{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:31:47Z","timestamp":1784903507881,"version":"3.55.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.00256","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T05:01:57Z","timestamp":1588654917000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Pathological and Incidental Findings in 403 Taiwanese Girls With Central Precocious Puberty at Initial Diagnosis"],"prefix":"10.3389","volume":"11","author":[{"given":"Chiao-Fan","family":"Chiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Jan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Pin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Sung","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"B1","first-page":"2899","article-title":"Disorders of pubertal development","volume-title":"Nelson Textbook of Pediatrics, 21th Edn.","author":"Garibaldi","year":"2020"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1542\/peds.2005-0012","article-title":"Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries","volume":"116","author":"Teilmann","year":"2005","journal-title":"Pediatrics."},{"key":"B3","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1210\/js.2019-00036","article-title":"Treatment of central precocious puberty","volume":"3","author":"Eugster","year":"2019","journal-title":"J Endocr Soc."},{"key":"B4","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1515\/jpem.2000.13.s1.687","article-title":"Etiology of central precocious puberty in males: the results of the Italian Study Group for Physiopathology of Puberty","volume":"13","author":"De Sanctis","year":"2000","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B5","doi-asserted-by":"publisher","first-page":"183","DOI":"10.6065\/apem.2013.18.4.183","article-title":"Boys with precocious or early puberty: incidence of pathological brain magnetic resonance imaging findings and factors related to newly developed brain lesions","volume":"18","author":"Choi","year":"2013","journal-title":"Ann Pediatr Endocrinol Metab."},{"key":"B6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3389\/fendo.2017.00213","article-title":"Precocious puberty or premature thelarche: analysis of a large patient series in a single tertiary center with special emphasis on 6- to 8-year-old girls","volume":"8","author":"Varimo","year":"2017","journal-title":"Front Endocrinol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e29829","DOI":"10.1371\/journal.pone.0029829","article-title":"Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty","volume":"7","author":"Mogensen","year":"2012","journal-title":"PLoS ONE."},{"key":"B8","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1136\/adc.88.5.414","article-title":"Cranial MRI scans are indicated in all girls with central precocious puberty","volume":"88","author":"Ng","year":"2003","journal-title":"Arch Dis Child."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e752","DOI":"10.1542\/peds.2008-1783","article-title":"Consensus statement on the use of gonadotropin-releasing hormone analogs in children","volume":"123","author":"Carel","year":"2009","journal-title":"Pediatrics."},{"key":"B10","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variations in pattern of pubertal changes in girls","volume":"44","author":"Marshall","year":"1969","journal-title":"Arch Dis Child."},{"key":"B11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1136\/adc.45.239.13","article-title":"Variations in the pattern of pubertal changes in boys","volume":"45","author":"Marshall","year":"1970","journal-title":"Arch Dis Child."},{"key":"B12","doi-asserted-by":"crossref","DOI":"10.1097\/00000441-195909000-00030","volume-title":"Radiographic Atlas of Skeletal Development of the Hand and Wrist","author":"Greulich","year":"1959"},{"key":"B13","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.jpeds.2012.06.015","article-title":"Pharmacodynamics of aqueous leuprolide acetate stimulation testing in girls: correlation between clinical diagnosis and time of peak luteinizing hormone level","volume":"161","author":"Chi","year":"2012","journal-title":"J Pediatr."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1210\/jc.2006-1569","article-title":"Assessment of basal and gonadotropin-releasing hormone-stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children","volume":"92","author":"Resende","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1210\/jcem-71-5-1251","article-title":"Gonadotropin secretory dynamics during puberty in normal girls and boys","volume":"71","author":"Oerter","year":"1990","journal-title":"J Clin Endocrinol Metab."},{"key":"B16","first-page":"2903","article-title":"Disorders of pubertal development","volume-title":"Nelson Textbook of Pediatrics, 21th Edn","author":"Garibaldi","year":"2020"},{"key":"B17","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1159\/000477584","article-title":"Long-term outcomes of patients with central precocious puberty due to hypothalamic hamartoma after GnRHa treatment: anthropometric, metabolic, and reproductive aspects","volume":"106","author":"Ramos","year":"2018","journal-title":"Neuroendocrinology."},{"key":"B18","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/epi.13758","article-title":"Medical management and antiepileptic drugs in hypothalamic hamartoma","volume":"58","author":"Helen Cross","year":"2017","journal-title":"Epilepsia."},{"key":"B19","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0387-7604(94)90080-9","article-title":"Precocious puberty in a case with probable Angelman syndrome","volume":"16","author":"Young","year":"1994","journal-title":"Brain Dev."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1210\/jc.2014-2702","article-title":"Routine screening by brain magnetic resonance imaging is not indicated in every girl with onset of puberty between the ages of 6 and 8 years","volume":"99","author":"Pedicelli","year":"2014","journal-title":"J Clin Endocrinol Metab."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e329","DOI":"10.3346\/jkms.2018.33.e329","article-title":"Prevalence of pathological brain lesions in girls with central precocious puberty: possible overestimation","volume":"33","author":"Yoon","year":"2018","journal-title":"J Korean Med Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"5906","DOI":"10.1210\/jc.2019-01252","article-title":"Clinical course of nonfunctional pituitary microadenoma in children: a single-center experience","volume":"104","author":"Thaker","year":"2019","journal-title":"J Clin Endocrinol Metab."},{"key":"B23","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1515\/jpem.2002.15.2.157","article-title":"Microadenomas of the pituitary gland in children with and without hypophyseal dysfunction in magnetic resonance imaging","volume":"15","author":"Hirsch","year":"2002","journal-title":"J Pediatr Endocrinol Metab."},{"key":"B24","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s11102-019-00940-4","article-title":"Pituitary incidentalomas in paediatric age are different from those described in adulthood","volume":"22","author":"Souteiro","year":"2019","journal-title":"Pituitary."},{"key":"B25","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1210\/jc.2010-1048","article-title":"Pituitary incidentaloma: an endocrine society clinical practice guideline","volume":"96","author":"Freda","year":"2011","journal-title":"J Clin Endocrinol Metab."},{"key":"B26","doi-asserted-by":"publisher","first-page":"20","DOI":"10.6065\/apem.2014.19.1.20","article-title":"Clinical and radiological findings of incidental Rathke's cleft cysts in children and adolescents","volume":"19","author":"Oh","year":"2014","journal-title":"Ann Pediatr Endocrinol Metab."},{"key":"B27","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1067\/S0022-3476(03)00328-7","article-title":"Selecting girls with precocious puberty for brain imaging: validation of European evidence-based diagnosis rule","volume":"143","author":"Chalumeau","year":"2003","journal-title":"J Pediatr."},{"key":"B28","unstructured":"FDADrug Safety Communication: FDA Evaluating the Risk of Brain Deposits with Repeated Use of Gadolinium-Based Contrast Agents for Magnetic Resonance Imaging (MRI)2015"},{"key":"B29","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/RLI.0000000000000575","article-title":"Gadolinium deposition in the brain in a large animal model: comparison of linear and macrocyclic gadolinium-based contrast agents","volume":"54","author":"Radbruch","year":"2019","journal-title":"Invest Radiol."}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00256\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T05:02:02Z","timestamp":1588654922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00256\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,5]]},"references-count":29,"alternative-id":["10.3389\/fendo.2020.00256"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.00256","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,5]]},"article-number":"256"}}