{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:32:27Z","timestamp":1791639147991,"version":"4.3.4"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2019.00731","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T11:39:04Z","timestamp":1571830744000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":52,"title":["The Clinicopathological Spectrum of Parathyroid Carcinoma"],"prefix":"10.3389","volume":"10","author":[{"given":"Amit","family":"Akirov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia L.","family":"Asa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Larouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Mete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Sawka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shereen","family":"Ezzat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1053\/ejso.2001.1122","article-title":"Parathyroid carcinoma: problems in diagnosis and the need for radical surgery even in recurrent disease","volume":"27","author":"Dotzenrath","year":"2001","journal-title":"Eur J Surg Oncol."},{"key":"B2","first-page":"251","article-title":"Nonfunctional parathyroid carcinoma Goetz","volume":"93","author":"Giessler","year":"2001","journal-title":"J Natl Med Assoc."},{"key":"B3","first-page":"659","article-title":"Incidental non-functional parathyroid carcinoma identified during thyroidectomy","volume":"10","author":"Mazeh","year":"2008","journal-title":"Isr Med Assoc J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/00001622-200001000-00007","article-title":"Update on the management of parathyroid tumors","volume":"12","author":"Fraker","year":"2000","journal-title":"Curr Opin Oncol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1007\/BF02067369","article-title":"Prognostic factors in parathyroid cancer: a review of 95 cases","volume":"16","author":"Sandelin","year":"1992","journal-title":"World J Surg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40463-016-0178-7","article-title":"The dangers of parathyroid biopsy","volume":"46","author":"Kim","year":"2017","journal-title":"J Otolaryngol Head Neck Surg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1530\/EDM-16-0113","article-title":"Diagnosis and treatment challenges of parathyroid carcinoma in a 27-year-old woman with multiple lung metastases","volume":"2017","author":"Rozhinskaya","year":"2017","journal-title":"Endocrinol Diabetes Metab Case Rep."},{"key":"B8","volume-title":"WHO Classification of Tumours of Endocrine Organs","author":"LLoyd","year":"2017"},{"key":"B9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.5146\/tjpath.2015.01316","article-title":"Parathyroid carcinoma: Diagnosis and clinical implications","volume":"31","author":"Duan","year":"2015","journal-title":"Turk Patoloji Derg."},{"key":"B10","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-40618-3_75","article-title":"Parathyroid","volume-title":"AJCC Cancer Staging Manual","author":"Landry","year":"2017"},{"key":"B11","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/(SICI)1097-0142(19990801)86:3<538::AID-CNCR25>3.0.CO;2-K","article-title":"Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995: a National Cancer Data Base Report. The American College of Surgeons Commission on Cancer and the American Cancer Society","volume":"86","author":"Hundahl","year":"1999","journal-title":"Cancer."},{"key":"B12","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1001\/jamasurg.2016.2310","article-title":"The American Association of endocrine surgeons guidelines for definitive management of primary hyperparathyroidism","volume":"151","author":"Wilhelm","year":"2016","journal-title":"JAMA Surg."},{"key":"B13","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s12022-012-9222-y","article-title":"Biomarkers of parathyroid carcinoma","volume":"23","author":"Erovic","year":"2012","journal-title":"Endocr Pathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"641","DOI":"10.3389\/fendo.2018.00641","article-title":"Intrathyroidal parathyroid carcinoma: an atypical thyroid lesion","volume":"9","author":"Alharbi","year":"2018","journal-title":"Front Endocrinol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.amjsurg.2010.09.025","article-title":"Incidence and prognosis of parathyroid gland carcinoma: a population-based study in the Netherlands estimating the preoperative diagnosis","volume":"202","author":"Schaapveld","year":"2011","journal-title":"Am J Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"368","DOI":"10.14310\/horm.2002.1367","article-title":"Parathyroid carcinoma as a challenging diagnosis: report of three cases","volume":"11","author":"Campenn\u00ec","year":"2012","journal-title":"Hormones."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1210\/jcem.78.6.8200932","article-title":"p53 abnromalities in in human carcinoma","volume":"78","author":"Cryns","year":"1994","journal-title":"J Clin Endocrinol Metab."},{"key":"B18","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1056\/NEJM199403173301105","article-title":"Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma","volume":"330","author":"Cryns","year":"1994","journal-title":"N Engl J Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1210\/jcem.77.5.8077300","article-title":"Genetic basis of endocrine disease 5. Molecular genetics of parathyroid gland neoplasia","volume":"77","author":"Arnold","year":"1993","journal-title":"J Intern Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1210\/js.2018-00043","article-title":"Comprehensive genomic characterization of parathyroid cancer identifies novel candidate driver mutations and core pathways","volume":"3","author":"Clarke","year":"2019","journal-title":"J Endocr Soc."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1002\/humu.23337","article-title":"Molecular genetics of syndromic and non-syndromic forms of parathyroid carcinoma","volume":"38","author":"Cardoso","year":"2017","journal-title":"Hum Mutat."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1080\/15476286.2019.1622962","article-title":"Circular RNA profile of parathyroid neoplasms: analysis of co-expression networks of circular RNAs and mRNAs","volume":"16","author":"Hu","year":"2019","journal-title":"RNA Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1007\/s00432-019-02945-9","article-title":"Genetic profiling as a clinical tool in advanced parathyroid carcinoma","volume":"145","author":"Kutahyalioglu","year":"2019","journal-title":"J Cancer Res Clin Oncol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s004280000228","article-title":"AgNOR quantity as a prognostic tool in hyperplastic and neoplastic parathyroid glands","volume":"437","author":"Tuccari","year":"2000","journal-title":"Virchows Arch."},{"key":"B25","first-page":"1201","article-title":"Parathyroids","volume-title":"Histology for Pathologists","author":"Asa","year":"2019"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1002\/cncr.22599","article-title":"Trends in the incidence and treatment of parathyroid cancer in the United States","volume":"109","author":"Lee","year":"2007","journal-title":"Cancer"},{"key":"B27","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/hed.22908","article-title":"Parathyroid cancer: outcome analysis of 16 patients treated at the Princess Margaret Hospital","volume":"35","author":"Erovic","year":"2013","journal-title":"Head Neck."},{"key":"B28","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s12020-016-1147-7","article-title":"Association of parathyroid carcinoma and thyroid disorders: a clinical review","volume":"56","author":"Campenn\u00ec","year":"2017","journal-title":"Endocrine."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1007\/s00268-009-9999-0","article-title":"Parathyroid carcinoma: Etiology, diagnosis, and treatment","volume":"33","author":"Okamoto","year":"2009","journal-title":"World J Surg."},{"key":"B30","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/PAS.0000000000001017","article-title":"Parafibromin-deficient (HPT-JT Type, CDC73 Mutated) parathyroid tumors demonstrate distinctive morphologic features","volume":"43","author":"Gill","year":"2019","journal-title":"Am J Surg Pathol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"4534","DOI":"10.1210\/jc.2017-01249","article-title":"CDC73-related disorders: Clinical manifestations and case detection in primary hyperparathyroidism","volume":"102","author":"Van Der Tuin","year":"2017","journal-title":"J Clin Endocrinol Metab."}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2019.00731\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T11:15:10Z","timestamp":1571915710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2019.00731\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,23]]},"references-count":31,"alternative-id":["10.3389\/fendo.2019.00731"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2019.00731","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,23]]},"article-number":"731"}}