{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:23:52Z","timestamp":1789457032850,"version":"build-2803163510"},"reference-count":166,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730042"],"award-info":[{"award-number":["81730042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.00447","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T05:30:42Z","timestamp":1596173442000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":69,"title":["Bisphenols and Leydig Cell Development and Function"],"prefix":"10.3389","volume":"11","author":[{"given":"Xiaoheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zina","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Shan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"bnz013","DOI":"10.1210\/endrev\/bnz013","article-title":"Stem leydig cells in the adult testis: characterization, regulation and potential applications","volume":"41","author":"Chen","year":"2020","journal-title":"Endocr Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3389\/fphys.2017.00430","article-title":"Insights into the development of the adult leydig cell lineage from stem leydig cells","volume":"8","author":"Ye","year":"2017","journal-title":"Front Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.chemosphere.2019.02.090","article-title":"The structure-activity relationship (SAR) for phthalate-mediated developmental and reproductive toxicity in males","volume":"223","author":"Li","year":"2019","journal-title":"Chemosphere."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.3389\/fphar.2019.01309","article-title":"Phthalate-Induced Fetal Leydig Cell Dysfunction Mediates Male Reproductive Tract Anomalies","volume":"10","author":"Wang","year":"2019","journal-title":"Front Pharmacol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1530\/rep.0.1220899","article-title":"Relaxin-like factor (RLF) serum concentrations and gubernaculum RLF receptor display in relation to pre- and neonatal development of rats","volume":"122","author":"Boockfor","year":"2001","journal-title":"Reproduction."},{"key":"B6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0303-7207(99)00188-4","article-title":"The role of the testicular factor INSL3 in establishing the gonadal position","volume":"160","author":"Adham","year":"2000","journal-title":"Mol Cell Endocrinol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1196\/annals.1282.012","article-title":"Genetic targeting of relaxin and insl3 signaling in mice","volume":"1041","author":"Feng","year":"2005","journal-title":"Ann N Y Acad Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.tem.2008.12.001","article-title":"Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence","volume":"20","author":"Hu","year":"2009","journal-title":"Trends Endocrinol Metab."},{"key":"B9","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1093\/humrep\/16.5.972","article-title":"Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects","volume":"16","author":"Skakkebaek","year":"2001","journal-title":"Hum Reprod."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e1216","DOI":"10.1542\/peds.2013-1429","article-title":"Hypospadias and residential proximity to pesticide applications","volume":"132","author":"Carmichael","year":"2013","journal-title":"Pediatrics."},{"key":"B11","doi-asserted-by":"publisher","first-page":"786","DOI":"10.3389\/fendo.2018.00786","article-title":"Endocrine disrupting chemicals interfere with leydig cell hormone pathways during testicular descent in idiopathic cryptorchidism","volume":"9","author":"Fenichel","year":"2018","journal-title":"Front Endocrinol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1359\/jbmr.080204","article-title":"Mutations in the insulin-like factor 3 receptor are associated with osteoporosis","volume":"23","author":"Ferlin","year":"2008","journal-title":"J Bone Miner Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"548","DOI":"10.2164\/jandrol.106.002345","article-title":"Elevated end-of-treatment serum INSL3 is associated with failure to completely suppress spermatogenesis in men receiving male hormonal contraception","volume":"28","author":"Amory","year":"2007","journal-title":"J Androl."},{"key":"B14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1289\/ehp.10753","article-title":"Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004","volume":"116","author":"Calafat","year":"2008","journal-title":"Environ Health Perspect."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1289\/ehp.0901716","article-title":"Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A","volume":"118","author":"Vandenberg","year":"2010","journal-title":"Environ Health Perspect."},{"key":"B16","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1080\/19440049.2013.868611","article-title":"A survey of bisphenol A and other bisphenol analogues in foodstuffs from nine cities in China","volume":"31","author":"Liao","year":"2013","journal-title":"Food Addit Contam Part A Chem Anal Control Expo Risk Assess."},{"key":"B17","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/jes.2008.20","article-title":"Bisphenol A (BPA) daily intakes in the United States: estimates from the 2003-2004 NHANES urinary BPA data","volume":"18","author":"Lakind","year":"2008","journal-title":"J Expo Sci Environ Epidemiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/humrep\/deu340","article-title":"A negative correlation between insulin-like peptide 3 and bisphenol A in human cord blood suggests an effect of endocrine disruptors on testicular descent during fetal development","volume":"30","author":"Chevalier","year":"2015","journal-title":"Hum Reprod."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e0169217","DOI":"10.1371\/journal.pone.0169217","article-title":"The association between exposure to environmental bisphenol A and gonadotropic hormone levels among men","volume":"12","author":"Liang","year":"2017","journal-title":"PLoS ONE."},{"key":"B20","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S0045-6535(99)00466-X","article-title":"Bisphenol A: emissions from point sources","volume":"41","author":"Furhacker","year":"2000","journal-title":"Chemosphere."},{"key":"B21","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/toxsci\/56.2.251","article-title":"Bisphenol A and related endocrine disruptors","volume":"56","author":"Safe","year":"2000","journal-title":"Toxicol Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"13136","DOI":"10.1021\/es303960k","article-title":"Distribution and preliminary exposure assessment of bisphenol AF (BPAF) in various environmental matrices around a manufacturing plant in China","volume":"46","author":"Song","year":"2012","journal-title":"Environ Sci Technol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"A703","DOI":"10.1289\/ehp.110-1241091","article-title":"Parent bisphenol A accumulation in the human maternal-fetal-placental unit","volume":"110","author":"Schonfelder","year":"2002","journal-title":"Environ Health Perspect."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5015507","DOI":"10.1002\/bmc.345","article-title":"Determination of bisphenol A in human breast milk by HPLC with column-switching and fluorescence detection","volume":"18","author":"Sun","year":"2004","journal-title":"Biomed Chromatogr."},{"key":"B25","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.tips.2011.01.001","article-title":"Impacts of environmental toxicants on male reproductive dysfunction","volume":"32","author":"Wong","year":"2011","journal-title":"Trends Pharmacol Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.envpol.2018.12.006","article-title":"In utero exposure to bisphenol A disrupts fetal testis development in rats","volume":"246","author":"Lv","year":"2019","journal-title":"Environ Pollut."},{"key":"B27","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s11010-019-03540-9","article-title":"Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes","volume":"458","author":"Soundararajan","year":"2019","journal-title":"Mol Cell Biochem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.toxlet.2006.08.012","article-title":"Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor gamma (ERRgamma) with high constitutive activity","volume":"167","author":"Takayanagi","year":"2006","journal-title":"Toxicol Lett."},{"key":"B29","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1093\/toxsci\/kft245","article-title":"Exposure to bisphenol A exacerbates migraine-like behaviors in a multibehavior model of rat migraine","volume":"137","author":"Vermeer","year":"2014","journal-title":"Toxicol Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1210\/en.2015-1924","article-title":"BPA Directly Decreases GnRH neuronal activity via noncanonical pathway","volume":"157","author":"Klenke","year":"2016","journal-title":"Endocrinology."},{"key":"B31","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1530\/REP-13-0423","article-title":"Bisphenol A modulates the metabolic regulator oestrogen-related receptor-alpha in T-cells","volume":"147","author":"Cipelli","year":"2014","journal-title":"Reproduction."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1182\/blood-2002-05-1546","article-title":"Induction of C\/EBPalpha activity alters gene expression and differentiation of human CD34+ cells","volume":"101","author":"Cammenga","year":"2003","journal-title":"Blood."},{"key":"B33","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.chemosphere.2016.11.066","article-title":"Activation of G protein-coupled receptor 30 by thiodiphenol promotes proliferation of estrogen receptor alpha-positive breast cancer cells","volume":"169","author":"Lei","year":"2017","journal-title":"Chemosphere."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1007\/s11356-018-3780-6","article-title":"The modulatory role of low concentrations of bisphenol A on tamoxifen-induced proliferation and apoptosis in breast cancer cells","volume":"26","author":"Huang","year":"2019","journal-title":"Environ Sci Pollut Res Int."},{"key":"B35","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1002\/(SICI)1097-4636(19990605)45:3&lt;192::AID-JBM5&gt;3.0.CO;2-A","article-title":"Estrogenicity of bisphenol A and bisphenol A dimethacrylate in vitro","volume":"45","author":"Schafer","year":"1999","journal-title":"J Biomed Mater Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1177\/0748233715603847","article-title":"The toxicological effects of bisphenol A and octylphenol on the reproductive system of prepubertal male rats","volume":"33","author":"Ahbab","year":"2017","journal-title":"Toxicol Ind Health."},{"key":"B37","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.mce.2018.03.003","article-title":"Bisphenol A stimulates differentiation of rat stem Leydig cells in vivo and in vitro","volume":"474","author":"Chen","year":"2018","journal-title":"Mol Cell Endocrinol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1699-0463.1998.tb01314.x","article-title":"Germ cell cancer and disorders of spermatogenesis: an environmental connection?","volume":"106","author":"Skakkebaek","year":"1998","journal-title":"APMIS."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1289\/EHP150","article-title":"Serum testosterone concentrations and urinary bisphenol A, Benzophenone-3, Triclosan, and paraben levels in male and female children and adolescents: NHANES 2011-2012","volume":"124","author":"Scinicariello","year":"2016","journal-title":"Environ Health Perspect."},{"key":"B40","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ijheh.2016.10.004","article-title":"Urine bisphenol A and pubertal development in boys","volume":"220","author":"Wang","year":"2017","journal-title":"Int J Hyg Environ Health."},{"key":"B41","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.fertnstert.2014.11.005","article-title":"A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound","volume":"103","author":"Eladak","year":"2015","journal-title":"Fertil Steril."},{"key":"B42","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.anireprosci.2019.06.006","article-title":"Do G-protein coupled estrogen receptor and bisphenol A analogs influence on Leydig cell epigenetic regulation in immature boar testis ex vivo?","volume":"207","author":"Pawlicki","year":"2019","journal-title":"Anim Reprod Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.tiv.2016.11.003","article-title":"Comparative toxicity, oxidative stress and endocrine disruption potential of plasticizers in JEG-3 human placental cells","volume":"38","author":"Perez-Albaladejo","year":"2017","journal-title":"Toxicol In Vitro."},{"key":"B44","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1210\/me.2004-0486","article-title":"Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes","volume":"19","author":"Bjornstrom","year":"2005","journal-title":"Mol Endocrinol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S1043-2760(98)00089-7","article-title":"The roles of oestrogen in the male","volume":"9","author":"Sharpe","year":"1998","journal-title":"Trends Endocrinol Metab."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1126\/science.286.5448.2328","article-title":"Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta","volume":"286","author":"Couse","year":"1999","journal-title":"Science."},{"key":"B47","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1590\/S0004-27302009000800005","article-title":"Estrogen receptors and function in the male reproductive system","volume":"53","author":"Lazari","year":"2009","journal-title":"Arq Bras Endocrinol Metabol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/bs.ctdb.2016.12.005","article-title":"Estrogen hormone biology","volume":"125","author":"Hamilton","year":"2017","journal-title":"Curr Top Dev Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/331091a0","article-title":"Identification of a new class of steroid hormone receptors","volume":"331","author":"Giguere","year":"1988","journal-title":"Nature."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1016\/j.bbadis.2015.06.016","article-title":"Constitutive activities of estrogen-related receptors: transcriptional regulation of metabolism by the ERR pathways in health and disease","volume":"1852","author":"Huss","year":"2015","journal-title":"Biochim Biophys Acta."},{"key":"B51","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0022-2836(03)00183-9","article-title":"Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition","volume":"327","author":"Gearhart","year":"2003","journal-title":"J Mol Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"4270","DOI":"10.1093\/emboj\/18.15.4270","article-title":"Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha, but not by ERbeta","volume":"18","author":"Vanacker","year":"1999","journal-title":"EMBO J."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1210\/mend.14.10.0532","article-title":"Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF","volume":"14","author":"Filardo","year":"2000","journal-title":"Mol Endocrinol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1210\/en.2004-1064","article-title":"Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells","volume":"146","author":"Thomas","year":"2005","journal-title":"Endocrinology."},{"key":"B55","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1210\/mend.16.1.0758","article-title":"Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis","volume":"16","author":"Filardo","year":"2002","journal-title":"Mol Endocrinol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.0022-202X.2004.12645.x","article-title":"17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression","volume":"123","author":"Kanda","year":"2004","journal-title":"J Invest Dermatol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1002\/hep.26752","article-title":"G-protein-coupled receptor 30\/adenylyl cyclase\/protein kinase A pathway is involved in estradiol 17ss-D-glucuronide-induced cholestasis","volume":"59","author":"Zucchetti","year":"2014","journal-title":"Hepatology."},{"key":"B58","doi-asserted-by":"publisher","first-page":"472720","DOI":"10.1155\/2013\/472720","article-title":"G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth","volume":"2013","author":"Petrie","year":"2013","journal-title":"Obstet Gynecol Int."},{"key":"B59","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1111\/j.1471-4159.2011.07270.x","article-title":"Estrogen destabilizes microtubules through an ion-conductivity-independent TRPV1 pathway","volume":"117","author":"Goswami","year":"2011","journal-title":"J Neurochem."},{"key":"B60","doi-asserted-by":"publisher","first-page":"C1262","DOI":"10.1152\/ajpcell.00501.2010","article-title":"G protein-coupled estrogen receptor 1-mediated effects in the rat myometrium","volume":"301","author":"Tica","year":"2011","journal-title":"Am J Physiol Cell Physiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1016\/j.celrep.2018.01.043","article-title":"Deciphering cell lineage specification during male sex determination with single-cell RNA sequencing","volume":"22","author":"Stevant","year":"2018","journal-title":"Cell Rep."},{"key":"B62","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/S0890-6238(03)00096-0","article-title":"Ultrastructural modifications in the mitochondrion of mouse Sertoli cells after inhalation of lead, cadmium or lead-cadmium mixture","volume":"17","author":"Bizarro","year":"2003","journal-title":"Reprod Toxicol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1242\/dev.01239","article-title":"Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination","volume":"131","author":"Schmahl","year":"2004","journal-title":"Development."},{"key":"B64","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1242\/dev.103.3.535","article-title":"The fate of fetal Leydig cells during the development of the fetal and postnatal rat testis","volume":"103","author":"Kerr","year":"1988","journal-title":"Development."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1210\/me.2015-1200","article-title":"Fetal leydig cells persist as an androgen-independent subpopulation in the postnatal testis","volume":"29","author":"Shima","year":"2015","journal-title":"Mol Endocrinol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.1210\/endo.139.9.6183","article-title":"Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells","volume":"139","author":"Ge","year":"1998","journal-title":"Endocrinology."},{"key":"B67","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1530\/jrf.0.1180195","article-title":"Ontogeny of oestrogen receptor alpha in gonads and sex ducts of fetal and newborn mice","volume":"118","author":"Nielsen","year":"2000","journal-title":"J Reprod Fertil."},{"key":"B68","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1677\/joe.0.1530485","article-title":"Immunolocalisation of oestrogen receptor-alpha within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood","volume":"153","author":"Fisher","year":"1997","journal-title":"J Endocrinol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1210\/en.2008-1311","article-title":"Increased exposure to estrogens disturbs maturation, steroidogenesis, and cholesterol homeostasis via estrogen receptor alpha in adult mouse Leydig cells","volume":"150","author":"Strauss","year":"2009","journal-title":"Endocrinology."},{"key":"B70","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1677\/joe.0.1650359","article-title":"Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs","volume":"165","author":"Pelletier","year":"2000","journal-title":"J Endocrinol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"R13","DOI":"10.1677\/joe.0.156r013","article-title":"Expression of oestrogen receptor beta (ER beta) occurs in multiple cell types, including some germ cells, in the rat testis","volume":"156","author":"Saunders","year":"1998","journal-title":"J Endocrinol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1210\/endo.139.6.6028","article-title":"Transcription and translation of estrogen receptor-beta in the male reproductive tract of estrogen receptor-alpha knock-out and wild-type mice","volume":"139","author":"Rosenfeld","year":"1998","journal-title":"Endocrinology."},{"key":"B73","doi-asserted-by":"publisher","first-page":"e92425","DOI":"10.1371\/journal.pone.0092425","article-title":"Activation of GPER-1 estradiol receptor downregulates production of testosterone in isolated rat Leydig cells and adult human testis","volume":"9","author":"Vaucher","year":"2014","journal-title":"PLoS ONE."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1097\/01.ju.0000179540.28209.de","article-title":"Immunolocalization of androgen receptor and estrogen receptors alpha and beta in human fetal testis and epididymis","volume":"174","author":"Shapiro","year":"2005","journal-title":"J Urol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1093\/humrep\/dem091","article-title":"Human fetal testis: source of estrogen and target of estrogen action","volume":"22","author":"Boukari","year":"2007","journal-title":"Hum Reprod."},{"key":"B76","doi-asserted-by":"publisher","first-page":"4835","DOI":"10.1210\/jcem.85.12.7029","article-title":"Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs","volume":"85","author":"Pelletier","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"key":"B77","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00418-014-1216-z","article-title":"Expression pattern of estrogen receptors alpha and beta and G-protein-coupled estrogen receptor 1 in the human testis","volume":"142","author":"Fietz","year":"2014","journal-title":"Histochem Cell Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"15840","DOI":"10.1038\/ncomms15840","article-title":"Insufficient antibody validation challenges oestrogen receptor beta research","volume":"8","author":"Andersson","year":"2017","journal-title":"Nat Commun."},{"key":"B79","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.tice.2018.04.003","article-title":"Insights into the role of estrogen-related receptors alpha, beta and gamma in tumor Leydig cells","volume":"52","author":"Kotula-Balak","year":"2018","journal-title":"Tissue Cell."},{"key":"B80","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1210\/en.2002-220292","article-title":"Estrogen receptor-alpha gene deficiency enhances androgen biosynthesis in the mouse Leydig cell","volume":"144","author":"Akingbemi","year":"2003","journal-title":"Endocrinology."},{"key":"B81","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1530\/REP-07-0025","article-title":"The effects of oestrogen receptors alpha and beta on testicular cell number and steroidogenesis in mice","volume":"134","author":"Gould","year":"2007","journal-title":"Reproduction."},{"key":"B82","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S0022-4731(83)80050-8","article-title":"Hormonal regulation of pig Leydig cells in culture","volume":"19","author":"Saez","year":"1983","journal-title":"J Steroid Biochem."},{"key":"B83","doi-asserted-by":"publisher","first-page":"253","DOI":"10.4103\/1008-682X.136447","article-title":"Alterations of gene profiles in Leydig-cell-regenerating adult rat testis after ethane dimethane sulfonate-treatment","volume":"17","author":"Zhang","year":"2015","journal-title":"Asian J Androl."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1210\/en.2001-211352","article-title":"Mullerian inhibiting substance blocks the protein kinase A-induced expression of cytochrome p450 17alpha-hydroxylase\/C(17-20) lyase mRNA in a mouse Leydig cell line independent of cAMP responsive element binding protein phosphorylation","volume":"143","author":"Laurich","year":"2002","journal-title":"Endocrinology."},{"key":"B85","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/75834","article-title":"StARTing to understand cholesterol transfer","volume":"7","author":"Stocco","year":"2000","journal-title":"Nat Struct Biol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1146\/annurev.physiol.63.1.193","article-title":"StAR protein and the regulation of steroid hormone biosynthesis","volume":"63","author":"Stocco","year":"2001","journal-title":"Annu Rev Physiol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1210\/en.2012-2226","article-title":"Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells","volume":"154","author":"Chung","year":"2013","journal-title":"Endocrinology."},{"key":"B88","doi-asserted-by":"publisher","first-page":"5607","DOI":"10.1074\/jbc.M110.188433","article-title":"Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1","volume":"286","author":"Mast","year":"2010","journal-title":"J Biol Chem."},{"key":"B89","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.semcdb.2016.03.003","article-title":"Development, function and fate of fetal Leydig cells","volume":"59","author":"Wen","year":"2016","journal-title":"Semin Cell Dev Biol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1210\/mend.13.5.0272","article-title":"Targeted disruption of the Insl3 gene causes bilateral cryptorchidism","volume":"13","author":"Zimmermann","year":"1999","journal-title":"Mol Endocrinol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/10364","article-title":"Cryptorchidism in mice mutant for Insl3","volume":"22","author":"Nef","year":"1999","journal-title":"Nat Genet."},{"key":"B92","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1210\/me.2010-0330","article-title":"Suppression of insulin-like3 receptor reveals the role of beta-catenin and Notch signaling in gubernaculum development","volume":"25","author":"Kaftanovskaya","year":"2011","journal-title":"Mol Endocrinol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/j.1365-2605.2006.00714.x","article-title":"Peripheral INSL3 concentrations decline with age in a large population of Australian men","volume":"29","author":"Anand-Ivell","year":"2006","journal-title":"Int J Androl."},{"key":"B94","doi-asserted-by":"publisher","first-page":"R87","DOI":"10.1530\/REP-13-0486","article-title":"Insulin-like factor 3 as a monitor of endocrine disruption","volume":"147","author":"Anand-Ivell","year":"2014","journal-title":"Reproduction."},{"key":"B95","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1289\/ehp.1408989","article-title":"Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes","volume":"123","author":"Rochester","year":"2015","journal-title":"Environ Health Perspect."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1093\/humrep\/16.5.1037","article-title":"Oestrogenic potencies of Zeranol, oestradiol, diethylstilboestrol, Bisphenol-A and genistein: implications for exposure assessment of potential endocrine disrupters","volume":"16","author":"Leffers","year":"2001","journal-title":"Hum Reprod."},{"key":"B97","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3390\/biology8020045","article-title":"Estrogenic compounds or adiponectin inhibit cyclic AMP response to human luteinizing hormone in mouse leydig tumor cells","volume":"8","author":"Nguyen","year":"2019","journal-title":"Biology."},{"key":"B98","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/jb\/mvm158","article-title":"Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma","volume":"142","author":"Matsushima","year":"2007","journal-title":"J Biochem."},{"key":"B99","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.mce.2017.05.002","article-title":"Estrogen receptor-related receptor gamma regulates testicular steroidogenesis through direct and indirect regulation of steroidogenic gene expression","volume":"452","author":"Park","year":"2017","journal-title":"Mol Cell Endocrinol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.toxlet.2011.09.001","article-title":"Inhibition of human and rat testicular steroidogenic enzyme activities by bisphenol A","volume":"207","author":"Ye","year":"2011","journal-title":"Toxicol Lett."},{"key":"B101","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1210\/en.2005-0046","article-title":"11\u03b2-Hydroxysteroid dehydrogenase 2 in rat Leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate","volume":"146","author":"Ge","year":"2005","journal-title":"Endocrinology."},{"key":"B102","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00441-005-0006-2","article-title":"Stress hormone and male reproductive function","volume":"322","author":"Hardy","year":"2005","journal-title":"Cell Tissue Res."},{"key":"B103","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.toxlet.2012.10.002","article-title":"Inhibition of human and rat 11beta-hydroxysteroid dehydrogenases activities by bisphenol A","volume":"215","author":"Guo","year":"2012","journal-title":"Toxicol Lett."},{"key":"B104","doi-asserted-by":"publisher","first-page":"4117","DOI":"10.1210\/en.2005-0300","article-title":"Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor","volume":"146","author":"De Gendt","year":"2005","journal-title":"Endocrinology."},{"key":"B105","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1096\/fj.14-255729","article-title":"Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and men","volume":"29","author":"O'hara","year":"2014","journal-title":"FASEB J."},{"key":"B106","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/dvg.1020080103","article-title":"Beta-glucuronidase activity is present in the microscopic epididymis of the Tfm\/Y mouse","volume":"8","author":"Scott","year":"1987","journal-title":"Dev Genet."},{"key":"B107","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1677\/joe.0.1310443","article-title":"Testicular steroidogenesis in the testicular feminized (Tfm) mouse: loss of 17 alpha-hydroxylase activity","volume":"131","author":"Murphy","year":"1991","journal-title":"J Endocrinol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/toxsci\/kfg150","article-title":"Antiandrogenic effects of bisphenol A and nonylphenol on the function of androgen receptor","volume":"75","author":"Lee","year":"2003","journal-title":"Toxicol Sci."},{"key":"B109","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1095\/biolreprod.112.107052","article-title":"Aging and luteinizing hormone effects on reactive oxygen species production and DNA damage in rat Leydig cells","volume":"88","author":"Beattie","year":"2013","journal-title":"Biol Reprod."},{"key":"B110","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.mce.2015.03.013","article-title":"Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse leydig cells","volume":"409","author":"Chen","year":"2015","journal-title":"Mol Cell Endocrinol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/1933719111415547","article-title":"Bisphenol A induces oxidative stress and decreases levels of insulin receptor substrate 2 and glucose transporter 8 in rat testis","volume":"19","author":"D'cruz","year":"2012","journal-title":"Reprod Sci."},{"key":"B112","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1177\/0748233712446728","article-title":"Lipoic acid mitigates bisphenol A-induced testicular mitochondrial toxicity in rats","volume":"29","author":"El-Beshbishy","year":"2013","journal-title":"Toxicol Ind Health."},{"key":"B113","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/19396368.2016.1182234","article-title":"Protective effect of Cordyceps militaris extract against bisphenol A induced reproductive damage","volume":"62","author":"Wang","year":"2016","journal-title":"Syst Biol Reprod Med."},{"key":"B114","doi-asserted-by":"publisher","first-page":"21635","DOI":"10.1007\/s11356-018-2229-2","article-title":"Alteration in apoptotic rate of testicular cells and sperms following administration of Bisphenol A (BPA) in Wistar albino rats","volume":"25","author":"Srivastava","year":"2018","journal-title":"Environ Sci Pollut Res Int."},{"key":"B115","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1046\/j.1525-1373.2000.22402.x","article-title":"Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals","volume":"224","author":"Gupta","year":"2000","journal-title":"Proc Soc Exp Biol Med."},{"key":"B116","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1093\/toxsci\/kfi198","article-title":"Gene expression changes induced in the testis by transplacental exposure to high and low doses of 17{alpha}-ethynyl estradiol, genistein, or bisphenol A","volume":"86","author":"Naciff","year":"2005","journal-title":"Toxicol Sci."},{"key":"B117","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1002\/bdrb.21020","article-title":"Effects of transplacental 17-alpha-Ethynyl estradiol or bisphenol A on the developmental profile of steroidogenic acute regulatory protein in the rat testis","volume":"95","author":"Horstman","year":"2012","journal-title":"Birth Defects Res B Dev Reprod Toxicol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"375","DOI":"10.2486\/indhealth.40.375","article-title":"Effects of in utero and lactational exposure to bisphenol A on somatic growth and anogenital distance in F1 rat offspring","volume":"40","author":"Kobayashi","year":"2002","journal-title":"Ind Health."},{"key":"B119","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/toxsci\/kfm306","article-title":"Gestational and lactational exposure to ethinyl estradiol, but not bisphenol A, decreases androgen-dependent reproductive organ weights and epididymal sperm abundance in the male long evans hooded rat","volume":"102","author":"Howdeshell","year":"2008","journal-title":"Toxicol Sci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1289\/ehp.5440","article-title":"Aggressive behavior and serum testosterone concentration during the maturation process of male mice: the effects of fetal exposure to bisphenol A","volume":"111","author":"Kawai","year":"2003","journal-title":"Environ Health Perspect."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.taap.2018.03.021","article-title":"Effects of continuous bisphenol A exposure from early gestation on 90day old rat testes function and sperm molecular profiles: A CLARITY-BPA consortium study","volume":"347","author":"Dere","year":"2018","journal-title":"Toxicol Appl Pharmacol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1095\/biolreprod.111.095349","article-title":"The industrial chemical bisphenol A (BPA) interferes with proliferative activity and development of steroidogenic capacity in rat leydig cells","author":"Nanjappa","year":"2012","journal-title":"Biol Reprod."},{"key":"B123","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.reprotox.2005.10.003","article-title":"Effects of bisphenol A given neonatally on reproductive functions of male rats","volume":"22","author":"Kato","year":"2006","journal-title":"Reprod Toxicol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1210\/en.2003-1174","article-title":"Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells","volume":"145","author":"Akingbemi","year":"2004","journal-title":"Endocrinology."},{"key":"B125","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1034\/j.1600-0722.2002.11201.x","article-title":"Effects of bisphenol A on adult male mouse fertility","volume":"110","author":"Al-Hiyasat","year":"2002","journal-title":"Eur J Oral Sci."},{"key":"B126","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1016\/S0024-3205(99)00502-0","article-title":"Exposure with the environmental estrogen bisphenol A disrupts the male reproductive tract in young mice","volume":"65","author":"Takao","year":"1999","journal-title":"Life Sci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.toxlet.2010.02.002","article-title":"Bisphenol A may cause testosterone reduction by adversely affecting both testis and pituitary systems similar to estradiol","volume":"194","author":"Nakamura","year":"2010","journal-title":"Toxicol Lett."},{"key":"B128","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1177\/153537020122600309","article-title":"Bisphenol A inhibits testicular functions and increases luteinizing hormone secretion in adult male rats","volume":"226","author":"Tohei","year":"2001","journal-title":"Exp Biol Med."},{"key":"B129","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1191\/0960327106ht638oa","article-title":"Effect of prenatal exposure to bisphenol A on the serum testosterone concentration of rats at birth","volume":"25","author":"Tanaka","year":"2006","journal-title":"Hum Exp Toxicol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1007\/s11356-012-0827-y","article-title":"Effects of perinatal exposure to bisphenol A and di(2-ethylhexyl)-phthalate on gonadal development of male mice","volume":"19","author":"Xi","year":"2011","journal-title":"Environ Sci Pollut Res Int."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.fct.2011.11.041","article-title":"Bisphenol A impairs insulin signaling and glucose homeostasis and decreases steroidogenesis in rat testis: an in vivo and in silico study","volume":"50","author":"D'cruz","year":"2012","journal-title":"Food Chem Toxicol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/toxsci\/kfu070","article-title":"Localization of cytochrome P450 and related enzymes in adult rat testis and downregulation by estradiol and bisphenol A","volume":"140","author":"Gilibili","year":"2014","journal-title":"Toxicol Sci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1093\/humrep\/der451","article-title":"Unconjugated bisphenol A cord blood levels in boys with descended or undescended testes","volume":"27","author":"Fenichel","year":"2012","journal-title":"Hum Reprod."},{"key":"B134","doi-asserted-by":"publisher","first-page":"973154","DOI":"10.1155\/2015\/973154","article-title":"Serum bisphenol A level in boys with cryptorchidism: a step to male infertility?","volume":"2015","author":"Komarowska","year":"2015","journal-title":"Int J Endocrinol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.reprotox.2015.11.002","article-title":"Bisphenol A and other phenols in human placenta from children with cryptorchidism or hypospadias","volume":"59","author":"Fernandez","year":"2016","journal-title":"Reprod Toxicol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1002\/bdra.22845","article-title":"In utero exposure to bisphenol-A and anogenital distance of male offspring","volume":"91","author":"Miao","year":"2011","journal-title":"Birth Defects Res Part A Clin Mol Teratol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1093\/humrep\/dev327","article-title":"Associations between maternal phenolic exposure and cord sex hormones in male newborns","volume":"31","author":"Liu","year":"2016","journal-title":"Hum Reprod."},{"key":"B138","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.envres.2017.11.002","article-title":"Urinary bisphenol A concentrations are associated with reproductive parameters in young men","volume":"161","author":"Adoamnei","year":"2018","journal-title":"Environ Res."},{"key":"B139","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.envint.2015.07.017","article-title":"Human exposure to endocrine disrupting chemicals and fertility: a case-control study in male subfertility patients","volume":"84","author":"Den Hond","year":"2015","journal-title":"Environ Int."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1021\/es9028292","article-title":"Urinary bisphenol A concentrations in relation to serum thyroid and reproductive hormone levels in men from an infertility clinic","volume":"44","author":"Meeker","year":"2010","journal-title":"Environ Sci Technol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1289\/ehp.1002037","article-title":"Are environmental levels of bisphenol a associated with reproductive function in fertile men?","volume":"118","author":"Mendiola","year":"2010","journal-title":"Environ Health Perspect."},{"key":"B142","doi-asserted-by":"publisher","first-page":"e51579","DOI":"10.1371\/journal.pone.0051579","article-title":"Differential effects of bisphenol A and diethylstilbestrol on human, rat and mouse fetal leydig cell function","volume":"7","author":"N'tumba-Byn","year":"2012","journal-title":"PLoS ONE."},{"key":"B143","doi-asserted-by":"publisher","first-page":"e0117226","DOI":"10.1371\/journal.pone.0117226","article-title":"An investigation of the endocrine-disruptive effects of bisphenol a in human and rat fetal testes","volume":"10","author":"Ben Maamar","year":"2015","journal-title":"PLoS ONE."},{"key":"B144","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1093\/humrep\/dex093","article-title":"Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis","volume":"32","author":"Desdoits-Lethimonier","year":"2017","journal-title":"Hum Reprod."},{"key":"B145","doi-asserted-by":"publisher","first-page":"e0191934","DOI":"10.1371\/journal.pone.0191934","article-title":"Effects of environmental bisphenol A exposures on germ cell development and leydig cell function in the human fetal testis","volume":"13","author":"Eladak","year":"2018","journal-title":"PLoS ONE."},{"key":"B146","doi-asserted-by":"publisher","first-page":"4655","DOI":"10.1021\/jf400445n","article-title":"Concentrations and profiles of bisphenol A and other bisphenol analogues in foodstuffs from the United States and their implications for human exposure","volume":"61","author":"Liao","year":"2013","journal-title":"J Agric Food Chem."},{"key":"B147","doi-asserted-by":"publisher","first-page":"9138","DOI":"10.1021\/es302004w","article-title":"Occurrence of eight bisphenol analogues in indoor dust from the United States and several Asian countries: implications for human exposure","volume":"46","author":"Liao","year":"2012","journal-title":"Environ Sci Technol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"108732","DOI":"10.1016\/j.envres.2019.108732","article-title":"Occurrence, fate and risk assessment of BPA and its substituents in wastewater treatment plant: a review","volume":"178","author":"Hu","year":"2019","journal-title":"Environ Res."},{"key":"B149","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1039\/c2an15961a","article-title":"Detection and quantification of traces of bisphenol A and bisphenol S in paper samples using analytical pyrolysis-GC\/MS","volume":"137","author":"Becerra","year":"2012","journal-title":"Analyst."},{"key":"B150","doi-asserted-by":"publisher","first-page":"113779","DOI":"10.1016\/j.envpol.2019.113779","article-title":"Bisphenol analogue concentrations in human breast milk and their associations with postnatal infant growth","volume":"259","author":"Jin","year":"2019","journal-title":"Environ Pollut."},{"key":"B151","doi-asserted-by":"publisher","first-page":"136100","DOI":"10.1016\/j.scitotenv.2019.136100","article-title":"Serum concentration of bisphenol analogues in pregnant women in China","volume":"707","author":"Li","year":"2019","journal-title":"Sci Total Environ."},{"key":"B152","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.talanta.2010.08.048","article-title":"Quantification of free and total bisphenol A and bisphenol B in human urine by dispersive liquid-liquid microextraction (DLLME) and heart-cutting multidimensional gas chromatography-mass spectrometry (MD-GC\/MS)","volume":"83","author":"Cunha","year":"2010","journal-title":"Talanta."},{"key":"B153","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.tox.2015.01.003","article-title":"Structural bisphenol analogues differentially target steroidogenesis in murine MA-10 Leydig cells as well as the glucocorticoid receptor","volume":"329","author":"Roelofs","year":"2015","journal-title":"Toxicology."},{"key":"B154","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/toxsci\/kfz173","article-title":"Characterization of estrogenic and androgenic activities for bisphenol A-like chemicals (BPs): in vitro estrogen and androgen receptors transcriptional activation, gene regulation, and binding profiles","volume":"172","author":"Pelch","year":"2019","journal-title":"Toxicol Sci."},{"key":"B155","doi-asserted-by":"publisher","first-page":"9954","DOI":"10.1038\/s41598-019-46272-y","article-title":"Discovery of novel oestrogen receptor alpha agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors","volume":"9","author":"Masuya","year":"2019","journal-title":"Sci Rep."},{"key":"B156","doi-asserted-by":"publisher","first-page":"134743","DOI":"10.1016\/j.scitotenv.2019.134743","article-title":"A tiered high-throughput screening approach for evaluation of estrogen and androgen receptor modulation by environmentally relevant bisphenol A substitutes","volume":"717","author":"Keminer","year":"2019","journal-title":"Sci Total Environ."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1021\/tx030011g","article-title":"Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor","volume":"16","author":"Fang","year":"2003","journal-title":"Chem Res Toxicol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/toxsci\/kfu231","article-title":"Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and alpha-fetoprotein","volume":"143","author":"Hong","year":"2015","journal-title":"Toxicol Sci."},{"key":"B159","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/toxsci\/kfi074","article-title":"Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds","volume":"84","author":"Kitamura","year":"2005","journal-title":"Toxicol Sci."},{"key":"B160","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.yrtph.2015.01.002","article-title":"Endocrine activity of alternatives to BPA found in thermal paper in Switzerland","volume":"71","author":"Goldinger","year":"2015","journal-title":"Regul Toxicol Pharmacol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1289\/ehp.0901819","article-title":"Bisphenol AF is a full agonist for the estrogen receptor ERalpha but a highly specific antagonist for ERbeta","volume":"118","author":"Matsushima","year":"2010","journal-title":"Environ Health Perspect."},{"key":"B162","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/tox.22554","article-title":"Mechanism of bisphenol AF-induced progesterone inhibition in human chorionic gonadotrophin-stimulated mouse Leydig tumor cell line (mLTC-1) cells","volume":"33","author":"Feng","year":"2018","journal-title":"Environ Toxicol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1093\/toxsci\/kfu081","article-title":"A short-term in vivo screen using fetal testosterone production, a key event in the phthalate adverse outcome pathway, to predict disruption of sexual differentiation","volume":"140","author":"Furr","year":"2014","journal-title":"Toxicol Sci."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1177\/0960327119862335","article-title":"Prenatal BPA and its analogs BPB, BPF, and BPS exposure and reproductive axis function in the male offspring of Sprague Dawley rats","volume":"38","author":"Ullah","year":"2019","journal-title":"Hum Exp Toxicol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.chemosphere.2018.06.089","article-title":"Bisphenol A and its analogs bisphenol B, bisphenol F, and bisphenol S: Comparative in vitro and in vivo studies on the sperms and testicular tissues of rats","volume":"209","author":"Ullah","year":"2018","journal-title":"Chemosphere."},{"key":"B166","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.fct.2018.08.024","article-title":"Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: A focus on the possible hormonal mode of action","volume":"121","author":"Ullah","year":"2018","journal-title":"Food Chem Toxicol."}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00447\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T07:38:51Z","timestamp":1667633931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00447\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":166,"alternative-id":["10.3389\/fendo.2020.00447"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.00447","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,31]]},"article-number":"447"}}