{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:42:47Z","timestamp":1770417767774,"version":"3.49.0"},"reference-count":30,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2018.00165","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T13:35:35Z","timestamp":1523972135000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Co-Occurrence of Pheochromocytoma-Paraganglioma and Cyanotic Congenital Heart Disease: A Case Report and Literature Review"],"prefix":"10.3389","volume":"9","author":[{"given":"Bingbin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingcheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Rong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/S0140-6736(05)67139-5","article-title":"Phaeochromocytoma","volume":"366","author":"Lenders","year":"2005","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"B3","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ijcard.2004.08.015","article-title":"Hematological management of the cyanotic adult with congenital heart disease","volume":"97","author":"Oechslin","year":"2004","journal-title":"Int J Cardiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1161\/CIRCULATIONAHA.106.627224","article-title":"Congenital heart disease in the general population: changing prevalence and age distribution","volume":"115","author":"Marelli","year":"2007","journal-title":"Circulation"},{"key":"B5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/ehjqcco\/qcx031","article-title":"New York Heart Association (NYHA) classification in adults with congenital heart disease: relation to objective measures of exercise and outcome","volume":"4","author":"Bredy","year":"2018","journal-title":"Eur Heart J"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1210\/jc.2014-3863","article-title":"Pheochromocytoma and paraganglioma in cyanotic congenital heart disease","volume":"100","author":"Opotowsky","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B7","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1056\/NEJM200002033420507","article-title":"Congenital heart disease in adults. Second of two parts","volume":"342","author":"Brickner","year":"2000","journal-title":"N Engl J Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1161\/01.CIR.29.5.750","article-title":"Cyanotic malformations of the heart with pheochromocytoma. A report of five cases","volume":"29","author":"Folger","year":"1964","journal-title":"Circulation"},{"key":"B9","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0046-8177(73)80012-7","article-title":"High altitude hypoxia and chemodectomas","volume":"4","author":"Saldana","year":"1973","journal-title":"Hum Pathol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"800","DOI":"10.7326\/0003-4819-92-6-800","article-title":"Carotid body paraganglioma regression with relief of hypoxemia","volume":"92","author":"Gruber","year":"1980","journal-title":"Ann Intern Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1002\/1097-0142(19860201)57:3<672::AID-CNCR2820570346>3.0.CO;2-C","article-title":"High-altitude paragangliomas diagnostic and therapeutic considerations","volume":"57","author":"Rodriguez-Cuevas","year":"1986","journal-title":"Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e0127471","DOI":"10.1371\/journal.pone.0127471","article-title":"Oxygen concentration controls epigenetic effects in models of familial paraganglioma","volume":"10","author":"Her","year":"2015","journal-title":"PLoS One"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1101\/gad.250167.114","article-title":"Human high-altitude adaptation: forward genetics meets the HIF pathway","volume":"28","author":"Bigham","year":"2014","journal-title":"Genes Dev"},{"key":"B14","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1055\/s-0031-1301302","article-title":"An update on the genetics of paraganglioma, pheochromocytoma, and associated hereditary syndromes","volume":"44","author":"Gimenez-Roqueplo","year":"2012","journal-title":"Horm Metab Res"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1056\/NEJMoa020152","article-title":"Germ-line mutations in nonsyndromic pheochromocytoma","volume":"346","author":"Neumann","year":"2002","journal-title":"N Engl J Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ccell.2017.01.001","article-title":"Comprehensive molecular characterization of pheochromocytoma and paraganglioma","volume":"31","author":"Fishbein","year":"2017","journal-title":"Cancer Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1093\/jnci\/djt201","article-title":"Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction","volume":"105","author":"Jochmanova","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"B18","doi-asserted-by":"publisher","first-page":"E2194","DOI":"10.1210\/jc.2012-2410","article-title":"Identification of a signaling axis HIF-1alpha\/microRNA-210\/ISCU independent of SDH mutation that defines a subgroup of head and neck paragangliomas","volume":"97","author":"Merlo","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"B19","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.1210\/jc.2006-0920","article-title":"Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations","volume":"91","author":"Pollard","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"B20","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s12022-017-9469-4","article-title":"A somatic HIF2alpha mutation-induced multiple and recurrent pheochromocytoma\/paraganglioma with polycythemia: clinical study with literature review","volume":"28","author":"Liu","year":"2017","journal-title":"Endocr Pathol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e7094","DOI":"10.1371\/journal.pone.0007094","article-title":"The Warburg effect is genetically determined in inherited pheochromocytomas","volume":"4","author":"Favier","year":"2009","journal-title":"PLoS One"},{"key":"B22","doi-asserted-by":"publisher","first-page":"T71","DOI":"10.1530\/ERC-15-0226","article-title":"15 years of paraganglioma: genetics and mechanism of pheochromocytoma-paraganglioma syndromes characterized by germline SDHB and SDHD mutations","volume":"22","author":"Baysal","year":"2015","journal-title":"Endocr Relat Cancer"},{"key":"B23","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1056\/NEJMoa1205119","article-title":"Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia","volume":"367","author":"Zhuang","year":"2012","journal-title":"N Engl J Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.beem.2010.10.004","article-title":"Pheochromocytomas: the (pseudo)-hypoxia hypothesis","volume":"24","author":"Favier","year":"2010","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"B25","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1373\/clinchem.2010.153320","article-title":"Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma","volume":"57","author":"Eisenhofer","year":"2011","journal-title":"Clin Chem"},{"key":"B26","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/ng768","article-title":"Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator","volume":"29","author":"Bamforth","year":"2001","journal-title":"Nat Genet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.yexcr.2004.10.003","article-title":"HIF-2alpha expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia","volume":"303","author":"Nilsson","year":"2005","journal-title":"Exp Cell Res"},{"key":"B28","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1634\/theoncologist.2008-0043","article-title":"Pheochromocytoma: current approaches and future directions","volume":"13","author":"Adler","year":"2008","journal-title":"Oncologist"},{"key":"B29","doi-asserted-by":"publisher","first-page":"84","DOI":"10.14216\/kjco.10024","article-title":"Asymptomatic pheochromocytoma","volume":"6","author":"Park","year":"2010","journal-title":"Korean J Clin Oncol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.pharmthera.2016.04.009","article-title":"Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer","volume":"164","author":"Wigerup","year":"2016","journal-title":"Pharmacol Ther"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fendo.2018.00165\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T13:35:36Z","timestamp":1523972136000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fendo.2018.00165\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":30,"alternative-id":["10.3389\/fendo.2018.00165"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2018.00165","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"article-number":"165"}}