{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:16:51Z","timestamp":1782281811103,"version":"3.54.5"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2019.00385","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T13:17:28Z","timestamp":1560345448000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Micro-RNAs 518d-3p and 618 Are Upregulated in Individuals With Type 1 Diabetes With Multiple Microvascular Complications"],"prefix":"10.3389","volume":"10","author":[{"given":"Daniele P.","family":"Santos-Bezerra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aritania S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel C.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon N.","family":"Admoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo V.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleide G.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana S.","family":"Pelaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Passarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ubiratan F.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia S.","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elizabeth R.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia","family":"Correa-Giannella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s11892-012-0302-7","article-title":"Metabolic memory and chronic diabetes complications: potential role for epigenetic mechanisms","volume":"12","author":"Intine","year":"2012","journal-title":"Curr Diab Rep"},{"key":"B3","doi-asserted-by":"publisher","first-page":"C558","DOI":"10.1152\/ajpcell.00148.2015","article-title":"Altered expression of uncoupling protein 2 in GLP-1-producing cells after chronic high glucose exposure: implications for the pathogenesis of diabetes mellitus","volume":"310","author":"Urbano","year":"2016","journal-title":"Am J Physiol Cell Physiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13148-015-0090-4","article-title":"Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes","volume":"7","author":"Prattichizzo","year":"2015","journal-title":"Clin Epigenet"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2015.05.001","article-title":"An overview of microRNAs","volume":"87","author":"Hammond","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"B6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.tcb.2011.12.001","article-title":"Secreted microRNAs: a new form of intercellular communication","volume":"22","author":"Chen","year":"2012","journal-title":"Trends Cell Biol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41598-017-18945-z","article-title":"Tissue and serum microRNA profile of oral squamous cell carcinoma patients","volume":"8","author":"Schneider","year":"2018","journal-title":"Sci Rep"},{"key":"B8","doi-asserted-by":"publisher","first-page":"5003","DOI":"10.1073\/pnas.1019055108","article-title":"Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma","volume":"108","author":"Arroyo","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"B9","doi-asserted-by":"publisher","first-page":"7223","DOI":"10.1093\/nar\/gkr254","article-title":"Characterization of extracellular circulating microRNA","volume":"39","author":"Turchinovich","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3109\/10715762.2015.1109083","article-title":"Thioredoxin interacting protein expression in the urinary sediment associates with renal function decline in type 1 diabetes","volume":"50","author":"Monteiro","year":"2016","journal-title":"Free Radic Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00592-016-0915-4","article-title":"MicroRNA-126 and micro-\/macrovascular complications of type 1 diabetes in the EURODIAB Prospective Complications Study","volume":"54","author":"Barutta","year":"2017","journal-title":"Acta Diabetol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.2337\/dbi15-0028","article-title":"Circulating microRNA biomarkers of diabetic retinopathy","volume":"65","author":"Joglekar","year":"2016","journal-title":"Diabetes"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.2337\/db15-0738","article-title":"Diabetic nephropathy: emerging biomarkers for risk assessment","volume":"64","author":"Badal","year":"2015","journal-title":"Diabetes"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1111\/ajt.13072","article-title":"Circulating microRNAs associate with diabetic nephropathy and systemic microvascular damage and normalize after simultaneous pancreas-kidney transplantation","volume":"15","author":"Bijkerk","year":"2015","journal-title":"Am J Transplant"},{"key":"B15","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3389\/fgene.2013.00094","article-title":"The impact of hemolysis on cell-free microRNA biomarkers","volume":"4","author":"Kirschner","year":"2013","journal-title":"Front Genet"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e24145","DOI":"10.1371\/journal.pone.0024145","article-title":"Haemolysis during sample preparation alters microRNA content of plasma","volume":"6","author":"Kirschner","year":"2011","journal-title":"PLoS ONE"},{"key":"B17","doi-asserted-by":"publisher","first-page":"757803","DOI":"10.1155\/2012\/757803","article-title":"PPARs in liver diseases and cancer: epigenetic regulation by MicroRNAs","volume":"2012","author":"Peyrou","year":"2012","journal-title":"PPAR Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.3892\/mmr.2014.2058","article-title":"MicroRNA-518d regulates PPAR\u03b1 protein expression in the placentas of females with gestational diabetes mellitus","volume":"9","author":"Zhao","year":"2014","journal-title":"Mol Med Rep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"15401","DOI":"10.1073\/pnas.1307211110","article-title":"Pathogenic role of diabetes-induced PPAR-\u03b1 down-regulation in microvascular dysfunction","volume":"110","author":"Hu","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B20","doi-asserted-by":"publisher","first-page":"4568","DOI":"10.1167\/iovs.13-13127","article-title":"Protective and antioxidant effects of PPAR\u03b1 in the ischemic retina","volume":"55","author":"Moran","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1016\/S0140-6736(07)61607-9","article-title":"Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial","volume":"370","author":"Keech","year":"2007","journal-title":"Lancet"},{"key":"B22","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1056\/NEJMoa1001288","article-title":"Effects of medical therapies on retinopathy progression in type 2 diabetes","volume":"363","author":"Chew","year":"2010","journal-title":"N Engl J Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e004025","DOI":"10.1136\/bmjopen-2013-004025","article-title":"Primary prevention of diabetic retinopathy with fibrates: a retrospective, matched cohort study","volume":"3","author":"Morgan","year":"2013","journal-title":"BMJ Open"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15569527.2017.1355314","article-title":"Evaluation of microRNA responses in ARPE-19 cells against the oxidative stress","volume":"2017","author":"Ayaz","year":"","journal-title":"Cutan Ocul Toxicol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.2337\/db16-1246","article-title":"Pathogenic role of microRNA-21 in diabetic retinopathy through downregulation of PPAR\u03b1","volume":"66","author":"Chen","year":"2017","journal-title":"Diabetes"},{"key":"B26","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s13206-015-9303-3","article-title":"Identification and characterization of MicroRNAs in acrolein-stimulated endothelial cells: implications for vascular disease","volume":"9","author":"Lee","year":"2015","journal-title":"BioChip J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"B28","doi-asserted-by":"publisher","first-page":"730","DOI":"10.4161\/epi.27996","article-title":"Targetome profiling and functional genetics implicate miR-618 in lymphomagenesis","volume":"9","author":"Fu","year":"2014","journal-title":"Epigenetics"},{"key":"B29","doi-asserted-by":"publisher","first-page":"4760","DOI":"10.1128\/MCB.05776-11","article-title":"Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2","volume":"31","author":"Wu","year":"2011","journal-title":"Mol Cell Biol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e58159","DOI":"10.1371\/journal.pone.0058159","article-title":"Differential expression of miR-145 in children with Kawasaki disease","volume":"8","author":"Shimizu","year":"2013","journal-title":"PLoS ONE"},{"key":"B31","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.ajpath.2016.11.007","article-title":"The increased transforming growth factor-\u03b2 signaling induced by diabetes protects retinal vessels","volume":"187","author":"Dagher","year":"2017","journal-title":"Am J Pathol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2019.00385\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T13:17:30Z","timestamp":1560345450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2019.00385\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,12]]},"references-count":31,"alternative-id":["10.3389\/fendo.2019.00385"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2019.00385","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,12]]},"article-number":"385"}}