{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:30:51Z","timestamp":1793799051619,"version":"4.6.1"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2019.00488","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T05:53:59Z","timestamp":1563342839000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":109,"title":["Melatonin Signaling a Key Regulator of Glucose Homeostasis and Energy Metabolism"],"prefix":"10.3389","volume":"10","author":[{"given":"Sharon","family":"Owino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella D. C.","family":"Buonfiglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Tchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Tosini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1210\/endo.143.1.8585","article-title":"Melatonin enters the cerebrospinal fluid through the pineal recess","volume":"143","author":"Tricoire","year":"2002","journal-title":"Endocrinology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1111\/bph.13536","article-title":"Update on melatonin receptors: IUPHAR Review 20","volume":"173","author":"Jockers","year":"2016","journal-title":"Br J Pharmacol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"E934","DOI":"10.1152\/ajpendo.1998.275.6.E934","article-title":"Pinealectomy causes glucose intolerance and decreases adipose cell responsiveness to insulin in rats","volume":"275","author":"Lima","year":"1998","journal-title":"Am J Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1210\/en.2010-1088","article-title":"Absence of melatonin induces night-time hepatic insulin resistance and increased gluconeogenesis due to stimulation of nocturnal unfolded protein response","volume":"152","author":"Nogueira","year":"2011","journal-title":"Endocrinology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"5311","DOI":"10.1210\/en.2009-0425","article-title":"Melatonin improves glucose homeostasis and endothelial vascular function in high-fat diet-fed insulin-resistant mice","volume":"150","author":"Nogueira","year":"2009","journal-title":"Endocrinology."},{"key":"B6","doi-asserted-by":"publisher","first-page":"5347","DOI":"10.1210\/en.2003-0693","article-title":"Melatonin reduces body weight gain in Sprague Dawley rats with diet-induced obesity","volume":"144","author":"Prunet-Marcassus","year":"2003","journal-title":"Endocrinology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/jpi.12137","article-title":"Melatonin, energy metabolism, and obesity: a review","volume":"56","author":"Prunet-Marcassus","year":"2014","journal-title":"J Pineal Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/0031-9384(85)90415-9","article-title":"Body weight, food intake and energy regulation in exercising and melatonin-treated Siberian hamsters","volume":"35","author":"Prunet-Marcassus","year":"1985","journal-title":"Physiol Behav."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1210\/endo.140.2.6674","article-title":"Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels","volume":"140","author":"Rasmussen","year":"1999","journal-title":"Endocrinology."},{"key":"B10","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1210\/en.141.2.487","article-title":"Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat","volume":"141","author":"Wolden-Hanson","year":"2000","journal-title":"Endocrinology."},{"key":"B11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.yfrne.2015.09.004","article-title":"New insights in leptin resistance mechanisms in mice","volume":"39","author":"Balland","year":"2015","journal-title":"Front Neuroendocrinol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.nutres.2015.07.001","article-title":"Melatonin reduces obesity and restores adipokine patterns and metabolism in obese (ob\/ob) mice","volume":"35","author":"Favero","year":"2015","journal-title":"Nutr Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/cen.12942","article-title":"Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: a randomized placebo-controlled trial","volume":"84","author":"Amstrup","year":"2016","journal-title":"Clin Endocrinol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.physbeh.2017.07.011","article-title":"Short photoperiod reverses obesity in Siberian hamsters via sympathetically induced lipolysis and Browning in adipose tissue","volume":"190","author":"Ryu","year":"2018","journal-title":"Physiol Behav."},{"key":"B15","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1194\/jlr.M087619","article-title":"Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function","volume":"60","author":"Liu","year":"2018","journal-title":"J Lip Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000448333","article-title":"Melatonin receptor 1 deficiency affects feeding dynamics and pro-opiomelanocortin expression in the arcuate nucleus and pituitary of mice","volume":"105","author":"Fischer","year":"2017","journal-title":"Neuroendocrinology."},{"key":"B17","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fendo.2018.00122","article-title":"Melatonin absence leads to long-term leptin resistance and overweight in rats","volume":"9","author":"Buonfiglio","year":"2018","journal-title":"Front. Endocrinol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/377527a0","article-title":"Transient increase in obese gene expression after food intake or insulin administration","volume":"377","author":"Saladin","year":"1995","journal-title":"Nature."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1172\/JCI1176","article-title":"Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function","volume":"101","author":"Ahima","year":"1998","journal-title":"J Clin Invest."},{"key":"B20","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3389\/fnins.2015.00190","article-title":"Pineal melatonin is a circadian time-giver for leptin rhythm in Syrian hamsters","volume":"9","author":"Chakir","year":"2015","journal-title":"Front Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1515\/hmbci-2014-0041","article-title":"Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats","volume":"21","author":"R\u00edos-Lugo","year":"2015","journal-title":"Hormone Mol Biol Clin Invest."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e12580","DOI":"10.1111\/jpi.12580","article-title":"Removing melatonin receptor type 1 signaling leads to selective leptin resistance in the arcuate nucleus","author":"Buonfiglio","year":"2019","journal-title":"J Pineal Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1111\/jpi.12089","article-title":"Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats","volume":"55","author":"Jim\u00e9nez-Aranda","year":"2013","journal-title":"J Pineal Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e12472","DOI":"10.1111\/jpi.12472","article-title":"Melatonin increases brown adipose tissue mass and function in Zucker diabetic fatty rats: implications for obesity control","volume":"64","author":"Fern\u00e1ndez","year":"2018","journal-title":"J Pineal Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol Rev."},{"key":"B26","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1467-789X.2010.00756.x","article-title":"Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity","volume":"12","author":"Tan","year":"2011","journal-title":"Obes Rev."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e12399","DOI":"10.1111\/jpi.12399","article-title":"Melatonin prevents obesity through modulation of gut microbiota in mice","volume":"62","author":"Xu","year":"2017","journal-title":"J Pineal Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/jpi.12462","article-title":"Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity","author":"Owino","year":"2018","journal-title":"J Pineal Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"E230","DOI":"10.1152\/ajpendo.00094.2013","article-title":"Melatonin acts through MT1\/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats","volume":"305","author":"Faria","year":"2013","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"B32","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1600-079X.2006.00334.x","article-title":"Melatonin stimulates glucose transport via insulin receptor substrate-1\/phosphatidylinositol 3-kinase pathway in C2C12 murine skeletal muscle cells","volume":"41","author":"Ha","year":"2006","journal-title":"J Pineal Res."},{"key":"B33","first-page":"995","article-title":"The regulation of insulin action in isolated adipocytes. Role of the periodicity of food intake, time of day and melatonin","volume":"27","author":"Lima","year":"1994","journal-title":"Braz J Med Biol Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.cmet.2016.04.009","article-title":"Increased melatonin signaling is a risk factor for type 2 diabetes","volume":"23","author":"Tuomi","year":"2016","journal-title":"Cell Metab."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1038\/oby.2010.24","article-title":"Removal of melatonin receptor type 1 induces insulin resistance in the mouse","volume":"18","author":"Contreras-Alcantara","year":"2010","journal-title":"Obesity."},{"key":"B36","doi-asserted-by":"publisher","first-page":"803","DOI":"10.2337\/db08-1054","article-title":"Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism","volume":"58","author":"Macotela","year":"2009","journal-title":"Diabetes."},{"key":"B37","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.genm.2009.02.002","article-title":"Gender differences in insulin resistance, body composition, and energy balance","volume":"1","author":"Geer","year":"2009","journal-title":"Gend Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41574-018-0130-1","article-title":"Melatonin in type 2 diabetes mellitus and obesity","volume":"15","author":"Karamitri","year":"2019","journal-title":"Nat Rev Endocrinol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/0304-3940(89)90153-5","article-title":"Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro","volume":"97","author":"Shibata","year":"1989","journal-title":"Neurosci Lett."},{"key":"B40","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/BF01252503","article-title":"Effects of melatonin on spontaneous electrical activity of neurons in rat suprachiasmatic nuclei: an in vitro iontophoretic study","volume":"78","author":"Stehle","year":"1989","journal-title":"J Neural Transm."},{"key":"B41","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1177\/074873049601100204","article-title":"Melatonin and light induce phase shifts of circadian activity rhythms in the C3H\/HeN mouse","volume":"11","author":"Benloucif","year":"1996","journal-title":"J Biol Rhythms."},{"key":"B42","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41574-018-0122-1","article-title":"Circadian clocks and insulin resistance","volume":"15","author":"Stenvers","year":"2018","journal-title":"Nat Rev Endocrinol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.molmet.2013.10.005","article-title":"Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock","volume":"3","author":"Dyar","year":"2014","journal-title":"Mol Metab."},{"key":"B44","doi-asserted-by":"publisher","first-page":"15172","DOI":"10.1073\/pnas.0806717105","article-title":"Physiological significance of a peripheral tissue circadian clock","volume":"105","author":"Lamia","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B45","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nature09253","article-title":"Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes","volume":"466","author":"Marcheva","year":"2010","journal-title":"Nature."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1038\/nm.2979","article-title":"Obesity in mice with adipocyte-specific deletion of clock component Arntl","volume":"18","author":"Paschos","year":"2012","journal-title":"Nat Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ejphar.2009.01.029","article-title":"Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose","volume":"606","author":"M\u00fchlbauer","year":"2009","journal-title":"Eur J Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e0148214","DOI":"10.1371\/journal.pone.0148214","article-title":"Melatonin signaling controls the daily rhythm in blood glucose levels independent of peripheral clocks","volume":"11","author":"Owino","year":"2016","journal-title":"PLoS ONE."},{"key":"B49","doi-asserted-by":"publisher","first-page":"E7997","DOI":"10.1073\/pnas.1705768114","article-title":"Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release","volume":"114","author":"Suofu","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"B50","doi-asserted-by":"publisher","first-page":"30539","DOI":"10.1038\/srep30539","article-title":"Genetic variants associated with gestational diabetes mellitus: a meta-analysis and subgroup analysis","volume":"6","author":"Wu","year":"2016","journal-title":"Sci Rep."},{"key":"B51","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1080\/09513590.2016.1276556","article-title":"MTNR1A and MTNR1B gene polymorphisms in women with gestational diabetes","volume":"33","author":"Tarnowski","year":"2017","journal-title":"Gynecol Endocrinol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ejogrb.2015.09.043","article-title":"Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese","volume":"195","author":"Song","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1159\/000355521","article-title":"Association between genetic variations in MTNR1A and MTNR1B genes and gestational diabetes mellitus in Han Chinese women","volume":"76","author":"Li","year":"2013","journal-title":"Gynecol Obstet Invest."},{"key":"B54","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/ng.1053","volume":"44","author":"Bonnefond","year":"2012","journal-title":"Nat Genet."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.2337\/db09-1757","article-title":"MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans","volume":"59","author":"Andersson","year":"2010","journal-title":"Diabetes."},{"key":"B56","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/ng.277","article-title":"A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk","volume":"41","author":"Bouatia-Naji","year":"2009","journal-title":"Nat Genet."},{"key":"B57","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/ng.288","article-title":"Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion","volume":"41","author":"Lyssenko","year":"2009","journal-title":"Nat Genet."},{"key":"B58","doi-asserted-by":"publisher","first-page":"eaan6622","DOI":"10.1126\/scisignal.aan6622","article-title":"Type 2 diabetes-associated variants of the MT2 melatonin receptor affect distinct modes of signaling","volume":"11","author":"Karamitri","year":"2018","journal-title":"Sci Signal."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1038\/ng.3437","article-title":"Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci","volume":"47","author":"Gaulton","year":"2015","journal-title":"Nat Genet."},{"key":"B60","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1016\/j.numecd.2011.01.006","article-title":"A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity","volume":"22","author":"Been","year":"2012","journal-title":"Nutr Metab Cardiovasc Dis."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1007\/s00125-016-3920-9","article-title":"Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank","volume":"59","author":"Gan","year":"2016","journal-title":"Diabetologia."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e0169781","DOI":"10.1371\/journal.pone.0169781","article-title":"Association study with 77 SNPs confirms the robust role for the rs10830963\/G of MTNR1B variant and identifies two novel associations in gestational diabetes mellitus development","volume":"12","author":"Rosta","year":"2017","journal-title":"PLoS ONE."},{"key":"B63","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/ng.290","article-title":"Variants in MTNR1B influence fasting glucose levels","volume":"41","author":"Prokopenko","year":"2009","journal-title":"Nat Genet."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.2337\/db08-1660","article-title":"G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans","volume":"58","author":"Spars\u00f8","year":"2009","journal-title":"Diabetes."},{"key":"B65","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/ng.609","article-title":"Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis","volume":"42","author":"Voight","year":"2010","journal-title":"Nat Genet."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1001\/jama.2013.2710","article-title":"Melatonin secretion and the incidence of type 2 diabetes","volume":"309","author":"McMullan","year":"2013","journal-title":"JAMA."},{"key":"B67","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1159\/000323542","article-title":"Melatonin receptor 1A gene polymorphism associated with polycystic ovary syndrome","volume":"72","author":"Li","year":"2011","journal-title":"Gynecol Obstet Invest."}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2019.00488\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T05:54:01Z","timestamp":1563342841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2019.00488\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,17]]},"references-count":67,"alternative-id":["10.3389\/fendo.2019.00488"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2019.00488","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,17]]},"article-number":"488"}}