse models of colitis","volume":"59","author":"Padua","year":"2016","journal-title":"J Mol Neurosci"},{"key":"B9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-3-319-35135-3_17","article-title":"Protective intestinal effects of pituitary adenylate cyclase activating polypeptide","volume-title":"Current Topics of Neurotoxicity 11 Pituitary Adenylate Cyclase Activating Polypeptide-PACAP","author":"Horvath","year":"2016"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0167-0115(99)00024-5","article-title":"Biological relevance of pituitary adenylate cyclase-activating polypeptide (PACAP) in the gastrointestinal tract","volume":"84","author":"Lauffer","year":"1999","journal-title":"Regul Pept"},{"key":"B11","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s004410050980","article-title":"Pituitary adenylate cyclase activating polypeptide (PACAP) in the gastrointestinal tract of the rat: distribution and effects of capsaicin or denervation","volume":"291","author":"Hannibal","year":"1998","journal-title":"Cell Tissue Res"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1210\/endo-129-5-2787","article-title":"Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testes","volume":"129","author":"Arimura","year":"1991","journal-title":"Endocrinology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0167-0115(01)00276-2","article-title":"PACAP 1-38 as neurotransmitter in the porcine antrum","volume":"101","author":"Tornoe","year":"2001","journal-title":"Regul Pept"},{"key":"B14","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/0306-4522(92)90064-9","article-title":"Pituitary adenylate cyclase activating peptide: a novel vasoactive intestinal peptide-like neuropeptide in the gut","volume":"46","author":"Sundler","year":"1992","journal-title":"Neuroscience"},{"key":"B15","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0167-0115(02)00192-1","article-title":"Distribution of PACAP and its mRNA in several nonneural tissues of rats demonstrated by sandwich enzyme immunoassay and RT-PCR technique","volume":"109","author":"Kantor","year":"2002","journal-title":"Regul Pept"},{"key":"B16","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0167-0115(95)00082-M","article-title":"Pituitary adenylate cyclase activating polypeptide is expressed in autonomic neurons","volume":"59","author":"Mulder","year":"1995","journal-title":"Regul Pept"},{"key":"B17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0006-8993(95)01150-1","article-title":"Expression of pituitary adenylate cyclase-activating polypeptide in dorsal root ganglia following axotomy: time course and coexistence","volume":"705","author":"Zhang","year":"1995","journal-title":"Brain Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/0306-4522(96)00168-6","article-title":"Pituitary adenylate cyclase activating peptide expression in the rat dorsal root ganglia: up-regulation after peripheral nerve injury","volume":"74","author":"Zhang","year":"1996","journal-title":"Neuroscience"},{"key":"B19","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/0196-9781(93)90131-Y","article-title":"Immunohistochemical localization of PACAP in the ovine digestive system","volume":"14","author":"Koves","year":"1993","journal-title":"Peptides"},{"key":"B20","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S0196-9781(99)00084-4","article-title":"Pituitary adenylate cyclase activating polypeptide (PACAP) is present in human and cat gastric glands","volume":"20","author":"Vincze","year":"1999","journal-title":"Peptides"},{"key":"B21","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/BF00318496","article-title":"Distribution of pituitary adenylyl cyclase activating peptide (PACAP) immunoreactivity in neurons of the guinea-pig digestive tract and their projections in the ileum and colon","volume":"279","author":"Portbury","year":"1995","journal-title":"Cell Tissue Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0167-0115(01)00314-7","article-title":"PACAP mediates the neural proliferative pathway of Mastomys enterochromaffin-like cell transformation","volume":"102","author":"Lauffer","year":"2001","journal-title":"Regul Pept"},{"key":"B23","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0928-4257(01)00014-6","article-title":"Comparative study on the appearance of various bioactive peptides in foregut derivates during the ontogenesis","volume":"95","author":"Vincze","year":"2001","journal-title":"J Physiol Paris"},{"key":"B24","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0303-7207(94)03467-8","article-title":"Sequence and expression of cDNA for pituitary adenylate cyclase activating polypeptide (PACAP) and growth hormone-releasing hormone (GHRH)-like peptide in catfish","volume":"108","author":"McRory","year":"1995","journal-title":"Mol Cell Endocrinol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1530\/REP-08-0422","article-title":"Expression and in vitro regulation of pituitary adenylate cyclase-activating polypeptide (pacap38) and its type I receptor (pac1-r) in the gonads of tilapia (Oreochromis mossambicus)","volume":"137","author":"Huang","year":"2009","journal-title":"Reproduction"},{"key":"B26","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.1242\/jeb.01260","article-title":"Ontogeny of the gut motility control system in zebrafish Danio rerio embryos and larvae","volume":"207","author":"Holmberg","year":"2004","journal-title":"J Exp Biol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cbpb.2012.09.003","article-title":"Structural and functional characterization of pituitary adenylyl cyclase-activating polypeptide (PACAP)\/PACAP-related peptide (PRP) and its receptor in olive flounder (Paralichthys olivaceus)","volume":"164","author":"Nam","year":"2013","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s12031-009-9178-7","article-title":"Distribution and molecular evolution of the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors in the lizard Podarcis sicula (Squamata, Lacertidae)","volume":"39","author":"Valiante","year":"2009","journal-title":"J Mol Neurosci"},{"key":"B29","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1242\/jeb.205.8.1123","article-title":"Distribution and effects of PACAP, VIP, nitric oxide and GABA in the gut of the African clawed frog Xenopus laevis","volume":"205","author":"Olsson","year":"2002","journal-title":"J Exp Biol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1556\/018.68.2017.3.1","article-title":"Changes in expression of neuropeptides and their receptors in the hypothalamus and gastrointestinal tract of calorie restricted hens","volume":"68","author":"Simon","year":"2017","journal-title":"Acta Biol Hung"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1016\/S0196-9781(00)00320-X","article-title":"Ontogeny of PACAP immunoreactivity in extrinsic and intrinsic innervation of chicken gut","volume":"21","author":"Salvi","year":"2000","journal-title":"Peptides"},{"key":"B32","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00441-002-0555-6","article-title":"Pituitary adenylate cyclase activating peptide (PACAP) immunoreactivity and mRNA expression in the duck gastrointestinal tract","volume":"308","author":"Mirabella","year":"2002","journal-title":"Cell Tissue Res"},{"key":"B33","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00429-003-0342-5","article-title":"Topography and neurochemistry of the enteric ganglia in the proventriculus of the duck (Anas platyrhynchos)","volume":"207","author":"Mirabella","year":"2003","journal-title":"Anat Embryol (Berl)"},{"key":"B34","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0304-3940(00)01450-6","article-title":"The relationships of nicotinamide adenine dinucleotide phosphate-d to nitric oxide synthase, vasoactive intestinal polypeptide, galanin and pituitary adenylate activating polypeptide in pigeon gut neurons","volume":"293","author":"Mirabella","year":"2000","journal-title":"Neurosci Lett"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/S0196-9781(00)00258-8","article-title":"Tissue distribution of PACAP27 and -38 in oligochaeta: PACAP27 is the predominant form in the nervous system of Lumbricus polyphemus","volume":"21","author":"Somogyvari-Vigh","year":"2000","journal-title":"Peptides"},{"key":"B36","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1196\/annals.1317.056","article-title":"Comparative anatomy of PACAP-immunoreactive structures in the ventral nerve cord ganglia of lumbricid oligochaetes","volume":"1070","author":"Molnar","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"B37","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0196-9781(99)00201-6","article-title":"Distribution of PACAP-like immunoreactivity in the nervous system of oligochaeta","volume":"21","author":"Reglodi","year":"2000","journal-title":"Peptides"},{"key":"B38","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s12031-008-9102-6","article-title":"Changes in the expression of PACAP-like compounds during the embryonic development of the earthworm Eisenia fetida","volume":"36","author":"Boros","year":"2008","journal-title":"J Mol Neurosci"},{"key":"B39","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s00441-009-0909-4","article-title":"Pituitary adenylate cyclase-activating polypeptide type 1 (PAC1) receptor is expressed during embryonic development of the earthworm","volume":"339","author":"Boros","year":"2010","journal-title":"Cell Tissue Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1159\/000064942","article-title":"Multiple actions of pituitary adenylyl cyclase activating peptide in nervous system development and regeneration","volume":"24","author":"Waschek","year":"2002","journal-title":"Dev Neurosci"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.2174\/1381612043383548","article-title":"Pituitary adenylate cyclase activating polypeptide: a potential neuroprotective peptide","volume":"10","author":"Somogyvari-Vigh","year":"2004","journal-title":"Curr Pharm Des"},{"key":"B42","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s12031-008-9125-z","article-title":"Expression of PACAP-like compounds during the caudal regeneration of the earthworm Eisenia fetida","volume":"36","author":"Varhalmi","year":"2008","journal-title":"J Mol Neurosci"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1210\/endo.135.6.7988457","article-title":"Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions","volume":"135","author":"Usdin","year":"1994","journal-title":"Endocrinology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"G728","DOI":"10.1152\/ajpgi.00138.2006","article-title":"Molecular cloning and functional expression of a VIP-specific receptor","volume":"291","author":"Zhou","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0167-0115(98)00112-8","article-title":"Selective expression of vasoactive intestinal peptide (VIP)2\/pituitary adenylate cyclase-activating polypeptide (PACAP)3 receptors in rabbit and guinea pig gastric and tenia coli smooth muscle cells","volume":"77","author":"Teng","year":"1998","journal-title":"Regul Pept"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1210\/en.2003-1058","article-title":"Distribution of the VPAC2 receptor in peripheral tissues of the mouse","volume":"145","author":"Harmar","year":"2004","journal-title":"Endocrinology"},{"key":"B47","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0022-3565(25)20124-0","article-title":"Inhibitory transmission in guinea pig stomach mediated by distinct receptors for pituitary adenylate cyclase-activating peptide","volume":"278","author":"Katsoulis","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"B48","first-page":"G1391","article-title":"Characterization of PACAP receptors and signaling pathways in rabbit gastric muscle cells","volume":"272","author":"Murthy","year":"1997","journal-title":"Am J Physiol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0167-0115(97)01031-8","article-title":"PACAP and VIP inhibit pyloric muscle through VIP\/PACAP-preferring receptors","volume":"71","author":"Parkman","year":"1997","journal-title":"Regul Pept"},{"key":"B50","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0167-0115(02)00003-4","article-title":"Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons","volume":"105","author":"Miampamba","year":"2002","journal-title":"Regul Pept"},{"key":"B51","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1749-6632.1998.tb11173.x","article-title":"The pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1-R) is expressed on gastric ECL cells: evidence by immunocytochemistry and RT-PCR","volume":"865","author":"Zeng","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"B52","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/S0016-5085(99)70184-8","article-title":"Pituitary adenylate cyclase-activating polypeptide modulates gastric enterochromaffin-like cell proliferation in rats","volume":"116","author":"Lauffer","year":"1999","journal-title":"Gastroenterology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s12031-010-9440-z","article-title":"PAC1 deficiency in a murine model induces gastric mucosa hypertrophy and higher basal gastric acid output","volume":"43","author":"Lu","year":"2011","journal-title":"J Mol Neurosci"},{"key":"B54","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1385\/JMN:26:1:085","article-title":"PACAP regulation of secretion and proliferation of pure populations of gastric ECL cells","volume":"26","author":"Oh","year":"2005","journal-title":"J Mol Neurosci"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1172\/JCI7537","article-title":"PACAP type I receptor activation regulates ECL cells and gastric acid secretion","volume":"104","author":"Zeng","year":"1999","journal-title":"J Clin Invest"},{"key":"B56","first-page":"183","article-title":"Phosphodiesterase isozymes involved in regulating acid secretion in the isolated mouse stomach","volume":"60","author":"Okuda","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0014-2999(01)00881-0","article-title":"Isolated rat stomach ECL cells generate prostaglandin E(2) in response to interleukin-1 beta, tumor necrosis factor-alpha and bradykinin","volume":"416","author":"Lindstrom","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1080\/003655101753352059","article-title":"Control of secretion from rat stomach ECL cells in situ and in primary culture","volume":"234","author":"Hakanson","year":"2001","journal-title":"Scand J Clin Lab Invest Suppl"},{"key":"B59","doi-asserted-by":"publisher","first-page":"G997","DOI":"10.1152\/ajpgi.2001.281.4.G997","article-title":"PACAP stimulates gastric acid secretion in the rat by inducing histamine release","volume":"281","author":"Sandvik","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1111\/j.1469-7793.2001.00663.x","article-title":"Gastrin and the neuropeptide PACAP evoke secretion from rat stomach histamine-containing (ECL) cells by stimulating influx of Ca2+ through different Ca2+ channels","volume":"535","author":"Lindstrom","year":"2001","journal-title":"J Physiol"},{"key":"B61","first-page":"233","article-title":"Properties of isolated gastric enterochromaffin-like cells","volume":"71","author":"Zeng","year":"1998","journal-title":"Yale J Biol Med"},{"key":"B62","first-page":"G1268","article-title":"Role of neuropeptide-sensitive L-type Ca(2+) channels in histamine release in gastric enterochromaffin-like cells","volume":"277","author":"Zeng","year":"1999","journal-title":"Am J Physiol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"G1048","DOI":"10.1152\/ajpgi.2000.279.5.G1048","article-title":"Regulation of parietal cell calcium signaling in gastric glands","volume":"279","author":"Athmann","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/sj.bjp.0705739","article-title":"Peripheral PACAP inhibits gastric acid secretion through somatostatin release in mice","volume":"142","author":"Piqueras","year":"2004","journal-title":"Br J Pharmacol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"G121","DOI":"10.1152\/ajpgi.2000.278.1.G121","article-title":"Inhibition of gastric acid secretion in rat stomach by PACAP is mediated by secretin, somatostatin, and PGE(2)","volume":"278","author":"Li","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0167-0115(02)00286-0","article-title":"Evidence on the presence of secretin cells in the gastric antral and oxyntic mucosa","volume":"111","author":"Chey","year":"2003","journal-title":"Regul Pept"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/0196-9781(95)00083-V","article-title":"Effect of PACAP on gastric acid secretion in rats","volume":"16","author":"Mungan","year":"1995","journal-title":"Peptides"},{"key":"B68","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/s11938-015-0065-8","article-title":"Gastric hypersecretory states: investigation and management","volume":"13","author":"Phan","year":"2015","journal-title":"Curr Treat Options Gastroenterol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1172\/JCI8732","article-title":"PACAP upsets stomach theory","volume":"104","author":"Wank","year":"1999","journal-title":"J Clin Invest"},{"key":"B70","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1097\/00001574-200211000-00002","article-title":"Gastric secretion","volume":"18","author":"Schubert","year":"2002","journal-title":"Curr Opin Gastroenterol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/sj.bjp.0707385","article-title":"Tachyphylaxis of the ECL-cell response to PACAP: receptor desensitization and\/or depletion of secretory products","volume":"152","author":"Bernsand","year":"2007","journal-title":"Br J Pharmacol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1038\/sj.bjp.0701953","article-title":"Prostaglandins inhibit secretion of histamine and pancreastatin from isolated rat stomach ECL cells","volume":"124","author":"Lindstrom","year":"1998","journal-title":"Br J Pharmacol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0167-0115(97)01018-5","article-title":"Neurohormonal regulation of histamine and pancreastatin secretion from isolated rat stomach ECL cells","volume":"71","author":"Lindstrom","year":"1997","journal-title":"Regul Pept"},{"key":"B74","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.regpep.2005.04.002","article-title":"Somatostatin, misoprostol and galanin inhibit gastrin- and PACAP-stimulated secretion of histamine and pancreastatin from ECL cells by blocking specific Ca2+ channels","volume":"130","author":"Bjorkqvist","year":"2005","journal-title":"Regul Pept"},{"key":"B75","first-page":"G192","article-title":"Modulation of secretin release by neuropeptides in secretin-producing cells","volume":"275","author":"Chang","year":"1998","journal-title":"Am J Physiol"},{"key":"B76","first-page":"G901","article-title":"Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release","volume":"263","author":"Felley","year":"1992","journal-title":"Am J Physiol"},{"key":"B77","first-page":"G303","article-title":"Region-specific antiproliferative effect of VIP and PACAP-(1-38) on rabbit enteric smooth muscle","volume":"276","author":"van Assche","year":"1999","journal-title":"Am J Physiol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1159\/000457798","article-title":"Backup mechanism maintains PACAP\/VIP-induced arterial relaxations in PACAP-deficient mice","volume":"54","author":"Ivic","year":"2017","journal-title":"J Vasc Res"},{"key":"B79","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0014-2999(98)00662-1","article-title":"Influence of selective VIP receptor agonists in the rat gastric fundus","volume":"359","author":"Robberecht","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1111\/nmo.12779","article-title":"Na+\/Ca2+ exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo","volume":"28","author":"Azuma","year":"2016","journal-title":"Neurogastroenterol Motil"},{"key":"B81","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/j.1365-2982.2005.00733.x","article-title":"Involvement of M(2) muscarinic receptors in relaxant response of circular muscle of mouse gastric antrum","volume":"18","author":"Takeuchi","year":"2006","journal-title":"Neurogastroenterol Motil"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1124\/jpet.105.094482","article-title":"Pharmacologic characterization of intrinsic mechanisms controlling tone and relaxation of porcine lower esophageal sphincter","volume":"316","author":"Farre","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"B83","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jphs.2016.10.003","article-title":"Overexpression of Na+\/Ca2+ exchanger 1 display enhanced relaxation in the gastric fundus","volume":"132","author":"Fujimoto","year":"2016","journal-title":"J Pharmacol Sci"},{"key":"B84","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/sj.bjp.0703625","article-title":"Evidence for VIP(1)\/PACAP receptors in the afferent pathway mediating surgery-induced fundic relaxation in the rat","volume":"131","author":"Boeckxstaens","year":"2000","journal-title":"Br J Pharmacol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s00424-005-1491-6","article-title":"Roles of PACAP and PHI as inhibitory neurotransmitters in the circular muscle of mouse antrum","volume":"451","author":"Toyoshima","year":"2006","journal-title":"Pflugers Arch"},{"key":"B86","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ejphar.2008.05.045","article-title":"Involvements of PHI-nitric oxide and PACAP-BK channel in the sustained relaxation of mouse gastric fundus","volume":"590","author":"Hagi","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"G740","DOI":"10.1152\/ajpgi.2000.279.4.G740","article-title":"Nitrergic and purinergic regulation of the rat pylorus","volume":"279","author":"Ishiguchi","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0167-0115(92)90022-M","article-title":"Pituitary adenylate cyclase activating polypeptide stimulates gallbladder motility in conscious dogs","volume":"42","author":"Mizumoto","year":"1992","journal-title":"Regul Pept"},{"key":"B89","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0165-1838(99)00103-4","article-title":"Inhibitory neural pathway regulating gastric emptying in rats","volume":"79","author":"Ishiguchi","year":"2000","journal-title":"J Auton Nerv Syst"},{"key":"B90","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s12031-014-0349-9","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) induces relaxations of peripheral and cerebral arteries, which are differentially impaired by aging","volume":"54","author":"Vamos","year":"2014","journal-title":"J Mol Neurosci"},{"key":"B91","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.neuropharm.2014.06.019","article-title":"The selective PAC1 receptor agonist maxadilan inhibits neurogenic vasodilation and edema formation in the mouse skin","volume":"85","author":"Banki","year":"2014","journal-title":"Neuropharmacology"},{"key":"B92","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1177\/0333102414523846","article-title":"PACAP-38 infusion causes sustained vasodilation of the middle meningeal artery in the rat: possible involvement of mast cells","volume":"34","author":"Bhatt","year":"2014","journal-title":"Cephalalgia"},{"key":"B93","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.neuropharm.2015.05.014","article-title":"Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson\u2019s disease model","volume":"108","author":"Lamine","year":"2016","journal-title":"Neuropharmacology"},{"key":"B94","doi-asserted-by":"publisher","first-page":"4865","DOI":"10.3748\/wjg.v16.i38.4865","article-title":"Possible key residues that determine left gastric artery blood flow response to PACAP in dogs","volume":"16","author":"Wei","year":"2010","journal-title":"World J Gastroenterol"},{"key":"B95","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1111\/j.1749-6632.1996.tb17512.x","article-title":"Effects of PACAP-VIP hybrid peptides on gastric blood flow in conscious dogs","volume":"805","author":"Naruse","year":"1996","journal-title":"Ann N Y Acad Sci"},{"key":"B96","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.neuroscience.2006.07.028","article-title":"Effect of pituitary adenylate cyclase activating polypeptide-38 on sensory neuropeptide release and neurogenic inflammation in rats and mice","volume":"143","author":"Nemeth","year":"2006","journal-title":"Neuroscience"},{"key":"B97","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.regpep.2014.08.002","article-title":"Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors","volume":"19","author":"Zhao","year":"2014","journal-title":"Regul Pept"},{"key":"B98","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s12031-013-0102-9","article-title":"Localization and chemical coding of the dorsal motor vagal nucleus (DMX) neurons projecting to the porcine stomach prepyloric area in the physiological state and after stomach partial resection","volume":"52","author":"Ganko","year":"2014","journal-title":"J Mol Neurosci"},{"key":"B99","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s12031-014-0274-y","article-title":"Prolonged acetylsalicylic-acid-supplementation-induced gastritis affects the chemical coding of the stomach innervating vagal efferent neurons in the porcine dorsal motor vagal nucleus (DMX)","volume":"54","author":"Ganko","year":"2014","journal-title":"J Mol Neurosci"},{"key":"B100","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s12031-012-9838-x","article-title":"Changes in pituitary adenylate cyclase-activating peptide 27-like immunoreactive nervous structures in the porcine descending colon during selected pathological processes","volume":"48","author":"Gonkowski","year":"2012","journal-title":"J Mol Neurosci"},{"key":"B101","first-page":"151","article-title":"Neither axotomy nor target-tissue inflammation changes the NOS- or VIP-synthesis rate in distal bowel-projecting neurons of the porcine inferior mesenteric ganglion (IMG)","volume":"40","author":"Majewski","year":"2002","journal-title":"Folia Histochem Cytobiol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S0143-4179(98)90081-6","article-title":"Changes in pituitary adenylate cyclase activating peptide and vasoactive intestinal peptide innervation of rat oxyntic mucosa during ulcer healing","volume":"32","author":"Mei","year":"1998","journal-title":"Neuropeptides"},{"key":"B103","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S0024-3205(98)00280-X","article-title":"Effects of pituitary adenylate cyclase activating polypeptide-27 on alkaline secretory and mucosal ulcerogenic responses in rat duodenum","volume":"63","author":"Yagi","year":"1998","journal-title":"Life Sci"},{"key":"B104","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.dld.2004.03.008","article-title":"Duodenal alkaline secretion: its mechanisms and role in mucosal protection against gastric acid","volume":"36","author":"Konturek","year":"2004","journal-title":"Dig Liver Dis"},{"key":"B105","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1006\/phrs.1998.0393","article-title":"Involvement of PACAP in acid-induced HCO3- response in rat duodenums","volume":"38","author":"Takeuchi","year":"1998","journal-title":"Pharmacol Res"},{"key":"B106","first-page":"5","article-title":"Duodenal mucosal protection by bicarbonate secretion and its mechanisms","volume":"55","author":"Konturek","year":"2004","journal-title":"J Physiol Pharmacol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1159\/000069707","article-title":"Effect of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide on pancreatic, hepatic and duodenal mucosal bicarbonate secretion in the pig","volume":"67","author":"Glad","year":"2003","journal-title":"Digestion"},{"key":"B108","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/978-3-319-35135-3_47","article-title":"PACAP and cancer","volume-title":"Current Topics of Neurotoxicity 11 Pituitary Adenylate Cyclase Activating Polypeptide-PACAP","author":"Moody","year":"2016"},{"key":"B109","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/MED.0000000000000218","article-title":"Vasoactive intestinal peptide\/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer","volume":"23","author":"Moody","year":"2016","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"B110","doi-asserted-by":"publisher","first-page":"6397","DOI":"10.1007\/s13277-014-1852-x","article-title":"VPAC1 overexpression is associated with poor differentiation in colon cancer","volume":"35","author":"Liu","year":"2014","journal-title":"Tumour Biol"},{"key":"B111","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s12031-012-9815-4","article-title":"PACAP immunoreactivity in human malignant tumor samples and cardiac diseases","volume":"48","author":"Szanto","year":"2012","journal-title":"J Mol Neurosci"},{"key":"B112","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s12031-015-0652-0","article-title":"Examination of PACAP-like immunoreactivity in urogenital tumor samples","volume":"59","author":"Tamas","year":"2016","journal-title":"J Mol Neurosci"},{"key":"B113","first-page":"1846","article-title":"In vitro identification of vasoactive intestinal peptide receptors in human tumors: implications for tumor imaging","volume":"36","author":"Reubi","year":"1995","journal-title":"J Nucl Med"},{"key":"B114","first-page":"3105","article-title":"Vasoactive intestinal peptide\/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin","volume":"60","author":"Reubi","year":"2000","journal-title":"Cancer Res"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.2000.tb06946.x","article-title":"In vitro evaluation of VIP\/PACAP receptors in healthy and diseased human tissues. Clinical implications","volume":"921","author":"Reubi","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"B116","volume-title":"HSDAVFTDNYTKLRKQ-NIe-AVKK-(3-OCH3,4-OH)-FLNSSV-GABA-L-(Dap-(BMA)2)-64Cu. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]","author":"Cheng","year":""},{"key":"B117","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1089\/cbr.2015.1947","article-title":"Evaluation of a PACAP peptide analogue labeled with (68)Ga using two different chelating agents","volume":"31","author":"Kumar","year":"2016","journal-title":"Cancer Biother Radiopharm"},{"key":"B118","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1530\/EC-14-0051","article-title":"VPAC2 receptor expression in human normal and neoplastic tissues: evaluation of the novel MAB SP235","volume":"4","author":"Schulz","year":"2015","journal-title":"Endocr Connect"},{"key":"B119","doi-asserted-by":"publisher","first-page":"8235","DOI":"10.1158\/1078-0432.CCR-04-0939","article-title":"Immunocytochemical identification of VPAC1, VPAC2, and PAC1 receptors in normal and neoplastic human tissues with subtype-specific antibodies","volume":"10","author":"Schulz","year":"2004","journal-title":"Clin Cancer Res"},{"key":"B120","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1196\/annals.1317.052","article-title":"Neuroendocrine tumors express PAC1 receptors","volume":"1070","author":"Lieu","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"B121","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s12031-009-9283-7","article-title":"PACAP induces signaling and stimulation of 5-hydroxytryptamine release and growth in neuroendocrine tumor cells","volume":"39","author":"Germano","year":"2009","journal-title":"J Mol Neurosci"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1016\/j.peptides.2007.05.006","article-title":"Gastrointestinal dysfunction in mice with a targeted mutation in the gene encoding vasoactive intestinal polypeptide: a model for the study of intestinal ileus and Hirschsprung\u2019s disease","volume":"28","author":"Lelievre","year":"2007","journal-title":"Peptides"},{"key":"B123","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.regpep.2009.12.012","article-title":"Contribution of endogenous nitrergic and peptidergic influences to the altered neurally-induced gastric contractile responses in strips from dystrophic (mdx) mice","volume":"160","author":"Garella","year":"2010","journal-title":"Regul Pept"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fendo.2018.00090\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T21:43:02Z","timestamp":1751492582000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fendo.2018.00090\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,19]]},"references-count":123,"alternative-id":["10.3389\/fendo.2018.00090"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2018.00090","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,19]]},"article-number":"90"}}