{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:13:23Z","timestamp":1787026403030,"version":"build-2736575974"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2018.00299","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:20:46Z","timestamp":1528158046000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Selecting Infants With Cryptorchidism and High Risk of Infertility for Optional Adjuvant Hormonal Therapy and Cryopreservation of Germ Cells: Experience From a Pilot Study"],"prefix":"10.3389","volume":"9","author":[{"given":"Jorgen","family":"Thorup","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Clasen-Linde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Hildorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine Gry","family":"Kristensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Yding","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1016\/S0140-6736(01)06274-2","article-title":"The importance of both an early orchidopexy and germ cell maturation for fertility","volume":"358","author":"Hadziselimovic","year":"2001","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1055\/s-2007-993194","article-title":"Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidism","volume":"220","author":"Hadziselimovic","year":"2008","journal-title":"Klin P\u00e4diatr"},{"key":"B3","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00441-005-1126-4","article-title":"Abnormalities of testicular descent","volume":"322","author":"Hutson","year":"2005","journal-title":"Cell Tissue Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.juro.2006.04.052","article-title":"Orchiopexy practice patterns in New York State from 1984-2002","volume":"176","author":"Capello","year":"2006","journal-title":"J Urol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1055\/s-0033-1349715","article-title":"Improved sperm count and motility in young men surgically treated for cryptorchidism in the first year of life","volume":"24","author":"Feyles","year":"2014","journal-title":"Eur J Pediatr Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1097\/00005392-199607000-00024","article-title":"Early treatment of cryptorchidism, semen quality and testicular endocrinology","volume":"156","author":"Taskinen","year":"1996","journal-title":"J Urol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/S0090-4295(00)00560-4","article-title":"Early orchiopexy: prepubertal intratubular germ cell neoplasia and fertility outcome","volume":"56","author":"Engeler","year":"2000","journal-title":"Urology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1016\/j.jpedsurg.2010.07.030","article-title":"What is new in cryptorchidism and hypospadias \u2013 a critical review on the testicular dysgenesis hypothesis","volume":"45","author":"Thorup","year":"2010","journal-title":"J Pediatr Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1159\/000443741","article-title":"Opinion: comment on evaluation and treatment of cryptorchidism: AUA\/AAP and Nordic consensus guidelines","volume":"96","author":"Hadziselimovic","year":"2016","journal-title":"Urol Int"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1097\/00005392-199509000-00096","article-title":"Quantitative histology of germ cells in the undescended testes of human fetuses, neonates and infants","volume":"154","author":"Cortes","year":"1995","journal-title":"J Urol"},{"key":"B11","first-page":"1","article-title":"Cryptorchidism: aspects of pathogenesis, histology and treatment","volume":"32","author":"Cortes","year":"1998","journal-title":"Scand J Urol Nephrol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1464-410X.1991.tb15325.x","article-title":"Histology of testicular biopsies taken at operation for bilateral maldescended testes in relation to fertility in adulthood","volume":"68","author":"Cortes","year":"1991","journal-title":"Br J Urol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/j.juro.2012.02.2551","article-title":"Bilateral undescended testes classified according to preoperative and postoperative status of gonadotropins and inhibin B in relation to testicular histopathology at bilateral orchiopexy in infant boys","volume":"188","author":"Thorup","year":"2012","journal-title":"J Urol"},{"key":"B14","first-page":"484","article-title":"Hodendystopie","volume-title":"Kinderurologie in Klinik and Praxis","author":"Hadziselimovic","year":"2000"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1097\/00005392-199709000-00130","article-title":"Treatment with a luteinizing hormone-releasing hormone analogue after successful orchiopexy markedly improves the chance of fertility later in life","volume":"158","author":"Hadziselimovi\u0107","year":"1997","journal-title":"J Urol"},{"key":"B16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-3-319-25910-9_9","article-title":"Hormonal treatment","volume-title":"Descent of the Testis","author":"Hutson","year":"2016"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1093\/humrep\/del508","article-title":"Methods of cryopreservation of testicular tissue with viable spermatogonia in pre-pubertal boys undergoing gonadotoxic cancer treatment","volume":"22","author":"Keros","year":"2007","journal-title":"Hum Reprod"},{"key":"B18","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1093\/humupd\/dmp054","article-title":"Options for fertility preservation in prepubertal boys","volume":"16","author":"Wyns","year":"2010","journal-title":"Hum Reprod Update"},{"key":"B19","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1093\/humrep\/dei331","article-title":"Cryopreservation of intact testicular tissue from boys with cryptorchidism","volume":"21","author":"Kvist","year":"2006","journal-title":"Hum Reprod"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1093\/humrep\/dex306","article-title":"Development of the testis in pre-pubertal boys with cancer after biopsy for fertility preservation","volume":"32","author":"Uijldert","year":"2017","journal-title":"Hum Reprod"},{"key":"B21","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ymeth.2016.02.013","article-title":"Experimental testicular tissue banking to generate spermatogenesis in the future: a multidisciplinary team approach","volume":"99","author":"Sadri-Ardekani","year":"2016","journal-title":"Methods"},{"key":"B22","doi-asserted-by":"publisher","first-page":"4341","DOI":"10.1210\/jc.2012-3065","article-title":"Present and future prospects of male fertility preservation for children and adolescents","volume":"97","author":"Jahnukainen","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1016\/j.juro.2013.01.058","article-title":"The relation between adult dark spermatogonia and other parameters of fertility potential in cryptorchid testes","volume":"190","author":"Thorup","year":"2013","journal-title":"J Urol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1605350","article-title":"Postnatal germ cell development in the cryptorchid testis: the key to explain why early surgery decreases the risk of malignancy","author":"Thorup","year":"2017","journal-title":"Eur J Pediatr Surg"},{"key":"B25","first-page":"38","article-title":"Hormonal therapy for the subfertility of cryptorchidism","volume":"55","author":"Huff","year":"2001","journal-title":"Horm Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1097\/01.ju.0000153562.07287.77","article-title":"Neoadjuvant gonadotropin-releasing hormone therapy before surgery may improve the fertility index in undescended testes: a prospective randomized trial","volume":"173","author":"Schwentner","year":"2005","journal-title":"J Urol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.urology.2008.10.078","article-title":"Neoadjuvant gonadotropin-releasing hormone therapy before surgery and effect on fertility index in unilateral undescended testes: a prospective randomized trial","volume":"73","author":"Jallouli","year":"2009","journal-title":"Urology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.jpurol.2005.11.007","article-title":"Effects of hormonal treatment on the contralateral descended testis in unilateral cryptorchidism","volume":"2","author":"Zivkovic","year":"2006","journal-title":"J Pediatr Urol"},{"key":"B29","first-page":"166","author":"Vincel","year":"2017"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1016\/S0022-5347(05)67763-4","article-title":"Hormonal treatment may harm the germ cells in 1 to 3-year-old boys with cryptorchidism","volume":"163","author":"Cortes","year":"2000","journal-title":"J Urol"},{"key":"B31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-3-319-25910-9_6","article-title":"The postnatal effects of cryptorchidism","volume-title":"Descent of the Testis","author":"Hutson","year":"2016"},{"key":"B32","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.stem.2016.01.017","article-title":"Complete meiosis from embryonic stem cell-derived germ cells in vitro","volume":"18","author":"Zhou","year":"2016","journal-title":"Cell Stem Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"11303","DOI":"10.1073\/pnas.91.24.11303","article-title":"Germline transmission of donor haplotype following spermatogonial transplantation","volume":"91","author":"Brinster","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B34","doi-asserted-by":"publisher","first-page":"11298","DOI":"10.1073\/pnas.91.24.11298","article-title":"Spermatogenesis following male germ-cell transplantation","volume":"91","author":"Brinster","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B35","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1095\/biolreprod66.1.21","article-title":"Germ cell transplantation in pigs","volume":"66","author":"Honaramooz","year":"2002","journal-title":"Biol Reprod"},{"key":"B36","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1093\/humrep\/17.1.55","article-title":"Germ cell transplantation into X-irradiated monkey testes","volume":"17","author":"Schlatt","year":"2002","journal-title":"Hum Reprod"},{"key":"B37","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1530\/rep.0.1260765","article-title":"Autologous and homologous transplantation of bovine spermatogonial stem cells","volume":"126","author":"Izadyar","year":"2003","journal-title":"Reproduction"},{"key":"B38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1095\/biolreprod.112.098913","article-title":"CD9 is expressed on human male germ cells that have a long-term repopulation potential after transplantation into mouse testes","volume":"87","author":"Zohni","year":"2012","journal-title":"Biol Reprod"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1093\/humrep\/der026","article-title":"Identification and characterization of repopulating spermatogonial stem cells from the adult human testis","volume":"26","author":"Izadyar","year":"2011","journal-title":"Hum Reprod"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1172\/JCI65822","article-title":"Eliminating malignant contamination from therapeutic human spermatogonial stem cells","volume":"123","author":"Dovey","year":"2013","journal-title":"J Clin Invest"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1634\/stemcells.2007-0143","article-title":"Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques","volume":"25","author":"Hermann","year":"2007","journal-title":"Stem Cells"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2018.00299\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:20:49Z","timestamp":1528158049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2018.00299\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,5]]},"references-count":41,"alternative-id":["10.3389\/fendo.2018.00299"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2018.00299","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,5]]},"article-number":"299"}}