{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:59:48Z","timestamp":1791950388698,"version":"4.3.4"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["634457"],"award-info":[{"award-number":["634457"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004914","name":"Ferring Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001063","name":"Raine Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001197","name":"Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001069","name":"Women and Infants Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001797","name":"Curtin University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001798","name":"Edith Cowan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001798","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2018.00288","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T07:43:04Z","timestamp":1528098184000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":53,"title":["The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20\u2009Years of Age"],"prefix":"10.3389","volume":"9","author":[{"given":"Roger J.","family":"Hart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Frederiksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota A.","family":"Doherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Keelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels E.","family":"Skakkebaek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noviani S.","family":"Minaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Newnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan E.","family":"Dickinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E.","family":"Pennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Norman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina M.","family":"Main","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1093\/humrep\/dev244","article-title":"Testicular function in a birth cohort of young men","volume":"30","author":"Hart","year":"2015","journal-title":"Hum Reprod"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e000990","DOI":"10.1136\/bmjopen-2012-000990","article-title":"Human semen quality in the new millennium: a prospective cross-sectional population-based study of 4867 men","volume":"2","author":"Jorgensen","year":"2012","journal-title":"BMJ Open"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1093\/humrep\/dep075","article-title":"Associations between andrological measures, hormones and semen quality in fertile Australian men: inverse relationship between obesity and sperm output","volume":"24","author":"Stewart","year":"2009","journal-title":"Hum Reprod"},{"key":"B4","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1071\/RD00103","article-title":"Estrogens and falling sperm counts","volume":"13","author":"Handelsman","year":"2001","journal-title":"Reprod Fertil Dev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1093\/humupd\/dmx022","article-title":"Temporal trends in sperm count: a systematic review and meta-regression analysis","volume":"23","author":"Levine","year":"2017","journal-title":"Hum Reprod Update"},{"key":"B6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1152\/physrev.00017.2015","article-title":"Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility","volume":"96","author":"Skakkebaek","year":"2016","journal-title":"Physiol Rev"},{"key":"B7","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1093\/humrep\/16.5.972","article-title":"Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects","volume":"16","author":"Skakkebaek","year":"2001","journal-title":"Hum Reprod"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.eururo.2013.11.004","article-title":"International variations and trends in testicular cancer incidence and mortality","volume":"65","author":"Znaor","year":"2014","journal-title":"Eur Urol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e33","DOI":"10.1016\/j.fertnstert.2007.12.026","article-title":"Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects","volume":"89","author":"Sharpe","year":"2008","journal-title":"Fertil Steril"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1093\/humrep\/dep174","article-title":"Does a testicular dysgenesis syndrome exist?","volume":"24","author":"Akre","year":"2009","journal-title":"Hum Reprod"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1016\/j.jpedsurg.2010.07.030","article-title":"What is new in cryptorchidism and hypospadias \u2013 a critical review on the testicular dysgenesis hypothesis","volume":"45","author":"Thorup","year":"2010","journal-title":"J Pediatr Surg"},{"key":"B12","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1093\/humupd\/dmw036","article-title":"The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis","volume":"23","author":"Bonde","year":"2016","journal-title":"Hum Reprod Update"},{"key":"B13","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/j.1365-2605.2007.00841.x","article-title":"Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans","volume":"31","author":"Janjua","year":"2008","journal-title":"Int J Androl"},{"key":"B14","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.reprotox.2010.11.001","article-title":"Reproductive and behavioral effects of diisononyl phthtalate (DINP) in perinatally exposed rats","volume":"31","author":"Boberg","year":"2011","journal-title":"Reprod Toxicol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.reprotox.2010.04.005","article-title":"Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats","volume":"30","author":"Christiansen","year":"2010","journal-title":"Reprod Toxicol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1365-2605.2009.01005.x","article-title":"Androgen action in the masculinization programming window and development of male reproductive organs","volume":"33","author":"MacLeod","year":"2010","journal-title":"Int J Androl"},{"key":"B17","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1289\/ehp.0900788","article-title":"Transcriptional biomarkers of steroidogenesis and trophoblast differentiation in the placenta in relation to prenatal phthalate exposure","volume":"118","author":"Adibi","year":"2010","journal-title":"Environ Health Perspect"},{"key":"B18","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.ijheh.2009.04.001","article-title":"Fetal exposure to phthalates \u2013 a pilot study","volume":"212","author":"Wittassek","year":"2009","journal-title":"Int J Hyg Environ Health"},{"key":"B19","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1289\/ehp.8075","article-title":"Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age","volume":"114","author":"Main","year":"2006","journal-title":"Environ Health Perspect"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e91204","DOI":"10.1172\/jci.insight.91204","article-title":"Experimentally induced testicular dysgenesis syndrome originates in the masculinization programming window","volume":"2","author":"van den Driesche","year":"2017","journal-title":"JCI Insight"},{"key":"B21","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1289\/ehp.1408163","article-title":"Prenatal phthalate exposures and anogenital distance in Swedish boys","volume":"123","author":"Bornehag","year":"2015","journal-title":"Environ Health Perspect"},{"key":"B22","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.envint.2008.05.012","article-title":"Association between prenatal exposure to phthalates and the health of newborns","volume":"35","author":"Huang","year":"2009","journal-title":"Environ Int"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1289\/ehp.1509870","article-title":"Prenatal exposure to phthalates and anogenital distance in male infants from a low-exposed Danish cohort (2010-2012)","volume":"124","author":"Jensen","year":"2016","journal-title":"Environ Health Perspect"},{"key":"B24","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/andr.12180","article-title":"Timing of prenatal phthalate exposure in relation to genital endpoints in male newborns","volume":"4","author":"Martino-Andrade","year":"2016","journal-title":"Andrology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1093\/ije\/dyw308","article-title":"Cohort profile: the western Australian pregnancy cohort (Raine) study-generation 2","volume":"46","author":"Straker","year":"2017","journal-title":"Int J Epidemiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/0140-6736(93)91944-H","article-title":"Effects of frequent ultrasound during pregnancy: a randomised controlled trial","volume":"342","author":"Newnham","year":"1993","journal-title":"Lancet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12884-017-1391-8","article-title":"The Raine study had no evidence of significant perinatal selection bias after two decades of follow up: a longitudinal pregnancy cohort study","volume":"17","author":"White","year":"2017","journal-title":"BMC Pregnancy Childbirth"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1002\/oby.21915","article-title":"Early life factors, obesity risk, and the metabolome of young adults","volume":"25","author":"Rauschert","year":"2017","journal-title":"Obesity (Silver Spring)"},{"key":"B29","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1093\/humupd\/dmp048","article-title":"World Health Organization reference values for human semen characteristics","volume":"16","author":"Cooper","year":"2010","journal-title":"Hum Reprod Update"},{"key":"B30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1023\/A:1009844109023","article-title":"Sperm chromatin structure assay is useful for fertility assessment","volume":"22","author":"Evenson","year":"2000","journal-title":"Methods Cell Sci"},{"key":"B31","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.cca.2009.09.003","article-title":"Development and validation of a sensitive liquid chromatography-tandem mass spectrometry assay to simultaneously measure androgens and estrogens in serum without derivatization","volume":"409","author":"Harwood","year":"2009","journal-title":"Clin Chim Acta"},{"key":"B32","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.urology.2006.09.012","article-title":"Testicular volume measurement: comparison of ultrasonography, orchidometry, and water displacement","volume":"69","author":"Sakamoto","year":"2007","journal-title":"Urology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1159\/000474300","article-title":"Ultrasonic testicular texture and size in 444 men from the general population: correlation to semen quality","volume":"24","author":"Lenz","year":"1993","journal-title":"Eur Urol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1530\/REP-13-0331","article-title":"The influence of antenatal exposure to phthalates on subsequent female reproductive development in adolescence: a pilot study","volume":"147","author":"Hart","year":"2014","journal-title":"Reproduction"},{"key":"B35","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1093\/jat\/34.7.400","article-title":"Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry","volume":"34","author":"Frederiksen","year":"2010","journal-title":"J Anal Toxicol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1289\/ehp.0901690","article-title":"Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls","volume":"118","author":"Wolff","year":"2010","journal-title":"Environ Health Perspect"},{"key":"B37","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.1210\/jc.2016-1646","article-title":"Early life events predict adult testicular function; data derived from the western Australian (Raine) birth cohort","volume":"101","author":"Hart","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"B38","first-page":"129","article-title":"Three inferential questions, two types of P-value. Supplementary material to the ASA\u2019s statement on p-values","volume":"70","author":"Lew","year":"2016","journal-title":"Am Stat"},{"key":"B39","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/00031305.2016.1154108","article-title":"The ASA\u2019s statement on p-values: context, process, and purpose","volume":"70","author":"Wasserstein","year":"2016","journal-title":"Am Stat"},{"key":"B40","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.rbmo.2017.11.009","article-title":"The impact of antenatal bisphenol A exposure on male reproductive function at 20-22 years of age","volume":"36","author":"Hart","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1289\/ehp.1205113","article-title":"Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men","volume":"120","author":"Joensen","year":"2012","journal-title":"Environ Health Perspect"},{"key":"B42","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/andr.12124","article-title":"Phthalate exposure and semen quality in fertile US men","volume":"4","author":"Thurston","year":"2016","journal-title":"Andrology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.envpol.2015.12.052","article-title":"Semen phthalate metabolites, semen quality parameters and serum reproductive hormones: a cross-sectional study in China","volume":"211","author":"Wang","year":"2016","journal-title":"Environ Pollut"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1289\/ehp.0901331","article-title":"Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth","volume":"118","author":"Boas","year":"2010","journal-title":"Environ Health Perspect"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1289\/ehp.8100","article-title":"Decrease in anogenital distance among male infants with prenatal phthalate exposure","volume":"113","author":"Swan","year":"2005","journal-title":"Environ Health Perspect"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1210\/jc.2016-3837","article-title":"Early prenatal phthalate exposure, sex steroid hormones, and newborn birth outcomes","volume":"102","author":"Sathyanarayana","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"B47","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3109\/10408444.2013.875983","article-title":"Reproductive and developmental effects of phthalate diesters in males","volume":"44","author":"Kay","year":"2014","journal-title":"Crit Rev Toxicol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"E341","DOI":"10.1210\/jc.2011-2411","article-title":"Do phthalates affect steroidogenesis by the human fetal testis? Exposure of human fetal testis xenografts to di-n-butyl phthalate","volume":"97","author":"Mitchell","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"B49","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1289\/ehp.1408248","article-title":"Comparative effects of di(n-butyl) phthalate exposure on fetal germ cell development in the rat and in human fetal testis xenografts","volume":"123","author":"van den Driesche","year":"2015","journal-title":"Environ Health Perspect"},{"key":"B50","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1530\/REP-13-0522","article-title":"Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected between 2006 and 2012","volume":"147","author":"Frederiksen","year":"2014","journal-title":"Reproduction"},{"key":"B51","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1289\/ehp.9357","article-title":"Ten years of mixing cocktails: a review of combination effects of endocrine-disrupting chemicals","volume":"115","author":"Kortenkamp","year":"2007","journal-title":"Environ Health Perspect"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2868","DOI":"10.1210\/en.2010-0108","article-title":"Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and\/or flutamide markedly reduces Sertoli cell number in the rat","volume":"15","author":"Auharek","year":"2010","journal-title":"Endocrinol Metab Clin North Am"},{"key":"B53","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.taap.2009.05.022","article-title":"Effect of mono-(2-ethylhexyl) phthalate on steroid production of human granulosa cells","volume":"239","author":"Reinsberg","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.taap.2008.03.002","article-title":"Aromatase inhibiting and combined estrogenic effects of parabens and estrogenic effects of other additives in cosmetics","volume":"230","author":"van Meeuwen","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1080\/01926230600642625","article-title":"Proposed mode of action for in utero effects of some phthalate esters on the developing male reproductive tract","volume":"34","author":"David","year":"2006","journal-title":"Toxicol Pathol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1289\/ehp.5658","article-title":"Mechanisms of phthalate ester toxicity in the female reproductive system","volume":"111","author":"Lovekamp-Swan","year":"2003","journal-title":"Environ Health Perspect"},{"key":"B57","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/10937400903094091","article-title":"Reproductive and developmental toxicity of phthalates","volume":"12","author":"Lyche","year":"2009","journal-title":"J Toxicol Environ Health B Crit Rev"},{"key":"B58","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1289\/ehp.1002635","article-title":"Many putative endocrine disruptors inhibit prostaglandin synthesis","volume":"119","author":"Kristensen","year":"2011","journal-title":"Environ Health Perspect"},{"key":"B59","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1002\/mnfr.200600243","article-title":"Metabolism of phthalates in humans","volume":"51","author":"Frederiksen","year":"2007","journal-title":"Mol Nutr Food Res"},{"key":"B60","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1289\/ehp.11610","article-title":"Concentrations of phthalate metabolites in milk, urine, saliva, and Serum of lactating North Carolina women","volume":"117","author":"Hines","year":"2009","journal-title":"Environ Health Perspect"},{"key":"B61","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.envint.2014.02.002","article-title":"Associations between serum phthalates and biomarkers of reproductive function in 589 adult men","volume":"66","author":"Specht","year":"2014","journal-title":"Environ Int"},{"key":"B62","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.ecoenv.2011.09.004","article-title":"Circulating levels of bisphenol A (BPA) and phthalates in an elderly population in Sweden, based on the prospective investigation of the vasculature in Uppsala seniors (PIVUS)","volume":"75","author":"Olsen","year":"2012","journal-title":"Ecotoxicol Environ Saf"},{"key":"B63","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s00204-003-0486-3","article-title":"Glucuronidation patterns of common urinary and serum monoester phthalate metabolites","volume":"77","author":"Silva","year":"2003","journal-title":"Arch Toxicol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2018.00288\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T08:47:36Z","timestamp":1528188456000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2018.00288\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,4]]},"references-count":63,"alternative-id":["10.3389\/fendo.2018.00288"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2018.00288","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,4]]},"article-number":"288"}}