{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T19:00:19Z","timestamp":1775588419793,"version":"3.50.1"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T00:00:00Z","timestamp":1529625600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2018.00337","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T04:21:41Z","timestamp":1529641301000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Peculiarities of Precocious Puberty in Boys and Girls With McCune-Albright Syndrome"],"prefix":"10.3389","volume":"9","author":[{"given":"Domenico","family":"Corica","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Aversa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Pepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Wasniewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1750-1172-3-12","article-title":"McCune-Albright syndrome","volume":"3","author":"Dumitrescu","year":"2008","journal-title":"Orphanet J Rare Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1210\/jc.2003-031225","article-title":"European Collaborative Study. Activating Gsalpha mutations: analysis of 113 patients with signs of McCune-Albright syndrome - a European Collaborative Study","volume":"89","author":"Lumbroso","year":"2004","journal-title":"J Clin Endocrinol Metab."},{"key":"B3","first-page":"395","article-title":"GNAS mutation detection is related to disease severity in girls with McCune-Albright syndrome and precocious puberty","volume":"4","author":"Wagoner","year":"2007","journal-title":"Pediatr Endocrinol Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1210\/jcem-58-6-1161","article-title":"Absence of pubertal gonadotropin secretion in girls with McCune-Albright syndrome","volume":"58","author":"Foster","year":"1984","journal-title":"J Clin Endocrinol Metab."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1056\/NEJM198410183111607","article-title":"Cyclical ovarian function resistant to treatment with an analogue of luteinizing hormone releasing hormone in McCune-Albright syndrome","volume":"311","author":"Comite","year":"1984","journal-title":"N Engl J Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1111\/j.1651-2227.1987.tb10576.x","article-title":"Precocious puberty in the McCune-Albright syndrome. Progression from gonadotrophin-independent to gonadotrophin-dependent puberty in a girl","volume":"76","author":"Pasquino","year":"1987","journal-title":"Acta Paediatr Scand."},{"key":"B7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1515\/JPEM.1998.11.1.77","article-title":"Secondary central precocious puberty in a girl with McCune-Albright syndrome responds to treatment with GnRH analogue","volume":"11","author":"Schmidt","year":"1998","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B8","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1365-2265.1986.tb03263.x","article-title":"Autonomous ovarian hyperfunction followed by gonadotrophin-dependent puberty in McCune-Albright syndrome","volume":"24","author":"Kaufman","year":"1986","journal-title":"Clin Endocrinol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"136","DOI":"10.17458\/per.vol15.2017.nau.treatmentgirlsboys","article-title":"Treatment of Girls and Boys with McCune-Albright Syndrome with Precocious Puberty - Update 2017","volume":"15","author":"Neyman","year":"2017","journal-title":"Pediatr Endocrinol Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1515\/JPEM.2006.19.S2.619","article-title":"Clinical presentation of McCune-Albright syndrome in males","volume":"19","author":"Wasniewska","year":"2006","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3538","DOI":"10.1093\/hmg\/ddl430","article-title":"Unexpected mosaicism of R201H-GNAS1 mutant bearing cells in the testes underlie macroorchidism without sexual precocity in McCune-Albright syndrome","volume":"15","author":"Rey","year":"2006","journal-title":"Hum Mol Genet."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1210\/jc.86.6.2625","article-title":"Dynamics of ovarian function in an adult woman with McCune-Albright syndrome","volume":"86","author":"Laven","year":"2001","journal-title":"J Clin Endocrinol Metab."},{"key":"B13","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1515\/JPEM.2006.19.S2.607","article-title":"McCune-Albright syndrome: persistence of autonomous ovarian hyperfunction during adolescence and early adult age","volume":"19","author":"Matarazzo","year":"2006","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B14","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1186\/1750-1172-7-S1-S4","article-title":"McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia","volume":"7","author":"Collins","year":"2012","journal-title":"Orphanet J Rare Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S1083-3188(97)70075-5","article-title":"Persistence of autonomous ovarian activity after discontinuation of therapy for precocious puberty in McCune-Albright syndrome","volume":"10","author":"Escobar","year":"1997","journal-title":"J Pediatr Adolesc Gynecol."},{"key":"B16","first-page":"903","article-title":"Ovarian function in three female patients with McCune-Albright syndrome with persistent autonomous ovarian activity","volume":"15","author":"Maesaka","year":"2002","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e169","DOI":"10.1016\/j.jpag.2015.04.001","article-title":"Postpubertal persistent hyperestrogenemia in McCune-Albright syndrome: unilateral oophorectomy improved fertility but detected an unexpected borderline epithelial ovarian tumor","volume":"28","author":"Chevalier","year":"2015","journal-title":"J Pediatr Adolesc Gynecol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1515\/jpem.2011.265","article-title":"Ovarian function in adolescents with McCune-Albright syndrome","volume":"24","author":"Sotomayor","year":"2011","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1001\/jama.1986.03380210076028","article-title":"McCune-Albright syndrome. Long-term follow-up","volume":"256","author":"Lee","year":"1986","journal-title":"JAMA"},{"key":"B20","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1530\/acta.0.1090254","article-title":"Testolactone treatment of precocious puberty in McCune-Albright syndrome","volume":"109","author":"Foster","year":"1985","journal-title":"Acta Endocrinol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1056\/NEJM198610303151802","article-title":"Treatment of precocious puberty in the McCune-Albright syndrome with the aromatase inhibitor testolactone","volume":"315","author":"Feuillan","year":"1986","journal-title":"N Engl J Med."},{"key":"B22","first-page":"647","article-title":"Long-term testolactone therapy for precocious puberty in girls with McCune-Albright syndrome","volume":"77","author":"Feuillan","year":"1993","journal-title":"J Clin Endocrinol Metab."},{"key":"B23","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1515\/JPEM.1999.12.1.81","article-title":"Ketoconazole treatment of gonadotropin independent precocious puberty in girls with McCune-Albright syndrome: a preliminary report","volume":"12","author":"Syed","year":"1999","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5730","DOI":"10.1210\/jc.2003-030864","article-title":"Lack of efficacy of fadrozole in treating precocious puberty in girls with the McCune-Albright syndrome","volume":"88","author":"Nunez","year":"2003","journal-title":"J Clin Endocrinol Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2751","DOI":"10.1210\/jc.2007-2090","article-title":"The aromatase inhibitor anastrozole is ineffective in the treatment of precocious puberty in girls with McCune-Albright syndrome","volume":"93","author":"Mieszczak","year":"2008","journal-title":"J Clin Endocrinol Metab."},{"key":"B26","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1515\/jpem-2011-0472","article-title":"Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome","volume":"25","author":"Alves","year":"2012","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1210\/jc.2006-2350","article-title":"Letrozole treatment of precocious puberty in girls with the McCune-Albright syndrome: a pilot study","volume":"92","author":"Feuillan","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1016\/j.jpag.2011.09.005","article-title":"Diagnosis and management of precocious puberty in atypical presentations of McCune-Albright syndrome: a case series review","volume":"25","author":"Bercaw-Pratt","year":"2012","journal-title":"J Pediatr Adolesc Gynecol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1530\/EJE-16-0526","article-title":"Long-term outcomes of letrozole treatment for precocious puberty in girls with McCune-Albright syndrome","volume":"175","author":"Estrada","year":"2016","journal-title":"Eur J Endocrinol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S0022-3476(03)00128-8","article-title":"Tamoxifen treatment for precocious puberty in McCune-Albright syndrome; a multicenter trial","volume":"143","author":"Eugster","year":"2003","journal-title":"J Pediatr."},{"key":"B31","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1515\/JPEM.2006.19.1.81","article-title":"Tamoxifen improved final height prediction in a girl with McCune-Albright syndrome: patient report and literature review","volume":"19","author":"Sawathiparnich","year":"2006","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B32","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1159\/000435881","article-title":"Tamoxifen improves final height prediction in girls with McCune-Albright syndrome: a long follow-up","volume":"84","author":"de","year":"2015","journal-title":"Horm Res Paediatr."},{"key":"B33","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1687-9856-2012-26","article-title":"Fulvestrant treatment of precocious puberty in girls with McCune-Albright syndrome","volume":"2012","author":"Sims","year":"2012","journal-title":"Int J Pediatr Endocrinol."},{"key":"B34","first-page":"174","article-title":"Sexual precocity due to McCune-Albright syndrome: report of a case","volume":"92","author":"Chen","year":"1993","journal-title":"J Formos Med Assoc."},{"key":"B35","first-page":"205","article-title":"McCune-Albright syndrome","volume":"5","author":"Feuillan","year":"1994","journal-title":"Curr Ther Endocrinol Metab."},{"key":"B36","first-page":"399","article-title":"A Case of Atypical McCune-Albright Syndrome with Vaginal Bleeding","volume":"21","author":"Rostampour","year":"2011","journal-title":"Iran J Pediatr."},{"key":"B37","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/BF03349073","article-title":"Effects of cyproterone acetate, LHRH agonist and ovarian surgery in McCune-Albright syndrome with precocious puberty and galactorrhea","volume":"11","author":"Carani","year":"1988","journal-title":"J Endocrinol Invest."},{"key":"B38","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1530\/acta.0.1150044","article-title":"The effects of cyproterone acetate on statural growth in children with precocious puberty","volume":"115","author":"Sorgo","year":"1987","journal-title":"Acta Endocrinol."},{"key":"B39","first-page":"29","article-title":"McCune Albright Syndrome (MCAS): a case series","volume":"40","author":"Rao","year":"2003","journal-title":"Indian Pediatr"},{"key":"B40","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1515\/JPEM.2006.19.S2.571","article-title":"Laparoscopic management of ovarian cysts in peripheral precocious puberty of McCune-Albright syndrome","volume":"19","author":"Gesmundo","year":"2006","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B41","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1542\/peds.8.5.684","article-title":"Sexual precocity in females; report of two cases, with arrest of precocity in the McCune-Albright syndrome after removal of a cystic ovary","volume":"8","author":"Pray","year":"1951","journal-title":"Pediatrics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1515\/jpem.2010.135","article-title":"McCune-Albright syndrome (MAS): early and extensive bone fibrous dysplasia involvement and \u201cmistaken identity\u201d oophorectomy","volume":"23","author":"Gucev","year":"2010","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.jpedsurg.2007.04.021","article-title":"Oophorectomy in McCune-Albright syndrome: a case of mistaken identity","volume":"42","author":"Nabhan","year":"2007","journal-title":"J Pediatr Surg."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1210\/jc.2003-031245","article-title":"Management of infertility in a patient presenting with ovarian dysfunction and McCune-Albright syndrome","volume":"89","author":"Laven","year":"2004","journal-title":"J Clin Endocrinol Metab."},{"key":"B45","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1530\/EJE-07-0482","article-title":"Restoration of ovulation after unilateral ovariectomy in a woman with McCune-Albright syndrome: a case report","volume":"158","author":"Lavou\u00e9","year":"2008","journal-title":"Eur J Endocrinol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"E314","DOI":"10.1210\/jc.2012-3551","article-title":"Virilizing sclerosing-stromal tumor of the ovary in a young woman with McCune Albright syndrome: clinical, pathological, and immunohistochemical studies","volume":"98","author":"Boussa\u00efd","year":"2013","journal-title":"J Clin Endocrinol Metab."},{"key":"B47","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/BF03349264","article-title":"Combined treatment with ketoconazole and cyproterone acetate in a boy with McCune-Albright syndrome and peripheral precocious puberty","volume":"31","author":"Messina","year":"2008","journal-title":"J Endocrinol Invest."},{"key":"B48","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1530\/EJE-07-0494","article-title":"Regulation of spermatogenesis in McCune-Albright syndrome: lessons from a 15-year follow-up","volume":"158","author":"De Luca","year":"2008","journal-title":"Eur J Endocrinol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1159\/000091279","article-title":"McCune-Albright syndrome in a boy may present with a monolateral macroorchidism as an early and isolated clinical manifestation","volume":"65","author":"Arrigo","year":"2006","journal-title":"Horm Res"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1007\/s12098-011-0380-6","article-title":"Macroorchidism in an Indian boy with McCune-Albright syndrome","volume":"78","author":"Rustagi","year":"2011","journal-title":"Indian J Pediatr."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1210\/jc.86.4.1778","article-title":"Macroorchidism due to autonomous hyperfunction of Sertoli cells and Gs gene mutation: an unusual expression of McCune-Albright syndrome in a prepubertal boy","volume":"86","author":"Coutant","year":"2001","journal-title":"J Clin Endocrinol Metab."},{"key":"B52","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1159\/000284365","article-title":"Unusual phenotypical variations in a boy with McCune-Albright syndrome","volume":"73","author":"Mamkin","year":"2010","journal-title":"Horm Res Paediatr."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1016\/S0022-5347(05)65506-1.","article-title":"The prevalence of testicular microlithiasis in an asymptomatic population of men 18 to 35 years old","volume":"166","author":"Peterson","year":"2001","journal-title":"J Urol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.jpeds.2004.06.083","article-title":"Testicular microlithiasis: an unreported feature of McCune-Albright syndrome in males","volume":"145","author":"Wasniewska","year":"2004","journal-title":"J Pediatr."},{"key":"B55","doi-asserted-by":"publisher","first-page":"E1782","DOI":"10.1210\/jc.2012-1791","article-title":"Characterization and management of testicular pathology in McCune-Albright syndrome","volume":"97","author":"Boyce","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"key":"B56","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1515\/JPEM.2005.18.1.33","article-title":"Paediatric management of endocrine complications in McCune-Albright syndrome","volume":"18","author":"Zacharin","year":"2005","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B57","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1507\/endocrj.EJ11-0214","article-title":"Combined treatment with bicalutamide and anastrozole in a young boy with peripheral precocious puberty due to McCune-Albright Syndrome","volume":"59","author":"Tessaris","year":"2012","journal-title":"Endocr J."},{"key":"B58","doi-asserted-by":"publisher","first-page":"286","DOI":"10.14310\/horm.2002.1515","article-title":"Adult height following a combined treatment of ketoconazole - cyproterone acetate - leuprolide depot in a boy with atypical McCune-Albright syndrome","volume":"14","author":"Messina","year":"2015","journal-title":"Hormones"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2018.00337\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T04:14:58Z","timestamp":1661487298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2018.00337\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,22]]},"references-count":58,"alternative-id":["10.3389\/fendo.2018.00337"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2018.00337","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,22]]},"article-number":"337"}}