{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:37:17Z","timestamp":1784734637787,"version":"3.55.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.00019","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:27:28Z","timestamp":1580171248000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Is Embryo Cryopreservation Causing Macrosomia\u2014and What Else?"],"prefix":"10.3389","volume":"11","author":[{"given":"Raoul","family":"Orvieto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Kirshenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Gleicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1056\/NEJMoa041032","article-title":"Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization","volume":"351","author":"Thurin","year":"2004","journal-title":"N Engl J Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.fertnstert.2014.04.018","article-title":"Clinical rationale for cryopreservation of entire embryo cohorts in lieu of fresh transfer","volume":"102","author":"Shapiro","year":"2014","journal-title":"Fertil Steril"},{"key":"B3","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.fertnstert.2011.05.050","article-title":"Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders","volume":"96","author":"Shapiro","year":"2011","journal-title":"Fertil Steril"},{"key":"B4","doi-asserted-by":"publisher","first-page":"CD011184","DOI":"10.1002\/14651858","article-title":"Fresh versus frozen embryo transfers in assisted reproduction","volume":"2017","author":"Wong","year":"2017","journal-title":"Cochrane Database Syst Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1093\/humrep\/dey388","article-title":"Higher probability of live-birth in high, but not normal, responders after first frozen-embryo transfer in a freeze-only cycle strategy compared to fresh embryo transfer: ameta-analysis","volume":"34","author":"Bosdou","year":"2019","journal-title":"Hum Reprod"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1093\/humupd\/dmy033","article-title":"Fresh versus elective frozen embryo transfer in IVF\/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes","volume":"25","author":"Roque","year":"2019","journal-title":"Hum Reprod Update"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/S0140-6736(18)32843-5","article-title":"Frozen versus fresh single blastocyst transfer in ovulating women: a multicenter, randomized controlled trial","volume":"393","author":"Wei","year":"2019","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1056\/NEJMoa1705334","article-title":"Transfer of fresh versus frozen embryos in ovulatory women","volume":"378","author":"Shi","year":"2018","journal-title":"N Engl J Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/humupd\/dms018","article-title":"Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF\/ICSI: a systematic review and meta-analysis","volume":"18","author":"Pandey","year":"2012","journal-title":"Hum Reprod Update"},{"key":"B10","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ajog.2010.11.040","article-title":"Aberrant fetal growth and early, late, and postneonatal mortality: an analysis of Milwaukee births, 1996\u20132007","volume":"204","author":"Chen","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"195.e1","DOI":"10.1016\/j.ajog.2018.10.012","article-title":"Risk of severe maternal morbidity by maternal fertility status: a US study in 8 States","volume":"220","author":"Luke","year":"2019","journal-title":"Am J Obstet Gynecol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.fertnstert.2015.09.007","article-title":"Assisted reproductive technology and the risk of pregnancy-related complications and adverse pregnancy outcomes in singleton pregnancies: a meta-analysis of cohort studies","volume":"105","author":"Qin","year":"2016","journal-title":"Fertil Steril."},{"key":"B13","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.fertnstert.2017.01.021","article-title":"Perinatal outcomes in children born after fresh or frozen embryo transfer: a Catalan cohort study based on 14,262 newborns","volume":"107","author":"Vidal","year":"2017","journal-title":"Fertil Steril."},{"key":"B14","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1097\/AOG.0b013e31822be65f","article-title":"Ovarian stimulation and low birth weight in newborns conceived through in vitro fertilization","volume":"118","author":"Kalra","year":"2011","journal-title":"Obstet Gynecol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.fertnstert.2012.03.028","article-title":"Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in vitro fertilization","volume":"97","author":"Imudia","year":"2012","journal-title":"Fertil Steril"},{"key":"B16","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1097\/AOG.0b013e318269c282","article-title":"Assisted reproductive technology and major birth defects in Western Australia","volume":"120","author":"Hansen","year":"2012","journal-title":"Obstet Gynecol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1056\/NEJMoa010035","article-title":"The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization","volume":"346","author":"Hansen","year":"2002","journal-title":"N Engl J Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0165-0378(01)00134-6","article-title":"Impact of ovarian stimulation on corpus luteum function and embryonic implantation","volume":"55","author":"Tavaniotou","year":"2002","journal-title":"J Reprod Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0002-9378(96)70400-3","article-title":"Relaxin secretion in in vitro fertilization pregnancies","volume":"174","author":"Haning","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.fertnstert.2012.05.049","article-title":"Adverse obstetric and perinatal outcomes of singleton pregnancies may be related to maternal factors associated with infertility rather than the type of assisted reproductive technology procedure used","volume":"98","author":"Hayashi","year":"2012","journal-title":"Fertil Steril."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e80398","DOI":"10.1371\/journal.pone.0080398","article-title":"Perinatal outcomes by mode of assisted conception and sub-fertility in an Australian data linkage cohort","volume":"9","author":"Marino","year":"2014","journal-title":"PLoS ONE"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1097\/01.AOG.0000290330.80256.97","article-title":"Infertility, infertility treatment, and fetal growth restriction","volume":"110","author":"Zhu","year":"2007","journal-title":"Obstet Gynecol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1093\/humrep\/dep477","article-title":"Perinatal outcome of children born after frozen and fresh embryo transfer: the Finnish cohort study 1995\u20132006","volume":"25","author":"Pelkonen","year":"2010","journal-title":"Hum Reprod."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1016\/j.fertnstert.2009.05.091","article-title":"Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995\u20132006","volume":"94","author":"Pinborg","year":"2010","journal-title":"Fertil Steril"},{"key":"B25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13048-018-0432-x","article-title":"Fresh versus frozen embryo transfer for full-term singleton birth: a retrospective cohort study","volume":"11","author":"Zhang","year":"2018","journal-title":"J Ovarian Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e1001633","DOI":"10.1371\/journal.pmed.1001633","article-title":"Human Development Stillbirth Collaborative Research Network. Fetal growth and risk of stillbirth: a population-based case-control study","volume":"11","author":"Bukowski","year":"2014","journal-title":"PLoS Med"},{"key":"B27","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10815-016-0850-x","article-title":"Increased risk of large-forgestational age birthweight in singleton siblings conceived with in vitro fertilization in frozen versus fresh cycles","volume":"34","author":"Luke","year":"2017","journal-title":"J Assist Reprod Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/bdr2.1219","article-title":"Large for gestational age and macrosomia in singletons born after frozen\/thawed embryo transfer (FET) in assisted reproductive technology (ART)","volume":"110","author":"Berntsen","year":"2018","journal-title":"Birth Defects Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.fertnstert.2017.10.020","article-title":"Obstetric complications after frozen versus fresh embryo transfer in women with polycystic ovary syndrome: results from a randomized trial","volume":"109","author":"Zhang","year":"2018","journal-title":"Fertil Steril."},{"key":"B30","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.fertnstert.2019.05.020","article-title":"Fresh versus frozen embryo transfer has no effect on childhood weight","volume":"112","author":"Ainsworth","year":"2019","journal-title":"Fertil Steril."},{"key":"B31","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1146\/annurev-biochem-052610-091920","article-title":"Programming of DNA methylation patterns","volume":"81","author":"Cedar","year":"2012","journal-title":"Ann Rev Biochem"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1016\/j.fertnstert.2010.03.025","article-title":"Embryo vitrification affects the methylation of the H19\/Igf2 differentially methylated domain and the expression of H19 and Igf2","volume":"93","author":"Wang","year":"2010","journal-title":"Fertil Steril"},{"key":"B33","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.fertnstert.2016.05.006","article-title":"Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of newborn infants","volume":"106","author":"Estill","year":"2016","journal-title":"Fertil Steril."},{"key":"B34","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13148-017-0318-6","article-title":"Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies","volume":"9","author":"Ghosh","year":"2017","journal-title":"Clin Epigenet."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1016\/j.fertnstert.2016.08.047","article-title":"Obstetric and perinatal outcomes after either fresh or thawed frozen embryo transfer: an analysis of 112,432 singleton pregnancies recorded in the human fertilisation and embryology authority anonymized dataset","volume":"106","author":"Maheshwari","year":"2016","journal-title":"Fertil Steril"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1093\/humrep\/det272","article-title":"Perinatal outcomes of children born after frozen-thawed embry transfer: a Nordic cohort study from the CoNARTaS group","volume":"28","author":"Wennerholm","year":"2013","journal-title":"Hum Reprod."},{"key":"B37","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.fertnstert.2018.11.043","article-title":"Risk of ischemic placental disease in fresh and frozen embryo transfer cycles","volume":"111","author":"Johnson","year":"2019","journal-title":"Fertil Steril"},{"key":"B38","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.fertnstert.2017.10.019","article-title":"Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis","volume":"109","author":"Sha","year":"2018","journal-title":"Fertil Steril"},{"key":"B39","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.fertnstert.2019.07.010","article-title":"Health outcomes for Massachusetts infants after fresh versus frozen embryo transfer","volume":"112","author":"Hwang","year":"2019","journal-title":"Fertil Steril"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1016\/j.fertnstert.2013.02.009","article-title":"Phenotypic differences in children conceived from fresh and thawed embryos in in vitro fertilization compared with naturally conceived children","volume":"99","author":"Green","year":"2013","journal-title":"Fertil Steril"},{"key":"B41","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s10815-016-0685-5","article-title":"Natural cycle frozen-thawed embryo transfer-can we improve cycle outcome?","volume":"33","author":"Orvieto","year":"2016","journal-title":"J Assist Reprod Genet"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1007\/s10815-017-0983-6","article-title":"Replacing single frozen-thawed euploid embryos in a natural cycle in ovulatory women may increase live birth rates compared to medicated cycles in anovulatory women","volume":"34","author":"Melnick","year":"2017","journal-title":"J Assist Reprod Genet"},{"key":"B43","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1161\/HYPERTENSIONAHA.118.12043","article-title":"Increased preeclampsia risk and reduced aortic compliance with in vitro fertilization cycles in the absence of a corpus luteum","volume":"73","author":"von","year":"2019","journal-title":"Hypertension."},{"key":"B44","doi-asserted-by":"publisher","first-page":"126.e1","DOI":"10.1016\/j.ajog.2019.03.010","article-title":"Neonatal and maternal outcome after frozen embryo transfer: increased risks in programmed cycles","volume":"221","author":"Ginstr\u00f6m Ernstad","year":"2019","journal-title":"Am J Obstet Gynecol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s10815-019-01420-1","article-title":"Increased pregnancy complications following frozen-thawed embryo transfer during an artificial cycle","volume":"36","author":"Jing","year":"2019","journal-title":"J Assist Reprod Genet."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1093\/humrep\/dez079","article-title":"Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus","volume":"34","author":"Saito","year":"2019","journal-title":"Hum Reprod."}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00019\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:27:30Z","timestamp":1580171250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00019\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,28]]},"references-count":46,"alternative-id":["10.3389\/fendo.2020.00019"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.00019","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,28]]},"article-number":"19"}}