{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:42:45Z","timestamp":1791301365270,"version":"4.1.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["NS073574"],"award-info":[{"award-number":["NS073574"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["NS102937"],"award-info":[{"award-number":["NS102937"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["K12GM074869"],"award-info":[{"award-number":["K12GM074869"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2018.00703","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:52:00Z","timestamp":1542934320000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":64,"title":["A Novel, Synthetic, Neuroactive Steroid Is Effective at Decreasing Depression-Like Behaviors and Improving Maternal Care in Preclinical Models of Postpartum Depression"],"prefix":"10.3389","volume":"9","author":[{"given":"Laverne","family":"Mel\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Hammond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,11,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1097\/01.AOG.0000183597.31630.db","article-title":"Perinatal depression: a systematic review of prevalence and incidence","volume":"106","author":"Gavin","year":"2005","journal-title":"Obstet Gynecol."},{"key":"B2","first-page":"301","article-title":"Perinatal mood disorders: position paper","volume":"34","author":"Steiner","year":"1998","journal-title":"Psychopharmacol Bull."},{"key":"B3","volume-title":"Risk Factors for Postpartum Depression","author":"Robertson","year":"2008"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.4088\/JCP.v67n0818","article-title":"Anxiety disorders during pregnancy and the postpartum period: a systematic review","volume":"67","author":"Ross","year":"2006","journal-title":"J Clin Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0033-3182(98)71355-6","article-title":"Hormonal changes in the postpartum and implications for postpartum depression","volume":"39","author":"Hendrick","year":"1998","journal-title":"Psychosomatics"},{"key":"B6","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1176\/appi.ajp.157.6.924","article-title":"Effects of gonadal steroids in women with a history of postpartum depression","volume":"157","author":"Bloch","year":"2000","journal-title":"AJP"},{"key":"B7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0029-7844(00)01112-1","article-title":"Serum allopregnanolone in women with postpartum \u201cblues\u201d","volume":"97","author":"Nappi","year":"2001","journal-title":"Obstet Gynecol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1159\/000358838","article-title":"Low serum allopregnanolone is associated with symptoms of depression in late pregnancy","volume":"69","author":"Hellgren","year":"2014","journal-title":"Neuropsychobiology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1523\/JNEUROSCI.4945-06.2007","article-title":"Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress","volume":"27","author":"Maguire","year":"2007","journal-title":"J Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neuron.2008.06.019","article-title":"GABA(A)R plasticity during pregnancy: relevance to postpartum depression","volume":"59","author":"Maguire","year":"2008","journal-title":"Neuron"},{"key":"B11","doi-asserted-by":"publisher","first-page":"9592","DOI":"10.1523\/JNEUROSCI.2162-09.2009","article-title":"Excitability changes related to GABAA receptor plasticity during pregnancy","volume":"29","author":"Maguire","year":"2009","journal-title":"J Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/nn1469","article-title":"Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety","volume":"8","author":"Maguire","year":"2005","journal-title":"Nat Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"12757","DOI":"10.1523\/JNEUROSCI.3340-09.2009","article-title":"Extrasynaptic GABAA receptors: form, pharmacology, and function","volume":"29","author":"Belelli","year":"2009","journal-title":"J Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"S84","DOI":"10.1016\/j.psyneuen.2009.06.019","article-title":"Steroid hormone fluctuations and GABA(A)R plasticity","volume":"34","author":"Maguire","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nrn1625","article-title":"Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors","volume":"6","author":"Farrant","year":"2005","journal-title":"Nat Rev Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2762518","DOI":"10.1155\/2016\/2762518","article-title":"Behavioral deficits in juveniles mediated by maternal stress hormones in mice","volume":"25016","author":"Maguire","year":"2016","journal-title":"Neural Plast."},{"key":"B17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0079-6123(06)60005-8","article-title":"The cellular, molecular and ionic basis of GABA(A) receptor signalling","volume":"160","author":"Farrant","year":"2007","journal-title":"Prog Brain Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/nn.2274","article-title":"Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis","volume":"12","author":"Hewitt","year":"2009","journal-title":"Nat Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"18198","DOI":"10.1523\/JNEUROSCI.2560-11.2011","article-title":"Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors","volume":"31","author":"Sarkar","year":"2011","journal-title":"J Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.psyneuen.2017.12.003","article-title":"Inability to suppress the stress-induced activation of the HPA axis engenders deficits in postpartum behaviors in mice","volume":"90","author":"Mel\u00f3n","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e2576","DOI":"10.1002\/hup.2576","article-title":"Open\u2013label, proof\u2013of\u2013concept study of brexanolone in the treatment of severe postpartum depression","volume":"32","author":"Kanes","year":"2017","journal-title":"Hum Psychopharmacol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S0140-6736(17)31264-3","article-title":"Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial","volume":"390","author":"Kanes","year":"2017","journal-title":"Lancet"},{"key":"B23","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1677\/joe.0.0130399","article-title":"Modification of the oestrous cycle of the mouse by external stimuli associated with the male","volume":"13","author":"Whitten","year":"1956","journal-title":"J Endocrinol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"Unit16.2","DOI":"10.1002\/0471140856.tx1602s11","article-title":"Guidelines for mating rodents","author":"Tyl","year":"2002","journal-title":"Curr Protocol Toxicol."},{"key":"B25","volume-title":"Guide for the Care and Use of Laboratory Animals.","year":"2011"},{"key":"B26","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.eplepsyres.2017.05.001","article-title":"Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models","volume":"134","author":"Hammond","year":"2017","journal-title":"Epilepsy Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"15327","DOI":"10.1038\/s41598-017-15609-w","article-title":"The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model","volume":"7","author":"Hawkins","year":"","journal-title":"Sci Rep."},{"key":"B28","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.psyneuen.2013.12.011","article-title":"Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors","volume":"41","author":"Lee","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.eplepsyres.2013.10.013","article-title":"Seizure-induced disinhibition of the HPA axis increases seizure susceptibility","volume":"108","author":"O'Toole","year":"2013","journal-title":"Epilepsy Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.eplepsyres.2014.10.003","article-title":"Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility","volume":"109","author":"MacKenzie","year":"2015","journal-title":"Epilepsy Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.lfs.2013.02.014","article-title":"An old method facing a new challenge: re-visiting housekeeping proteins as internal reference control for neuroscience research","volume":"92","author":"Li","year":"2013","journal-title":"Life Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.1007\/s00213-014-3617-z","article-title":"Phosphorylation of GABA(A) receptors influences receptor trafficking and neurosteroid actions","volume":"231","author":"Comenencia-Ortiz","year":"2014","journal-title":"Psychopharmacology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.neuropharm.2016.10.010","article-title":"Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase-\u00e1C-dependent mechanism","volume":"113","author":"Modgil","year":"2017","journal-title":"Neuropharmacology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1113\/jphysiol.2007.146233","article-title":"Attenuated hypothalamo-pituitary-adrenal axis responses to immune challenge during pregnancy: the neurosteroid opioid connection","volume":"586","author":"Brunton","year":"2008","journal-title":"J Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"6449","DOI":"10.1523\/JNEUROSCI.0708-09.2009","article-title":"Central opioid inhibition of neuroendocrine stress responses in pregnancy in the rat is induced by the neurosteroid allopregnanolone","volume":"29","author":"Brunton","year":"2009","journal-title":"J Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3109\/10253890.2010.482628","article-title":"Allopregnanolone and suppressed hypothalamo-pituitary-adrenal axis stress responses in late pregnancy in the rat","volume":"14","author":"Brunton","year":"2011","journal-title":"Stress"},{"key":"B37","doi-asserted-by":"publisher","first-page":"3557","DOI":"10.1007\/s00213-014-3599-x","article-title":"Allopregnanolone as a Mediator of Affective Switching in Reproductive Mood Disorders","volume":"231","author":"Schiller","year":"2014","journal-title":"Psychopharmacology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/IJWH.S6938","article-title":"Treatment of postpartum depression: clinical, psychological and pharmacological options","volume":"3","author":"Fitelson","year":"2011","journal-title":"Int J Women's Health"},{"key":"B39","first-page":"2247","article-title":"Postpartum major depression: detection and treatment","volume":"59","author":"Epperson","year":"1999","journal-title":"Am Fam Phys."}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2018.00703\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:52:02Z","timestamp":1542934322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2018.00703\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,23]]},"references-count":39,"alternative-id":["10.3389\/fendo.2018.00703"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2018.00703","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734616034.793560289","asserted-by":"object"}]},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,23]]},"article-number":"703"}}