{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:50:26Z","timestamp":1783486226379,"version":"3.55.0"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001254","name":"Ipsen Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2019.00149","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:53:59Z","timestamp":1552956839000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Should We Assess Pituitary Function in Children After a Mild Traumatic Brain Injury? A Prospective Study"],"prefix":"10.3389","volume":"10","author":[{"given":"Claire","family":"Briet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Lefranc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Toussaint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Boudailliez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Bony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.wneu.2016.03.045","article-title":"Epidemiology of global pediatric traumatic brain injury: qualitative review","volume":"91","author":"Dewan","year":"2016","journal-title":"World Neurosurg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"760","DOI":"10.3171\/2016.1.JNS152385","article-title":"Impact of Glasgow Coma Scale score and pupil parameters on mortality rate and outcome in pediatric and adult severe traumatic brain injury: a retrospective, multicenter cohort study","volume":"126","author":"Emami","year":"2016","journal-title":"J Neurosurg."},{"key":"B3","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1210\/jc.2011-2284","article-title":"Permanent hypopituitarism is rare after structural traumatic brain injury in early childhood","volume":"97","author":"Heather","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"key":"B4","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/cen.12237","article-title":"Pituitary dysfunction after traumatic brain injury in children: is there a need for ongoing endocrine assessment?","volume":"79","author":"Casano-Sancho","year":"2013","journal-title":"Clin Endocrinol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1515\/JPEM.2006.19.5.691","article-title":"Hypothalamo-hypophysial dysfunction after traumatic brain injury in children and adolescents: a preliminary retrospective and prospective study","volume":"19","author":"Einaudi","year":"2006","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B6","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s11102-012-0446-0","article-title":"Measurement of height velocity is an useful marker for monitoring pituitary function in patients who had traumatic brain injury","volume":"16","author":"Bellone","year":"2013","journal-title":"Pituitary."},{"key":"B7","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1089\/neu.2013.2916","article-title":"Hypopituitarism in pediatric survivors of inflicted traumatic brain injury","volume":"31","author":"Auble","year":"2014","journal-title":"J Neurotrauma."},{"key":"B8","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1111\/j.1365-2265.2010.03857.x","article-title":"Evaluation of pituitary function after traumatic brain injury in childhood","volume":"73","author":"Khadr","year":"2010","journal-title":"Clin Endocrinol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1089\/neu.2010.1408","article-title":"Pituitary function at long-term follow-up of childhood traumatic brain injury","volume":"27","author":"Moon","year":"2010","journal-title":"J Neurotrauma."},{"key":"B10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1136\/adc.2007.121137","article-title":"Pituitary function in paediatric survivors of severe traumatic brain injury","volume":"93","author":"Poomthavorn","year":"2008","journal-title":"Arch Dis Child."},{"key":"B11","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s40618-013-0020-2","article-title":"Is routine endocrine evaluation necessary after paediatric traumatic brain injury?","volume":"37","author":"Salomon-Estebanez","year":"2014","journal-title":"J Endocrinol Invest."},{"key":"B12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1089\/neu.2005.369ER","article-title":"Abnormalities of pituitary function after traumatic brain injury in children","volume":"24","author":"Niederland","year":"2007","journal-title":"J Neurotrauma."},{"key":"B13","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1136\/archdischild-2016-311609","article-title":"Pituitary dysfunction after traumatic brain injury: are there definitive data in children?","volume":"102","author":"Casano-Sancho","year":"2017","journal-title":"Arch Dis child."},{"key":"B14","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.ghir.2008.08.007","article-title":"Growth hormone deficient patients after traumatic brain injury\u2013baseline characteristics and benefits after growth hormone replacement\u2013an analysis of the German KIMS database","volume":"18","author":"Kreitschmann-Andermahr","year":"2008","journal-title":"Growth Horm IGF Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.jpeds.2010.07.004","article-title":"Endocrine dysfunction following traumatic brain injury in children","volume":"157","author":"Kaulfers","year":"2010","journal-title":"J Pediatrics."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1177\/0009922810376234","article-title":"Traumatic brain injury in children and adolescents: surveillance for pituitary dysfunction","volume":"49","author":"Norwood","year":"2010","journal-title":"Clin Pediatrics."},{"key":"B17","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1007\/BF03345336","article-title":"Hypopituitarism induced by traumatic brain injury in the transition phase","volume":"28","author":"Aimaretti","year":"2005","journal-title":"J Endocrinol Invest."},{"key":"B18","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1111\/j.1469-8749.2012.04291.x","article-title":"Weight gain after childhood traumatic brain injury: a matter of concern","volume":"54","author":"Jourdan","year":"2012","journal-title":"Dev Med Child Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s00381-013-2334-y","article-title":"Prospective investigation of anterior pituitary function in the acute phase and 12 months after pediatric traumatic brain injury","volume":"30","author":"Ulutabanca","year":"2014","journal-title":"Childs Nerv Syst."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1210\/jc.2013-4129","article-title":"Prevalence of pituitary dysfunction after severe traumatic brain injury in children and adolescents: a large prospective study","volume":"99","author":"Personnier","year":"2014","journal-title":"J Clin Endocrinol Metab."},{"key":"B21","doi-asserted-by":"publisher","first-page":"80","DOI":"10.5507\/bp.2016.047","article-title":"Prospective study of hypothalamo-hypophyseal dysfunction in children and adolescents following traumatic brain injury","volume":"161","author":"Krahulik","year":"2017","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"B22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0140-6736(74)91639-0","article-title":"Assessment of coma and impaired consciousness","volume":"2","author":"Teasdale","year":"1974","journal-title":"Lancet."},{"key":"B23","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1111\/acem.13014","article-title":"Performance of the Pediatric glasgow coma scale score in the evaluation of children with blunt head trauma","volume":"23","author":"Borgialli","year":"2016","journal-title":"Acad Emerg Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1530\/EJE-09-0601","article-title":"Hypopituitarism following traumatic brain injury: prevalence is affected by the use of different dynamic tests and different normal values","volume":"162","author":"Kokshoorn","year":"2010","journal-title":"Eur J Endocrinol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3426","DOI":"10.1210\/jc.2012-1981","article-title":"Clinical review: current state and future perspectives in the diagnosis of diabetes insipidus: a clinical review","volume":"97","author":"Fenske","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"key":"B26","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0140-6736(98)85043-5","article-title":"Pituitary insufficiency","volume":"352","author":"Lamberts","year":"1998","journal-title":"Lancet."},{"key":"B27","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1530\/eje.1.01911","article-title":"Evaluation of adrenal function in patients with growth hormone deficiency and hypothalamic-pituitary disorders: comparison between insulin-induced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests","volume":"152","author":"Maghnie","year":"2005","journal-title":"Eur J Endocrinol."},{"key":"B28","first-page":"25","article-title":"The assessment of the hypothalamo-pituitary-adrenal axis in pituitary disease: are there short cuts?","volume":"26","author":"Dickstein","year":"2003","journal-title":"J Endocrinol Invest."},{"key":"B29","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1046\/j.1365-2265.2000.01028.x","article-title":"Establishment of reference values for standard dose short synacthen test (250 microgram), low dose short synacthen test (1 microgram) and insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in normal subjects","volume":"53","author":"Gonzalbez","year":"2000","journal-title":"Clin Endocrinol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3238\/arztebl.2010.0437","article-title":"The rational use of pituitary stimulation tests","volume":"107","author":"Petersenn","year":"2010","journal-title":"Dtsch Arztebl Int."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1210\/jc.2012-1759","article-title":"Serum thyroid hormone levels in healthy children from birth to adulthood and in short children born small for gestational age","volume":"97","author":"Lem","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1210\/jc.2006-1569","article-title":"Assessment of basal and gonadotropin-releasing hormone-stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children","volume":"92","author":"Resende","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e108838","DOI":"10.1371\/journal.pone.0108838","article-title":"Testosterone trajectories and reference ranges in a large longitudinal sample of male adolescents","volume":"9","author":"Khairullah","year":"2014","journal-title":"PLoS ONE."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e752","DOI":"10.1542\/peds.2008-1783","article-title":"Consensus statement on the use of gonadotropin-releasing hormone analogs in children","volume":"123","author":"Carel","year":"2009","journal-title":"Pediatrics."},{"key":"B35","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1159\/000066265","article-title":"European audit of current practice in diagnosis and treatment of childhood growth hormone deficiency","volume":"58","author":"Juul","year":"2002","journal-title":"Horm Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1210\/jc.2008-0509","article-title":"Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop","volume":"93","author":"Cohen","year":"2008","journal-title":"J Clin Endocrinol Metab."},{"key":"B37","first-page":"537","article-title":"The effects of estrogen priming and puberty on the growth hormone response to standardized treadmill exercise and arginine-insulin in normal girls and boys","volume":"79","author":"Marin","year":"1994","journal-title":"J Clin Endocrinol Metab."},{"key":"B38","first-page":"3323","article-title":"Reliability of provocative tests to assess growth hormone secretory status","volume":"81","author":"Ghigo","year":"1996","journal-title":"J Clin Endocrinol Metab."},{"key":"B39","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1530\/EJE-14-0165","article-title":"Clinical evidence-based cutoff limits for GH stimulation tests in children with a backup of results with reference to mass spectrometry","volume":"171","author":"Wagner","year":"2014","journal-title":"Eur J Endocrinol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1530\/EJE-07-0631","article-title":"Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia","volume":"157","author":"Ho","year":"2007","journal-title":"Eur J Endocrinol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"4168","DOI":"10.1210\/jc.85.11.4168","article-title":"Estrogen priming effect on growth hormone (GH) provocative test: a useful tool for the diagnosis of GH deficiency","volume":"85","author":"Martinez","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"key":"B42","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1203\/00006450-200011000-00010","article-title":"Growth hormone stimulation testing in both short and normal statured children: use of an immunofunctional assay","volume":"48","author":"Mauras","year":"2000","journal-title":"Pediatr Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1056\/NEJM198411293112203","article-title":"Impaired growth hormone responses to growth hormone-releasing factor in obesity","volume":"311","author":"Williams","year":"1984","journal-title":"N Engl J Med"},{"key":"B44","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1227\/00006123-199009000-00014","article-title":"Mild head injury classification","volume":"27","author":"Williams","year":"1990","journal-title":"Neurosurgery."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.3390\/jcm4081536","article-title":"Update of endocrine dysfunction following pediatric traumatic brain injury","volume":"4","author":"Reifschneider","year":"2015","journal-title":"J Clin Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s11102-011-0360-x","article-title":"Endocrine changes after pediatric traumatic brain injury","volume":"15","author":"Rose","year":"2012","journal-title":"Pituitary."},{"key":"B47","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1159\/000452150","article-title":"Guidelines for growth hormone and insulin-like growth factor-I treatment in children and adolescents: growth hormone deficiency, idiopathic short stature, and primary insulin-like growth factor-I deficiency","volume":"86","author":"Grimberg","year":"2016","journal-title":"Horm Res Paediatr"},{"key":"B48","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1210\/jcem.85.11.6984","article-title":"Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society","volume":"85","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3450","DOI":"10.1210\/jc.2016-1257","article-title":"Reference values for insulin-like growth factor I (IGF-I) serum concentrations: comparison of six immunoassays","volume":"101","author":"Chanson","year":"2016","journal-title":"J Clin Endocrinol Metab."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1001\/jama.298.12.1429","article-title":"Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review","volume":"298","author":"Schneider","year":"2007","journal-title":"JAMA."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta17230","article-title":"Risk Adjustment In Neurocritical care (RAIN)\u2013prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study","author":"Harrison","year":"2013","journal-title":"Health Technol Assess."},{"key":"B52","doi-asserted-by":"publisher","first-page":"28203","DOI":"10.1038\/srep28203","article-title":"Serum concentrations of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein after pediatric traumatic brain injury","volume":"6","author":"Mondello","year":"2016","journal-title":"Sci Rep."},{"key":"B53","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1097\/JSM.0000000000000478","article-title":"Use of blood biomarkers in the assessment of sports-related concussion-a systematic review in the context of their biological significance","volume":"28","author":"O'Connell","year":"2017","journal-title":"Clin J Sport Med"},{"key":"B54","doi-asserted-by":"publisher","first-page":"641","DOI":"10.3389\/fneur.2017.00641","article-title":"Derivation of a three biomarker panel to improve diagnosis in patients with mild traumatic brain injury","volume":"8","author":"Peacock","year":"2017","journal-title":"Front Neurol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e0193278","DOI":"10.1371\/journal.pone.0193278","article-title":"Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury","volume":"13","author":"Lagerstedt","year":"2018","journal-title":"PLoS ONE."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5782","article-title":"Systemic estrone production and injury induced sex hormone steroidogenesis after severe traumatic brain injury: a prognostic indicator of TBI-related mortality","author":"Rakholia","year":"2018","journal-title":"J Neurotrauma."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1080\/02699052.2018.1471738","article-title":"Higher exosomal tau, amyloid-beta 42 and IL-10 are associated with mild TBIs and chronic symptoms in military personnel","volume":"32","author":"Gill","year":"2018","journal-title":"Brain Inj"},{"key":"B58","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1210\/jc.2013-2397","article-title":"Prevalence of posttraumatic growth hormone deficiency is highly dependent on the diagnostic set-up: results from The Danish National Study on Posttraumatic Hypopituitarism","volume":"99","author":"Klose","year":"2014","journal-title":"J Clin Endocrinol Metab."}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2019.00149\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:54:02Z","timestamp":1552956842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2019.00149\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":58,"alternative-id":["10.3389\/fendo.2019.00149"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2019.00149","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"article-number":"149"}}