{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:17:25Z","timestamp":1787584645544,"version":"build-2736575974"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2018.00734","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T04:35:47Z","timestamp":1544502947000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Effects of FSH on Sperm DNA Fragmentation: Review of Clinical Studies and Possible Mechanisms of Action"],"prefix":"10.3389","volume":"9","author":[{"given":"Monica","family":"Muratori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,12,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1210\/en.2018-00452","article-title":"FSH receptor signaling: complexity of interactions and signal diversity","volume":"159","author":"Ulloa-Aguirre","year":"2018","journal-title":"Endocrinology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.beem.2018.01.001","article-title":"Pharmacogenetics of G-protein-coupled receptors variants: FSH receptor and infertility treatment","volume":"32","author":"Santi","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"key":"B3","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/humupd\/dmy019","article-title":"Clinical relevance of genetic variants of gonadotrophins and their receptors in controlled ovarian stimulation: a systematic review and meta-analysis","volume":"24","author":"Alviggi","year":"2018","journal-title":"Hum Reprod Update"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1210\/jcem.85.9.6789","article-title":"Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype","volume":"85","author":"Perez","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"key":"B5","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1097\/01.fpc.0000167330.92786.5e","article-title":"Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation","volume":"15","author":"Behre","year":"2005","journal-title":"Pharmacogenet Genomics"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1093\/humrep\/dew167","article-title":"Treatment with human, recombinant FSH improves sperm DNA fragmentation in idiopathic infertile men depending on the FSH receptor polymorphism p","volume":"31","author":"Simoni","year":"2016","journal-title":"Hum Reprod."},{"key":"B7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12881-017-0441-4","article-title":"The susceptibility of FSHB\u2212211G > T and FSHR G-29A, 919A > G, 2039A > G polymorphisms to men infertility: an association study and meta-analysis","volume":"18","author":"Wu","year":"","journal-title":"BMC Med Genet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1046\/j.1365-2265.1999.00846.x","article-title":"Role of FSH in the regulation of spermatogenesis: clinical aspects","volume":"51","author":"Nieschlag","year":"1999","journal-title":"Clin Endocrinol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/ng0297-201","article-title":"Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility","volume":"15","author":"Kumar","year":"1997","journal-title":"Nat Genet."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1210\/endo.141.5.7456","article-title":"The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction","volume":"141","author":"Abel","year":"2000","journal-title":"Endocrinology"},{"key":"B11","doi-asserted-by":"crossref","first-page":"13612","DOI":"10.1073\/pnas.95.23.13612","article-title":"Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance","volume":"95","author":"Dierich","year":"1998","journal-title":"Proc Natl Acad Sci USA."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1016\/S0015-0282(16)57619-5","article-title":"Recombinant human follicle-stimulating hormone and human chorionic gonadotropin for induction of spermatogenesis in a hypogonadotropic male","volume":"63","author":"Kliesch","year":"1995","journal-title":"Fertil Steril."},{"key":"B13","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1507\/endocrj.EJ17-0001","article-title":"Gonadotoropin actions on spermatogenesis and hormonal therapies for spermatogenic disorders [Review]","volume":"64","author":"Shiraishi","year":"2017","journal-title":"Endocr J"},{"key":"B14","first-page":"133","article-title":"Effect of follicle-stimulating hormone on sperm quality and pregnancy rate","volume":"6","author":"Baccetti","year":"2004","journal-title":"Asian J Androl."},{"key":"B15","doi-asserted-by":"publisher","first-page":"588","DOI":"10.2164\/jandrol.111.013326","article-title":"Recombinant human FSH reduces sperm DNA fragmentation in men with idiopathic oligoasthenoteratozoospermia","volume":"33","author":"Colacurci","year":"2012","journal-title":"J Androl."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1016\/S0015-0282(03)02202-7","article-title":"Recombinant human follicle-stimulating hormone as a pretreatment for idiopathic oligoasthenoteratozoospermic patients undergoing intracytoplasmic sperm injection","volume":"80","author":"Caroppo","year":"2003","journal-title":"Fertil Steril."},{"key":"B17","doi-asserted-by":"publisher","first-page":"679","DOI":"10.2164\/jandrol.108.007278","article-title":"The efficacy of recombinant human follicle-stimulating hormone in the treatment of various types of male-factor infertility at a single university hospital","volume":"30","author":"Efesoy","year":"2009","journal-title":"J Androl."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s40618-018-0843-y","article-title":"The use of follicle stimulating hormone (FSH) for the treatment of the infertile man: position statement from the Italian Society of Andrology and Sexual Medicine (SIAMS)","volume":"41","author":"Barbonetti","year":"2018","journal-title":"J Endocrinol Invest."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005071.pub4","article-title":"Gonadotrophins for idiopathic male factor subfertility","author":"Attia","year":"2013","journal-title":"Cochrane Database Syst Rev."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1530\/EC-15-0050","article-title":"FSH treatment of male idiopathic infertility improves pregnancy rate: a meta-analysis","author":"Santi","year":"2015","journal-title":"Endocr Connect"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1056\/NEJMoa003005","article-title":"Sperm morphology, motility, and concentration in fertile and infertile men","volume":"345","author":"Guzick","year":"2001","journal-title":"N Engl J Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1093\/humrep\/deu082","article-title":"Semen analysis and prediction of natural conception","volume":"29","author":"Leushuis","year":"2014","journal-title":"Hum Reprod."},{"key":"B23","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1111\/andr.12333","article-title":"Short-term FSH treatment and sperm maturation: a prospective study in idiopathic infertile men","volume":"5","author":"Casamonti","year":"2017","journal-title":"Andrology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"566","DOI":"10.2164\/jandrol.109.008912","article-title":"Spermatozoa bound to solid state hyaluronic acid show chromatin structure with high DNA chain integrity: an acridine orange fluorescence study","volume":"31","author":"Yagci","year":"2010","journal-title":"J Androl."},{"key":"B25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/aja.2011.59","article-title":"Mechanisms and clinical correlates of sperm DNA damage","volume":"14","author":"Tamburrino","year":"2012","journal-title":"Asian J Androl."},{"key":"B26","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1111\/andr.12381","article-title":"DNA fragmentation in spermatozoa: a historical review","volume":"5","author":"Rex","year":"2017","journal-title":"Andrology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1080\/14647270410001720464","article-title":"Bizzaro: the presence of abnormal spermatozoa in the ejaculate: did apoptosis fail?","volume":"7","author":"Sakkas","year":"2004","journal-title":"Hum Fertil."},{"key":"B28","doi-asserted-by":"publisher","first-page":"109","DOI":"10.2119\/molmed.2014.00158","article-title":"Investigation on the origin of sperm DNA fragmentation: role of apoptosis, immaturity and oxidative stress","volume":"21","author":"Muratori","year":"2015","journal-title":"Mol Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/S1472-6483(10)61886-X","article-title":"Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodelling during spermatogenesis","volume":"7","author":"Sakkas","year":"2003","journal-title":"Reprod Biomed Online"},{"key":"B30","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1093\/biolre\/iox104","article-title":"Reactive oxygen species and protein modifications in spermatozoa","volume":"97","author":"O'Flaherty","year":"2017","journal-title":"Biol Reprod."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1002\/mrd.22871","article-title":"Reactive oxygen species as mediators of sperm capacitation and pathological damage","volume":"84","author":"Aitken","year":"2017","journal-title":"Mol Reprod Dev."},{"key":"B32","doi-asserted-by":"publisher","first-page":"488","DOI":"10.2164\/jandrol.108.005132","article-title":"Oxidative stress: a common factor in testicular dysfunction","volume":"29","author":"Turner","year":"2008","journal-title":"J Androl."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1093\/humrep\/deu204","article-title":"Potential importance of transition metals in the induction of DNA damage by sperm preparation media","volume":"29","author":"Aitken","year":"2014","journal-title":"Hum Reprod."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003624","article-title":"Variation of DNA fragmentation levels during density gradient sperm selection for assisted reproduction techniques: a possible new male predictive parameter of pregnancy?","author":"Muratori","year":"2016","journal-title":"Medicine"},{"key":"B35","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1095\/biolreprod.109.076836","article-title":"DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress","volume":"81","author":"De","year":"2009","journal-title":"Biol Reprod."},{"key":"B36","doi-asserted-by":"publisher","first-page":"272","DOI":"10.4103\/1008-682X.174854","article-title":"DNA fragmentation in two cytometric sperm populations: relationship with clinical and ultrasound characteristics of the male genital tract","volume":"19","author":"Lotti","year":"2017","journal-title":"Asian J Androl."},{"key":"B37","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/j.1939-4640.2003.tb02670.x","article-title":"Spontaneous DNA fragmentation in swim-up selected human spermatozoa during long term incubation","volume":"24","author":"Muratori","year":"2003","journal-title":"J Androl."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1016\/j.fertnstert.2009.05.059","article-title":"Processing of semen can result in increased sperm DNA fragmentation","volume":"92","author":"Toro","year":"2009","journal-title":"Fertil Steril."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1016\/j.fertnstert.2008.08.136","article-title":"A dynamic assessment of sperm DNA fragmentation versus sperm viability in proven fertile human donors","volume":"92","author":"Gos\u00e1lvez","year":"2009","journal-title":"Fertil Steril."},{"key":"B40","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/S0015-0282(00)01495-3","article-title":"Influence of initial semen quality on the integrity of human sperm DNA following semen processing","volume":"74","author":"Zini","year":"2000","journal-title":"Fertil Steril."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1093\/humrep\/14.4.1039","article-title":"Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic","volume":"14","author":"Evenson","year":"1999","journal-title":"Hum Reprod."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e221","DOI":"10.1111\/j.1365-2605.2009.00995.x","article-title":"Sperm chromatin structure assay as an independent predictor of fertility in vivo: a case-control study","volume":"33","author":"Giwercman","year":"2010","journal-title":"Int J Androl."},{"key":"B43","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.fertnstert.2015.06.005","article-title":"DNA fragmentation in brighter sperm predicts male fertility independently from age and semen parameters","volume":"104","author":"Muratori","year":"2015","journal-title":"Fertil Steril."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.1093\/humrep\/des261","article-title":"The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis","volume":"27","author":"Robinson","year":"2012","journal-title":"Hum Reprod."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165125","article-title":"Measuring sperm DNA fragmentation and clinical outcomes of medically assisted reproduction: a systematic review and meta-analysis","author":"Cissen","year":"2016","journal-title":"PLoS ONE"},{"key":"B46","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4103\/1008-682X.182822","article-title":"A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome","volume":"19","author":"Simon","year":"2017","journal-title":"Asian J Androl."},{"key":"B47","doi-asserted-by":"publisher","first-page":"935","DOI":"10.21037\/tau.2016.10.03","article-title":"Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios","volume":"5","author":"Agarwal","year":"2016","journal-title":"Transl Androl Urol."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007411.pub3","article-title":"Antioxidants for male subfertility","author":"Showell","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"B49","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1210\/endo.136.1.7828558","article-title":"Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages","volume":"136","author":"Billig","year":"1995","journal-title":"Endocrinology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1210\/endo.137.5.8612566","article-title":"Specific immunoneutralization of FSH leads to apoptotic cell death of the pachytene spermatocytes and spermatogonial cells in the rat","volume":"137","author":"Shetty","year":"1996","journal-title":"Endocrinology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1677\/JOE-07-0637","article-title":"Pathways involved in testicular germ cell apoptosis in immature rats after FSH suppression","volume":"197","author":"Ruwanpura","year":"2008","journal-title":"J Endocrinol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1095\/biolreprod.107.065912","article-title":"Follicle-stimulating hormone affects spermatogonial survival by regulating the intrinsic apoptotic pathway in adult rats","volume":"78","author":"Ruwanpura","year":"2008","journal-title":"Biol Reprod."},{"key":"B53","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.rbmo.2018.06.023","article-title":"Sperm DNA fragmentation index as a promisig predictive tool for male infertility diagnosis and treatment management \u2013 meta-analyses","volume":"37","author":"Santi","year":"2018","journal-title":"RBMO"},{"key":"B54","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.rbmo.2014.02.014","article-title":"Spermatid count as a predictor of response to FSH therapy","volume":"29","author":"Garolla","year":"2014","journal-title":"Reprod Biomed Online"},{"key":"B55","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s10815-013-9951-y","article-title":"Lower sperm DNA fragmentation after r-FSH administration in functional hypogonadotropic hypogonadism","volume":"30","author":"Ruvolo","year":"2013","journal-title":"J Assist Reprod Genet."},{"key":"B56","doi-asserted-by":"publisher","first-page":"747","DOI":"10.3275\/7745","article-title":"Effects of highly purified follicle-stimulating hormone on sperm DNA damage in men with male idiopathic subfertility: a pilot study","volume":"34","author":"Palomba","year":"2011","journal-title":"J Endocrinol Invest."},{"key":"B57","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1007\/s12020-016-1037-z","article-title":"FSH treatment in infertile males candidate to assisted reproduction improved sperm DNA fragmentation and pregnancy rate","volume":"56","author":"Garolla","year":"2017","journal-title":"Endocrine"},{"key":"B58","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3389\/fendo.2018.00383","article-title":"Recombinant FSH Improves Sperm DNA Damage in Male Infertility: A Phase II Clinical Trial","volume":"9","author":"Colacurci","year":"2018","journal-title":"Front Endocrinol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"336","DOI":"10.2164\/jandrol.109.008508","article-title":"Small variations in crucial steps of TUNEL assay coupled to flow cytometry greatly affect measures of sperm DNA fragmentation","volume":"31","author":"Muratori","year":"2010","journal-title":"J Androl."},{"key":"B60","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1002\/cyto.a.20615","article-title":"Comparing flow cytometry and fluorescence microscopy for analyzing human sperm DNA fragmentation by TUNEL labeling","volume":"73","author":"Muratori","year":"2008","journal-title":"Cytometry A"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.fertnstert.2011.09.034","article-title":"Toward a pharmacogenetic approach to male infertility: polymorphism of follicle-stimulating hormone beta-subunit promoter","volume":"96","author":"Ferlin","year":"2011","journal-title":"Fertil Steril."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1210\/endo.137.4.8625923","article-title":"Hormonal regulation of apoptosis in early antral follicles: follicle-stimulating hormone as a major survival factor","volume":"137","author":"Chun","year":"1996","journal-title":"Endocrinology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1210\/en.2005-1281","article-title":"Opposing effects of glutathione depletion and follicle-stimulating hormone on reactive oxygen species and apoptosis in cultured preovulatory rat follicles","volume":"147","author":"Tsai-Turton","year":"2006","journal-title":"Endocrinology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1093\/humrep\/17.7.1811","article-title":"In vitro effects of FSH and testosterone withdrawal on caspase activation and DNA fragmentation in different cell types of human seminiferous epithelium","volume":"17","author":"Tesarik","year":"2002","journal-title":"Hum Reprod."},{"key":"B65","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/sj.cdd.4400799","article-title":"Developmental regulation of the bcl-2 family during spermatogenesis: insights into the sterility of bcl-w-\/- male mice","volume":"8","author":"Meehan","year":"2001","journal-title":"Cell Death Differ."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1210\/me.2005-0395","article-title":"Involvement of p38 mitogen-activated protein kinase and inducible nitric oxide synthase in apoptotic signaling of murine and human male germ cells after hormone deprivation","volume":"20","author":"Vera","year":"2006","journal-title":"Mol Endocrinol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1210\/mend.14.8.0500","article-title":"Follicle-Stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB\/Akt) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinase-independent signaling by FSH in granulosa cells","volume":"14","author":"Gonzalez-Robayna","year":"2000","journal-title":"Mol Endocrinol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1093\/humrep\/12.9.1955","article-title":"The effect of follicle stimulating hormone therapy on human sperm structure (Notulae seminologicae 11)","volume":"12","author":"Baccetti","year":"1997","journal-title":"Hum Reprod."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1095\/biolreprod62.5.1146","article-title":"Qualitative and quantitative decline in spermatogenesis of the follicle-stimulating hormone receptor knockout (FORKO) mouse","volume":"62","author":"Krishnamurthy","year":"2000","journal-title":"Biol Reprod."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1095\/biolreprod52.5.1149","article-title":"Relationship between the presence of endogenous nicks and sperm chromatin packaging in maturing and fertilizing mouse spermatozoa","volume":"52","author":"Sakkas","year":"1995","journal-title":"Biol Reprod."},{"key":"B71","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1095\/biolreprod.103.022541","article-title":"Transient DNA strand breaks during mouse and human spermiogenesis new insights in stage specificity and link to chromatin remodeling","volume":"70","author":"Marcon","year":"2004","journal-title":"Biol Reprod."},{"key":"B72","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.fertnstert.2009.03.033","article-title":"\u201cPhysiologic ICSI\u201d: hyaluronic acid (HA) favors selection of spermatozoa without DNA fragmentation and with normal nucleus, resulting in improvement of embryo quality","volume":"93","author":"Parmegiani","year":"2010","journal-title":"Fertil Steril."}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2018.00734\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T04:35:49Z","timestamp":1544502949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2018.00734\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,11]]},"references-count":72,"alternative-id":["10.3389\/fendo.2018.00734"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2018.00734","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,11]]},"article-number":"734"}}