{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:17:40Z","timestamp":1791001060989,"version":"4.1.0"},"reference-count":127,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2019.00570","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:26:59Z","timestamp":1567470419000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":173,"title":["Dysregulated Mitochondrial Dynamics and Metabolism in Obesity, Diabetes, and Cancer"],"prefix":"10.3389","volume":"10","author":[{"given":"Wenting","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"Mitochondrial dynamics\u2014mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","journal-title":"N Engl J Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1126\/science.39.1000.330","article-title":"Mitochondria in tissue culture","volume":"39","author":"Lewis","year":"1914","journal-title":"Science."},{"key":"B3","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/aja.1000170304","article-title":"Mitochondria (and other cytoplasmic structures) in tissue cultures","volume":"17","author":"Lewis","year":"1915","journal-title":"Am J Anat."},{"key":"B4","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1146\/annurev-genet-110410-132529","article-title":"Fusion and fission: interlinked processes critical for mitochondrial health","volume":"46","author":"Chan","year":"2012","journal-title":"Annu Rev Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cmet.2017.05.016","article-title":"Mitochondrial dynamics in regulating the unique phenotypes of cancer and stem cells","volume":"26","author":"Chen","year":"2017","journal-title":"Cell Metabol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/nrm3013","article-title":"Mitochondrial fusion and fission in cell life and death","volume":"11","author":"Westermann","year":"2010","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development","volume":"160","author":"Chen","year":"2003","journal-title":"J Cell Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"15927","DOI":"10.1073\/pnas.0407043101","article-title":"OPA1 requires mitofusin 1 to promote mitochondrial fusion","volume":"101","author":"Cipolat","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1091\/mbc.E09-03-0252","article-title":"Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion","volume":"20","author":"Song","year":"2009","journal-title":"Mol Biol Cell."},{"key":"B10","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.cmet.2014.03.011","article-title":"Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation","volume":"19","author":"Mishra","year":"2014","journal-title":"Cell Metabol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/s1534-5807(01)00055-7","article-title":"The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis","volume":"1","author":"Frank","year":"2001","journal-title":"Dev Cell."},{"key":"B12","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/ng1341","article-title":"Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot\u2013Marie\u2013Tooth neuropathy type 2A","volume":"36","author":"Zuchner","year":"2004","journal-title":"Nat Genet."},{"key":"B13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/79944","article-title":"OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28","volume":"26","author":"Alexander","year":"2000","journal-title":"Nat Genet."},{"key":"B14","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/79936","article-title":"Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy","volume":"26","author":"Delettre","year":"2000","journal-title":"Nat Genet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0092-8674(00)80319-0","article-title":"Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase","volume":"90","author":"Hales","year":"1997","journal-title":"Cell."},{"key":"B16","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1242\/jcs.114.5.867","article-title":"Control of mitochondrial morphology by a human mitofusin","volume":"114","author":"Santel","year":"2001","journal-title":"J Cell Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"4343","DOI":"10.1091\/mbc.e02-06-0330","article-title":"Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins","volume":"13","author":"Legros","year":"2002","journal-title":"Mol Biol Cell."},{"key":"B18","doi-asserted-by":"publisher","first-page":"26185","DOI":"10.1074\/jbc.M503062200","article-title":"Disruption of fusion results in mitochondrial heterogeneity and dysfunction","volume":"280","author":"Chen","year":"2005","journal-title":"J Biol Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1126\/science.1099793","article-title":"Structural basis of mitochondrial tethering by mitofusin complexes","volume":"305","author":"Koshiba","year":"2004","journal-title":"Science."},{"key":"B20","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1083\/jcb.151.2.341","article-title":"The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria","volume":"151","author":"Wong","year":"2000","journal-title":"J Cell Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1091\/mbc.e02-12-0788","article-title":"Mgm1p, a Dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane","volume":"14","author":"Sesaki","year":"2003","journal-title":"Mol Biol Cell."},{"key":"B22","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/sj.cdd.4402048","article-title":"OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis","volume":"14","author":"Olichon","year":"2007","journal-title":"Cell Death Differ."},{"key":"B23","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1083\/jcb.200704110","article-title":"OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L","volume":"178","author":"Song","year":"2007","journal-title":"J Cell Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1083\/jcb.201308006","article-title":"The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission","volume":"204","author":"Anand","year":"2014","journal-title":"J Cell Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1083\/jcb.200906084","article-title":"Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1","volume":"187","author":"Ehses","year":"2009","journal-title":"J Cell Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1242\/jcs.159186","article-title":"OPA1 processing in cell death and disease\u2014the long and short of it","volume":"129","author":"MacVicar","year":"2016","journal-title":"J Cell Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"7115","DOI":"10.1074\/jbc.M116.762567","article-title":"The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure","volume":"292","author":"Lee","year":"2017","journal-title":"J Biol Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1056\/NEJMoa064436","article-title":"A lethal defect of mitochondrial and peroxisomal fission","volume":"356","author":"Waterham","year":"2007","journal-title":"N Engl J Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/ncb1907","article-title":"Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice","volume":"11","author":"Ishihara","year":"2009","journal-title":"Nat Cell Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1083\/jcb.200903065","article-title":"The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice","volume":"186","author":"Wakabayashi","year":"2009","journal-title":"J Cell Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1091\/mbc.E12-10-0721","article-title":"Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission","volume":"24","author":"Loson","year":"2013","journal-title":"Mol Biol Cell."},{"key":"B32","first-page":"239","article-title":"MiD49 and MiD51: new mediators of mitochondrial fission and novel targets for cardioprotection","volume":"1","author":"Samangouei","year":"2018","journal-title":"Cond Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"5409","DOI":"10.1128\/mcb.23.15.5409-5420.2003","article-title":"The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1","volume":"23","author":"Yoon","year":"2003","journal-title":"Mol Cell Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1242\/jcs.01058","article-title":"Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology","volume":"117","author":"Stojanovski","year":"2004","journal-title":"J Cell Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1091\/mbc.E07-12-1287","article-title":"The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells","volume":"19","author":"Gandre-Babbe","year":"2008","journal-title":"Mol Biol Cell."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1083\/jcb.201007152","article-title":"Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells","volume":"191","author":"Otera","year":"2010","journal-title":"J Cell Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/embor.2011.54","article-title":"MiD49 and MiD51, new components of the mitochondrial fission machinery","volume":"12","author":"Palmer","year":"2011","journal-title":"EMBO Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"27584","DOI":"10.1074\/jbc.M113.479873","article-title":"Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission","volume":"288","author":"Palmer","year":"2013","journal-title":"J Biol Chem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"11521","DOI":"10.1074\/jbc.M607279200","article-title":"Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission","volume":"282","author":"Taguchi","year":"2007","journal-title":"J Biol Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/sj.embor.7401062","article-title":"Reversible phosphorylation of Drp1 by cyclic AMP\u2013dependent protein kinase and calcineurin regulates mitochondrial fission and cell death","volume":"8","author":"Cribbs","year":"2007","journal-title":"EMBO Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.molcel.2015.01.002","article-title":"Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth","volume":"57","author":"Kashatus","year":"2015","journal-title":"Mol Cell."},{"key":"B42","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.molcel.2015.01.003","article-title":"Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors","volume":"57","author":"Serasinghe","year":"2015","journal-title":"Mol Cell."},{"key":"B43","doi-asserted-by":"publisher","first-page":"21583","DOI":"10.1074\/jbc.C700083200","article-title":"Cyclic AMP\u2013dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology","volume":"282","author":"Chang","year":"2007","journal-title":"J Biol Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"15803","DOI":"10.1073\/pnas.0808249105","article-title":"Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria","volume":"105","author":"Cereghetti","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B45","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.devcel.2007.11.019","article-title":"Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax\/Bak-dependent mitochondrial outer membrane permeabilization","volume":"14","author":"Cassidy-Stone","year":"2008","journal-title":"Dev Cell."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13813450802676335","article-title":"Mitochondrial dynamics as a bridge between mitochondrial dysfunction and insulin resistance","volume":"115","author":"Zorzano","year":"2009","journal-title":"Arch Physiol Biochem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.2337\/diabetes.54.9.2685","article-title":"Expression of Mfn2, the Charcot\u2013Marie\u2013Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6","volume":"54","author":"Bach","year":"2005","journal-title":"Diabetes."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1093\/hmg\/ddi149","article-title":"The Charcot\u2013Marie\u2013Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system","volume":"14","author":"Pich","year":"2005","journal-title":"Hum Mole Genet."},{"key":"B49","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.cell.2013.09.003","article-title":"Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance","volume":"155","author":"Schneeberger","year":"2013","journal-title":"Cell."},{"key":"B50","doi-asserted-by":"publisher","first-page":"11249","DOI":"10.1073\/pnas.1606786113","article-title":"Critical reappraisal confirms that mitofusin 2 is an endoplasmic reticulum\u2013mitochondria tether","volume":"113","author":"Naon","year":"2016","journal-title":"Proc Natl Acad Sci USA."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.15252\/embj.201694914","article-title":"Mfn2 is critical for brown adipose tissue thermogenic function","volume":"36","author":"Boutant","year":"2017","journal-title":"EMBO J."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.15252\/embr.201643827","article-title":"Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis","volume":"18","author":"Mahdaviani","year":"2017","journal-title":"EMBO Rep."},{"key":"B53","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1161\/circulationaha.113.008476","article-title":"Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients","volume":"130","author":"Montaigne","year":"2014","journal-title":"Circulation."},{"key":"B54","doi-asserted-by":"publisher","first-page":"3552","DOI":"10.2337\/db15-1725","article-title":"Mfn1 deficiency in the liver protects against diet-induced insulin resistance and enhances the hypoglycemic effect of metformin","volume":"65","author":"Kulkarni","year":"2016","journal-title":"Diabetes."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e92810","DOI":"10.1371\/journal.pone.0092810","article-title":"Impaired mitochondrial dynamics and bioenergetics in diabetic skeletal muscle","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS ONE."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1016\/j.cmet.2017.05.010","article-title":"Mitochondrial dynamics mediated by mitofusin 1 is required for POMC neuron glucose-sensing and insulin release control","volume":"25","author":"Ramirez","year":"2017","journal-title":"Cell Metabol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"4371","DOI":"10.1038\/emboj.2011.365","article-title":"Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis","volume":"30","author":"Pidoux","year":"2011","journal-title":"EMBO J."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.cmet.2017.04.021","article-title":"Age-associated loss of OPA1 in muscle impacts muscle mass, metabolic homeostasis, systemic inflammation, and epithelial senescence","volume":"25","author":"Tezze","year":"2017","journal-title":"Cell Metabol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e96553","DOI":"10.15252\/embj.201796553","article-title":"Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency","volume":"37","author":"Rodriguez-Nuevo","year":"2018","journal-title":"EMBO J."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.15252\/embj.201696179","article-title":"OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance","volume":"36","author":"Pereira","year":"2017","journal-title":"EMBO J."},{"key":"B61","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1152\/physiolgenomics.00190.2010","article-title":"Adipose tissue transcriptome changes during obesity development in female dogs","volume":"43","author":"Grant","year":"2011","journal-title":"Physiol Genomics."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1091\/mbc.E10-12-0933","article-title":"The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells","volume":"22","author":"Zhang","year":"2011","journal-title":"Mol Biol Cell."},{"key":"B63","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2337\/db13-0340","article-title":"Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt\u2013mTOR\u2013NFkappaB\u2013Opa-1 signaling pathway","volume":"63","author":"Parra","year":"2014","journal-title":"Diabetes."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e1663","DOI":"10.1038\/cddis.2014.595","article-title":"Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation","volume":"6","author":"Touvier","year":"2015","journal-title":"Cell Death Dis."},{"key":"B65","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.molmet.2018.11.012","article-title":"The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle","volume":"21","author":"Moore","year":"2019","journal-title":"Mol Metabol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1152\/japplphysiol.01064.2013","article-title":"Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle","volume":"117","author":"Fealy","year":"2014","journal-title":"J Appl Physiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.2337\/db16-1088","article-title":"Direct substrate delivery into mitochondrial fission-deficient pancreatic islets rescues insulin secretion","volume":"66","author":"Kabra","year":"2017","journal-title":"Diabetes."},{"key":"B68","doi-asserted-by":"publisher","first-page":"7514383","DOI":"10.1155\/2018\/7514383","article-title":"The causal role of mitochondrial dynamics in regulating insulin resistance in diabetes: link through mitochondrial reactive oxygen species","volume":"2018","author":"Lin","year":"2018","journal-title":"Oxid Med Cell Longev."},{"key":"B69","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1210\/en.2018-00445","article-title":"In vivo deletion of beta-cell Drp1 impairs insulin secretion without affecting islet oxygen consumption","volume":"159","author":"Hennings","year":"2018","journal-title":"Endocrinology."},{"key":"B70","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1128\/mcb.05603-11","article-title":"Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle","volume":"32","author":"Jheng","year":"2012","journal-title":"Mol Cell Biol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1038\/s41467-019-10226-9","article-title":"DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass","volume":"10","author":"Favaro","year":"2019","journal-title":"Nat Commun."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1007\/s00125-015-3704-7","article-title":"Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration","volume":"58","author":"Wang","year":"2015","journal-title":"Diabetologia."},{"key":"B73","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.cmet.2017.01.003","article-title":"DRP1 suppresses leptin and glucose sensing of POMC neurons","volume":"25","author":"Santoro","year":"2017","journal-title":"Cell Metabol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1016\/j.celrep.2017.02.035","article-title":"Dynamin-related protein 1\u2013dependent mitochondrial fission changes in the dorsal vagal complex regulate insulin action","volume":"18","author":"Filippi","year":"2017","journal-title":"Cell Rep."},{"key":"B75","doi-asserted-by":"publisher","first-page":"e0185764","DOI":"10.1371\/journal.pone.0185764","article-title":"Insulin-stimulated lipid accumulation is inhibited by ROS-scavenging chemicals, but not by the Drp1 inhibitor mdivi-1","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS ONE."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.2337\/diabetes.51.10.2944","article-title":"Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes","volume":"51","author":"Kelley","year":"2002","journal-title":"Diabetes."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.15252\/embr.201744341","article-title":"Let's burn whatever you have: mitofusin 2 metabolically re-wires brown adipose tissue","volume":"18","author":"Scheideler","year":"2017","journal-title":"EMBO Rep."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1091\/mbc.E17-09-0538","article-title":"OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells","volume":"29","author":"Rogne","year":"2018","journal-title":"Mol Biol Cell."},{"key":"B79","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1038\/emboj.2012.70","article-title":"Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice","volume":"31","author":"Quiros","year":"2012","journal-title":"EMBO J."},{"key":"B80","doi-asserted-by":"publisher","first-page":"E597","DOI":"10.3390\/cells8060597","article-title":"Inhibition of the fission machinery mitigates OPA1 Impairment in adult skeletal muscles","volume":"8","author":"Romanello","year":"2019","journal-title":"Cells."},{"key":"B81","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s12032-015-0515-0","article-title":"Mitofusin-2 over-expresses and leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma","volume":"32","author":"Lou","year":"2015","journal-title":"Med Oncol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.1096\/fj.201701095R","article-title":"Cystathionine beta-synthase regulates mitochondrial morphogenesis in ovarian cancer","volume":"32","author":"Chakraborty","year":"2018","journal-title":"FASEB J."},{"key":"B83","doi-asserted-by":"publisher","first-page":"5006","DOI":"10.1158\/0008-5472.CAN-15-2921","article-title":"Metabolic stress\u2013induced phosphorylation of KAP1 Ser473 blocks mitochondrial fusion in breast cancer cells","volume":"76","author":"Cheng","year":"2016","journal-title":"Cancer Res."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1002\/jcb.27518","article-title":"Mitochondrial dynamic alterations regulate melanoma cell progression","volume":"120","author":"Dal Yontem","year":"2018","journal-title":"J Cell Biochem."},{"key":"B85","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3892\/ijo.2018.4380","article-title":"miR-125a induces apoptosis, metabolism disorder and migration impairment in pancreatic cancer cells by targeting Mfn2-related mitochondrial fission","volume":"53","author":"Pan","year":"2018","journal-title":"Int J Oncol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.cell.2019.04.010","article-title":"Deficient endoplasmic reticulum\u2013mitochondrial phosphatidylserine transfer causes liver disease","volume":"177","author":"Hernandez-Alvarez","year":"2019","journal-title":"Cell."},{"key":"B87","doi-asserted-by":"publisher","first-page":"727","DOI":"10.2131\/jts.43.727","article-title":"5-Fluorouracil inhibits neural differentiation via Mfn1\/2 reduction in human induced pluripotent stem cells","volume":"43","author":"Yamada","year":"2018","journal-title":"J Toxicol Sci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1016\/j.biocel.2012.07.012","article-title":"Mitochondrial dynamics is affected by 17beta-estradiol in the MCF-7 breast cancer cell line. Effects on fusion and fission related genes","volume":"44","author":"Sastre-Serra","year":"2012","journal-title":"Int J Biochem Cell Biol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"3399","DOI":"10.1038\/s41467-018-05655-x","article-title":"The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function","volume":"9","author":"Quintana-Cabrera","year":"2018","journal-title":"Nat Commun."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1016\/j.celrep.2017.01.070","article-title":"Control of mitochondrial remodeling by the ATPase inhibitory factor 1 unveils a pro-survival relay via OPA1","volume":"18","author":"Faccenda","year":"2017","journal-title":"Cell Rep."},{"key":"B91","doi-asserted-by":"publisher","first-page":"4901","DOI":"10.1038\/onc.2017.98","article-title":"Mitochondrial elongation\u2013mediated glucose metabolism reprogramming is essential for tumour cell survival during energy stress","volume":"36","author":"Li","year":"2017","journal-title":"Oncogene."},{"key":"B92","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/nn.3960","article-title":"Mitochondrial control by DRP1 in brain tumor initiating cells","volume":"18","author":"Xie","year":"2015","journal-title":"Nat Neurosci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1126\/science.61.1588.575","article-title":"Iron, the oxygen-carrier of respiration-ferment","volume":"61","author":"Warburg","year":"1925","journal-title":"Science."},{"key":"B94","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1085\/jgp.8.6.519","article-title":"The metabolism of tumors in the body","volume":"8","author":"Warburg","year":"1927","journal-title":"J Gen Physiol."},{"key":"B95","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science."},{"key":"B96","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40170-016-0145-9","article-title":"Warburg effect(s)\u2014a biographical sketch of Otto Warburg and his impacts on tumor metabolism","volume":"4","author":"Otto","year":"2016","journal-title":"Cancer Metabol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.cell.2012.02.032","article-title":"Cellular metabolism and disease: what do metabolic outliers teach us?","volume":"148","author":"DeBerardinis","year":"2012","journal-title":"Cell."},{"key":"B98","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nrc2981","article-title":"Regulation of cancer cell metabolism","volume":"11","author":"Cairns","year":"2011","journal-title":"Nat Rev Cancer."},{"key":"B99","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nature22379","article-title":"Nutrient acquisition strategies of mammalian cells","volume":"546","author":"Palm","year":"2017","journal-title":"Nature."},{"key":"B100","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/489511a","article-title":"When more is less","volume":"489","author":"Jiang","year":"2012","journal-title":"Nature."},{"key":"B101","doi-asserted-by":"publisher","first-page":"e981994","DOI":"10.4161\/23723556.2014.981994","article-title":"The cancer cell \u2018energy grid\u2019: TGF-beta1 signaling coordinates metabolism for migration","volume":"2","author":"Jiang","year":"2015","journal-title":"Mol Cell Oncol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"3908","DOI":"10.1038\/onc.2014.321","article-title":"Metabolic reprogramming during TGFbeta1-induced epithelial-to-mesenchymal transition","volume":"34","author":"Jiang","year":"2015","journal-title":"Oncogene."},{"key":"B103","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1096\/fj.11-196543","article-title":"Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer","volume":"26","author":"Rehman","year":"2012","journal-title":"FASEB J."},{"key":"B104","doi-asserted-by":"publisher","first-page":"4814","DOI":"10.1038\/onc.2012.494","article-title":"Mitochondrial dynamics regulates migration and invasion of breast cancer cells","volume":"32","author":"Zhao","year":"2013","journal-title":"Oncogene."},{"key":"B105","doi-asserted-by":"publisher","first-page":"60021","DOI":"10.18632\/oncotarget.11047","article-title":"Crosstalk between the mitochondrial fission protein, Drp1, and the cell cycle is identified across various cancer types and can impact survival of epithelial ovarian cancer patients","volume":"7","author":"Tanwar","year":"2016","journal-title":"Oncotarget."},{"key":"B106","doi-asserted-by":"publisher","first-page":"620","DOI":"10.4149\/neo_2013_080","article-title":"Cell-cycle arrest at G2\/M and proliferation inhibition by adenovirus-expressed mitofusin-2 gene in human colorectal cancer cell lines","volume":"60","author":"Cheng","year":"2013","journal-title":"Neoplasma."},{"key":"B107","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.bbrc.2012.03.118","article-title":"Depletion of mitochondrial fission factor DRP1 causes increased apoptosis in human colon cancer cells","volume":"421","author":"Inoue-Yamauchi","year":"2012","journal-title":"Biochem Biophys Res Commun."},{"key":"B108","doi-asserted-by":"publisher","first-page":"279745","DOI":"10.1101\/279745","article-title":"Mitochondrial fusion suppresses pancreatic cancer growth via reduced oxidative metabolism","volume":"2018","author":"Yu","year":"2018","journal-title":"bioRxiv."},{"key":"B109","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ceb.2016.02.001","article-title":"Regulators of mitochondrial dynamics in cancer","volume":"39","author":"Senft","year":"2016","journal-title":"Curr Opin Cell Biol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.molcel.2016.02.022","article-title":"Mitofusins, from mitochondria to metabolism","volume":"61","author":"Schrepfer","year":"2016","journal-title":"Mol Cell."},{"key":"B111","doi-asserted-by":"publisher","first-page":"41718","DOI":"10.1038\/srep41718","article-title":"MFN2 suppresses cancer progression through inhibition of mTORC2\/Akt signaling","volume":"7","author":"Xu","year":"2017","journal-title":"Sci Rep."},{"key":"B112","doi-asserted-by":"publisher","first-page":"S373","DOI":"10.1007\/s12032-010-9662-5","article-title":"Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma","volume":"28","author":"Jin","year":"2011","journal-title":"Med Oncol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12957-016-0922-5","article-title":"Clinical significance of mitofusin-2 and its signaling pathways in hepatocellular carcinoma","volume":"14","author":"Wu","year":"2016","journal-title":"World J Surg Oncol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"13005","DOI":"10.3390\/ijms140713005","article-title":"Anti-tumor effects of Mfn2 in gastric cancer","volume":"14","author":"Zhang","year":"2013","journal-title":"Int J Mol Sci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"2798070","DOI":"10.1155\/2018\/2798070","article-title":"Mitofusin2 induces cell autophagy of pancreatic cancer through inhibiting the PI3K\/Akt\/mTOR signaling pathway","volume":"2018","author":"Xue","year":"2018","journal-title":"Oxid Med Cell Longev."},{"key":"B116","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1159\/000488410","article-title":"Mitofusin-2 triggers cervical carcinoma cell Hela apoptosis via mitochondrial pathway in mouse model","volume":"46","author":"Wang","year":"2018","journal-title":"Cell Physiol Biochem."},{"key":"B117","doi-asserted-by":"publisher","first-page":"41351","DOI":"10.7554\/eLife.41351","article-title":"Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation","volume":"8","author":"Yao","year":"2019","journal-title":"eLife."},{"key":"B118","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/labinvest.2012.144","article-title":"OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma","volume":"93","author":"Zhao","year":"2013","journal-title":"Lab Invest."},{"key":"B119","doi-asserted-by":"publisher","first-page":"27134","DOI":"10.1074\/jbc.M114.594812","article-title":"p53 is required for cisplatin-induced processing of the mitochondrial fusion protein L-Opa1 that is mediated by the mitochondrial metallopeptidase Oma1 in gynecologic cancers","volume":"289","author":"Kong","year":"2014","journal-title":"J Biol Chem."},{"key":"B120","doi-asserted-by":"publisher","first-page":"32177","DOI":"10.1002\/ijc.32177","article-title":"Targeted OMA1 therapies for cancer","volume":"2019","author":"Alavi","year":"2019","journal-title":"Int J Cancer."},{"key":"B121","doi-asserted-by":"publisher","first-page":"e0122308","DOI":"10.1371\/journal.pone.0122308","article-title":"Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration","volume":"10","author":"Ferreira-da-Silva","year":"2015","journal-title":"PLoS ONE."},{"key":"B122","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1038\/onc.2016.425","article-title":"SIRT4 inhibits malignancy progression of NSCLCs, through mitochondrial dynamics mediated by the ERK\u2013Drp1 pathway","volume":"36","author":"Fu","year":"2017","journal-title":"Oncogene."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1002\/dneu.22519","article-title":"To mdivi-1 or not to mdivi-1: is that the question?","volume":"77","author":"Smith","year":"2017","journal-title":"Dev Neurobiol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1096\/fj.12-226225","article-title":"Dynamin-related protein 1 (Drp1)\u2013mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission","volume":"28","author":"Sharp","year":"2014","journal-title":"FASEB J."},{"key":"B125","doi-asserted-by":"publisher","first-page":"4180","DOI":"10.18632\/oncotarget.1944","article-title":"Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells","volume":"5","author":"Qian","year":"2014","journal-title":"Oncotarget."},{"key":"B126","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.devcel.2017.02.020","article-title":"The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species","volume":"40","author":"Bordt","year":"2017","journal-title":"Dev Cell."},{"key":"B127","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3389\/Fcell.2018.00113","article-title":"Metabolic targeting of breast cancer cells with the 2-deoxy-D-glucose and the mitochondrial bioenergetics inhibitor MDIVI-1","volume":"6","author":"Lucantoni","year":"2018","journal-title":"Front Cell Dev Biol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2019.00570\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T02:01:18Z","timestamp":1664244078000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2019.00570\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":127,"alternative-id":["10.3389\/fendo.2019.00570"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2019.00570","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]},"article-number":"570"}}