{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:16:24Z","timestamp":1792523784612,"version":"4.5.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.00038","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T04:48:21Z","timestamp":1580878101000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Child Head Circumference and Placental MFSD2a Expression Are Associated to the Level of MFSD2a in Maternal Blood During Pregnancy"],"prefix":"10.3389","volume":"11","author":[{"given":"Mar\u00eda","family":"S\u00e1nchez-Campillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Ruiz-Palacios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J.","family":"Ruiz-Alcaraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Prieto-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Eliseo","family":"Blanco-Carnero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Zornoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Ruiz-Pastor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Demmelmair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"S\u00e1nchez-Sol\u00eds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Koletzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Larqu\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/1753-0407.12422","article-title":"Gestational diabetes mellitus:current knowledge and unmet needs","volume":"8","author":"Koning","year":"2016","journal-title":"J Diabetes."},{"key":"B2","doi-asserted-by":"publisher","first-page":"R43","DOI":"10.1530\/EJE-15-0378","article-title":"Endocrinology of pregnancy: gestational diabetes mellitus: definition, aetiological and clinical aspects","volume":"174","author":"Baz","year":"2016","journal-title":"Eur J Endocrinol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1111\/j.1471-0528.2006.00989.x","article-title":"The short- and long-term implications of maternal obesity on the mother and her offspring","volume":"113","author":"Catalano","year":"2006","journal-title":"BJOG."},{"key":"B4","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1056\/NEJM199109263251303","article-title":"Correlations between antepartum maternal metabolism and child intelligence","volume":"325","author":"Rizzo","year":"1991","journal-title":"N Engl J Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"963735","DOI":"10.1155\/2012\/963735","article-title":"Associations of existing diabetes, gestational diabetes, and glycosuria with offspring IQ and educational attainment: the Avon Longitudinal Study of Parents and Children","volume":"2012","author":"Fraser","year":"2012","journal-title":"Exp Diabetes Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e0162113","DOI":"10.1371\/journal.pone.0162113","article-title":"The influence of gestational diabetes on neurodevelopment of children in the first two years of life: a prospective study","volume":"11","author":"Cai","year":"2016","journal-title":"PLoS ONE"},{"key":"B7","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1093\/jn\/137.4.855","article-title":"Dietary (n-3) fatty acids and brain development","volume":"137","author":"Innis","year":"2007","journal-title":"J Nutr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1159\/000017478","article-title":"The role of dietary n-6 and n-3 fatty acids in the developing brain","volume":"22","author":"Innis","year":"2000","journal-title":"Dev Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1385\/JMN:16:2-3:237","article-title":"The role of docosahexaenoic acid containing phospholipids in modulating G protein-coupled signaling pathways: visual transduction","volume":"16","author":"Litman","year":"2001","journal-title":"J Mol Neurosci"},{"key":"B10","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.1017\/S0007114512001481","article-title":"Omega 3 fatty acids, gestation and pregnancy outcomes","volume":"107","author":"Larqu\u00e9","year":"2012","journal-title":"Br J Nutr"},{"key":"B11","doi-asserted-by":"publisher","first-page":"E826","DOI":"10.1152\/ajpendo.00291.2013","article-title":"Materno-fetal transfer of docosahexaenoic acid is impaired by gestational diabetes mellitus","volume":"305","author":"Pag\u00e1n","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B12","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/S11745-000-0602-2","article-title":"Fetal erythrocyte phospholipid polyunsaturated fatty acids are altered in pregnancy complicated with gestational diabetes mellitus","volume":"35","author":"Wijendran","year":"2000","journal-title":"Lipids"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1093\/ajcn\/82.6.1162","article-title":"Unfavorable effect of type 1 and type 2 diabetes on maternal and fetal essential fatty acid status: a potential marker of fetal insulin resistance","volume":"82","author":"Min","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"B14","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/ejcn.2014.104","article-title":"Is low docosahexaenoic acid associated with disturbed rhythms and neurodevelopment in offsprings of diabetic mothers?","volume":"68","author":"Zornoza-Moreno","year":"2014","journal-title":"Eur J Clin Nutr"},{"key":"B15","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/nature13241","article-title":"Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid","volume":"509","author":"Nguyen","year":"2014","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"10501","DOI":"10.1074\/jbc.M116.721340","article-title":"Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid (DHA) in eye and is important for photoreceptor cell development","volume":"291","author":"Wong","year":"2016","journal-title":"J Biol Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nature13324","article-title":"Mfsd2a is critical for the formation and function of the blood-brain barrier","volume":"509","author":"Ben-Zvi","year":"2014","journal-title":"Nature."},{"key":"B18","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/ng.3313","article-title":"A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome","volume":"47","author":"Alakbarzade","year":"2015","journal-title":"Nat Genet."},{"key":"B19","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1038\/ng.3311","article-title":"Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome","volume":"47","author":"Guemez-Gamboa","year":"2015","journal-title":"Nat Genet."},{"key":"B20","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s10048-018-0556-6","article-title":"Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination","volume":"19","author":"Harel","year":"2018","journal-title":"Neurogenetics."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3566","DOI":"10.1128\/MCB.23.10.3566-3574.2003","article-title":"Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation","volume":"23","author":"Frendo","year":"2003","journal-title":"Mol Cell Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"17532","DOI":"10.1073\/pnas.0807413105","article-title":"A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2","volume":"105","author":"Esnault","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B23","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.clnu.2016.01.014","article-title":"Placental MFSD2a transporter is related to decreased DHA in cord blood of women with treated gestational diabetes","volume":"36","author":"Prieto-S\u00e1nchez","year":"2017","journal-title":"Clin Nutr."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.placenta.2014.06.105","article-title":"Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta","volume":"31","author":"Soygur","year":"2016","journal-title":"Histol Histopathol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.placenta.2012.10.012","article-title":"MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion","volume":"34","author":"Toufaily","year":"2013","journal-title":"Placenta."},{"key":"B26","first-page":"278","article-title":"Criteria for the oral glucose tolerance test in pregnancy","volume":"13","author":"O'Sullivan","year":"1964","journal-title":"Diabetes."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.2337\/diab.28.12.1039","article-title":"Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance","volume":"28","author":"Group","year":"1979","journal-title":"Natl Diab Data Group Diab."},{"key":"B28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1471-0528.1994.tb13077.x","article-title":"Charts of fetal size: 3. Abdominal measurements","volume":"101","author":"Chitty","year":"1994","journal-title":"Br J Obstet Gynaecol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/S1575-0922(08)75845-5","article-title":"Spanish growth studies 2008. New anthropometric standards","volume":"55","author":"Carrascosa","year":"2008","journal-title":"Endocrinol Nutr."},{"key":"B30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1042\/BJ20051194","article-title":"A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration","volume":"392","author":"Ruiz-Alcaraz","year":"2005","journal-title":"Biochem J"},{"key":"B32","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"E1250","DOI":"10.3390\/nu10091250","article-title":"Short-term fish oil treatment changes the composition of phospholipids while not affecting the expression of Mfsd2a Omega-3 transporter in the brain and liver of the 5xFAD mouse model of Alzheimer's disease","volume":"10","author":"Milanovic","year":"2018","journal-title":"Nutrients"},{"key":"B34","doi-asserted-by":"publisher","first-page":"120","DOI":"10.2337\/dc08-0679","article-title":"Gestational diabetes mellitus upsets the proportion of fatty acids in umbilical arterial but not venous plasma","volume":"32","author":"Ortega-Senovilla","year":"2009","journal-title":"Diabetes Care"},{"key":"B35","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jprot.2015.07.020","article-title":"Proteomic-driven biomarker discovery in gestational diabetes mellitus: a review","volume":"127","author":"Singh","year":"2015","journal-title":"J Proteomics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"9383","DOI":"10.1074\/jbc.M116.721035","article-title":"Structural insights into the transport mechanism of the human sodium-dependent lysophosphatidylcholine transporter MFSD2A","volume":"291","author":"Quek","year":"2016","journal-title":"J Biol Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"11756","DOI":"10.1073\/pnas.1018098108","article-title":"A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin","volume":"108","author":"Reiling","year":"2011","journal-title":"Proc Natl Acad Sci USA."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e50629","DOI":"10.1371\/journal.pone.0050629","article-title":"Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism","volume":"7","author":"Berger","year":"2012","journal-title":"PLoS ONE."},{"key":"B39","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1017\/S0007114517002951","article-title":"DHA supplementation during pregnancy as phospholipids or TAG produces different placental uptake but similar fetal brain accretion in neonatal piglets","volume":"118","author":"G\u00e1zquez","year":"2017","journal-title":"Br J Nutr."},{"key":"B40","doi-asserted-by":"publisher","first-page":"E1107","DOI":"10.3390\/nu11051107","article-title":"Maternal omega-3 nutrition, placental transfer and fetal brain development in gestational diabetes and preeclampsia","volume":"11","author":"Devarshi","year":"2019","journal-title":"Nutrients"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e1534","DOI":"10.1542\/peds.2007-2671","article-title":"Head growth in preterm infants: correlation with magnetic resonance imaging and neurodevelopmental outcome","volume":"121","author":"Cheong","year":"2008","journal-title":"Pediatrics."},{"key":"B42","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1203\/PDR.0b013e3181d026da","article-title":"Impact of breast milk on intelligence quotient, brain size, and white matter development","volume":"67","author":"Isaacs","year":"2010","journal-title":"Pediatr Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1385\/JMN:16:2-3:201","article-title":"Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain","volume":"16","author":"Lagarde","year":"2001","journal-title":"J Mol Neurosci"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e2006443","DOI":"10.1371\/journal.pbio.2006443","article-title":"The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain","volume":"16","author":"Chan","year":"2018","journal-title":"PLoS Biol."},{"key":"B45","first-page":"257","article-title":"The major facilitator superfamily","volume":"1","author":"Saier","year":"1999","journal-title":"J Mol Microbiol Biotechnol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"117","DOI":"10.4049\/jimmunol.1801585","article-title":"The lysophosphatidylcholine transporter MFSD2A is essential for CD8(+) memory T cell maintenance and secondary response to infection","volume":"203","author":"Piccirillo","year":"2019","journal-title":"J Immunol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00038\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T23:50:51Z","timestamp":1614297051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00038\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,5]]},"references-count":46,"alternative-id":["10.3389\/fendo.2020.00038"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.00038","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,5]]},"article-number":"38"}}