{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:00:29Z","timestamp":1782730829139,"version":"3.54.5"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.00470","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T04:24:09Z","timestamp":1595391849000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Is the Observed Decrease in Body Temperature During Industrialization Due to Thyroid Hormone-Dependent Thermoregulation Disruption?"],"prefix":"10.3389","volume":"11","author":[{"given":"Pieter","family":"Vancamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Demeneix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e49555","DOI":"10.7554\/eLife.49555","article-title":"Decreasing human body temperature in the United States since the industrial revolution","volume":"9","author":"Protsiv","year":"2020","journal-title":"Elife."},{"key":"B2","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1055\/a-1014-2510","article-title":"More than fever - novel concepts in the regulation of body temperature by thyroid hormones","volume":"128","author":"Mittag","year":"2019","journal-title":"Exp Clin Endocrinol Diabetes."},{"key":"B3","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/nrendo.2013.238","article-title":"Thyroid hormones and skeletal muscle\u2014new insights and potential implications","volume":"10","author":"Salvatore","year":"2014","journal-title":"Nat Rev Endocrinol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1152\/physrev.00009.2005","article-title":"Thermogenic mechanisms and their hormonal regulation","volume":"86","author":"Silva","year":"2006","journal-title":"Physiol Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1210\/jc.82.4.1118","article-title":"Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement 1","volume":"82","author":"Al-Adsani","year":"1997","journal-title":"J Clin Endocrinol Metab."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1210\/jc.2017-00224","article-title":"Thyroid function variation in the normal range, energy expenditure, and body composition in L-T4\u2013Treated Subjects","volume":"102","author":"Samuels","year":"2017","journal-title":"J Clin Endocrinol Metab."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1002\/1873-3468.13070","article-title":"Of mice and men - environmental temperature, body temperature, and treatment of obesity","volume":"592","author":"Reitman","year":"2018","journal-title":"FEBS Lett."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1073\/pnas.1616255114","article-title":"A hypothalamic circuit that controls body temperature","volume":"114","author":"Zhao","year":"2017","journal-title":"Proc Natl Acad Sci USA."},{"key":"B9","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.molmet.2019.05.005","article-title":"At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1","volume":"25","author":"Dittner","year":"2019","journal-title":"Mol Metab."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.1016\/j.celrep.2019.05.054","article-title":"Thyroid-Hormone-Induced Browning of white adipose tissue does not contribute to thermogenesis and glucose consumption","volume":"27","author":"Johann","year":"2019","journal-title":"Cell Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.molmet.2016.01.008","article-title":"Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance","volume":"5","author":"Alvarez-Crespo","year":"2016","journal-title":"Mol Metab."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1210\/en.2004-1544","article-title":"Temperature homeostasis in transgenic mice lacking thyroid hormone receptor-\u03b1 gene products","volume":"146","author":"Marrif","year":"2005","journal-title":"Endocrinology."},{"key":"B13","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1093\/emboj\/17.2.455","article-title":"Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1","volume":"17","author":"Wikstrom","year":"1998","journal-title":"EMBO J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"16241","DOI":"10.1073\/pnas.1310300110","article-title":"Inappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor 1","volume":"110","author":"Warner","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B15","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10540-005-2885-6","article-title":"Adaptive activation of thyroid hormone and energy expenditure","volume":"25","author":"Bianco","year":"2005","journal-title":"Biosci Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1210\/jc.2016-3086","article-title":"Human brown adipose tissue temperature and fat fraction are related to its metabolic activity","volume":"102","author":"Koskensalo","year":"2017","journal-title":"J Clin Endocrinol Metab."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1136\/bmj.1.1744.1180","article-title":"Sporadic cretinism treated by administration of the thyroid gland","volume":"1","author":"Railton","year":"1894","journal-title":"BMJ."},{"key":"B18","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1136\/bmj.2.1606.796","article-title":"Note on the treatment of myx dema by hypodermic injections of an extract of the thyroid gland of a sheep","volume":"2","author":"Murray","year":"1891","journal-title":"BMJ."},{"key":"B19","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/BF01708403","article-title":"Myxoedema coma: response of thyroid hormones with oral and intravenous high-dose L-thyroxine treatment","volume":"17","author":"Arlot","year":"1991","journal-title":"Intensive Care Med."},{"key":"B20","first-page":"23","article-title":"Supraphysiological cyclic dosing of sustained release T3 in order to reset low basal body temperature","volume":"25","author":"Friedman","year":"2006","journal-title":"Health Sci J."},{"key":"B21","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1001\/jama.2019.9052","article-title":"Subclinical hypothyroidism","volume":"322","author":"Biondi","year":"2019","journal-title":"JAMA."},{"key":"B22","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/j.1365-2265.2009.03697.x","article-title":"Metabolic cardiovascular disease risk factors and their clustering in subclinical hypothyroidism","volume":"72","author":"Ashizawa","year":"2010","journal-title":"Clin Endocrinol."},{"key":"B23","unstructured":"DemeneixB\n            SlamaR\n          Endocrine Disruptors: From Scientific Evidence to Human Health Protection.2019"},{"key":"B24","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.mce.2011.09.005","article-title":"Thyroid effects of endocrine disrupting chemicals","volume":"355","author":"Boas","year":"2012","journal-title":"Mol Cell Endocrinol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"A118","DOI":"10.1289\/EHP358","article-title":"Project TENDR: targeting environmental neuro-developmental risks the TENDR consensus statement","volume":"124","author":"Bennett","year":"2016","journal-title":"Environ Health Perspect."},{"key":"B26","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S2213-8587(15)00327-7","article-title":"Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study","volume":"4","author":"Korevaar","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"105123","DOI":"10.1016\/j.envint.2019.105123","article-title":"Association of urinary bisphenols and triclosan with thyroid function during early pregnancy","volume":"133","author":"Derakhshan","year":"2019","journal-title":"Environ Int."},{"key":"B28","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1172\/JCI65252","article-title":"Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions","volume":"123","author":"Mittag","year":"2013","journal-title":"J Clin Invest."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e12573","DOI":"10.1111\/jne.12573","article-title":"Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area","volume":"30","author":"Harder","year":"2018","journal-title":"J Neuroendocrinol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1289\/ehp.1002727","article-title":"Environmental chemicals in pregnant women in the United States: NHANES 2003\u20132004","volume":"119","author":"Woodruff","year":"2011","journal-title":"Environ Health Perspect."},{"key":"B31","doi-asserted-by":"publisher","first-page":"43786","DOI":"10.1038\/srep43786","article-title":"Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in xenopus embryos","volume":"7","author":"Fini","year":"2017","journal-title":"Sci Rep."},{"key":"B32","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.etap.2010.03.002","article-title":"Subacute toxicity of p,p\u2032-DDT on rat thyroid: Hormonal and histopathological changes","volume":"29","author":"Tebourbi","year":"2010","journal-title":"Environ Toxicol Pharmacol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.envint.2007.12.001","article-title":"Thyroid disruption at birth due to prenatal exposure to \u03b2-hexachlorocyclohexane","volume":"34","author":"\u00c1lvarez-Pedrerol","year":"2008","journal-title":"Environ Int."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e103337","DOI":"10.1371\/journal.pone.0103337","article-title":"Perinatal exposure of mice to the pesticide ddt impairs energy expenditure and metabolism in adult female offspring","volume":"9","author":"La Merrill","year":"2014","journal-title":"PLoS ONE."},{"key":"B35","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3109\/07420528.2014.983603","article-title":"Evidence of a diurnal thermogenic handicap in obesity","volume":"32","author":"Grimaldi","year":"2015","journal-title":"Chronobiol Int."},{"key":"B36","doi-asserted-by":"publisher","first-page":"101","DOI":"10.2147\/DMSO.S95296","article-title":"Early-life chemical exposures and risk of metabolic syndrome","volume":"10","author":"De Long","year":"2017","journal-title":"Diabetes Metab Syndr Obes."},{"key":"B37","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/nrendo.2017.51","article-title":"Endocrine-disrupting chemicals and the regulation of energy balance","volume":"13","author":"Nadal","year":"2017","journal-title":"Nat Rev Endocrinol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1126\/science.aat9219","article-title":"Regulate to reduce chemical mixture risk","volume":"361","author":"Kortenkamp","year":"2018","journal-title":"Science."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.3390\/ijms18122583","article-title":"Thyroid disrupting chemicals","volume":"18","author":"Calsolaro","year":"2017","journal-title":"Int J Mol Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3389\/fendo.2019.00743","article-title":"Pesticides with potential thyroid hormone-disrupting effects: a review of recent data","volume":"10","author":"Leemans","year":"2019","journal-title":"Front Endocrinol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1136\/oemed-2017-104431","article-title":"Occupational pesticide exposure and subclinical hypothyroidism among male pesticide applicators","volume":"75","author":"Lerro","year":"2018","journal-title":"Occup Environ Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"5185","DOI":"10.1210\/jc.2002-020209","article-title":"Thyroid hormone action is disrupted by bisphenol a as an antagonist","volume":"87","author":"Moriyama","year":"2002","journal-title":"J Clin Endocrinol Metab."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e33814","DOI":"10.1371\/journal.pone.0033814","article-title":"Short-Term treatment with bisphenol-a leads to metabolic abnormalities in adult male mice","volume":"7","author":"Batista","year":"2012","journal-title":"PLoS ONE."},{"key":"B44","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.metabol.2017.01.024","article-title":"Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo","volume":"70","author":"Scotney","year":"2017","journal-title":"Metabolism."},{"key":"B45","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.physbeh.2017.05.026","article-title":"The mouse thermoregulatory system: its impact on translating biomedical data to humans","volume":"179","author":"Gordon","year":"2017","journal-title":"Physiol Behav."}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00470\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T04:24:16Z","timestamp":1595391856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00470\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":45,"alternative-id":["10.3389\/fendo.2020.00470"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.00470","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,22]]},"article-number":"470"}}