{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:51:26Z","timestamp":1793199086347,"version":"4.5.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.00016","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T05:39:42Z","timestamp":1582004382000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Antibodies Against Hypothalamus and Pituitary Gland in Childhood-Onset Brain Tumors and Pituitary Dysfunction"],"prefix":"10.3389","volume":"11","author":[{"given":"Giuseppa","family":"Patti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Calandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"De Bellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Gallizia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Crocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Napoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria Elsa","family":"Allegri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan F.","family":"Thiabat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bellastella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ida","family":"Maiorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Garr\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Parodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Maghnie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascia","family":"di Iorgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1056\/NEJM200010053431403","article-title":"Central diabetes insipidus in children and young adults","volume":"343","author":"Maghnie","year":"2000","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1007\/s00381-006-0078-7","article-title":"Lymphocytic hypophysitis with central diabetes insipidus and subsequent hypopituitarism masking a suprasellar germinoma in a 13-year-old girl","volume":"22","author":"Mikami-Terao","year":"2006","journal-title":"Childs Nerv Syst"},{"key":"B3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000224342","article-title":"Isolated lymphocytic infiltration of pituitary stalk preceding the diagnosis of germinoma in 2 prepubertal children treated with growth hormone","volume":"72","author":"Edouard","year":"2009","journal-title":"Horm Res"},{"key":"B4","first-page":"13","article-title":"Pituitary germinoma presenting as a pseudotumoral lymphocytic hypophysitis in a man","volume":"63","author":"Torremocha","year":"2002","journal-title":"Ann Endocrinol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/B978-0-444-52138-5.00004-9","article-title":"Immunology of brain tumors","volume":"104","author":"Roth","year":"2012","journal-title":"Handb Clin Neurol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1517\/14712598.2012.648180","article-title":"Immunotherapy targeting glioma stem cells\u2014insights and perspectives","volume":"12","author":"Li","year":"2012","journal-title":"Expert Opin Biol Ther."},{"key":"B7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1080\/14737175.2018.1425617","article-title":"Immunotherapy for brain tumors: understanding early successes and limitations","volume":"18","author":"Lieberman","year":"2018","journal-title":"Expert Rev Neurother"},{"key":"B8","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1080\/14737140.2018.1451749","article-title":"CAR T-cell therapy for glioblastoma: ready for the next round of clinical testing?","volume":"18","author":"Prinzing","year":"2018","journal-title":"Expert Rev Anticancer Ther"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1007\/s00381-010-1245-4","article-title":"The role of inflammation in the genesis of the cystic component of craniopharyngiomas","volume":"26","author":"Pettorini","year":"2010","journal-title":"Childs Nerv Syst."},{"key":"B10","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1093\/jnen\/nly008","article-title":"Central nervous system germinomas express programmed death ligand 1","volume":"77","author":"Wildeman","year":"2018","journal-title":"J Neuropathol Exp Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1530\/eje.0.1390635","article-title":"Evolution of childhood central diabetes insipidus into panhypopituitarism with a large hypothalamic mass: is \u201clymphocytic infundibuloneurohypophysitis\u201d in children a different entity?","volume":"139","author":"Maghnie","year":"1998","journal-title":"Eur J Endocrinol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/his.13295","article-title":"What's new in pituitary pathology?","volume":"72","author":"Asa","year":"2018","journal-title":"Histopathology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1111\/j.1365-2265.1994.tb02518.x","article-title":"Antipituitary antibodies in patients with pituitary abnormalities and hormonal deficiency","volume":"40","author":"Maghnie","year":"1994","journal-title":"Clin Endocrinol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/BF02029353","article-title":"Organ-and non-organ-specific auto-antibodies in children with hypopituitarism on growth hormone therapy","volume":"154","author":"Maghnie","year":"1995","journal-title":"Eur J Pediatr."},{"key":"B15","doi-asserted-by":"publisher","first-page":"3750","DOI":"10.1210\/jc.2010-0551","article-title":"Predictive role of the immunostaining pattern of immunofluorescence and the titers of antipituitary antibodies at presentation for the occurrence of autoimmune hypopituitarism in patients with autoimmune polyendocrine syndromes over a five-year follow-up","volume":"95","author":"Bellastella","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"B16","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1365-2265.2011.04056.x","article-title":"Detection of antipituitary and antihypothalamus antibodies to investigate the role of pituitary or hypothalamic autoimmunity in patients with selective idiopathic hypopituitarism","volume":"75","author":"De Bellis","year":"2011","journal-title":"Clin Endocrinol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.1210\/jc.2012-2269","article-title":"Involvement of hypothalamus autoimmunity in patients with autoimmune hypopituitarism: role of antibodies to hypothalamic cells","volume":"97","author":"De Bellis","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"B18","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.autrev.2008.04.016","article-title":"Pituitary autoimmunity: 30 years later","volume":"7","author":"Caturegli","year":"2008","journal-title":"Autoimmun Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1210\/jc.2011-1591","article-title":"Central hypothyroidism in a patient with pituitary autoimmunity: evidence for TSH-independent thyroid hormone synthesis","volume":"97","author":"Barbesino","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"key":"B20","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/s11102-011-0355-7","article-title":"Prevalence of antipituitary antibodies in acromegaly","volume":"15","author":"Guaraldi","year":"2012","journal-title":"Pituitary."},{"key":"B21","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s12020-018-1666-5","article-title":"Autoimmune pituitary involvement in Prader-Willi syndrome: new perspective for further research","volume":"62","author":"Grugni","year":"2018","journal-title":"Endocrine."},{"key":"B22","doi-asserted-by":"publisher","first-page":"4190","DOI":"10.1210\/en.2011-1004","article-title":"From pituitary expansion to empty sella: disease progression in a mouse model of autoimmune hypophysitis","volume":"152","author":"Lupi","year":"2011","journal-title":"Endocrinology."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1210\/jc.2006-0040","article-title":"Antipituitary antibodies recognizing growth hormone (GH)-producing cells in children with idiopathic GH deficiency and in children with idiopathic short stature","volume":"91","author":"De Bellis","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"B24","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1210\/jc.2002-021054","article-title":"Antipituitary antibodies in adults with apparently idiopathic growth hormone deficiency and in adults with autoimmune endocrine diseases","volume":"88","author":"De Bellis","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"B25","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1365-2265.2006.02616.x","article-title":"Idiopathic central diabetes insipidus in children and young adults is commonly associated with vasopressin-cell antibodies and markers of autoimmunity","volume":"66","author":"Maghnie","year":"2007","journal-title":"Clin Endocrinol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1210\/jc.2002-020791","article-title":"Central diabetes insipidus and autoimmunity: relationship between the occurrence of antibodies to arginine vasopressin-secreting cells and clinical, immunological, and radiological features in a large cohort of patients with central diabetes insipidus of known and unknown etiology","volume":"88","author":"Pivonello","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"B27","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1210\/jc.83.2.609","article-title":"Cytosolic autoantigens in lymphocytic hypophysitis","volume":"83","author":"Crock","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"B28","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1046\/j.1365-2265.2001.01210.x","article-title":"Serum antibodies to human pituitary membrane antigen in patients with autoimmune lymphocytic hypophysitis and infundibulo neurohypophysitis","volume":"54","author":"Nishiki","year":"2001","journal-title":"Clin Endocrinol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/S0022-3476(85)80190-6","article-title":"Diabetes insipidus in children. A possibile autoimmune type with vasopressin cell antibodies","volume":"107","author":"Scherbaum","year":"1985","journal-title":"J Pediatr"},{"key":"B30","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/S0140-6736(83)91328-4","article-title":"Autoantibodies to vasopressin cells in idiopathic diabetes insipidus: evidence for an autoimmune variant","volume":"1","author":"Scherbaum","year":"1983","journal-title":"Lancet"},{"key":"B31","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/j.1365-2265.1986.tb01707.x","article-title":"Autoimmune cranial diabetes insipidus: its association with other endocrine diseases and with histiocytosis X","volume":"25","author":"Scherbaum","year":"1986","journal-title":"Clin Endocrinol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3825","DOI":"10.1210\/jcem.87.8.8757","article-title":"Longitudinal study of vasopressin-cell antibodies and of hypothalamic-pituitary region on magnetic resonance imaging in patients with autoimmune and idiopathic complete central diabetes insipidus","volume":"87","author":"De Bellis","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1210\/jcem.84.9.5945","article-title":"A longitudinal study of vasopressin cell antibodies, posterior pituitary function, and magnetic resonance imaging evaluations in subclinical autoimmune central diabetes insipidus","volume":"84","author":"De Bellis","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"key":"B34","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/s11102-009-0187-x","article-title":"Pituitary and systemic autoimmunity in a case of intrasellar germinoma","volume":"14","author":"Gutenberg","year":"2011","journal-title":"Pituitary."},{"key":"B35","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1007\/s004310051074","article-title":"Lymphocytic hypophysitis with central diabetes insipidus and consequent panhypopituitarism preceding a multifocal, intracranial germinomain a prepubertal girl","volume":"158","author":"Bettendorf","year":"1999","journal-title":"Eur J Pediatr"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s00701-002-1027-1","article-title":"Neurohypophyseal germinoma histologically misidentified as granulomatous hypophysitis","volume":"144","author":"Endo","year":"2002","journal-title":"Acta Neurochir."},{"key":"B37","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1023\/A:1009923029942","article-title":"Lymphocytic hypophysitis masking a suprasellar germinoma in a 12-year-old girl. A case report","volume":"1","author":"Fehn","year":"1999","journal-title":"Pituitary."},{"key":"B38","first-page":"349","article-title":"Pituitary germinoma and lymphocytic hypophysitis: a pitfall. Report of two cases","volume":"23","author":"Houdouin","year":"2003","journal-title":"Ann Pathol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"67","DOI":"10.14310\/horm.2002.11171","article-title":"An intrasellar germinoma with normal cerebrospinal fluid beta-HCG concentrations misdiagnosed as hypophysitis","volume":"5","author":"Ozbey","year":"2006","journal-title":"Hormones"},{"key":"B40","doi-asserted-by":"publisher","first-page":"429","DOI":"10.2176\/nmc.46.429","article-title":"Histological features of intracranial germinomas not disappearing immediately after radiotherapy","volume":"46","author":"Utsuki","year":"2006","journal-title":"Neurol Med Chir"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00016\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T05:39:46Z","timestamp":1582004386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00016\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":40,"alternative-id":["10.3389\/fendo.2020.00016"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.00016","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"article-number":"16"}}