{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:37:50Z","timestamp":1793907470874,"version":"4.8.0"},"reference-count":160,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000191","name":"Kidney Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2018.00302","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T04:22:39Z","timestamp":1528172559000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":161,"title":["Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and Beyond"],"prefix":"10.3389","volume":"9","author":[{"given":"Claire E.","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1146\/annurev-physiol-020911-153238","article-title":"Cell biology and pathology of podocytes","volume":"74","author":"Greka","year":"2012","journal-title":"Annu Rev Physiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1083\/jcb.201410017","article-title":"Review series: the cell biology of renal filtration","volume":"209","author":"Scott","year":"2015","journal-title":"J Cell Biol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/01.mnh.0000447018.28852.b6","article-title":"Advances in slit diaphragm signaling","volume":"23","author":"New","year":"2014","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"B4","first-page":"531","article-title":"An ultrastructural study of glomerular basement membrane synthesis","volume":"58","author":"Striker","year":"1970","journal-title":"Am J Pathol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.bbrc.2010.04.069","article-title":"Molecular make-up of the glomerular filtration barrier","volume":"396","author":"Patrakka","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3166","DOI":"10.1681\/ASN.2017020143","article-title":"The evolving complexity of the podocyte cytoskeleton","volume":"28","author":"Schell","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"749010","DOI":"10.1155\/2012\/749010","article-title":"The glomerular filtration barrier: components and crosstalk","volume":"2012","author":"Menon","year":"2012","journal-title":"Int J Nephrol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1083\/jcb.98.4.1591","article-title":"Identification and characterization of podocalyxin \u2013 the major sialoprotein of the renal glomerular epithelial cell","volume":"98","author":"Kerjaschki","year":"1984","journal-title":"J Cell Biol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94137","article-title":"Injury-induced actin cytoskeleton reorganization in podocytes revealed by super-resolution microscopy","volume":"2","author":"Suleiman","year":"2017","journal-title":"JCI Insight"},{"key":"B10","doi-asserted-by":"publisher","first-page":"35068","DOI":"10.1038\/srep35068","article-title":"Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury","volume":"6","author":"Randles","year":"2016","journal-title":"Sci Rep"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1681\/ASN.2016101119","article-title":"N-degradomic analysis reveals a proteolytic network processing the podocyte cytoskeleton","volume":"28","author":"Rinschen","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1681\/ASN.V1111","article-title":"The glomerular slit diaphragm is a modified adherens junction","volume":"11","author":"Reiser","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1083\/jcb.111.3.1255","article-title":"The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium","volume":"111","author":"Schnabel","year":"1990","journal-title":"J Cell Biol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"7962","DOI":"10.1073\/pnas.96.14.7962","article-title":"Nephrin is specifically located at the slit diaphragm of glomerular podocytes","volume":"96","author":"Ruotsalainen","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1172\/JCI22562","article-title":"Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography","volume":"114","author":"Wartiovaara","year":"2004","journal-title":"J Clin Invest"},{"key":"B16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1096\/fj.02-0242fje","article-title":"NEPH1 defines a novel family of podocin interacting proteins","volume":"17","author":"Sellin","year":"2003","journal-title":"FASEB J"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e86177","DOI":"10.1172\/jci.insight.86177","article-title":"A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes","volume":"1","author":"Grahammer","year":"2016","journal-title":"JCI Insight"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1172\/JCI200112849","article-title":"Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin","volume":"108","author":"Schwarz","year":"2001","journal-title":"J Clin Invest"},{"key":"B19","first-page":"805","article-title":"The altered glomerular filtration slits seen in puromycin aminonucleoside nephrosis and protamine sulfate-treated rats contain the tight junction protein ZO-1","volume":"141","author":"Kurihara","year":"1992","journal-title":"Am J Pathol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"297","DOI":"10.2147\/IJNRD.S113071","article-title":"Formation of tight junctions between neighboring podocytes is an early ultrastructural feature in experimental crescentic glomerulonephritis","volume":"9","author":"Succar","year":"2016","journal-title":"Int J Nephrol Renovasc Dis"},{"key":"B21","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1681\/ASN.2015121324","article-title":"Inducible expression of claudin-1 in glomerular podocytes generates aberrant tight junctions and proteinuria through slit diaphragm destabilization","volume":"28","author":"Gong","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S1097-2765(00)80057-X","article-title":"Positionally cloned gene for a novel glomerular protein \u2013 nephrin \u2013 is mutated in congenital nephrotic syndrome","volume":"1","author":"Kestil\u00e4","year":"1998","journal-title":"Mol Cell"},{"key":"B23","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.semcdb.2014.07.016","article-title":"Glomerular development \u2013 shaping the multi-cellular filtration unit","volume":"36","author":"Schell","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1046\/j.1523-1755.1999.00719.x","article-title":"Nephrin localizes to the slit pore of the glomerular epithelial cell","volume":"56","author":"Holzman","year":"1999","journal-title":"Kidney Int"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1016\/S0002-9440(10)64829-8","article-title":"Role of nephrin in cell junction formation in human nephrogenesis","volume":"157","author":"Ruotsalainen","year":"2000","journal-title":"Am J Pathol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3109\/01677063.2014.918976","article-title":"A brief overview on IRM function across evolution","volume":"28","author":"Helmst\u00e4dter","year":"2014","journal-title":"J Neurogenet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e0128490","DOI":"10.1371\/journal.pone.0128490","article-title":"The cell adhesion molecules roughest, Hibris, kin of irre and sticks and stones are required for long range spacing of the Drosophila wing disc sensory sensilla","volume":"10","author":"Linneweber","year":"2015","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1111\/j.1523-1755.2004.00898.x","article-title":"Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane","volume":"66","author":"Nishibori","year":"2004","journal-title":"Kidney Int"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1093\/hmg\/ddg360","article-title":"Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains","volume":"12","author":"Huber","year":"2003","journal-title":"Hum Mol Genet"},{"key":"B30","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1681\/ASN.2007040452","article-title":"Specific podocin mutations correlate with age of onset in steroid-resistant nephrotic syndrome","volume":"19","author":"Hinkes","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1038\/ki.2008.27","article-title":"A missense mutation in podocin leads to early and severe renal disease in mice","volume":"73","author":"Philippe","year":"2008","journal-title":"Kidney Int"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1128\/MCB.05051-11","article-title":"Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane","volume":"31","author":"Arif","year":"2011","journal-title":"Mol Cell Biol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1128\/MCB.00020-16","article-title":"Structural analysis of the Myo1c and Neph1 complex provides insight into the intracellular movement of Neph1","volume":"36","author":"Arif","year":"2016","journal-title":"Mol Cell Biol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/hmg\/10.1.1","article-title":"The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death","volume":"10","author":"Putaala","year":"2001","journal-title":"Hum Mol Genet"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1097\/01.ASN.0000016142.29721.22","article-title":"Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions","volume":"13","author":"Rantanen","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1128\/MCB.24.2.550-560.2004","article-title":"Early glomerular filtration defect and severe renal disease in podocin-deficient mice","volume":"24","author":"Roselli","year":"2004","journal-title":"Mol Cell Biol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"4829","DOI":"10.1128\/MCB.21.14.4829-4836.2001","article-title":"Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN","volume":"21","author":"Donoviel","year":"2001","journal-title":"Mol Cell Biol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1111\/nep.12667","article-title":"NPHS1 gene mutations confirm congenital nephrotic syndrome in four Brazilian cases: a novel mutation is described","volume":"21","author":"Guaragna","year":"2016","journal-title":"Nephrology (Carlton)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/humu.22485","article-title":"NPHS2 mutations in steroid-resistant nephrotic syndrome: a mutation update and the associated phenotypic spectrum","volume":"35","author":"Bouchireb","year":"2014","journal-title":"Hum Mutat"},{"key":"B40","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1093\/hmg\/11.4.379","article-title":"Genotype\/phenotype correlations of NPHS1 and NPHS2 mutations in nephrotic syndrome advocate a functional inter-relationship in glomerular filtration","volume":"11","author":"Koziell","year":"2002","journal-title":"Hum Mol Genet"},{"key":"B41","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1136\/jmedgenet-2013-101713","article-title":"Digenic inheritance in medical genetics","volume":"50","author":"Sch\u00e4ffer","year":"2013","journal-title":"J Med Genet"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1681\/ASN.2014040405","article-title":"Nephrin preserves podocyte viability and glomerular structure and function in adult kidneys","volume":"26","author":"Li","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1681\/ASN.2009040379","article-title":"Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndrome","volume":"20","author":"Mollet","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e0186574","DOI":"10.1371\/journal.pone.0186574","article-title":"An inducible mouse model of podocin-mutation-related nephrotic syndrome","volume":"12","author":"Tabatabaeifar","year":"2017","journal-title":"PLoS One"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1016\/S0002-9440(10)63080-5","article-title":"CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain","volume":"159","author":"Shih","year":"2001","journal-title":"Am J Pathol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"20716","DOI":"10.1074\/jbc.M301689200","article-title":"Fyn binds to and phosphorylates the kidney slit diaphragm component nephrin","volume":"278","author":"Verma","year":"2003","journal-title":"J Biol Chem"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1097\/01.ASN.0000146689.88078.80","article-title":"SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin","volume":"15","author":"Li","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/j.1432-1033.2004.04408.x","article-title":"Characterization of the interactions of the nephrin intracellular domain","volume":"272","author":"Liu","year":"2005","journal-title":"FEBS J"},{"key":"B49","doi-asserted-by":"publisher","first-page":"9814","DOI":"10.1073\/pnas.0504166102","article-title":"Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex","volume":"102","author":"Lehtonen","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B50","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/ng1592","article-title":"TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function","volume":"37","author":"Reiser","year":"2005","journal-title":"Nat Genet"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1038\/labinvest.3700347","article-title":"MAGI-1 is a component of the glomerular slit diaphragm that is tightly associated with nephrin","volume":"85","author":"Hirabayashi","year":"2005","journal-title":"Lab Invest"},{"key":"B52","doi-asserted-by":"publisher","first-page":"14110","DOI":"10.1073\/pnas.0602587103","article-title":"beta-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity","volume":"103","author":"Quack","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B53","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/nature04662","article-title":"Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes","volume":"440","author":"Jones","year":"2006","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1172\/JCI27414","article-title":"Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization","volume":"116","author":"Verma","year":"2006","journal-title":"J Clin Invest"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.2337\/db06-0693","article-title":"Nephrin is critical for the action of insulin on human glomerular podocytes","volume":"56","author":"Coward","year":"2007","journal-title":"Diabetes"},{"key":"B56","doi-asserted-by":"publisher","first-page":"23033","DOI":"10.1074\/jbc.M803143200","article-title":"Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity","volume":"283","author":"Hartleben","year":"2008","journal-title":"J Biol Chem"},{"key":"B57","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/sj.ki.5002691","article-title":"Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes","volume":"73","author":"Zhu","year":"2008","journal-title":"Kidney Int"},{"key":"B58","doi-asserted-by":"publisher","first-page":"F235","DOI":"10.1152\/ajprenal.00140.2008","article-title":"Nephrin binds to the COOH terminus of a large-conductance Ca2+-activated K+ channel isoform and regulates its expression on the cell surface","volume":"295","author":"Kim","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e4194","DOI":"10.1371\/journal.pone.0004194","article-title":"An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms","volume":"4","author":"Hirose","year":"2009","journal-title":"PLoS One"},{"key":"B60","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1681\/ASN.2008080871","article-title":"Loss of podocyte aPKClambda\/iota causes polarity defects and nephrotic syndrome","volume":"20","author":"Huber","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1681\/ASN.2008111219","article-title":"Nephrin deficiency activates NF-kappaB and promotes glomerular injury","volume":"20","author":"Hussain","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"8951","DOI":"10.1074\/jbc.M806851200","article-title":"Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-{gamma}1","volume":"284","author":"Harita","year":"2009","journal-title":"J Biol Chem"},{"key":"B63","doi-asserted-by":"publisher","first-page":"25285","DOI":"10.1074\/jbc.M109.087239","article-title":"CIN85\/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes","volume":"285","author":"Tossidou","year":"2010","journal-title":"J Biol Chem"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1681\/ASN.2009090921","article-title":"Anion exchanger 1 interacts with nephrin in podocytes","volume":"21","author":"Wu","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/ki.2010.64","article-title":"Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease","volume":"77","author":"Veron","year":"2010","journal-title":"Kidney Int"},{"key":"B66","doi-asserted-by":"publisher","first-page":"39933","DOI":"10.1074\/jbc.M111.241620","article-title":"Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytes","volume":"286","author":"Bertuccio","year":"2011","journal-title":"J Biol Chem"},{"key":"B67","doi-asserted-by":"publisher","first-page":"376543","DOI":"10.1155\/2011\/376543","article-title":"Podocyte protein, nephrin, is a substrate of protein tyrosine phosphatase 1B","volume":"2011","author":"Aoudjit","year":"2011","journal-title":"J Signal Transduct"},{"key":"B68","doi-asserted-by":"publisher","first-page":"F549","DOI":"10.1152\/ajprenal.00566.2009","article-title":"Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes","volume":"300","author":"Babayeva","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1091\/mbc.E11-12-1010","article-title":"Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking","volume":"23","author":"Wasik","year":"2012","journal-title":"Mol Biol Cell"},{"key":"B70","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1111\/j.1742-4658.2012.08682.x","article-title":"SIRP\u03b1 interacts with nephrin at the podocyte slit diaphragm","volume":"279","author":"Kajiho","year":"2012","journal-title":"FEBS J"},{"key":"B71","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1172\/JCI60070","article-title":"Crk1\/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease","volume":"122","author":"George","year":"2012","journal-title":"J Clin Invest"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1016\/j.ajpath.2013.06.022","article-title":"Excess podocyte semaphorin-3A leads to glomerular disease involving plexinA1-nephrin interaction","volume":"183","author":"Reidy","year":"2013","journal-title":"Am J Pathol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1038\/ki.2013.556","article-title":"Crk1\/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis","volume":"85","author":"George","year":"2014","journal-title":"Kidney Int"},{"key":"B74","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1074\/jbc.M114.612721","article-title":"Increased SHP-1 protein expression by high glucose levels reduces nephrin phosphorylation in podocytes","volume":"290","author":"Denhez","year":"2015","journal-title":"J Biol Chem"},{"key":"B75","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1128\/MCB.00956-15","article-title":"Shp2 associates with and enhances nephrin tyrosine phosphorylation and is necessary for foot process spreading in mouse models of podocyte injury","volume":"36","author":"Verma","year":"2015","journal-title":"Mol Cell Biol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1681\/ASN.2017030285","article-title":"ShcA adaptor protein promotes nephrin endocytosis and is upregulated in proteinuric nephropathies","volume":"29","author":"Martin","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1046\/j.1523-1755.2003.00097.x","article-title":"Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases","volume":"64","author":"Lahdenper\u00e4","year":"2003","journal-title":"Kidney Int"},{"key":"B78","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1016\/j.febslet.2012.05.002","article-title":"Perspective: dynamics of receptor tyrosine kinase signaling complexes","volume":"586","author":"Mayer","year":"2012","journal-title":"FEBS Lett"},{"key":"B79","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1074\/jbc.M117.794412","article-title":"Src homology 2 domains enhance tyrosine phosphorylation in vivo by protecting binding sites in their target proteins from dephosphorylation","volume":"293","author":"Jadwin","year":"2018","journal-title":"J Biol Chem"},{"key":"B80","doi-asserted-by":"publisher","first-page":"4917","DOI":"10.1128\/MCB.23.14.4917-4928.2003","article-title":"Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling","volume":"23","author":"Huber","year":"2003","journal-title":"Mol Cell Biol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"22676","DOI":"10.1074\/jbc.M110.122929","article-title":"Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture","volume":"285","author":"Garg","year":"2010","journal-title":"J Biol Chem"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1681\/ASN.2009010056","article-title":"Nck proteins maintain the adult glomerular filtration barrier","volume":"20","author":"Jones","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"F951","DOI":"10.1152\/ajprenal.00536.2009","article-title":"p21-activated kinases regulate actin remodeling in glomerular podocytes","volume":"298","author":"Zhu","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"e28710","DOI":"10.1371\/journal.pone.0028710","article-title":"Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin","volume":"6","author":"Venkatareddy","year":"2011","journal-title":"PLoS One"},{"key":"B85","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1128\/MCB.01770-07","article-title":"Phosphorylated YDXV motifs and Nck SH2\/SH3 adaptors act cooperatively to induce actin reorganization","volume":"28","author":"Blasutig","year":"2008","journal-title":"Mol Cell Biol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3345\/kjp.2017.60.3.55","article-title":"Genetics of hereditary nephrotic syndrome: a clinical review","volume":"60","author":"Ha","year":"2017","journal-title":"Korean J Pediatr"},{"key":"B87","doi-asserted-by":"publisher","first-page":"12959","DOI":"10.1074\/jbc.M110.204024","article-title":"PKC alpha mediates beta-arrestin2-dependent nephrin endocytosis in hyperglycemia","volume":"286","author":"Quack","year":"2011","journal-title":"J Biol Chem"},{"key":"B88","doi-asserted-by":"publisher","first-page":"39513","DOI":"10.1038\/srep39513","article-title":"Angiotensin II increases glomerular permeability by \u03b2-arrestin mediated nephrin endocytosis","volume":"6","author":"K\u00f6nigshausen","year":"2016","journal-title":"Sci Rep"},{"key":"B89","doi-asserted-by":"publisher","first-page":"24035","DOI":"10.1074\/jbc.M113.452904","article-title":"Planar cell polarity pathway regulates nephrin endocytosis in developing podocytes","volume":"288","author":"Babayeva","year":"2013","journal-title":"J Biol Chem"},{"key":"B90","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1681\/ASN.2011010027","article-title":"Notch promotes dynamin-dependent endocytosis of nephrin","volume":"23","author":"Waters","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"e0179217","DOI":"10.1371\/journal.pone.0179217","article-title":"A novel in vivo method to quantify slit diaphragm protein abundance in murine proteinuric kidney disease","volume":"12","author":"Haase","year":"2017","journal-title":"PLoS One"},{"key":"B92","doi-asserted-by":"publisher","first-page":"e40566","DOI":"10.1371\/journal.pone.0040566","article-title":"Shp2 activates Fyn and Ras to regulate RBL-2H3 mast cell activation following Fc\u03b5RI aggregation","volume":"7","author":"Fang","year":"2012","journal-title":"PLoS One"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1074\/jbc.M112.439463","article-title":"Direct regulation of nephrin tyrosine phosphorylation by Nck adaptor proteins","volume":"288","author":"New","year":"2013","journal-title":"J Biol Chem"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1038\/nm.2052","article-title":"Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy","volume":"15","author":"Geraldes","year":"2009","journal-title":"Nat Med"},{"key":"B95","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1096\/fj.11-202994","article-title":"Glomerular VEGF resistance induced by PKC\u03b4\/SHP-1 activation and contribution to diabetic nephropathy","volume":"26","author":"Mima","year":"2012","journal-title":"FASEB J"},{"key":"B96","doi-asserted-by":"publisher","first-page":"E1188","DOI":"10.1152\/ajpendo.00560.2012","article-title":"Expression of SHP-1 induced by hyperglycemia prevents insulin actions in podocytes","volume":"304","author":"Drapeau","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B97","doi-asserted-by":"publisher","first-page":"3705","DOI":"10.2337\/db16-0254","article-title":"Persistent insulin resistance in podocytes caused by epigenetic changes of SHP-1 in diabetes","volume":"65","author":"Lizotte","year":"2016","journal-title":"Diabetes"},{"key":"B98","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/5584_2017_62","article-title":"Regulation of nephrin phosphorylation in diabetes and chronic kidney injury","volume":"966","author":"Denhez","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"12346","DOI":"10.1038\/s41598-017-12382-8","article-title":"C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation","volume":"7","author":"Lee","year":"2017","journal-title":"Sci Rep"},{"key":"B100","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/ki.2008.19","article-title":"Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis","volume":"73","author":"Uchida","year":"2008","journal-title":"Kidney Int"},{"key":"B101","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s10157-009-0241-z","article-title":"Phosphorylation status of nephrin in human membranous nephropathy","volume":"14","author":"Ohashi","year":"2010","journal-title":"Clin Exp Nephrol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1681\/ASN.2015091048","article-title":"Nephrin tyrosine phosphorylation is required to stabilize and restore podocyte foot process architecture","volume":"27","author":"New","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B103","doi-asserted-by":"publisher","first-page":"12799","DOI":"10.1074\/jbc.M116.724245","article-title":"Nephrin suppresses hippo signaling through the adaptor proteins Nck and WTIP","volume":"291","author":"Keyvani Chahi","year":"2016","journal-title":"J Biol Chem"},{"key":"B104","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/MNH.0000000000000376","article-title":"Protein phosphatases and podocyte function","volume":"27","author":"Geraldes","year":"2018","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"B105","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrneph.2016.22","article-title":"Podocyte biology: phosphorylation preserves podocytes","volume":"12","author":"Carney","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nature10879","article-title":"Phase transitions in the assembly of multivalent signalling proteins","volume":"483","author":"Li","year":"2012","journal-title":"Nature"},{"key":"B107","doi-asserted-by":"publisher","first-page":"e04123","DOI":"10.7554\/eLife.04123","article-title":"Phase transitions of multivalent proteins can promote clustering of membrane receptors","volume":"3","author":"Banjade","year":"2014","journal-title":"Elife"},{"key":"B108","doi-asserted-by":"publisher","first-page":"E6426","DOI":"10.1073\/pnas.1508778112","article-title":"Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck","volume":"112","author":"Banjade","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B109","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1681\/ASN.2009010011","article-title":"Phosphorylation of nephrin triggers its internalization by raft-mediated endocytosis","volume":"20","author":"Qin","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"a016725","DOI":"10.1101\/cshperspect.a016725","article-title":"Molecular structure, function, and dynamics of clathrin-mediated membrane traffic","volume":"6","author":"Kirchhausen","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B111","doi-asserted-by":"publisher","first-page":"4401","DOI":"10.1172\/JCI65289","article-title":"Role of dynamin, synaptojanin, and endophilin in podocyte foot processes","volume":"122","author":"Soda","year":"2012","journal-title":"J Clin Invest"},{"key":"B112","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fped.2017.00032","article-title":"Endocytic trafficking at the mature podocyte slit diaphragm","volume":"5","author":"Swiatecka-Urban","year":"2017","journal-title":"Front Pediatr"},{"key":"B113","doi-asserted-by":"publisher","first-page":"28932","DOI":"10.1074\/jbc.M112.389452","article-title":"Dynamin-mediated nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells","volume":"287","author":"Jeon","year":"2012","journal-title":"J Biol Chem"},{"key":"B114","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1053\/ajkd.2002.35676","article-title":"A missense mutation in the nephrin gene impairs membrane targeting","volume":"40","author":"Shimizu","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"B115","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1093\/ndt\/18.1.70","article-title":"Altered ultrastructural distribution of nephrin in minimal change nephrotic syndrome","volume":"18","author":"Wernerson","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"B116","doi-asserted-by":"publisher","first-page":"e10185","DOI":"10.1371\/journal.pone.0010185","article-title":"Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis","volume":"5","author":"Tossidou","year":"2010","journal-title":"PLoS One"},{"key":"B117","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1681\/ASN.2014040340","article-title":"Deficiency of the planar cell polarity protein Vangl2 in podocytes affects glomerular morphogenesis and increases susceptibility to injury","volume":"26","author":"Rocque","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"B118","doi-asserted-by":"publisher","first-page":"2637","DOI":"10.1093\/hmg\/10.23.2637","article-title":"Defective nephrin trafficking caused by missense mutations in the NPHS1 gene: insight into the mechanisms of congenital nephrotic syndrome","volume":"10","author":"Liu","year":"2001","journal-title":"Hum Mol Genet"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1097\/01.ASN.0000129826.28932.FD","article-title":"Defective trafficking of nephrin missense mutants rescued by a chemical chaperone","volume":"15","author":"Liu","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"B120","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1093\/hmg\/ddp232","article-title":"Predisposition to relapsing nephrotic syndrome by a nephrin mutation that interferes with assembly of functioning microdomains","volume":"18","author":"Shono","year":"2009","journal-title":"Hum Mol Genet"},{"key":"B121","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/sj.ki.5002110","article-title":"A familial childhood-onset relapsing nephrotic syndrome","volume":"71","author":"Kitamura","year":"2007","journal-title":"Kidney Int"},{"key":"B122","doi-asserted-by":"publisher","first-page":"e0184575","DOI":"10.1371\/journal.pone.0184575","article-title":"ARF6 mediates nephrin tyrosine phosphorylation-induced podocyte cellular dynamics","volume":"12","author":"Lin","year":"2017","journal-title":"PLoS One"},{"key":"B123","doi-asserted-by":"publisher","first-page":"e0148906","DOI":"10.1371\/journal.pone.0148906","article-title":"Integrin ligation results in nephrin tyrosine phosphorylation in vitro","volume":"11","author":"Verma","year":"2016","journal-title":"PLoS One"},{"key":"B124","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1159\/000432406","article-title":"Co-inheritance of functional podocin variants with heterozygous collagen IV mutations predisposes to renal failure","volume":"130","author":"Stefanou","year":"2015","journal-title":"Nephron"},{"key":"B125","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1681\/ASN.2014030278","article-title":"A potential role for mechanical forces in the detachment of podocytes and the progression of CKD","volume":"26","author":"Kriz","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00467-016-3358-9","article-title":"Mechanical challenges to the glomerular filtration barrier: adaptations and pathway to sclerosis","volume":"32","author":"Kriz","year":"2017","journal-title":"Pediatr Nephrol"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.kint.2017.02.032","article-title":"Potential relevance of shear stress for slit diaphragm and podocyte function","volume":"91","author":"Kriz","year":"2017","journal-title":"Kidney Int"},{"key":"B128","doi-asserted-by":"publisher","first-page":"e1519","DOI":"10.1038\/cddis.2014.476","article-title":"The Hippo Pathway is controlled by angiotensin II signaling and its reactivation induces apoptosis in podocytes","volume":"5","author":"Wennmann","year":"2014","journal-title":"Cell Death Dis"},{"key":"B129","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1681\/ASN.2014090916","article-title":"Podocyte-specific deletion of yes-associated protein causes FSGS and progressive renal failure","volume":"27","author":"Schwartzman","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1681\/ASN.2014090940","article-title":"Genome-wide analysis of Wilms\u2019 tumor 1-controlled gene expression in podocytes reveals key regulatory mechanisms","volume":"26","author":"Kann","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"B131","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s00467-016-3395-4","article-title":"Genotype-phenotype analysis of pediatric patients with WT1 glomerulopathy","volume":"32","author":"Ahn","year":"2017","journal-title":"Pediatr Nephrol"},{"key":"B132","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00467-017-3801-6","article-title":"Analysis of 24 genes reveals a monogenic cause in 11.1% of cases with steroid-resistant nephrotic syndrome at a single center","volume":"33","author":"Tan","year":"2018","journal-title":"Pediatr Nephrol"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1126\/science.1106215","article-title":"A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis","volume":"308","author":"Winn","year":"2005","journal-title":"Science"},{"key":"B134","doi-asserted-by":"publisher","first-page":"F393","DOI":"10.1152\/ajprenal.00186.2015","article-title":"TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases","volume":"309","author":"Ilatovskaya","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1007\/s00467-015-3224-1","article-title":"Calcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapies","volume":"31","author":"Wieder","year":"2016","journal-title":"Pediatr Nephrol"},{"key":"B136","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1126\/science.aal4178","article-title":"A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models","volume":"358","author":"Zhou","year":"2017","journal-title":"Science"},{"key":"B137","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nrneph.2018.4","article-title":"Renal physiology: TRPC5 inhibition to treat progressive kidney disease","volume":"14","author":"van der Wijst","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1681\/ASN.2015030318","article-title":"TRPC6 G757D loss-of-function mutation associates with FSGS","volume":"27","author":"Riehle","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B139","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1681\/ASN.2011040370","article-title":"Balancing calcium signals through TRPC5 and TRPC6 in podocytes","volume":"22","author":"Greka","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1091\/mbc.e10-12-0929","article-title":"Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-\u03b31 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis","volume":"22","author":"Kanda","year":"2011","journal-title":"Mol Biol Cell"},{"key":"B141","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.semnephrol.2016.09.005","article-title":"Personalized comments on challenges and opportunities in kidney disease therapeutics: the glom-NExT symposium","volume":"36","author":"Greka","year":"2016","journal-title":"Semin Nephrol"},{"key":"B142","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1091\/mbc.E15-04-0223","article-title":"Angiotensin II down-regulates nephrin-Akt signaling and induces podocyte injury: role of c-Abl","volume":"27","author":"Yang","year":"2016","journal-title":"Mol Biol Cell"},{"key":"B143","doi-asserted-by":"publisher","first-page":"12047","DOI":"10.1038\/s41598-017-12134-8","article-title":"Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function","volume":"7","author":"Sagar","year":"2017","journal-title":"Sci Rep"},{"key":"B144","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s11427-015-4844-1","article-title":"An update: the role of nephrin inside and outside the kidney","volume":"58","author":"Li","year":"2015","journal-title":"Sci China Life Sci"},{"key":"B145","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s00418-011-0903-2","article-title":"Comparative analysis of Neph gene expression in mouse and chicken development","volume":"137","author":"V\u00f6lker","year":"2012","journal-title":"Histochem Cell Biol"},{"key":"B146","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1681\/ASN.V11122306","article-title":"Evaluation of a new tool for exploring podocyte biology: mouse Nphs1 5\u2019 flanking region drives LacZ expression in podocytes","volume":"11","author":"Moeller","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"B147","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1093\/hmg\/ddr106","article-title":"The podocyte protein nephrin is required for cardiac vessel formation","volume":"20","author":"Wagner","year":"2011","journal-title":"Hum Mol Genet"},{"key":"B148","doi-asserted-by":"publisher","first-page":"161","DOI":"10.18926\/AMO\/32022","article-title":"Nephrin is an important component of the barrier system in the testis","volume":"55","author":"Liu","year":"2001","journal-title":"Acta Med Okayama"},{"key":"B149","doi-asserted-by":"publisher","first-page":"190","DOI":"10.2337\/db09-0655","article-title":"Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release","volume":"59","author":"Fornoni","year":"2010","journal-title":"Diabetes"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1681\/ASN.2015020210","article-title":"Nephrin contributes to insulin secretion and affects mammalian target of rapamycin signaling independently of insulin receptor","volume":"27","author":"Villarreal","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1681\/ASN.2015080960","article-title":"Nephrin trafficking beyond the kidney \u2013 role in glucose-stimulated insulin secretion in \u03b2 cells","volume":"27","author":"Lehtonen","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B152","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1111\/tra.12178","article-title":"Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity","volume":"15","author":"Gu","year":"2014","journal-title":"Traffic"},{"key":"B153","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/nm.3843","article-title":"Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models","volume":"21","author":"Schiffer","year":"2015","journal-title":"Nat Med"},{"key":"B154","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1681\/ASN.2015080888","article-title":"Klotho may ameliorate Proteinuria by targeting TRPC6 channels in podocytes","volume":"28","author":"Kim","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1681\/ASN.2015080885","article-title":"Sildenafil prevents podocyte injury via PPAR-\u03b3-mediated TRPC6 inhibition","volume":"28","author":"Sonneveld","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B156","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1056\/NEJMc1400502","article-title":"Abatacept in B7-1-positive proteinuric kidney disease","volume":"370","author":"Greka","year":"2014","journal-title":"N Engl J Med"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.354","article-title":"An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model","volume":"5","author":"Zhou","year":"2017","journal-title":"Pharmacol Res Perspect"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1681\/ASN.2017060690","article-title":"Laminin-521 protein therapy for glomerular basement membrane and podocyte abnormalities in a model of pierson syndrome","volume":"29","author":"Lin","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"B159","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.chembiol.2017.11.006","article-title":"GDC-0879, a BRAFV600EInhibitor, protects kidney podocytes from death","volume":"25","author":"Sieber","year":"2018","journal-title":"Cell Chem Biol"},{"key":"B160","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1158\/0008-5472.CAN-08-3563","article-title":"Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase\/mitogen-activated protein kinase pathway suppression","volume":"69","author":"Hoeflich","year":"2009","journal-title":"Cancer Res"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2018.00302\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:59:28Z","timestamp":1661389168000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2018.00302\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,5]]},"references-count":160,"alternative-id":["10.3389\/fendo.2018.00302"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2018.00302","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,5]]},"article-number":"302"}}